Avaliação da mutagenicidade e da estrogenicidade dos extratos etanólicos padronizados, frações e substâncias isoladas de Arrabidaea brachypoda (DC.) Bureau

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Atenção temporal e análise da interferência da característica do estímulo na percepção

Attention is a phenomenon that allows the selection of relevant stimuli in order to prioritize them and improve their processing. This modulation could occur in any step of the process: in an early stage or in a late stage, more precisely, in a perceptive or motor stage. However, even with a rich literature about attention in time, there are still some divergences about how this modulation occurs. A hypothesis about it says that temporal attention would only be able to prepare the motor system to respond. The perceptual modulation would only occur when the temporal expectation is in combination with another expectation of a property with neuronal receptive field. In this situation, the receptive field's pre-activation is the explanation of how temporal attention would be capable to modulate perceptual process. The crucial objective was to test this hypothesis. In other words, it was to verify if the feature expectation of a stimulus (Gabor orientation) and its temporal expectancy interferes in perception quality. Two experiments were made: the first one tested the voluntary temporal expectation, and the second one tested the automatic temporal expectation. Our data shows that both Feature-based Attention and Temporal Attention improve the process of perception. Temporal expectation effects just occur in situations of competitive environment. Hypothesis verification was not conclusive, because of methodological problems

Avaliação de atividade mutagênica de Astronium fraxinifolium, Astronium urundeuva e Serjania marginata Casar

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Estudo da especificidade e toxicidade do inibidor de hipusinação GC7 utilizando o modelo de Saccharomyces cerevisiae

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Síntese, caracterização e avaliação farmacológica de derivados N-acilhidrazônicos para a prevenção de aterotrombose

Atherosclerosis is a chronic inflammatory disease characterized by accumulation of lipid and fibrous components in arterial vessels, giving rise to atheromas. Development of Atheromatou plaques leads to arterial steatosis, triggering ischemic events. Atherotrombosis has a strong correlation with atherosclerosis, where rupture of atheromatous plaques cause release of vessel wall's pro-thrombotic components, activating platelet aggregation and thromosis. Due to the major role played by platelets on thrombus-embolic conditions, drugs that inhibit platelet aggregation demonstrate great relevance for atherothrombosis prevention, reducing patient mortality. Currently, there are a variety of drugs acting on several different targets, preventing platelet activation. However, these therapies demosntrate side effects such as thrombocytopenia, neutropenia, hemorrhage and low oral availability. Thus, the application of molecular modifications such as hybridization can produce novel, more efficient antiplatelet aggregation inhibitors. In this project we describe the synthesis and characterization of novel N-acilhydrazone compounds, acting through multiple mechanisms such as platelet calcium chelation and nitric oxide donation by furoxanic subunits. Furthermore, we demonstrate that such compounds exhibit biological activity in in vivo bleeding time, in vitro antiplatelet aggregation and in vivo antinociceptive assays. Therefore, novel N-acilhydrazone compounds demonstrate potential as antiplatelet drugs for atherothrombosis prevention.

A gramática pela fábula ou: a fábula pela gramática

With the purpose of analyzing the function developed byt the fable, this paper begins with its definition, historically linked to the rhetorical art, the teaching force and the literary value, to reach a grammatical analysis of the narrative structure in which genre is presented. From the functionalist point of view, the function determines the structure, and, accordingly, this study shows the fable resolved in specific modes of activation of the utterance formation basic processes such as the establishment of predications and the creation of the referential network of its participants. Since the beginning, the discursive activation of properties is crucial, which, working toward specific goals, configure linguistic characteristics that define the specific nature of the fable

Alterações dimensionais em pacientes submetidos à expansão rápida da maxila com aparelho do tipo Haas

The maxillary atresia is a alteration in the transverse dimension that can result in a unilateral or bilateral crossbite. For correction of atresia of the upper dental arch appliances with the intent to expand the arch of orthopedic or orthodontic manner are used, obtaining across-compatibility between the dental arches. The purpose of this study was to evaluate the dimensional changes of the maxillary in patients in the mixed dentition with atresia in the upper dental arch, using occlusal radiographs taken before, after rapid maxillary expansion and after removal of the appliance. Methods: the sample consisted of 35 patients who used the appliance type conventional Haas, in the mixed dentition, according to the standard protocol for installation, activation, containment and removal of the appliances rapid maxillary expansion. Results: the results confirm that the suture opening occurs in greater quantities in the anterior (4.3 mm) than posterior to (3.74 mm), representing a triangular opening of 7 degrees on average with the posterior opening 87% of the quantity of anterior opening. The molars region expanded about 5 mm, and the base bone 3.7 mm, representing a 74% bone expansion of the expansion teeth.

Necessidade de ancoragem do grupo A e o controle biomecanico da mola T pré-ativada por curvatura para o fechamento de espacos

Contemporary orthodontics has sought, beyond the esthetic, occlusal and functional goals, treatments even faster and with less visits to the orthodontist — especially in patients that require dental extractions in which the generated space becomes a nuisance. The segmented arch technic (SAT), by the use of a "T" loop spring, has provided such results within these requirements. Therefore, this study aimed to appraise and demonstrate the confection, activation and biomechanical control of "T" loop spring, in the group with high anchorage necessity (group A), for retraction of anterior teeth; as well as to present a case report, with high anterior retraction necessity, treated with "T" loop spring.

Efeitos de diferentes sistemas de clareamento dental sobre a rugosidade e morfologia superficial do esmalte e de uma resina composta restauradora

The aim of this study was to evaluate and compare the roughness and superficial morphology of enamel and a composite restorative resin after different bleaching techniques application. Material and Methods: Bovine incisors were selected and standardized cavities were prepared on the buccal surface, which were restored with composite resin. The teeth were distributed according to the following treatments: G1- bleaching with 10% carbamide peroxide (CP); G2 - bleaching with 38% hydrogen peroxide (HP); and G3 - bleaching with 38% of HP associated to light irradiation. For G1, the bleaching gel was applied for 8 hours daily during 21 days. For G2 and G3, 3 sessions were performed, consisting of 3 applications of 15 minutes each, with 7 days of intervals between the sessions. For G3, the LED (470nm) light was used to activate the bleaching agent for 6 minutes. The surface of enamel and composite resin were evaluated before and after the bleaching procedures using a roughness tester and an atomic force microscope. Results: The results showed significant differences in surface roughness of enamel after bleaching only for G1 (Wilcoxon, p<0.05). For composite resin, neither group showed a statistical difference compared to control (Mann-Whitney, p>0.05). Conclusion: It was concluded that the increase in the roughness of enamel occurred only after bleaching therapy using a gel with 10% of CP. The bleaching procedures evaluated in this investigation did not increase the roughness or cause changes in the superficial morphology of the composite resin.

Avaliação de parâmetros de desempenho muscular em jovens sedentárias com dor lombar

Pós-graduação em Desenvolvimento Humano e Tecnologias - IBRC

Estudo da migração de células peritoneais na paracoccidioidomicose experimental murina: avalaição do efeito da estimulaçao de células peritoneais por lectina sobra a evolução da lesão paracoccidióidica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

The horn of plenty de McQueen: uma conjunção paródica entre o design, a moda e a arte no contemporâneo

Pós-graduação em Design - FAAC

Desenvolvimento de uma rede neuro-fuzzy para a previsão da carga

Pós-graduação em Engenharia Elétrica - FEIS

Caracterização dos mecanismos de ação da imunoterapia intravesical com P-MAPA envolvendo as vias de sinalização dor receptores Toll-like (TLR) 2 e 4 na progressão do câncer de bexiga não-músculo invasivo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Juventude, drogas e biopolítica

In this article, we tackle the issue of youth and drugs as something linked to biopower and biopolitics, both concepts developed by Michael Foucault. Youth and drugs are taken and analyzed in situations involving the management of crime linked to the risks and deviations from the law, abuse and dependence. The youth; irreverent, courageous, healthy, idealistic, and that wanted to change the world for the better as we have seen in the past, is now strongly related to violence, dangerous activities, moral and social risks, drug addiction, criminality, and others negative images. To deal with these young people, tolerance and small punishments of yore are not enough anymore. The young people emerge as a segment of the population subject to various actions and programs. The drugs now are seen as matters of security and public health. There is a shifting and repositioning in the discourse about the young - from minor, drugged, and criminal to lawbreaker, user and drug addict. The change is subtle, but represents a modulation in the devices of social control. Beyond the consent of the young to get rid of drugs, there is a search for the creation of a wide area of monitoring of their behavior through the activation of community protection networks. The belief that the young are more impressionable and vulnerable, and that action on the cause of the problem or risk reduction are the most efficient ways of management, taking responsibility away from personal and family sphere and transferring it to the State, contributes to the increasing control of young people nowadays.