Synopsis theologiae 25

Invokaatio: In nomine Jesu!

De justificatione hominis peccatoris coram Deo, ad amussim aphorismi apostolici Rom: 3:24.25

Variantti B.

Chronicon episcoporum Finlandensium 25

Arkit: 1 arkintunnukseton lehti, 3C-3D4.

Dissfrtatio [!] philologica ... fidem Jobi ex cap. XIX:25, 26, 27. Considerans, qvam ex decrete celeberrimi consistorii Acad. Aboens. adprobante ampliss. facult. phil. publico bonorum examini sistit mag. Matthias Hallenius, facult. theol. adjunctus & pastor in Lundå, respondente Gabriele Tålpo, Aboensi, ad diem Deo volente, XXVII Julii, anni MDCCXLI. In auditorio maximo, horis ante meridiem solitis

Invokaatio: In nomine Jesu!

Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis

Our objective was to evaluate the concentrations of serum 25-hydroxyvitamin D [25(OH)D], serum calcium, serum phosphorus, alkaline phosphatase, and parathormone (PTH) in patients with polyarticular juvenile idiopathic arthritis (JIA) and to associate them with disease duration and activity, bone mineral density and use of medications. In a cross-sectional and controlled study, 30 patients with polyarticular JIA were evaluated and compared to 30 healthy individuals matched for age and gender. Clinical status, anthropometry, laboratory markers in both patients and controls, and bone mineral density, only in the patients, were measured. Of the 30 patients included in the study, 23 (76.7%) were female and 16 (53.3%) non-Caucasian; mean age was 14 years (range = 4 to 20 years). Mean disease duration was 5 years (range = 1 to 12 years). The mean concentrations of serum albumin-corrected calcium (9.04 ± 0.41 mg/dL) and alkaline phosphatase (153.3 ± 100.1 IU) were significantly lower in patients with JIA than in controls (P < 0.0001 and P = 0.001, respectively). No differences in 25(OH)D, PTH or serum phosphorus were observed between JIA and control subjects. Regarding 25(OH)D concentration, 8 patients (26.7%) and 5 controls (16.7%) had 25(OH)D concentrations compatible with deficiency (lower than 20 ng/mL) and 14 patients (46.7%) and 18 controls (60%) had concentrations compatible with insufficiency (20-32 ng/mL). These values were not associated with disease activity, use of medications or bone mineral density. We observed a high frequency of 25(OH)D insufficiency and deficiency in the study sample. The compromised bone metabolism emphasizes the importance of follow-up of JIA patients.

Low serum concentrations of 25-hydroxyvitamin D in children and adolescents with systemic lupus erythematosus

We evaluated the concentrations of 25-hydroxyvitamin D [25(OH)D] in children and adolescents with juvenile systemic lupus erythematosus (JSLE) and associated them with disease duration and activity, use of medication (chloroquine and glucocorticoids), vitamin D intake, calcium and alkaline phosphatase levels, and bone mineral density. Thirty patients with JSLE were evaluated and compared to 30 healthy individuals, who were age and gender matched. Assessment was performed of clinical status, disease activity, anthropometry, laboratory markers, and bone mineral density. The 30 patients included 25 (83.3%) females and 16 (53.3%) Caucasians, with a mean age of 13.7 years. The mean age at diagnosis was 10.5 years and mean disease duration was 3.4 years. Mean levels of calcium, albumin, and alkaline phosphatase were significantly lower in patients with JSLE compared with controls (P<0.001, P=0.006, and P<0.001, respectively). Twenty-nine patients (97%) and 23 controls (77%) had 25(OH)D concentrations lower than 32 ng/mL, with significant differences between them (P<0.001). Fifteen patients (50%) had vitamin D levels <20 ng/mL and 14 had vitamin D levels between 20 and 32 ng/mL. However, these values were not associated with greater disease activity, higher levels of parathormone, medication intake, or bone mineral density. Vitamin D concentrations were similar with regard to ethnic group, body mass index, height for age, and pubertal stage. Significantly more frequently than in controls, we observed insufficient serum concentrations of 25(OH)D in patients with JSLE; however, we did not observe any association with disease activity, higher levels of parathormone, lower levels of alkaline phosphatase, use of medications, or bone mineral density alterations.

Treatment with 1,25(OH)2D3induced HDAC2 expression and reduced NF-κB p65 expression in a rat model of OVA-induced asthma

Recent evidence indicates that a deficiency of 1,25-dihydroxyvitamin D3 (1,25[OH]2D3) may influence asthma pathogenesis; however, its roles in regulating specific molecular transcription mechanisms remain unclear. We aimed to investigate the effect of 1,25(OH)2D3 on the expression and enzyme activity of histone deacetylase 2 (HDAC2) and its synergistic effects with dexamethasone (Dx) in the inhibition of inflammatory cytokine secretion in a rat asthma model. Healthy Wistar rats were randomly divided into 6 groups: control, asthma, 1,25(OH)2D3 pretreatment, 1,25(OH)2D3 treatment, Dx treatment, and Dx and 1,25(OH)2D3 treatment. Pulmonary inflammation was induced by ovalbumin (OVA) sensitization and challenge (OVA/OVA). Inflammatory cells and cytokines in the bronchoalveolar lavage (BAL) fluid and histological changes in lung tissue were examined. Nuclear factor kappa B (NF-κB) p65 and HDAC2 expression levels were assessed with Western blot analyses and quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR). Enzyme activity measurements and immunohistochemical detection of HDAC2 were also performed. Our data demonstrated that 1,25(OH)2D3 reduced the airway inflammatory response and the level of inflammatory cytokines in BAL. Although NF-κB p65 expression was attenuated in the pretreatment and treatment groups, the expression and enzyme activity of HDAC2 were increased. In addition, 1,25(OH)2D3 and Dx had synergistic effects on the suppression of total cell infusion, cytokine release, and NF-κB p65 expression, and they also increased HDAC2 expression and activity in OVA/OVA rats. Collectively, our results indicated that 1,25(OH)2D3might be useful as a novel HDAC2 activator in the treatment of asthma.

Colesterol, 7-cetocolesterol e 25-hidroxicolesterol em maionese

A maionese é um alimento com predominância lipídica característica. O sistema antioxidante artificial usado resulta em longa vida-de-prateleira do produto. Mas não existem conhecimentos suficientes quanto à estabilidade oxidativa do colesterol incorporado à maionese, através do ovo. Neste trabalho foi confirmada a oxidação do colesterol contido na maionese, pela presença do 7-Cetocolesterol (7-Ceto),1,99±0,59µg/g, em amostras recém-fabricadas (~15 dias), de 7-Ceto, 8,30±4,03 a 22,86±3,06µg/g, e de 25-Hidroxicolesterol, 2,21±1,94 a 13,98±2,72µg/g, em amostras comerciais (A,B,C,D e E) com tempos de fabricação de 30 a 210 dias, e de 7-Ceto, 8,44±6,78µg/g, em amostras coletadas em domicílios (produto em uso, mantido em geladeira), quantificados por HPLC. O somatório dos óxidos de colesterol (OsC) analisados nas amostras A/E correspondeu a 2,07-4,94% em relação ao colesterol (50,66±3,08-73,36±3,53mg/100g). Os resultados obtidos são significativos em relação às atividades biológicas deletérias atribuídas aos OsC, e quanto ao aspecto tecnológico envolvido na produção da maionese.

Valtatien 25 palvelutasotarkastelu välillä valtatie 1-maantie 132

Tässä esiselvityksessä on palvelutasolähtöisesti tarkasteltu valtatien 25 merkitystä ja suunniteltu valtatien 1 ja maantien 132 välisen tiejakson kehittämistoimenpiteitä pitkämatkaisen liikenteen ja kuljetusten kannalta ottaen myös huomioon paikallisen liikenteen ja maankäytön tarpeet. Tarve selvitykseen on tullut erityisesti Vihdin maankäytön suunnittelusta. Vihti on voimakkaasti kasvava kunta ja Nummela, joka on kasvanut valtatien 25 molemmin puolin, sen päätaajama. Valtatiellä 25 on Vihdin kunnan läpi kulkevaa pitkämatkaista liikennettä noin 3 000 ajoneuvoa vuorokaudessa. Vihtiin päättyvää/ Vihdistä alkavaa liikennettä on lännestä noin 6 000 ja idästä noin 1 700 ajoneuvoa vuorokaudessa. Lännestä tulevalla tai sinne menevällä liikenteellä selvästi merkittävin lähtö-/määräpaikka on Lohja. Valtakunnallisten ja alueellisten suunnitelmien perusteella valtatien 25 strategiseksi kehittämistavoitteeksi asetettiin elinkeinoelämän toimintaedellytysten turvaaminen ja toimivien arjen matkojen varmistaminen. Strategisen tavoiteasettelun pohjalta määritettiin kulkumuodoittain ja tiejaksoittain tavoitteet eri palvelutasotekijöiden tasolle ottaen huomioon eri tiejaksoilla painottuvat matka- ja kuljetusvirrat sekä ympäröivä maankäyttö. Palvelutasotekijöistä priorisoitiin korkeimmalle turvallisuus kaikilla kulkumuodoilla sekä kuljetusten matka-aika, ennakoitavuus ja hallittavuus. Palvelutasotavoitteiden saavuttamiseksi valtatien 25 tehokkaimpia parantamistoimenpiteitä ovat ne, jotka palvelevat samalla useamman ongelmallisen palvelutasotekijän, erityisesti liikenneturvallisuuden ja ennakoitavuuden, nostamista tavoiteltavalle palvelutasolle. Suositeltaviksi nousevia toimenpiteitä pitkällä aikavälillä ovat toisen ajoradan rakentaminen valtatien 1 ja 2 välille, keskikaiteellisten ohituskaistojen rakentaminen, liittymien parantaminen ja yksityistiejärjestelyt, selkeiden maankäyttöratkaisujen toteuttaminen ja rinnakkaisteiden/-katujen rakentaminen niiden tueksi sekä kevyen liikenteen alikulkukäytävien toteuttaminen. Näiden lisäksi tarvitaan ongelmallisimmissa pisteissä tai lyhyillä jaksoilla monia pienempiä toimenpiteitä, joissa korostuvat erityisesti liikenneturvallisuusnäkökulmat. Tärkeää on jatkossa maankäytön ja liikenteen suunnittelun yhteistyö, jotta varmistetaan tavoiteltava palvelutaso.