Las paradojas de la arquitectura política

Este texto propone una recepción del texto "Las paradojas del arte político” escrito por el filósofo Jacques Rancière, con el objetivo de cuestionar las capacidades políticas que el diseño arquitectónico ha desplegado durante la modernidad en diferentes formatos.

Contenido y alcance del acto preparatorio punible de ordenar en el artículo (8) (2) (e) (viii) del Estatuto de Roma

“La Unidad de Víctimas de la Fiscalía de la CPI envió en agosto de 2015 a la Clínica Jurídica Internacional de la Universidad del Rosario la siguiente pregunta: “En cuanto al rechazo de la cámara de la solicitud de autorización para apelar presentada por la Defensa en el caso Ntaganda contra la “Solicitud de Defensa de autorización para apelar la decisión sobre la confirmación de los cargos de fecha 09 de junio 2014” de la Sala de cuestiones preliminares I, No ICC-01/04-02/06-322, 7 de Julio de 2014), el artículo 8(2)(e)(viii) del Estatuto de Roma requiere que la Fiscalía demuestre que una orden específica fue dada por el autor para ejecutar el desplazamiento ilegal de la población civil? ¿Y cuál es la relación (semejanzas y diferencias) entre el delito de desplazamiento ilegal en virtud del artículo 8 (2) (e) (viii) del Estatuto de Roma, y el crimen de persecución en virtud del artículo 7 (1) (h)? En términos más generales, ¿cuál es el ámbito de aplicación del crimen de guerra de desplazar a la población civil en virtud del artículo 8 (2) (e) (viii) del Estatuto de Roma? Por favor, incluya en su respuesta un análisis de la historia de la redacción de la disposición pertinente (s) del Estatuto de Roma y los Elementos de los crímenes, así como de la jurisprudencia pertinente de otros tribunales penales internacionales sobre el crimen de guerra de desplazar a la población civil…”

Contributos para o estudo da arquitectura cisterciense, em Portugal, no âmbito do Projecto ORFEUS: forma e música

Abstract This communication reflects the work done in the Department of Civil Engineering and Architecture at the University of Beira Interior (Portugal), and still ongoing, in the framework of the project ORFEUS - The Tridentine Reform and music in the cloistral silence: the Monastery of S. Bento de Cástris (Project FCT EXPL/EPH-PAT/2253/2013) and aims to bring the debate to a contribution to the study of the specificity of the monastery of St. Bento de Cástris in the context of Cistercian architecture, in which the shape and the music are intertwined. In this way, two dissertations have been developed in Architecture (integrated master course of architecture of the University of Beira Interior) within the project ORFEUS, which are divided by the importance and contributions of the Cistercian Architecture in contemporary religious architecture, the morphology of the Cistercian churches and the relationship between architecture and music in the specific case study of the church of the monastery of St. Bento de Cástris. Resumo Esta comunicação reflecte o trabalho desenvolvido no Departamento de Engenharia Civil e Arquitectura da Universidade da Beira Interior, e ainda em curso, no âmbito do Projecto ORFEUS - A Reforma tridentina e a música no silêncio claustral: o mosteiro de S. Bento de Cástris (Projecto FCT EXPL/EPH- PAT/2253/2013) e pretende-se com esta comunicação trazer a debate um contributo para o estudo da especificidade do Mosteiro de S. Bento de Cástris, no contexto da arquitectura cisterciense, no qual a forma e a música se entrelaçam. Neste sentido foram desenvolvidas duas dissertações de mestrado integrado em Arquitectura, no âmbito do Projecto ORFEUS, que se repartem pela importância e contributos da Arquitectura Cisterciense na Arquitectura religiosa contemporânea, a morfologia das igrejas cistercienses e a relação entre a arquitectura e música patente no estudo de caso da igreja do Mosteiro de S. Bento de Cástris.

Do Espírito do Lugar - Música, Estética, Silêncio, Espaço, Luz I e II Residências Cistercienses de São Bento de Cástris (2013, 2014).

As Residências Cistercienses em S. Bento de Cástris que se vêm realizando desde 2013 têm como primeiro objectivo reinventar na contemporaneidade a densidade histórica do discurso cisterciense, integrando a realidade deste mosteiro tanto numa ampla geografia da Ordem de Cister em Portugal e na Europa, como na história da região e do país. Inspiradas nas questões da História, da Arte, da Arquitectura, da Música, do Património e da Paisagem, as Residências Cistercienses em Cástris vêm apostando no debate de questões actuais ligadas aos espaços monásticos e ao seu futuro, nomeadamente os cistercienses. Esta aposta concretiza-se também no presente trabalho, DO ESPÍRITO DO LUGAR. ESTÉTICA. SILÊNCIO, ESPAÇO, LUZ, resultado das I e II Residências Cistercienses (2013 e 2014), e integra estudos que se reportam especialmente ao Silêncio e às suas várias linguagens e significados e às dimensões da Estética monástico-religiosa, com algum privilégio para as temáticas da Música. A apropriação do mosteiro pelo silêncio e pela música e a apreciação do espólio musical e instrumental de S. Bento de Cástris permitem uma melhor percepção das diversidades conjunturais e dos seus ritmos, aliando-se às dimensões de valorização patrimonial, eacompanhando-as de sugestões estéticas na pintura, escultura, pintura mural, azulejaria…, no sentido da fruição plena dos espaços. A riqueza deste evento, a Residência Cisterciense no mosteiro de S. Bento de Cástris, permitirá que o futuro deste património, de tanta diversidade e espessura histórico-cultural, continue a ser debatido e a justificar edições futuras resultantes dos trabalhos de investigação aí apresentados e debatidos.

La convivialità urbana nei quartieri di Milano, Bologna e Roma. Un'analisi mixed-methods sulle Social Streets

Le Social Street sono gruppi di vicini di casa che vogliono ricreare legami di convivialità avendo notato un indebolimento delle relazioni sociali nei loro quartieri. Nascono come gruppi online, tramite la piattaforma Facebook, per materializzarsi in incontri offline andando a costruire legami conviviali grazie pratiche di socialità, inclusività e gratuità. Questa Tesi ha come obiettivo l’analisi dei profili socio-demografici degli Streeter e dei quartieri coinvolti per comprendere come sia possibile creare convivialità e come la variabile urbana intervenga in questi processi. Inoltre, si vuole comprendere le dinamiche di attaccamento al quartiere, gli interessi portati avanti dagli Streeter, il loro profilo civico e il posizionamento di quest’esperienza rispetto all’associazionismo tradizionale. Per perseguire l’obiettivo della ricerca, sono state studiate le tre città che vedono la maggiore presenza di Social Street: Milano, Bologna, Roma. La ricerca ha previsto sia un’analisi degli Streeter grazie a un questionario online replicato in tutti i contesti. Inoltre, sono state realizzate 131 interviste ad amministratori e fondatori di Social Street e condotte osservazioni etnografiche e netnografiche. I risultati mostrano come gli Streeter siano appartenenti alle classi medio-alte, tra trenta e cinquanta anni, che hanno sperimentato la mobilità tra un quartiere e l’altro o tra diversi contesi nazionali ed internazionali e trovano nelle Social Street un modo per creare legami di vicinato che hanno perso nei loro trasferimenti. Gli stessi quartieri dove si diffondono le Social Street sono agiati e vi è una buona corrispondenza tra Streeter e modello della centralità sociale elaborato da Milbrath (1965) per cui anche la partecipazione civica è molto sentita tra gli aderenti alle Social Street. Il contributo di questa Tesi al dibattito sociologico risiede nell’aver offerto un’analisi empirica di un’azione collettiva a livello urbano, quella delle Social Street, mostrando come vi sia circolarità tra azione e contesto grazie all’azione mutualistica conviviale.

Dentro la strada. La via di Roma come sequenza di spazi pubblici.

Il presente lavoro si pone come conclusione del Laboratorio di Sintesi “Riqualificare la città del dopoguerra”, nel corso del quale si sono condotte analisi sulla città di Ravenna con una attenzione particolare al suo asse stradale ‘Via di Roma’ e ai possibili scenari di riqualificazione dei suoi spazi pubblici. L’intento di questo lavoro è, dunque, rigenerare gli spazi pubblici dei quartieri risalenti al periodo del ‘dopoguerra’– i quali si trovano lungo l’asse di Via di Roma – intervenendo direttamente su di essa con un progetto che si ponga in continuità con la città esistente e che abbia l’obiettivo di migliorarne qualitativamente alcuni suoi aspetti, senza di fatto voler modificare le preesistenze architettoniche.La strategia di riqualificazione dell’area si sostanzia in una focalizzazione del progetto sugli spazi pubblici. È proprio la fruizione di questi luoghi, unitamente all’attaccamento ad essi da parte della collettività, ad aver guidato e motivato l’intervento. Esso è, dunque, concepito come un sistema unitario, in quanto elemento che uniforma Via di Roma, che tuttavia non ignora la tripartizione di questa area. È infatti possibile indentificare nell’intervento due diverse tipologie di azioni, dettate dal contesto cittadino circostante. A nord e a sud viene preso in considerazione il tessuto periferico progettato e costruito nel ‘dopoguerra’, mentre nella parte di città compresa tra le porte l’intervento mira a valorizzare la posizione centrale rispetto al nucleo Romano originale. Ne risulta una suddivisione del paesaggio urbano simmetrica rispetto al centro storico ed in armonia con la pre-esistente tripartizione sopra menzionata.

L'Oratorio e la cura. Assistenza e medicina nella Roma dei papi (secc. XVI-XVII)

La tesi è incentrata sul rapporto tra una comunità religiosa maschile, la Congregazione dell'Oratorio di Roma dei secoli XVI e XVII, e il concetto di cura, mettendo in dialogo storia sociale, storia religiosa e storia della medicina. La prima parte indaga il coinvolgimento degli Oratoriani nella rete caritativa urbana, sottolineando il loro contributo nello sviluppo e nell'amministrazione di una serie di ospedali, ma anche il loro impegno pratico nella cura spirituale e corporale dei malati. La seconda parte prende in esame i professionisti sanitari che frequentavano l'Oratorio, inquadrando il loro rapporto con i padri nel quadro di una più ampia rete di connessioni sociali e politiche nella Roma pontificia. Inoltre, mettendo in rilievo le specificità di speziali, barbieri-chirurghi e medici, l'indagine considera il loro coinvolgimento nella vita religiosa della comunità e la messa a frutto del loro sapere, in ambito umanistico e anatomico. La terza parte studia il complesso rapporto dei sacerdoti con il proprio corpo e con la salute. Viene rilevato il peso delle condizioni sanitarie nell’accettazione di nuovi membri, i legami tra estetica, identità sociale e medicina, ma si prendono in considerazione anche l’ambigua funzione del cibo – inteso come strumento di ascesi che di cura – e il funzionamento concreto dell'organizzazione medica della comunità. Inoltre, un capitolo analizza la circolazione del sapere medico, evidenziando il ruolo della biblioteca, la raccolta e lo scambio di ricette mediche e l'importanza della spezieria comunitaria, mentre un altro capitolo si focalizza sui viaggi terapeutici e sulla pratica del termalismo. L'ultima parte è incentrata sulla peste romana del 1656-57, analizzando il modo in cui la Congregazione affrontò lo scoppio e lo sviluppo dell'epidemia, sia in casa che in città, per sottolineare il fragile e ambiguo equilibrio che definirono tra carità e tutela della salute.

An Isoflavone From Dipteryx Alata Vogel Is Active Against The In Vitro Neuromuscular Paralysis Of Bothrops Jararacussu Snake Venom And Bothropstoxin I, And Prevents Venom-induced Myonecrosis.

Snakebite is a neglected disease and serious health problem in Brazil, with most bites being caused by snakes of the genus Bothrops. Although serum therapy is the primary treatment for systemic envenomation, it is generally ineffective in neutralizing the local effects of these venoms. In this work, we examined the ability of 7,8,3'-trihydroxy-4'-methoxyisoflavone (TM), an isoflavone from Dipteryx alata, to neutralize the neurotoxicity (in mouse phrenic nerve-diaphragm preparations) and myotoxicity (assessed by light microscopy) of Bothrops jararacussu snake venom in vitro. The toxicity of TM was assessed using the Salmonella microsome assay (Ames test). Incubation with TM alone (200 μg/mL) did not alter the muscle twitch tension whereas incubation with venom (40 μg/mL) caused irreversible paralysis. Preincubation of TM (200 μg/mL) with venom attenuated the venom-induced neuromuscular blockade by 84% ± 5% (mean ± SEM; n = 4). The neuromuscular blockade caused by bothropstoxin-I (BthTX-I), the major myotoxic PLA2 of this venom, was also attenuated by TM. Histological analysis of diaphragm muscle incubated with TM showed that most fibers were preserved (only 9.2% ± 1.7% were damaged; n = 4) compared to venom alone (50.3% ± 5.4% of fibers damaged; n = 3), and preincubation of TM with venom significantly attenuated the venom-induced damage (only 17% ± 3.4% of fibers damaged; n = 3; p < 0.05 compared to venom alone). TM showed no mutagenicity in the Ames test using Salmonella strains TA98 and TA97a with (+S9) and without (-S9) metabolic activation. These findings indicate that TM is a potentially useful compound for antagonizing the neuromuscular effects (neurotoxicity and myotoxicity) of B. jararacussu venom.

Nebivolol Reduces Central Blood Pressure In Stage I Hypertensive Patients: Experimental Single Cohort Study.

Assessment of central blood pressure (BP) has grown substantially over recent years because evidence has shown that central BP is more relevant to cardiovascular outcomes than peripheral BP. Thus, different classes of antihypertensive drugs have different effects on central BP despite similar reductions in brachial BP. The aim of this study was to investigate the effect of nebivolol, a β-blocker with vasodilator properties, on the biochemical and hemodynamic parameters of hypertensive patients. Experimental single cohort study conducted in the outpatient clinic of a university hospital. Twenty-six patients were recruited. All of them underwent biochemical and hemodynamic evaluation (BP, heart rate (HR), central BP and augmentation index) before and after 3 months of using nebivolol. 88.5% of the patients were male; their mean age was 49.7 ± 9.3 years and most of them were overweight (29.6 ± 3.1 kg/m2) with large abdominal waist (102.1 ± 7.2 cm). There were significant decreases in peripheral systolic BP (P = 0.0020), diastolic BP (P = 0.0049), HR (P < 0.0001) and central BP (129.9 ± 12.3 versus 122.3 ± 10.3 mmHg; P = 0.0083) after treatment, in comparison with the baseline values. There was no statistical difference in the augmentation index or in the biochemical parameters, from before to after the treatment. Nebivolol use seems to be associated with significant reduction of central BP in stage I hypertensive patients, in addition to reductions in brachial systolic and diastolic BP.

Predictive Value Of Phase I Trials For Safety In Later Trials And Final Approved Dose: Analysis Of 61 Approved Cancer Drugs.

Phase I trials use a small number of patients to define a maximum tolerated dose (MTD) and the safety of new agents. We compared data from phase I and registration trials to determine whether early trials predicted later safety and final dose. We searched the U.S. Food and Drug Administration (FDA) website for drugs approved in nonpediatric cancers (January 1990-October 2012). The recommended phase II dose (R2PD) and toxicities from phase I were compared with doses and safety in later trials. In 62 of 85 (73%) matched trials, the dose from the later trial was within 20% of the RP2D. In a multivariable analysis, phase I trials of targeted agents were less predictive of the final approved dose (OR, 0.2 for adopting ± 20% of the RP2D for targeted vs. other classes; P = 0.025). Of the 530 clinically relevant toxicities in later trials, 70% (n = 374) were described in phase I. A significant relationship (P = 0.0032) between increasing the number of patients in phase I (up to 60) and the ability to describe future clinically relevant toxicities was observed. Among 28,505 patients in later trials, the death rate that was related to drug was 1.41%. In conclusion, dosing based on phase I trials was associated with a low toxicity-related death rate in later trials. The ability to predict relevant toxicities correlates with the number of patients on the initial phase I trial. The final dose approved was within 20% of the RP2D in 73% of assessed trials.

Pyrimidine-5'-nucleotidase Campinas, A New Mutation (p.r56g) In The Nt5c3 Gene Associated With Pyrimidine-5'-nucleotidase Type I Deficiency And Influence Of Gilbert's Syndrome On Clinical Expression.

Pyrimidine-5'-nucleotidase type I (P5'NI) deficiency is an autosomal recessive condition that causes nonspherocytic hemolytic anemia, characterized by marked basophilic stippling and pyrimidine nucleotide accumulation in erythrocytes. We herein present two African descendant patients, father and daughter, with P5'N deficiency, both born from first cousins. Investigation of the promoter polymorphism of the uridine diphospho glucuronosyl transferase 1A (UGT1A) gene revealed that the father was homozygous for the allele (TA7) and the daughter heterozygous (TA6/TA7). P5'NI gene (NT5C3) gene sequencing revealed a further change in homozygosity at amino acid position 56 (p.R56G), located in a highly conserved region. Both patients developed gallstones; however the father, who had undergone surgery for the removal of stones, had extremely severe intrahepatic cholestasis and, liver biopsy revealed fibrosis and siderosis grade III, leading us to believe that the homozygosity of the UGT1A polymorphism was responsible for the more severe clinical features in the father. Moreover, our results show how the clinical expression of hemolytic anemia is influenced by epistatic factors and we describe a new mutation in the P5'N gene associated with enzyme deficiency, iron overload, and severe gallstone formation. To our knowledge, this is the first description of P5'N deficiency in South Americans.

Effects Of Partial Inhibition Of Respiratory Complex I On H2o 2 Production By Isolated Brain Mitochondria In Different Respiratory States.

The aim of this work was to characterize the effects of partial inhibition of respiratory complex I by rotenone on H2O2 production by isolated rat brain mitochondria in different respiratory states. Flow cytometric analysis of membrane potential in isolated mitochondria indicated that rotenone leads to uniform respiratory inhibition when added to a suspension of mitochondria. When mitochondria were incubated in the presence of a low concentration of rotenone (10 nm) and NADH-linked substrates, oxygen consumption was reduced from 45.9 ± 1.0 to 26.4 ± 2.6 nmol O2 mg(-1) min(-1) and from 7.8 ± 0.3 to 6.3 ± 0.3 nmol O2 mg(-1) min(-1) in respiratory states 3 (ADP-stimulated respiration) and 4 (resting respiration), respectively. Under these conditions, mitochondrial H2O2 production was stimulated from 12.2 ± 1.1 to 21.0 ± 1.2 pmol H2O2 mg(-1) min(-1) and 56.5 ± 4.7 to 95.0 ± 11.1 pmol H2O2 mg(-1) min(-1) in respiratory states 3 and 4, respectively. Similar results were observed when comparing mitochondrial preparations enriched with synaptic or nonsynaptic mitochondria or when 1-methyl-4-phenylpyridinium ion (MPP(+)) was used as a respiratory complex I inhibitor. Rotenone-stimulated H2O2 production in respiratory states 3 and 4 was associated with a high reduction state of endogenous nicotinamide nucleotides. In succinate-supported mitochondrial respiration, where most of the mitochondrial H2O2 production relies on electron backflow from complex II to complex I, low rotenone concentrations inhibited H2O2 production. Rotenone had no effect on mitochondrial elimination of micromolar concentrations of H2O2. The present results support the conclusion that partial complex I inhibition may result in mitochondrial energy crisis and oxidative stress, the former being predominant under oxidative phosphorylation and the latter under resting respiration conditions.

National Institutes Of Health Consensus Development Project On Criteria For Clinical Trials In Chronic Graft-versus-host Disease: I. The 2014 Diagnosis And Staging Working Group Report.

The 2005 National Institutes of Health (NIH) Consensus Conference proposed new criteria for diagnosing and scoring the severity of chronic graft-versus-host disease (GVHD). The 2014 NIH consensus maintains the framework of the prior consensus with further refinement based on new evidence. Revisions have been made to address areas of controversy or confusion, such as the overlap chronic GVHD subcategory and the distinction between active disease and past tissue damage. Diagnostic criteria for involvement of mouth, eyes, genitalia, and lungs have been revised. Categories of chronic GVHD should be defined in ways that indicate prognosis, guide treatment, and define eligibility for clinical trials. Revisions have been made to focus attention on the causes of organ-specific abnormalities. Attribution of organ-specific abnormalities to chronic GVHD has been addressed. This paradigm shift provides greater specificity and more accurately measures the global burden of disease attributed to GVHD, and it will facilitate biomarker association studies.

Oropouche Virus Infection And Pathogenesis Is Restricted By Mavs, Irf-3, Irf-7, And Type I Ifn Signaling Pathways In Non-myeloid Cells.

Oropouche virus (OROV) is a member of the Orthobunyavirus genus in the Bunyaviridae family and a prominent cause of insect-transmitted viral disease in Central and South America. Despite its clinical relevance, little is known about OROV pathogenesis. To define the host defense pathways that control OROV infection and disease, we evaluated OROV pathogenesis and immune responses in primary cells and mice that were deficient in the RIG-I-like receptor signaling pathway (MDA5, RIG-I, or MAVS), downstream regulatory transcription factors (IRF-3 or IRF-7), IFN-β, or the receptor for type I IFN signaling (IFNAR). OROV replicated to higher levels in primary fibroblasts and dendritic cells lacking MAVS signaling, the transcription factors IRF-3 and IRF-7, or IFNAR. In mice, deletion of IFNAR, MAVS, or IRF-3 and IRF-7 resulted in uncontrolled OROV replication, hypercytokinemia, extensive liver damage, and death whereas wild-type (WT) congenic animals failed to develop disease. Unexpectedly, mice with a selective deletion of IFNAR on myeloid cells (CD11c Cre(+) Ifnar(f/f) or LysM Cre(+) Ifnar(f/f)) did not sustain enhanced disease with OROV or La Crosse virus, a closely related encephalitic orthobunyavirus. In bone marrow chimera studies, recipient irradiated Ifnar(-/-) mice reconstituted with WT hematopoietic cells sustained high levels of OROV replication and liver damage, whereas WT mice reconstituted with Ifnar(-/-) bone marrow were resistant to disease. Collectively, these results establish a dominant protective role for MAVS, IRF-3 and IRF-7, and IFNAR in restricting OROV virus infection and tissue injury, and suggest that IFN signaling in non-myeloid cells contributes to the host defense against orthobunyaviruses. Oropouche virus (OROV) is an emerging arthropod-transmitted orthobunyavirus that causes episodic outbreaks of a debilitating febrile illness in humans in countries of South and Central America. The continued expansion of the range and number of its arthropod vectors increases the likelihood that OROV will spread into new regions. At present, the pathogenesis of OROV in humans or other vertebrate animals remains poorly understood. To define cellular mechanisms of control of OROV infection, we performed infection studies in a series of primary cells and mice that were deficient in key innate immune genes involved in pathogen recognition and control. Our results establish that a MAVS-dependent type I IFN signaling pathway has a dominant role in restricting OROV infection and pathogenesis in vivo.