933 resultados para neurotrophic signals


Relevância:

20.00% 20.00%

Publicador:

Resumo:

By 2030, half of the EU’s electricity demand will be covered by renewables and will need to be accompanied by flexible conventional back-up resources. Due to the high upfront costs inherent to renewables and the progressively lower running times associated with back-up capacity, the cost of capital will have a proportionately greater impact on total costs than today. This report examines how electricity markets can be designed to provide long-term price signals, thereby reducing the cost of capital for these technologies and allowing for a more efficient transition. It finds that current market arrangements are unable to provide long-term price signals. To address this issue, we argue that a system for long-term contracts with a regulated counterparty could be implemented. A centralised system where capacity or energy or a combination of both is contracted, could be introduced for conventional and renewable capacity, based on a regional adequacy assessment and with a competitive bidding system in place to ensure cost-effectiveness. Member states face a number of legislative barriers while implementing these types of systems, however, which could be reduced by merging legislation and setting EU framework rules for the design of these contractual agreements.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Vertebrate limbs develop in a temporal proximodistal sequence, with proximal regions specified and generated earlier than distal ones. Whereas considerable information is available on the mechanisms promoting limb growth, those involved in determining the proximodistal identity of limb parts remain largely unknown. We show here that retinoic acid (RA) is an upstream activator of the proximal determinant genes Meis1 and Meis2. RA promotes proximalization of limb cells and endogenous RA signaling is required to maintain the proximal Meis domain in the limb. RA synthesis and signaling range, which initially span the entire lateral plate mesoderm, become restricted to proximal limb domains by the apical ectodermal ridge (AER) activity following limb initiation. We identify fibroblast growth factor (FGF) as the main molecule responsible for this AER activity and propose a model integrating the role of FGF in limb cell proliferation, with a specific function in promoting distalization through inhibition of RA production and signaling.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Master thesis discusses the analysis of changes in biological signals on time based on dynamic time warping algorithm (DTW). Special attention is paid to problems of tiny changes analysis incomplex nonstationary biological signals. Electrocardiographic (ECG) signals are used as an example inthis study; in particular, repolarization segments of heart beat cycles. The aim of the research is studyingthe possibility of applying DTW algorithm for the analysis of small changes in the repolarization segments of heart beat cycles. The research has the following tasks:- Studying repolarization segments of heart beat cycles, andmethods of their analysis;- Studying DTW algorithm and its modifications, finding the most appropriate modification for analyzing changes in biological signals;- Development of methods for analyzing the warping path(output parameter of DTW algorithm).

Relevância:

20.00% 20.00%

Publicador:

Resumo:

The problem of similarity measurement of biological signals is considered on this article. The dynamic time warping algorithm is used as a possible solution. A short overview of this algorithm and its modifications are given. Testing procedure for different modifications of DTW, which are based on artificial test signals, are presented.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Arizona Department of Transportation, Phoenix

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Texas State Department of Highways and Public Transportation, Transportation Planning Division, Austin

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Federal Highway Administration, Washington, D.C.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Texas Department of Transportation, Austin

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Federal Highway Administration, Washington, D.C.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Federal Highway Administration, Office of Research and Development, Washington, D.C.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Federal Highway Administration, Office of Research and Development, Washington, D.C.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Federal Highway Administration, Office of Research and Development, Washington, D.C.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Mode of access: Internet.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

National Highway Traffic Safety Administration, Washington, D.C.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Turner-Fairbank Highway Research Center, McLean, Va.