Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

One of the more intriguing aspects of transforming growth factor beta 1 (TGF beta 1) is its ability to function as both a mitogenic factor for certain mesenchymal cells and a potent growth inhibitor of lymphoid, endothelial, and epithelial cells. Data are presented indicating that c-myc may play a pivotal role in both the mitogenic and antiproliferative actions of TGF beta 1. In agreement with previous studies using C3H/10T1/2 fibroblasts constitutively expressing an exogenous c-myc cDNA, we show that AKR-2B fibroblasts expressing a chimeric estrogen-inducible form of c-myc (mycER) are able to form colonies in soft agar in the presence of TGF beta 1 only when c-myc is activated by hormone. Whereas these findings support a synergistic role for c-myc in mitogenic responses to TGF beta 1, we also find that c-myc can antagonize the growth-inhibitory response to TGF beta 1. Mouse keratinocytes (BALB/MK), which are normally growth-arrested by TGF beta 1, are rendered insensitive to the growth-inhibitory effects of TGF beta 1 upon mycER activation. This ability of mycER activation to block TGF beta 1-induced growth arrest was found to occur only when the fusion protein was induced with hormone in the early part of G1. Addition of estradiol late in G1 had no suppressive effect on TGF beta 1-induced growth inhibition.

The Battle of the Bulge: The Surprising Last Stand Against State Marijuana Legalization

Although marijuana possession remains a federal crime, twenty-three states now allow use of marijuana for medical purposes and four states have adopted tax-and-regulate policies permitting use and possession by those twenty-one and over. In this article, I examine recent developments regarding marijuana regulation. I show that the Obama administration, after initially sending mixed signals, has taken several steps indicating an increasingly accepting position toward marijuana law reform in states; however the current situation regarding the dual legal status of marijuana is at best an unstable equilibrium. I also focus on what might be deemed the last stand of marijuana-legalization opponents, in the form of lawsuits filed by several states, sheriffs, and private plaintiffs challenging marijuana reform in Colorado (and by extension elsewhere). This analysis offers insights for federalism scholars regarding the speed with which marijuana law reform has occurred, the positions taken by various state and federal actors, and possible collaborative federalism solutions to the current state-federal standoff.

Sundry extracts on the subject of the taxation of College &c., ca. 1798-1801

Notebook with brown paper cover containing handwritten extracts from the charters and related legislation of New England academic, charitable, and commercial institutions regarding their ability to hold real estate and related tax exemptions. Most of the listed documents are dated in the 1780s and 1790s. The notebook also contains extracts from "Argument in the case of Poor's rate, charged on the College of Christ & Emmanuel in the University of Cambridge 1768." The item title is transcribed from a handwritten inscription on the back cover.

No. 5 Copy of Treasurer's Account of Rents &c, [1799]

Two folio-sized leaves containing a one-page handwritten list of the "Accounts of Houses in Cambridge belonging to the College" with purchase dates between 1790 and 1795, sale prices, and rent amounts, and a list of repair amounts. The statements are attested by Ebenezer Storer, the College Treasurer.

8. Statement of Facts &c, [1799]

One folio-sized leaf containing a handwritten statement of accounting figures titled "Statement of Facts and Modern Estimates: Monies annually paid by or in behalf of the University in Cambridge."

Battle of Cold Harbor, Virginia and vicinity, 1864 (Raster Image)

This layer is a georeferenced raster image of the untitled historic paper manuscript map: [Map of the Battle of Cold Harbor, Virginia and vicinity]. Scale not given. Covers a portion of Hanover County, Virginia, showing features in the region surrounding the Cold Harbor Battlefield, Virginia, 1864. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Virginia State Plane South Coordinate System (in Meters) (Fipszone 4502). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, towns and villages, drainage, dwellings with names of inhabitants, troop locations with dates, and more. This layer is part of a selection of digitally scanned and georeferenced historic maps of the Civil War from the Harvard Map Collection. Many items from this selection are from a collection of maps deposited by the Military Order of the Loyal Legion of the United States Commandery of the State of Massachusetts (MOLLUS) in the Harvard Map Collection in 1938. These maps typically portray both natural and manmade features, in particular showing places of military importance. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Battle of Quebec, Canada, 1759 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Plan of the military & naval operation under the command of the immortal Wolfe, & vice admiral Saunders, before Quebec, J. Wyld, Sculp. ; Alfred Hawkins. It was published by Jas. Wyld, May 1, 1841. Scale [ca. 1:23,700]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Universal Transverse Mercator (UTM) Zone 19N NAD 1983 coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, built-up areas and selected buildings, fortifications, troop and ship dispositions and places of military interest for the Battle of Quebec, 1759, and more. Relief is shown by hachures. Includes indexes, notes, tables, views, and inset: Detail of the action fought on the plains of Abraham Septr. 13th. 1759. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

The 84th infantry division in the battle of Germany, November 1944-May 1945,

"First published ... in May 1946."