Effects of Bisphenol A on ion channels: Experimental evidence and molecular mechanisms

Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) produced in huge quantities in the manufacture of polycarbonate plastics and epoxy resins. It is present in most humans in developed countries, acting as a xenoestrogen and it is considered an environmental risk factor associated to several diseases. Among the whole array of identified mechanisms by which BPA can interfere with physiological processes in living organisms, changes on ion channel activity is one of the most poorly understood. There is still little evidence about BPA regulation of ion channel expression and function. However, this information is key to understand how BPA disrupts excitable and non-excitable cells, including neurons, endocrine cells and muscle cells. This report is the result of a comprehensive literature review on the effects of BPA on ion channels. We conclude that there is evidence to say that these important molecules may be key end-points for EDCs acting as xenoestrogens. However, more research on channel-mediated BPA effects is needed. Particularly, mechanistic studies to unravel the pathophysiological actions of BPA on ion channels at environmentally relevant doses.

Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study

A classic T-cell phenotype in systemic lupus erythematosus (SLE) is the downregulation and replacement of the CD3ζ chain that alters T-cell receptor signaling. However, genetic associations with SLE in the human CD247 locus that encodes CD3ζ are not well established and require replication in independent cohorts. Our aim was therefore to examine, localize and validate CD247-SLE association in a large multiethnic population. We typed 44 contiguous CD247 single-nucleotide polymorphisms (SNPs) in 8922 SLE patients and 8077 controls from four ethnically distinct populations. The strongest associations were found in the Asian population (11 SNPs in intron 1, 4.99 × 10(-4) < P < 4.15 × 10(-2)), where we further identified a five-marker haplotype (rs12141731-rs2949655-rs16859085-rs12144621-rs858554; G-G-A-G-A; P(hap) = 2.12 × 10(-5)) that exceeded the most associated single SNP rs858554 (minor allele frequency in controls = 13%; P = 4.99 × 10(-4), odds ratio = 1.32) in significance. Imputation and subsequent association analysis showed evidence of association (P < 0.05) at 27 additional SNPs within intron 1. Cross-ethnic meta-analysis, assuming an additive genetic model adjusted for population proportions, showed five SNPs with significant P-values (1.40 × 10(-3) < P< 3.97 × 10(-2)), with one (rs704848) remaining significant after Bonferroni correction (P(meta) = 2.66 × 10(-2)). Our study independently confirms and extends the association of SLE with CD247, which is shared by various autoimmune disorders and supports a common T-cell-mediated mechanism.

Aclamación de las musas al nacimiento del Principe de las Españas nuestro señor.

Mode of access: Internet.

Diario de la preñez y parto de la Reina Nuestra Señora /

Mode of access: Internet.

The history of the reign of George the Third from his accession in 1760 till the present time : with an introduction exhibiting the state of the chief European nations at the period of his accession /

Sólo los vols. I y IV por Macfarlan

Cours de la science militaire : a l'usage de l'Infanterie, de la Cavalerie, de l'Artillerie, du Genie [et] de la Marine /

Mode of access: Internet.

Le liure des statuts [et] ordonnances de l'Ordre et milice du Benoist Sainct Esprit, etably par le tres-chrestien roy de France [et] de Pologne Henry troisiéme de ce nom.

Mode of access: Internet.

Agnès Sorel et Charles VII : essai sur l'état politique et moral de la France au XVe siècle /

La h. de lám. es un retr. de Agnés Sorel.

Ordenanzas de su magestad para el regimen, disciplina, subordinacion, y servicio de la infanteria, cavalleria, y dragones de sus exercitos, en guarnicion, y en campaña.

Mode of access: Internet.

Sonetos a diferentes assumptos, que recogiò la curiosidad de cierto aficionado a la poesia.

Mode of access: Internet.

Les vies des hommes illustres de la France /

Mode of access: Internet.

La Tromba di ribellione spezzata : Risposta Ad un Libro sedizioso intitolato lo Spartimento del Fauoloso Leone per difesa de' Diritti del Re Cattolico Filippo V.

Mode of access: Internet.

Tesoros de Cornelio á Lápide : extracto de los comentarios de este célebre autor sobre la Sagrada Escritura.

Mode of access: Internet.

Mémoires et correspondance politique et militaire du Roi Joseph /

Contiene : Tom. 1 - Tom. 2 - Tom. 6 - Tom. 7 - Tom. 9.

Oracion funebre con que el Real Colegio de la Compañia de Jesus de Salamanca celebró las Reales Exequias de nuestro joven monarca D. Luis Primero de este nombre, y alguna noticia del aparato lugubre que se dexaba vèr en la Iglesia de dicho Real Colegio /

Mode of access: Internet.