Exhaled breath condensate as a matrix for combustion-based nanoparticle exposure and health effect evaluation

Health assessment and medical surveillance of workers exposed to combustion nanoparticles are challenging. The aim was to evaluate the feasibility of using exhaled breath condensate (EBC) from healthy volunteers for (1) assessing the lung deposited dose of combustion nanoparticles and (2) determining the resulting oxidative stress by measuring hydrogen peroxide (H2O2) and malondialdehyde (MDA). Methods: Fifteen healthy nonsmoker volunteers were exposed to three different levels of sidestream cigarette smoke under controlled conditions. EBC was repeatedly collected before, during, and 1 and 2 hr after exposure. Exposure variables were measured by direct reading instruments and by active sampling. The different EBC samples were analyzed for particle number concentration (light-scattering-based method) and for selected compounds considered oxidative stress markers. Results: Subjects were exposed to an average airborne concentration up to 4.3×10(5) particles/cm(3) (average geometric size ∼60-80 nm). Up to 10×10(8) particles/mL could be measured in the collected EBC with a broad size distribution (50(th) percentile ∼160 nm), but these biological concentrations were not related to the exposure level of cigarette smoke particles. Although H2O2 and MDA concentrations in EBC increased during exposure, only H2O2 showed a transient normalization 1 hr after exposure and increased afterward. In contrast, MDA levels stayed elevated during the 2 hr post exposure. Conclusions: The use of diffusion light scattering for particle counting proved to be sufficiently sensitive to detect objects in EBC, but lacked the specificity for carbonaceous tobacco smoke particles. Our results suggest two phases of oxidation markers in EBC: first, the initial deposition of particles and gases in the lung lining liquid, and later the start of oxidative stress with associated cell membrane damage. Future studies should extend the follow-up time and should remove gases or particles from the air to allow differentiation between the different sources of H2O2 and MDA.

Residual venous obstruction, alone and in combination with D-dimer, as a risk factor for recurrence after anticoagulation withdrawal following a first idiopathic deep vein thrombosis in the prolong study.

OBJECTIVE: This study aims to assess the predictive value of residual venous obstruction (RVO) for recurrent venous thrombo-embolism (VTE) in a study using D-dimer to predict outcome. DESIGN: This is a multicentre randomised open-label study. METHODS: Patients with a first episode of idiopathic VTE were enrolled on the day of anticoagulation discontinuation when RVO was determined by compression ultrasonography in those with proximal deep vein thrombosis (DVT) of the lower limbs. D-dimer was measured after 1 month. Patients with normal D-dimer did not resume anticoagulation while patients with abnormal D-dimer were randomised to resume anticoagulation or not. The primary outcome measure was recurrent VTE over an 18-month follow-up. RESULTS: A total of 490 DVT patients were analysed (after excluding 19 for different reasons and 118 for isolated pulmonary embolism (PE)). Recurrent DVT occurred in 19% (19/99) of patients with abnormal D-dimer who did not resume anticoagulation and 10% (31/310) in subjects with normal D-dimer (adjusted hazard ratio: 2.1; p = 0.02). Recurrences were similar in subjects either with (11%, 17/151) or without RVO (13%, 32/246). Recurrent DVT rates were also similar for normal D-dimer, with or without RVO, and for abnormal D-dimer, with or without RVO. CONCLUSIONS: Elevated D-dimer at 1 month after anticoagulation withdrawal is a risk factor for recurrence, while RVO at the time of anticoagulation withdrawal is not.

Confidences de Mlle Mars (Nouvelle édition) / recueillies par Mme Roger de Beauvoir

Collection : Collection Michel Lévy

[Palerme. Palais des Normands, chapelle palatine]

Référence bibliographique : Weigert, 310

Iowa Highway Research Board Research and Development Activities FY 2015

This report, entitled Iowa Highway Research and Development Activities FY 2015, is submitted in compliance with Iowa Code section 310.36 and 312.3A, which direct the submission of a report of the Secondary Road Research Fund and the Street Research Fund, respectively. It is a report of the status of research and development projects in process on June 30, 2015. It is also a report on projects completed during the fiscal year beginning July 1, 2014 and ending June 30, 2015. Detailed information on each of the research and development projects mentioned in this report is available from the office of Research and Analytics, Performance and Technology Division, Iowa Department of Transportation. All approved reports are also online for viewing at http://www.iowadot.gov/research/pdf/IHRBAnnualReport.pdf.

Resistência de genótipos de feijão-de-corda ao pulgão-preto

O objetivo deste trabalho foi avaliar a resistência de genótipos de feijão-de-corda (Vigna unguiculata) ao pulgão-preto (Aphis craccivora). Foram realizados experimentos com e sem chance de escolha em casa de vegetação, na Universidade Federal do Ceará. O delineamento utilizado foi o de blocos ao acaso com vinte tratamentos, representados pelos genótipos 421-07-44, Chumbinho, Zebu, EPACE 10, Frade Preto, Inhumã, João Paulo II, Manteiguinha, Maranhão, Pitiúba, Quarenta Dias, Seridó, Sete Semanas, TVu 1037, TVu 1888, TVu 310, TVu 36, TVu 408P2, TVu 410 e VITA 7. Verificou-se que TVu 408P2, TVu 1037 e TVu 410 foram preteridos por adultos e ninfas do pulgão-preto, em ambos experimentos. Os genótipos TVu 408P2, TVu 410, TVu 36 e TVu 1037 apresentam resistência provavelmente do tipo antibiose ou antixenose. O genótipo 421-07-44 mostrou-se suscetível ao pulgão-preto.

Correlações genéticas entre escores visuais e características reprodutivas em bovinos Nelore usando inferência bayesiana

O objetivo deste trabalho foi estimar a herdabilidade e as correlações genéticas entre escores visuais e características reprodutivas de animais da raça Nelore. As características avaliadas foram: precocidade, musculatura, e escores de conformação à desmama (PD, MD e CD, respectivamente) e ao sobreano (PS, MS e CS, respectivamente); idade ao primeiro parto (IPP); e perímetro escrotal (PE). Foram utilizadas informações de 66.244 animais, nascidos entre 1990 e 2006. Os parâmetros genéticos foram estimados em análises bicaracterísticas, com inferência bayesiana. Foi utilizado um modelo linear para IPP e PE, e um modelo não linear ("threshold") para os escores visuais. As herdabilidades estimadas foram: CD, 0,19±0,02; PD, 0,23±0,02; MD, 0,20±0,02; CS, 0,26±0,01; PS, 0,33±0,02; MS, 0,32±0,02; IPP, 0,16±0,03; e PE, 0,36±0,02. As correlações genéticas estimadas entre os escores visuais e IPP foram negativas, de -0,18±0,03 a -0,29±0,02. Correlações genéticas positivas foram obtidas entre os escores visuais e o PE, de 0,19±0,01 a 0,31±0,01. A seleção de animais com os maiores escores visuais, principalmente ao sobreano, permite melhorar o desempenho reprodutivo dos rebanhos

A study of the effect of sartorius transposition on lymph flow after ilioinguinal node dissection.

Ilioinguinal dissection is associated with a high rate of lymphatic complications. Prolonged lymph flow causes greatest concern and preventive strategies are needed. A retrospective study of 28 consecutive patients undergoing groin dissection for melanoma metastases was performed to evaluate the influence of sartorius muscle transposition on lymph flow. Modification of the surgical technique with transposition of the sartorius muscle was not associated with reduced drainage time (P = 0.66). A 2-staged approach, with initial sentinel lymph node resection and lymph node dissection in a second operation, however, lead to shortened duration of the lymph flow (P = 0.01). Prolonged lymphorrhea was more frequent in older (P = 0.03), obese (P = 0.02) patients affected by diabetes mellitus (P = 0.03) and hypertension (P = 0.04).

Description des objets d'arts [sic] qui composent le cabinet de feu M. le Baron V. Denon... : estampes et ouvrages à figures : [Vente, 12 février 1827 et jours suivants] / par Duchesne Ainé

[Vente. Art. 1827-02-12. Paris]

Genótipos de sorgo para produção de barra de cereais

O objetivo deste trabalho foi desenvolver uma barra de cereais com pipoca de sorgo e avaliá-la quanto à aceitação do produto por consumidores, assim como identificar genótipos de sorgo e distintos modos de processamento para a produção de pipoca visando maior rendimento. Foram avaliados os processamentos sem (STH) e com tratamento hidrotérmico (CTH) dos grãos antes do pipoqueamento. O tratamento CTH reduziu o percentual de piruás em cerca de 36% e aumentou o rendimento da produção de pipoca em cerca de 80%. No STH, os genótipos BRS 310, BR 501, BR 506 e CMSXS 283 produziram menor percentual de piruás e maior capacidade de expansão. No CTH, 'BRS 310' e 'CMSXS 283' apresentaram melhor desempenho. Uma pesquisa sobre a aceitação e a intenção de compra das barras de cereais foi realizada em Londrina, PR e no Rio de Janeiro, RJ. Verificou-se que o produto foi aceito por 98, 4 e 76, 5% dos consumidores, e a média de aceitação, em uma escala de 1 a 9, foi de 7, 7 em Londrina e de 7, 1 no Rio de Janeiro. Quanto à intenção de compra, verificou-se que 88, 8% dos londrinenses e 80, 6% dos cariocas atribuíram notas acima de 4 ("talvez não comprasse, talvez comprasse") na escala de 7 pontos utilizada.

Hydrogen and oxygen isotope behaviors during variable degrees of upper mantle melting: Example from the basaltic glasses from Macquarie Island

We present measurements of hydrogen and oxygen isotopes in MORB glasses from Macquarie Island (SW. Pacific Ocean) coupled with determination of bulk H2O content by two independent techniques: total dehydration and FTIR. The incompatible trace elements in these glasses vary by a factor of 12 to 17, with K2O varying from 0.1 to 1.7 wt.%; these ranges reflect a variable degree of closed-system mantle melting, estimated from 1 to 15%. Water concentrations determined by the two techniques match well, yielding a range from 0.25 to 1.49 wt.% which correlates positively with all of the measured incompatible trace elements, suggesting that water is un-degassed, and behaves conservatively during mantle melting. Also, the agreement between the FTIR-determined and extracted water contents gives us confidence that the measured isotopic values of hydrogen reflect that of the mantle. Comparison of the range of water content with that of other incompatible trace elements allows estimation of the water partition coefficient in lherzolite, 0.0208 (ranging from 0.017 to 0.023), and the water content in the source, 386 ppm (ranging from 370 to 440 ppm). We observe a fairly narrow range in delta D and delta O-18 values of -75.5 +/- 4.5 parts per thousand and 5.50 +/- 0 .05 parts per thousand respectively, that can be explained by partial melting of normal lherzolitic mantle. The measured delta D and delta O-18 values of Macquarie Island glasses that range from nepheline- to hypersthene-normative, and from MORB to EMORB in composition, are identical to those in average global MORB. The observed lack of variation of delta D and delta O-18 with 1 to 15% degree of mantle melting is consistent with a bulk melting model of delta D and delta O-18 fractionation, in which water is rapidly scavenged into the first partial melt. The narrow ranges of delta D and delta O-18 in normal mantle are mostly due to the buffering effect of clino- and orthopyroxenes in the residual assemblage; additionally, fast ``wet'' diffusion of oxygen and hydrogen isotopes through the melting regions may further smooth isotopic differences. (C) 2012 Elsevier B.V. All rights reserved.

Missale [avec notation en neumes].

Notes marginales : départ d'Antoine Limousin, enfant de chœur à Saint-Maur, en 1678 (26 mars 1678, f. 7v) ; serments du nouvel abbé de Saint-Maur (XVe-XVIe s., f. 8v et XVe s., f. 150) ; « Husson fil. Jeh. Hua » (XVe s., f. 299v).

Feijão-caupi autoclavado na nutrição de juvenis de tambaqui

O objetivo deste trabalho foi determinar o efeito da inclusão de feijão-caupi (Vigna unguiculata) na ração sobre o desempenho de juvenis de tambaqui (Colossoma macropomum). O experimento foi conduzido em delineamento inteiramente casualizado, com três repetições de 20 juvenis de tambaqui (10 g), alocados em caixas d'água de 310 L. Os peixes foram alimentados por 60 dias com rações isonitrogenadas e isoenergéticas, com seis níveis de inclusão de feijão-caupi: 0, 5, 10, 15, 20 e 25%. Foram determinadas as relações corporais e de desempenho produtivo. Não houve diferença significativa entre os tratamentos. Juvenis de tambaqui podem ser alimentados com inclusão de até 25% de feijão-caupi na ração.

Prévention de la maladie veineuse chronique: quels conseils donner à nos patients [Prevention of chronic venous disease: which advice for our patients?].

Chronic venous disease (CVD) is a major public health problem due to its high prevalence and socioeconomic costs. In absence of adequate care, it can lead to chronic venous insufficiency (CVI). Disturbed venous-flow patterns lead to venous hypertension. Therefore, prevention of CVD involves venous hypertension reduction. In primary prevention, it is essential to inform the patient about necessary lifestyle changes. In case of CVD, it is essential to propose treatment (compression, venoactive drugs, and interventional treatments) to avoid CVI appearance and eventually offer the best therapy solutions for CVI complications.