Towards and ab initio description of magnetism in ionic solids

The physical contributions to the KNiF3 magnetic exchange coupling integral have been obtained from specially designed ab initio cluster model calculations. Three important mechanisms have been identified. These are the delocalization of the magnetic orbitals into the anion p band, the variational contribution of the second-order interactions, and the many-body terms hidden in the two-body operator and the Heisenberg Hamiltonian.

Clinical characteristics and outcome of inpatients versus outpatients with venous thromboembolism: findings from the RIETE Registry.

BACKGROUND: Patients with venous thromboembolism (VTE) treated with anticoagulants are at risk of death from pulmonary embolism (PE) and/or bleeding. However, whether patients who develop VTE in hospital have a higher complication rate than those who develop VTE in an outpatient setting is unclear. PATIENTS AND METHODS: RIETE is an ongoing, prospective registry of consecutive patients with acute, objectively confirmed, symptomatic VTE. We compared the 3-month incidence of fatal PE and fatal bleeding in patients in whom the VTE had developed while in hospital for another medical condition (inpatients) with those who presented to the emergency ward because of VTE (outpatients). RESULTS: Up to April 2008, 22,133 patients with acute VTE were enrolled: 10,461 (47%) presented with PE, 11,672 with deep vein thrombosis. Overall, 6445 (29%) were inpatients. During the study period, those who developed VTE as inpatients had a significantly higher incidence of fatal PE (2.1% vs. 1.5%; odds ratio: 1.4; 95% CI: 1.1-1.7), overall death (7.0% vs. 5.4%; odds ratio: 1.3; 95% CI: 1.2-1.5), and major bleeding (2.9% vs. 2.1%; odds ratio: 1.4; 95% CI: 1.1-1.6) than outpatients. The incidence of fatal bleeding was not significantly increased (0.7% vs. 0.5%; odds ratio: 1.2; 95% CI: 0.9-1.8). In multivariable analysis, inpatient status was significantly associated with a higher risk for fatal PE (odds ratio: 1.3; 95% CI: 1.1-1.7). CONCLUSIONS: VTE occurring in hospitalized patients carries a significantly higher risk for death of PE than in outpatients, underscoring the importance of VTE prevention strategies in the hospital setting.

El exilio de la razón: Isabel de Bohemia y Simone Weil ante la ciencia cartesiana

Casi 300 años distancian la correspondencia de Isabel de Bohemia con Descartes de la lectura que del autor hace Simone Weil. Las dos, sin embargo, muestran una sutil comprensión de la aportación cartesiana y un empeño por hacerse cargo del significado de la misma en la constitución de la ciencia moderna, considerando las implicaciones de la sustitución de la geometría por el álgebra. Las dos subrayan también las dificultades queencuentran en el cartesianismo a la hora de enfocar la relación entre autoconocimiento einvestigación del mundo natural, un problema cuyas consecuencias centrarán buena partedel debate teórico del siglo XX.La investigación de las posibles coincidencias entre estas lecturas pretende aportar una perspectiva en la que se clarifican aspectos decisivos tanto del interés de estas autoras por la fundarnentación de la ciencia, como de los términos en los que, desde su origen, seplantean problemas que continúan abiertos.Casi 300 años distancian la correspondencia de Isabel de Bohemia con Descartes de la lectura que del autor hace Simone Weil. Las dos, sin embargo, muestran una sutil comprensión de la aportación cartesiana y un empeño por hacerse cargo del significado de la misma en la constitución de la ciencia moderna, considerando las implicaciones de la sustitución de la geometría por el álgebra. Las dos subrayan también las dificultades que encuentran en el cartesianismo a la hora de enfocar la relación entre autoconocimiento einvestigación del mundo natural, un problema cuyas consecuencias centrarán buena partedel debate teórico del siglo XX.La investigación de las posibles coincidencias entre estas lecturas pretende aportar una perspectiva en la que se clarifican aspectos decisivos tanto del interés de estas autoras por la fundarnentación de la ciencia, como de los términos en los que, desde su origen, seplantean problemas que continúan abiertos.

Years of valor,1969.

This book was written by Edith Wasson McElroy and published by the Iowa Civil War Centennial Commission. It follows the Meigs, a fictitious family from the late 1680's in England to 1865 in Iowa. The Meigs personify the way of life, in a typical Iowa home during this period. Their experiences are those of many early Iowa pioneers and brings to life and into reality, early Iowa life and the Civil War in its climax.

COLOX: a new blood-based test for colorectal cancer (CRC)screening

BACKGROUND: The objective is to develop a cost-effective, reliable and non invasive screening test able to detect early CRCs and adenomas. This is done on a nucleic acids multigene assay performed on peripheral blood mononuclear cells (PBMCs). METHODS: A colonoscopy-controlled study was conducted on 179 subjects. 92 subjects (21 CRC, 30 adenoma >1 cm and 41 controls) were used as training set to generate a signature. Other 48 subjects kept blinded (controls, CRC and polyps) were used as a test set. To determine organ and disease specificity 38 subjects were used: 24 with inflammatory bowel disease (IBD),14 with other cancers (OC). Blood samples were taken and PBMCs were purified. After the RNA extraction, multiplex RT-qPCR was applied on 92 different candidate biomarkers. After different univariate and multivariate analysis 60 biomarkers with significant p-values (<0.01) were selected. 2 distinct biomarker signatures are used to separate patients without lesion from those with CRC or with adenoma, named COLOX CRC and COLOX POL. COLOX performances were validated using random resampling method, bootstrap. RESULTS: COLOX CRC and POL tests successfully separate patients without lesions from those with CRC (Se 67%, Sp 93%, AUC 0.87), and from those with adenoma > 1cm (Se 63%, Sp 83%, AUC 0.77). 6/24 patients in the IBD group and 1/14 patients in the OC group have a positive COLOX CRC. CONCLUSION: The two COLOX tests demonstrated a high Se and Sp to detect the presence of CRCs and adenomas > 1 cm. A prospective, multicenter, pivotal study is underway in order to confirm these promising results in a larger cohort.

Towards and ab initio description of magnetism in ionic solids

The physical contributions to the KNiF3 magnetic exchange coupling integral have been obtained from specially designed ab initio cluster model calculations. Three important mechanisms have been identified. These are the delocalization of the magnetic orbitals into the anion p band, the variational contribution of the second-order interactions, and the many-body terms hidden in the two-body operator and the Heisenberg Hamiltonian.

Extranjero, nada menos que una palabra mayor

El articulo, partiendo de la no transparencia del atributo ((extranjeros y tomando como pre-texto a Simmel y Durkheim, analiza la posición social que el ccextranjero* ocupa en el espacio social e imaginari0 de la sociedad de la que forma parte y, asi mismo, el papel que determinadas agencias y agentes sociales juegan en la producción y reproducción de aquella figura social.

[Palestrina. Barrière antique]

Référence bibliographique : Weigert, 322