Structural change and productivity growth, 20 years later: old problems, new opportunities

Includes bibliography

Latin America on its path into the digital age: where are we?

Includes bibliography

Theory and practice of industrial policy: evidence from the Latin American experience

Includes bibliography

Innovation and technology policy (ITP) for catching up: a three phase life cycle framework for industrializing economies

Includes bibliography

Pension reform in Europe in the 90's and lessons for Latin America

Includes bibliography

Market failure and technological policy

Includes bibliography

The ongoing history of a Chilean metal products and machinery firm

Includes bibliography

Structural change and productivity growth 20 years later: old problems, new opportunities. Summary

Includes bibliography

Nasal administration of liquid crystal precursor mucoadhesive vehicle as an alternative antiretroviral therapy

The purpose of this study was to develop a mucoadhesive stimuli-sensitive drug delivery system for nasal administration of zidovudine (AZT). The system was prepared by formulating a low viscosity precursor of a liquid crystal phase, taking advantage of its lyotropic phase behavior. Flow rheology measurements showed that the formulation composed of PPG-5-CETETH-20, oleic acid and water (55, 30, 15% w/w), denominated P, has Newtonian flow behavior. Polarized light microscopy (PLM) revealed that formulation P is isotropic, whereas its 1:1 (w/w) dilution with artificial nasal mucus (ANM) changed the system to an anisotropic lamellar phase (PD). Oscillatory frequency sweep analysis showed that PD has a high storage modulus (G′) at nasal temperatures. Measurement of the mucoadhesive force against excised porcine nasal mucosa or a mucin disk proved that the transition to the lamellar phase tripled the work of mucoadhesion. Ex vivo permeation studies across porcine nasal mucosa exhibited an 18-fold rise in the permeability of AZT from the formulation. The Weibull mathematical model suggested that the AZT is released by Fickian diffusion mechanisms. Hence, the physicochemical characterization, combined with ex vivo studies, revealed that the PPG-5-CETETH-20, oleic acid, and water formulation could form a mucoadhesive matrix in contact with nasal mucus that promoted nasal absorption of the AZT. For an in vivo assessment, the plasma concentrations of AZT in rats were determined by HPLC method following intravenous and intranasal administration of AZT-loaded P formulation (PA) and AZT solution, respectively, at a dose of 8 mg/kg. The intranasal administration of PA resulted in a fast absorption process (Tmax = 6.7 min). Therefore, a liquid crystal precursor formulation administered by the nasal route might represent a promising novel tool for the systemic delivery of AZT and other antiretroviral drugs. In the present study, the uptake of AZT absorption in the nasal mucosa was demonstrated, providing new foundations for clinical trials in patients with AIDS. © 2012 Elsevier B.V. All rights reserved.

Parasitism level by helminths and weight gain of calves kept in organic and conventional grazing

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Studies of nucleon resonance structure in exclusive meson electroproduction

Studies of the structure of excited baryons are key factors to the N* program at Jefferson Lab (JLab). Within the first year of data taking with the Hall B CLAS12 detector following the 12 GeV upgrade, a dedicated experiment will aim to extract the N* electrocouplings at high photon virtualities Q 2. This experiment will allow exploration of the structure of N* resonances at the highest photon virtualities ever achieved, with a kinematic reach up to Q2 = 12 GeV2. This high-Q 2 reach will make it possible to probe the excited nucleon structures at distance scales ranging from where effective degrees of freedom, such as constituent quarks, are dominant through the transition to where nearly massless bare-quark degrees of freedom are relevant. In this document, we present a detailed description of the physics that can be addressed through N* structure studies in exclusive meson electroproduction. The discussion includes recent advances in reaction theory for extracting N* electrocouplings from meson electroproduction off protons, along with Quantum Chromodynamics (QCD)-based approaches to the theoretical interpretation of these fundamental quantities. This program will afford access to the dynamics of the nonperturbative strong interaction responsible for resonance formation, and will be crucial in understanding the nature of confinement and dynamical chiral symmetry breaking in baryons, and how excited nucleons emerge from QCD. © 2013 World Scientific Publishing Company.

Understanding the process of greening of Brazilian business schools

This study analyses business schools' incorporating environmental management issues into their core activities, defined through teaching, research, outreach and management. Taking into account the relative lack of literature on this theme, case study fieldwork is utilized. Two case studies were conducted at Brazilian business schools. The results were analyzed using the conceptual background of barriers to organizational change, transition to a more sustainable society, and path dependence. The main findings indicate that: (a) the incorporation of environmental management issues tends to begin with researching and teaching; (b) this incorporation process depends on the personal motivation of few or single faculty researchers; (c) the trajectory of the analyzed business schools is marked by advances and stagnation, when analyzing the incorporation of environmental management issues to its four core activities; (d) paradoxically, the analyzed business schools can be considered academic leaders in the field, but have had difficulties in adopting environmental management practices internally; (e) there is a path dependence effect in this process; (f) there are barriers to organizational change towards green business schools; (g) institutional entrepreneurs are important to the process of greening. This research represents the first research shedding light to understanding the process of greening of Brazilian business schools while considering the multidimensional aspects (teaching, research, outreach and university management). © 2013 Elsevier Ltd. All rights reserved.

Can savannas become forests? A coupled analysis of nutrient stocks and fire thresholds in central Brazil

Aims: The effects of fire ensure that large areas of the seasonal tropics are maintained as savannas. The advance of forests into these areas depends on shifts in species composition and the presence of sufficient nutrients. Predicting such transitions, however, is difficult due to a poor understanding of the nutrient stocks required for different combinations of species to resist and suppress fires. Methods: We compare the amounts of nutrients required by congeneric savanna and forest trees to reach two thresholds of establishment and maintenance: that of fire resistance, after which individual trees are large enough to survive fires, and that of fire suppression, after which the collective tree canopy is dense enough to minimize understory growth, thereby arresting the spread of fire. We further calculate the arboreal and soil nutrient stocks of savannas, to determine if these are sufficient to support the expansion of forests following initial establishment. Results: Forest species require a larger nutrient supply to resist fires than savanna species, which are better able to reach a fire-resistant size under nutrient limitation. However, forest species require a lower nutrient supply to attain closed canopies and suppress fires; therefore, the ingression of forest trees into savannas facilitates the transition to forest. Savannas have sufficient N, K, and Mg, but require additional P and Ca to build high-biomass forests and allow full forest expansion following establishment. Conclusions: Tradeoffs between nutrient requirements and adaptations to fire reinforce savanna and forest as alternate stable states, explaining the long-term persistence of vegetation mosaics in the seasonal tropics. Low-fertility limits the advance of forests into savannas, but the ingression of forest species favors the formation of non-flammable states, increasing fertility and promoting forest expansion. © 2013 Springer Science+Business Media Dordrecht.

Diversidade e sazonalidade da acarofauna de Hymenaea martiana Hayne (Leguminosae) em gradiante de tamanho de plantas

Pós-graduação em Biologia Animal - IBILCE

A formação teórica de Bukhárin e a transição na URSS: 1906-1921

Pós-graduação em Ciências Sociais - FFC