Granular flow and design studies in flighted rotating drums

Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2013

Optimal design in the presence of random or fixed block effects

Magdeburg, Univ., Fak. für Mathematik, Diss., 2014

Optimal experimental design for parameter identification and model selection

Magdeburg, Univ., Fak. für Elektrotechnik und Informationstechnik, Diss., 2014

Process design based on CO 2-expanded liquids as solvents

Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2014

Design, modeling and control of an autonomous field robot for white asparagus harvesting

Magdeburg, Univ., Fak. für Maschinenbau, Diss., 2014

Die Vermittlung des heimlichen Lehrplans im Klassenraum : - Beobachtungen zu genderspezifischen Interaktionen mittels experimentellem Design

Der heimliche Lehrplan beschreibt soziale Werte, Normen und Regeln, welcher als Sozialisationsprozess den Schulalltag beeinflusst. Die eigens für die Thesis erstellten Hypothesen fragen nach der Validität der Methode sowie genderspezifischen Interaktionen. Schwerpunkt dieser Bachelor-Thesis sind Beobachtungen in zwei Sekundarschulen. Das Untersuchungsdesign ist experimentell an den Erhebungsbogen von zwei amerikanischen Wissenschaftlerinnen aus dem Jahr 1993 angelehnt. Nach einer Pretestphase sowie Modifizierungsprozess wurde das gewonnene Material quantitativ mithilfe des SPSS-Programms und qualitativ durch die Inhaltsanalyse aufbereitet und ausgewertet. Die Hypothesen werden durch die Auswertung und mithilfe von Gütekriterien beantwortet, sodass die Methodenvalidität größtenteils belegt werden kann. Tendenzen für geschlechterspezifische Interaktionen sind erkennbar, allerdings schwer zu generalisieren. Im Fazit wird die Bedeutung des heimlichen Lehrplans sowie die Geschlechtergerechtigkeit in Schulen diskutiert.

Flow design optimization of blood pumps considering hemolysis

Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2015

Optimal designs for the prediction in hierarchical random coefficient regression models

Magdeburg, Univ., Fak. für Mathematik, Diss., 2015

Design of biped robot walking with double-support phase

Otto-von-Guericke-Universität Magdeburg, Fakultät für Maschinenbau, Univ., Dissertation, 2015

Functional design of the air ventilation apparatus and overland excurions by teleosts / Karel F. Liem.

n.s. no.37(1987)

On the design of peer punishment experiments

We discuss how technologies of peer punishment might bias the results that are observed in experiments. A crucial parameter is the “fine-to-fee” ratio, which describes by how much the punished subjects income is reduced relatively to the fee the punishing subject has to pay to inflict punishment. We show that a punishment technology commonly used in experiments embeds a variable fine-to-fee ratio and show that it confounds the empirical findings about why, whom, and how much subjects punish.

Competition with forward contracts: a laboratory analysis motivated by electricity market design

We use experiments to study the efficiency effects for a market as a whole of adding the possibility of forward contracting to a pre-existing spot market. We deal separately with the cases where spot market competition is in quantities and where it is in supply functions. In both cases we compare the effect of adding a contract market with the introduction of an additional competitor, changing the market structure from a triopoly to a quadropoly. We find that, as theory suggests, for both types of competition the introduction of a forward market significantly lowers prices. The combination of supply function competition with a forward market leads to high efficiency levels.

1st National Accessiblity Plan 2004-2012: achieving equal opportunities and full participation through design for all

According to official statistics, disabled people in Spain number 3.5 million and make up 8.8% of the Spanish population. This group of people are increasingly being recognised as members of society with equal rights, and many of their demands are gradually being transformed into solutions that benefit society as a whole. One example is improved accessibility. Accessible built environments are more human and inclusive places, as well as being easier to get around. Improved accessibility is now recognised as a requirement shared by all members of society, although it is achieved thanks to the demands of disabled people and their representatives. The 1st National Accessibility Plan is a strategic framework for action aimed at ensuring that new products, services and built environments are designed to be accessible for as many people as possible (Design for All) and that existing ones are gradually duly adapted.

T Cells Bearing a Chimeric Antigen Receptor against Prostate-Specific Membrane Antigen Mediate Vascular Disruption and Result in Tumor Regression.

Aberrant blood vessels enable tumor growth, provide a barrier to immune infiltration, and serve as a source of protumorigenic signals. Targeting tumor blood vessels for destruction, or tumor vascular disruption therapy, can therefore provide significant therapeutic benefit. Here, we describe the ability of chimeric antigen receptor (CAR)-bearing T cells to recognize human prostate-specific membrane antigen (hPSMA) on endothelial targets in vitro as well as in vivo. CAR T cells were generated using the anti-PSMA scFv, J591, and the intracellular signaling domains: CD3ζ, CD28, and/or CD137/4-1BB. We found that all anti-hPSMA CAR T cells recognized and eliminated PSMA(+) endothelial targets in vitro, regardless of the signaling domain. T cells bearing the third-generation anti-hPSMA CAR, P28BBζ, were able to recognize and kill primary human endothelial cells isolated from gynecologic cancers. In addition, the P28BBζ CAR T cells mediated regression of hPSMA-expressing vascular neoplasms in mice. Finally, in murine models of ovarian cancers populated by murine vessels expressing hPSMA, the P28BBζ CAR T cells were able to ablate PSMA(+) vessels, cause secondary depletion of tumor cells, and reduce tumor burden. Taken together, these results provide a strong rationale for the use of CAR T cells as agents of tumor vascular disruption, specifically those targeting PSMA. Cancer Immunol Res; 3(1); 68-84. ©2014 AACR.