Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin gamma 1 chain

The prion protein (PrP(C)) is highly expressed in the nervous system, and its abnormal conformer is associated with prion diseases. PrP(C) is anchored to cell membranes by glycosylphosphatidylinositol, and transmembrane proteins are likely required for PrP(C)-mediated intracellular signaling. Binding of laminin (Ln) to PrP(C) modulates neuronal plasticity and memory. We addressed signaling pathways triggered by PrP(C)-Ln interaction in order to identify transmembrane proteins involved in the transduction of PrP(C)-Ln signals. The Ln gamma 1-chain peptide, which contains the Ln binding site for PrP(C), induced neuritogenesis through activation of phospholipase C (PLC), Ca(2+) mobilization from intracellular stores, and protein kinase C and extracellular signal-regulated kinase (ERK1/2) activation in primary cultures of neurons from wild-type, but not PrP(C)-null mice. Phage display, coimmunoprecipitation, and colocalization experiments showed that group I metabotropic glutamate receptors (mGluR1/5) associate with PrP(C). Expression of either mGluR1 or mGluR5 in HEK293 cells reconstituted the signaling pathways mediated by PrP(C)-Ln gamma 1 peptide interaction. Specific inhibitors of these receptors impaired PrP(C)-Ln gamma 1 peptide-induced signaling and neuritogenesis. These data show that group I mGluRs are involved in the transduction of cellular signals triggered by PrP(C)-Ln, and they support the notion that PrP(C) participates in the assembly of multiprotein complexes with physiological functions on neurons.-Beraldo, F. H., Arantes, C. P., Santos, T. G., Machado, C. F., Roffe, M., Hajj, G. N., Lee, K. S., Magalhaes, A. C., Caetano, F. A., Mancini, G. L., Lopes, M. H., Americo, T. A., Magdesian, M. H., Ferguson, S. S. G., Linden, R., Prado, M. A. M., Martins, V. R. Metabotropic glutamate receptors trans-duce signals for neurite outgrowth after binding of the prion protein to laminin gamma 1 chain. FASEB J. 25, 265-279 (2011). www.fasebj.org

Electrochemical Control of the Time-Dependent Intensity Fluctuations in Surface-Enhanced Raman Scattering (SERS)

Time-dependent fluctuations in surface-enhanced Raman scattering (SERS) intensities were recorded from a roughened silver electrode immersed in diluted solutions of rhodamine 6G (R6G) and congo red (CR). These fluctuations were attributed to a small number of SERS-active molecules probing regions of extremely high electromagnetic field (hot spots) at the nanostructured surface. The time-dependent distribution of SERS intensities followed a tailed statistics at certain applied potentials, which has been linked to single-molecule dynamics. The shape of the distribution was reversibly tuned by the applied voltage. Mixtures of both dyes, R6G and CR, at low concentrations were also investigated. Since R6G is a cationic dye and CR is an anionic dye, the statistics of the SERS intensity distribution of either dye in a mixture were independently controlled by adjusting the applied potential. The potential-controlled distribution of SERS intensities was interpreted by considering the modulation of the surface coverage of the adsorbed dye by the interfacial electric field. This interpretation was supported by a two-dimensional Monte Carlo simulation that took into account the time evolution of the surface configuration of the adsorbed species and their probability to populate a hypothetical hot spot. The potential-controlled SERS dynamics reported here is a first step toward the spectroelectrochemical investigation of redox processes at the single-molecule level by SERS.

Essays on growth and environment

This thesis consists of a summary and four self-contained papers. Paper [I] Following the 1987 report by The World Commission on Environment and Development, the genuine saving has come to play a key role in the context of sustainable development, and the World Bank regularly publishes numbers for genuine saving on a national basis. However, these numbers are typically calculated as if the tax system is non-distortionary. This paper presents an analogue to genuine saving in a second best economy, where the government raises revenue by means of distortionary taxation. We show how the social cost of public debt, which depends on the marginal excess burden, ought to be reflected in the genuine saving. We also illustrate by presenting calculations for Greece, Japan, Portugal, U.K., U.S. and OECD average, showing that the numbers published by the World Bank are likely to be biased and may even give incorrect information as to whether the economy is locally sustainable. Paper [II] This paper examines the relationships among per capita CO2 emissions, per capita GDP and international trade based on panel data spanning the period 1960-2008 for 150 countries. A distinction is also made between OECD and Non-OECD countries to capture the differences of this relationship between developed and developing economies. We apply panel unit root and cointegration tests, and estimate a panel error correction model. The results from the error correction model suggest that there are long-term relationships between the variables for the whole sample and for Non-OECD countries. Finally, Granger causality tests show that there is bi-directional short-term causality between per capita GDP and international trade for the whole sample and between per capita GDP and CO2 emissions for OECD countries. Paper [III] Fundamental questions in economics are why some regions are richer than others, why their growth rates differ, whether their growth rates tend to converge, and what key factors contribute to explain economic growth. This paper deals with the average income growth, net migration, and changes in unemployment rates at the municipal level in Sweden. The aim is to explore in depth the effects of possible underlying determinants with a particular focus on local policy variables. The analysis is based on a three-equation model. Our results show, among other things, that increases in the local public expenditure and income taxe rate have negative effects on subsequent income income growth. In addition, the results show conditional convergence, i.e. that the average income among the municipal residents tends to grow more rapidly in relatively poor local jurisdictions than in initially “richer” jurisdictions, conditional on the other explanatory variables. Paper [IV] This paper explores the relationship between income growth and income inequality using data at the municipal level in Sweden for the period 1992-2007. We estimate a fixed effects panel data growth model, where the within-municipality income inequality is one of the explanatory variables. Different inequality measures (Gini coefficient, top income shares, and measures of inequality in the lower and upper part of the income distribution) are examined. We find a positive and significant relationship between income growth and income inequality measured as the Gini coefficient and top income shares, respectively. In addition, while inequality in the upper part of the income distribution is positively associated with the income growth rate, inequality in the lower part of the income distribution seems to be negatively related to the income growth. Our findings also suggest that increased income inequality enhances growth more in municipalities with a high level of average income than in municipalities with a low level of average income.

Sobre a inexistente relação entre política industrial e comércio exterior

Ao contrário do que se encontra na literatura internacional, em nosso país a defesa da intervenção governamental para promoção da atividade industrial está, via de regra, associada à necessidade de melhoria de nossas contas externas. Este artigo discute possíveis elos entre política industrial e comércio exterior, centrando em argumentos comumente encontrados no debate de crescimento e de apoio à indústria no Brasil. Discutiremos a racionalidade destes argumentos tanto do ponto de vista macroeconômico quanto microeconômico, e mostraremos que, enquanto no primeiro caso há graves inconsistências lógicas e teóricas, no segundo a evidência é amplamente desfavorável ou os argumentos em geral não se aplicam. Discutiremos também se experiências internacionais de crescimento rápido (e de expansão de comércio exterior) podem ser creditadas a políticas industriais e se estas podem ser facilmente reproduzidas no país. Nosso diagnóstico aqui também é pessimista

Sources of comparative advantages in Brazil

Based on the Heckscher-Ohlin-Vanek model, this paper investigates relative factor abundance in Brazil, as revealed by its international trade. We study two different time periods: one characterized by high trade barriers (1980 to 1985) and the trade liberalization period (1990 to 1995). Two alternative methodologies are used: the estimation of factor intensity regressions on net exports and the direct computation of factor content in net exports. In the factor intensity regression, we incorporate technological changes that might have occurred over time, and those turned out to be significant. Both methods yield the same results: the Brazilian international trade reveals relative abundance in capital, land and unskilled labor, and scarcity in skilled labor, with qualitatively equivalent results for the two time periods studied.

Impacts of the proposals for tariff reductions in non-agricultural market access (Nama)

O Estudo Visa Avaliar os Impactos de Propostas Alternativas de Redução da Proteção Tarifária de Bens Não-Agrícolas Sobre a Economia Brasileira Usando um Modelo de Equilíbrio Geral Computável. Foram Simulados os Impactos da Implementação de Cortes Tarifários de Acordo com Diferentes Coeficientes para a Fórmula Suíça. as Simulações Foram Realizadas com o Modelo Gtap e Todos os Choques Tarifários Foram Calculados a Partir de Informações da Base de Dados Macmap. Além de Analisar Resultados Macroeconômicos e Setoriais, Também foi Testada a Sensibilidade dos Resultados em Relação ao Aumento das Elasticidades de Armington e À Ocorrência de uma Simultânea Liberalização de Tarifas Sobre Bens Agrícolas.

Exchange rate: fix, float, or manage it?

The Exchange Rate is the Most Strategic of the Four Macroeconomic Prices. it Determines not Only Exports and Imports, But Also Real Wages, Consumption and the Savings Rate. Conventional Theory Holds That it is Impossible to Manage It, and That the Only Alternatives are to Fix or to Float It. the Experience of the East Asian Countries, That Use it Strategically, Demonstrates That This Claim is False.

Comércio internacional, politica comercial brasileira e a atuação da Câmara de Comércio Exterior (CAMEX) na condução das políticas para o setor

The proposal of this study is to present an assessment of the performance of the Brazilian Government Chamber of Foreign Trade (Camex), which is a board of the Council of Government responsible for the formulation, implementation and coordination of the Brazilian trade policy. The study begins with a historical approach to the international trade and the Brazilian foreign trade, mentioning its origins, features and interfaces with the economic development of the country. Based on the approach aforementioned, several interviews were made with authorities, who have remarkable knowledge about the subject, in order to obtain their views, experiences and suggestions concerning the performance of Camex since its creation in 1995. The list of interviewees includes authorities that are currently responsibles for the conduct of the policy on foreign trade, representatives of the organized society, and authorities who were in important positions in this segment of the federal public administration, regarding both the Minister of State, as Director of Cacex and the Executive Secretary of Camex. The conclusions of the study indicate that the Camex has not been succeeding in fully exercise its mandate of formulate, implement and coordinate the foreign trade policy of Brazil. A combination of factors contributes to this situation, especially its small strutcure, the fact that some ministries compete in the segment of foreign trade ¿don't understand¿ Chamber¿s real purpose, and, at last, the absence of a political mandate"(words taken from Motta Veiga) that would fortify its existing legal mandate. Finally, the study suggests some changes in the current organizational modeling of Camex, especially in its hierarchical position in the federal public administration."

Estratégias de internacionalização: investimentos diretos externos de multinacionais brasileiras

With the improvement of the international trade on the last decades, the Brazilian firms are searching to operate beyond the national borders in order to guarantee its presence on the key markets. The dissertation aimed to analyze the motivations and the strategies of internationalization implemented by the firms: Petrobras, Vale, Embraer, Gerdau and Marcopolo as well as determine the existence of a dominant strategy. In order to do that, Dunning¿s eclectic paradigm and the strategies of internationalization supported by him were revised along with the main literature from Brazilian authors on the internationalization process of the selected firms. The comparative analysis between the strategies of internationalization selected and the industrial sector, origin of capital and the preferred mode of entrance on the markets were done through an exploratory research, with a qualitative character and collection of secondary data from the internationalization process of the firms. At the end of this research, it was possible to identify that each firm had adopted a predominant strategy however it was also possible to observe that new strategies were aggregated in complementation of the previous one. Besides that, no evidence was found between the predominant strategy of internationalization and the origin of the capital neither with the preferred mode of entrance.

Opções estratégicas para o sistema portuário brasileiro

Ao longo da última década muitos estudos apontaram que a economia brasileira não desempenhou de acordo com o seu potencial. Muitos defendem que a falta de qualidade do sistema portuário brasileiro interfere de forma significativa nesse contexto. Com o uso da metodologia Strategic Options Development and Analysis foi possível identificar principais fatores que resultam na deficiência do setor no Brasil, assim como propor opções estratégicas para mitigar ou solucionar os problemas. Oito entrevistas foram conduzidas com empresas que conjuntamente pudessem representar uma perspectiva holística da cadeia de comércio exterior. Como resultado, um modelo baseado nos mapas cognitivos dos entrevistados foi criado e sete fatores foram apontados como os mais relevantes entraves do setor. During the last decade, several studies indicated that the Brazilian economy was not performing as expected or according to its potential. Many argue that the lack of quality in the seaport system acts as a determinant driver in this context. The usage of Strategic Options Development and Analysis methodology permits identifying the main factors that result in this sector lagging behind in Brazil, as well as suggests strategic options to mitigate or solve the problems permanently. Eight in-depth interviews were conducted with companies that together represent a holistic perspective of the international trade process. As a result, a framework based on the interviewees´ individual cognitive maps was created and seven factors were pointed as the sector´s most relevant issues.

Poder judiciário fluminense e capixaba diante do comércio internacional e do pré-sal: novos desafios

As transformações recentes das relações sociais e econômicas incrementados pelo dinamismo do comércio internacional, sua crescente complexidade e as recémdescobertas reservas petrolíferas na camada pré-sal, aliadas ao fenômeno da globalização, contribuem para o processo de internacionalização do Direito. Esse cenário tem demandado, ainda, novos instrumentos de solução dos conflitos e de controle social, exigindo dos magistrados brasileiros maior expertise no julgamento das demandas contemporâneas. Diante desse cenário, é necessário construir alternativas que realmente busquem modificar as estruturas vigentes na teoria, na práxis e no ensino do Direito. Assim, o objetivo geral desta pesquisa é contribuir para a eficiência da prestação jurisdicional dos magistrados, seja no âmbito estadual ou federal, que atuam no Estado do Rio de Janeiro e Espírito Santo, diante dos novos desafios que terão em face do comércio internacional e do pré-sal. Com a finalidade de alcançar seu escopo, a pesquisa, no Capítulo 1, trata dos conceitos, princípios e metodologia para atingir o objetivo geral da pesquisa. O Capítulo 2 ocupa-se da abordagem das disciplinas relevantes para uma eficiente prestação jurisdicional do pré-sal e do comércio internacional. Em seguida, o Capítulo 3 trata de analisar o conteúdo das disciplinas ministradas nas Escolas de Magistratura Estadual do Rio de Janeiro e Federal da 2ª Região, bem como as provas para ingresso à carreira da magistratura federal e estadual do Rio de Janeiro e Espírito Santo, no que tange à existência de disciplinas como Direito do Petróleo, Gás e Energia, Direito Econômico, Direito Internacional Público e Privado, Exploração & Produção, Direito do Mar, Direito Marítimo, Direito da Navegação Marítima, Direito Portuário, Direito Aduaneiro e Direito Ambiental. Por fim, serão feitas algumas considerações e apresentadas as referências da pesquisa.

Aspectos do comércio entre China e Brasil e seus impactos

O presente trabalho tem como objetivo clarificar alguns pontos da relação comercial entre Brasil e China. Em grande parte é um trabalho descritivo, que utiliza diferentes agregações de produtos (Sistema harmônico; Broad Economic Categories), a fim de construir um cenário completo desta relação. Efeitos totais na produção brasileira, oriundos da demanda Chinesa por produtos Brasileiros também são analisados. Para tal utilizamos o ferramental de Matriz de Insumo Produto. Este efeito também é construído para o comércio do Brasil com os outros países do Mundo, e uma comparação é estabelecida. No fim do trabalho temos um estudo sobre possibilidades de comércio que ainda não foram exploradas entre esses dois países.

Globalization and the Industrial Revolution (revised)

This paper argues that trade specialization played an indispensable role in supporting the Industrial Revolution. We calibrate a two-good and two-sector overlapping generations model to Englandís historical development and investigate how much different Englandís development path would have been if it had not globalized in 1840. The open-economy model is able to closely match the data, but the closed-economy model cannot explain the fall in the value of land relative to wages observed in the 19th century. Without globalization, the transition period in the British economy would be considerably longer than that observed in the data and key variables, such as the share of labor force in agriculture, would have converged to Ögures very distant from the actual ones.

Comparative advantage, heterogeneous firms and variable mark-ups

We develop a model of comparative advantage with monopolistic competition, that incorporates heterogeneous firms and endogenous mark-ups. We analyse how these features vary across countries with different factor endowments, and across markets of different size. In this model we can obtain trade gains via two channels. First, when we open the economy, most productive firms start to export their product, then, they demand more producing factors and wages rises, thus, those firms that are less productive will be forced to stop to produce. Second channel is via endogenous mark-ups, when we open the economy, the competition gets ``tougher'', then, mark-ups falls, thus, those firms that are less productive will stop to produce. We also show that comparative advantage works as a ``third channel'' of trade gains, because, all trade gains results are magnified in comparative advantage industry of both countries. We also make a numerical exercise to see how endogenous variables of the model vary when trade costs fall.

Export-led recoveries in small open industrialized economies

This paper studies the role of Vertical Specialization-based trade and foreign damand push as elements capable of explaining export-led recoveries in small open industrialized economies. The empirical evidence on export-led recoveries is reviewed. Data supporting the growing importance of vertical specialization for international trade are presented. I compare the performance of two versions of a small open economy model, calibrated to mimic Canadian Business Cycles. The …rst one is based upon Schmitt-Grohe(1998). The second incorporates Vertical- Specialization-based trade. I show that an arti…cial economy featuring Vertical-Specializationbased trade in conjunction with an exogenous AR(2) process for foreign output displays improved impulse responses to a foreign output shock and is able to mimic the contribution of Canadian exports to output growth during economic recoveries.