922 resultados para 1057


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Sediments from Sites 1057 and 1061 of Ocean Drilling Program Leg 172 on the Blake Outer Ridge exhibit nearly isotropic magnetic susceptibility. Resolving the degree of anisotropy of magnetic susceptibility proved difficult in many samples because of the generally weak magnetic susceptibility of the sediments relative to the noise level of the susceptibility meters used. Lineation varies from 1.0 to 1.013 and foliation varies from 1.0 to 1.08 in the samples that pass rejection criteria. In general the foliation is better resolved than the lineation, particularly at Site 1061, where the foliation exhibits long-term trends that mimic the mean susceptibility. The changes in the foliation at this site are likely the result of changes in the magnetic mineralogy of the sediment. The poorly developed or absent magnetic fabric in the sediments overall can be attributed to high carbonate concentrations and to a circulation regime that was diffuse or with currents too weak to effectively align magnetic particles.

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On cover: C00-1018-1057.

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En la p. 186 verso comienzan "estos versos de Ioan del Enzina ... dexo el Marques de Tarifa escriptos en su libro que por auerle acompañado el en su peregrinación quiso tambien que este viage acompañasse el suyo ..."

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Contiene: T.I: Les pièces relatives a l'histoire de la Ville d'Amiens, depuis l'an 1057, date de la plus ancienne de ces pièces, jusqu'au XVe siècle ([2], CCLXXII, 909 p.). T.II: Les pièces relatives a l'histoire de la Ville d'Amiens, depuis le XVe siècle jusqu'au XVIIe ([6], LXXV, 1141 p.). T.III: Les pièces relatives a l'histoire minicipale de la Ville d'Amiens depuis le XVIIe siècle jusqu'en 1789, et a celle des villes, bourgs et villages de l'Amiénois (XXXII, 698 p.). T.IV: Les pièces relatives à lh?istoire municipale d'Abbeville et à celle des villes, bourgs et villages de la basse Picardie (VIII, 885 p.)

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Cover title.

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Este trabalho investigativo teve como objeto a avaliação institucional e auto-avaliação enquanto instrumentos inseridos no Sistema Nacional de Avaliação do Ensino Superior e concebidos no âmbito das Políticas Públicas de Avaliação consolidadas no Brasil na década 90. O objetivo central foi de identificar os sentidos que a avaliação institucional e a auto-avaliação têm para os professores do Centro Universitário Senac de São Paulo. A hipótese, construída durante a investigação é que o docente não estabelece relações diretas e imediatas entre seu trabalho cotidiano na escola e nos estágios e s processos de avaliação institucional e auto-avaliação do qual participa. O estudo situa-se num contexto do ensino superior no Brasil em que a temática da avaliação adquiriu relevância e centralidade. Contexto de mudança no sistema capitalista, de revisão do papel do Estado, de difusão do neoliberalismo e de busca de maior controle e regulação do Sistema de ensino Superior. A metodologia escolhidos para colher os dados foram: a entrevista reflexiva realizada de forma aberta e semi-estruturada; fontes documentais e históricas da instituição; fontes bibliográficas; observações feitas na instituição. O trabalho de campo foi realizado junto ao Curso de Hotelaria, do Centro Universitário Senac/SP, instituição particular de ensino superior. Os resultados apontaram para um professor que não estabelece relações diretas e imediatas entre seu trabalho cotidiano e os processos de avaliação institucional nem as relações desta com a auto-avaliação da qual participa. Isto não significa que haja uma visão ingênua do mesmo da ação avaliativa institucional. Observou-se que o nível de participação dos professores nestes processos é muito mais na execução do que na concepção dos mesmos não sendo o processo de avaliação institucional acompanhado de um aprimoramento dos canais participativos para a vida acadêmica

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A atual situação económica financeira de Portugal não se encontra tão favorável quanto o desejável. Hoje, mais do que nunca, as organizações vêm-se obrigadas a reforçar o nível de competitividade. O capital intelectual tem sido descrito pela literatura como o conjunto de recursos intangíveis capaz de criar valor organizacional e vantagem competitiva, daí ser necessário investir nele. Identifica-se como um fenómeno resultante da combinação de três dimensões: capital humano, estrutural e relacional. Apenas com a combinação e transformação de tais intangíveis o valor organizacional dá-se e o conhecimento revela-se elemento fundamental do capital intelectual. Investigações recentes no meio académico mostram que as organizações reconhecem a importância estratégica do capital intelectual. No entanto, como entrave, persiste a dificuldade em defini-lo, identifica-lo e medi-lo eficazmente. Perceber a influência do Capital Intelectual no desempenho organizacional tornou-se essencial. Em geral, alguns autores sustentam uma conceção otimista quanto à existência de uma relação significativa entre o capital intelectual e o desempenho organizacional. Contudo, apenas o clarificam numa perspetiva de criação e manutenção de vantagens competitivas sustentáveis. Não clarificam a relação causa-efeito entre as componentes do capital intelectual e o desempenho organizacional. Este estudo tem como objetivo principal averiguar até que ponto investir em capital intelectual revela maior desempenho organizacional em PME (Pequenas e Médias Empresas) e grandes empresas. Para o seu fim, examinou-se as relações existentes entre as três componentes do capital intelectual e a influência destas no desempenho organizacional. Trata-se de um estudo confirmatório possível a partir de um questionário e de uma amostra (PME e grandes empresas de Portugal) significativa. Para analisar os dados utilizamos o programa SPSS (Statistical Package for Social Science for Windows) e AMOS (Analysis of Moment Structures). Os resultados indicam que investir em Capital Intelectual contribui positivamente para uma melhor performance organizacional.

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The coordination of the functional activities of intestinal CYP3A4 and P-gp in limiting the absorption of xenobiotics in Caco-2 cells was investigated. Growing Caco-2 cells were exposed to increasing concentrations of doxorubicin (1-2 μM) in plastic flasks to encourage a subpopulation of cells, that displayed an intrinsically higher multidrug resistance (mdr) phenotype than the parent cells, to survive and grow. Doxorubicin-exposed (hereinafter referred to as type I cells) and nonexposed Caco-2 cells (parent cells) on collagen-coated inserts were also treated with either 0 (control) or 0.25 μM 1α,25-dihydroxyvitamin D3 to promote cellular CYP3A4 expression. Increased P-gp protein expression, as detected by Western blotting, was noted in type I cells (213±54.35%) compared to that of parent cells (100±6.05%). Furthermore, they retained significantly less [3H]vincristine sulphate (p<0.05), a P-gp substrate, after efflux (272.89±11.86 fmol/mg protein) than the parent cells (381.39±61.82 fmol/mg protein). The expression of CYP3A4 in parental cells after 1α,25-dihydroxyvitamin D3 treatment was quantified to be 76.2±7.6 pmol/mg protein and comparable with that found in human jejunal enterocytes (70.0±20.0 pmol/mg protein). Type I cells, however, expressed a very low quantity of CYP3A4 both before and after the treatment that was beyond the minimum detection limit of Western blotting. Functionally, the rates of 1-hydroxylation of midazolam by CYP3A for both cell types ranged from 257.0±20.0 to 1057.0±46.0 pmol/min/mg protein. Type I cells, although having a higher P-gp expression and activity comparatively, metabolized midazolam less extensively than the parent cells. The results suggested that there were noncoordinated functional activities of intestinal CYP3A4 and P-gp in Caco-2 cells, although they both functioned independently to minimize intestinal epithelial absorption of xenobiotics. © 2002 Wiley-Liss, Inc. and the American Pharmaceutical Association.

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Original Paper European Journal of Information Systems (2001) 10, 135–146; doi:10.1057/palgrave.ejis.3000394 Organisational learning—a critical systems thinking discipline P Panagiotidis1,3 and J S Edwards2,4 1Deloitte and Touche, Athens, Greece 2Aston Business School, Aston University, Aston Triangle, Birmingham, B4 7ET, UK Correspondence: Dr J S Edwards, Aston Business School, Aston University, Aston Triangle, Birmingham, B4 7ET, UK. E-mail: j.s.edwards@aston.ac.uk 3Petros Panagiotidis is Manager responsible for the Process and Systems Integrity Services of Deloitte and Touche in Athens, Greece. He has a BSc in Business Administration and an MSc in Management Information Systems from Western International University, Phoenix, Arizona, USA; an MSc in Business Systems Analysis and Design from City University, London, UK; and a PhD degree from Aston University, Birmingham, UK. His doctorate was in Business Systems Analysis and Design. His principal interests now are in the ERP/DSS field, where he serves as project leader and project risk managment leader in the implementation of SAP and JD Edwards/Cognos in various major clients in the telecommunications and manufacturing sectors. In addition, he is responsible for the development and application of knowledge management systems and activity-based costing systems. 4John S Edwards is Senior Lecturer in Operational Research and Systems at Aston Business School, Birmingham, UK. He holds MA and PhD degrees (in mathematics and operational research respectively) from Cambridge University. His principal research interests are in knowledge management and decision support, especially methods and processes for system development. He has written more than 30 research papers on these topics, and two books, Building Knowledge-based Systems and Decision Making with Computers, both published by Pitman. Current research work includes the effect of scale of operations on knowledge management, interfacing expert systems with simulation models, process modelling in law and legal services, and a study of the use of artifical intelligence techniques in management accounting. Top of pageAbstract This paper deals with the application of critical systems thinking in the domain of organisational learning and knowledge management. Its viewpoint is that deep organisational learning only takes place when the business systems' stakeholders reflect on their actions and thus inquire about their purpose(s) in relation to the business system and the other stakeholders they perceive to exist. This is done by reflecting both on the sources of motivation and/or deception that are contained in their purpose, and also on the sources of collective motivation and/or deception that are contained in the business system's purpose. The development of an organisational information system that captures, manages and institutionalises meaningful information—a knowledge management system—cannot be separated from organisational learning practices, since it should be the result of these very practices. Although Senge's five disciplines provide a useful starting-point in looking at organisational learning, we argue for a critical systems approach, instead of an uncritical Systems Dynamics one that concentrates only on the organisational learning practices. We proceed to outline a methodology called Business Systems Purpose Analysis (BSPA) that offers a participatory structure for team and organisational learning, upon which the stakeholders can take legitimate action that is based on the force of the better argument. In addition, the organisational learning process in BSPA leads to the development of an intrinsically motivated information organisational system that allows for the institutionalisation of the learning process itself in the form of an organisational knowledge management system. This could be a specific application, or something as wide-ranging as an Enterprise Resource Planning (ERP) implementation. Examples of the use of BSPA in two ERP implementations are presented.

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Fourier-phase information is important in determining the appearance of natural scenes, but the structure of natural-image phase spectra is highly complex and difficult to relate directly to human perceptual processes. This problem is addressed by extending previous investigations of human visual sensitivity to the randomisation and quantisation of Fourier phase in natural images. The salience of the image changes induced by these physical processes is shown to depend critically on the nature of the original phase spectrum of each image, and the processes of randomisation and quantisation are shown to be perceptually equivalent provided that they shift image phase components by the same average amount. These results are explained by assuming that the visual system is sensitive to those phase-domain image changes which also alter certain global higher-order image statistics. This assumption may be used to place constraints on the likely nature of cortical processing: mechanisms which correlate the outputs of a bank of relative-phase-sensitive units are found to be consistent with the patterns of sensitivity reported here.