Leucemias agudas secundarias a tratamiento con quimioterapia y/o radioterapia: estudio de 23 pacientes en un solo centro.

L’ús d’agents citotòxics ha incrementat la incidència de leucèmies agudes secundàries (LAS). De 23 LAS diagnosticades en 20 anys, s’analitzaren els agents citotòxics, caraterístiques clínico-biològiques, tractament i pronòstic. Els agents rebuts a la neoplàsia prèvia fóren: alquilants, inhibidors de la DNA topoisomerasa II, antitubulina i radioteràpia. El 95% de les LAS presentàven alteracions citogenètiques. Tretze pacients reberen quimioteràpia intensiva (amb un trasplantament de progenitors hematopoètics [TPH] en 3) i 10 només suport (supervivència mediana de 3 en front a 0,079 anys, p=0,004). El pronòstic i la resposta al tractament fóren dolents, però associaciar quimioteràpia i TPH podria perllongar la supervivència.

Clinical evaluation of a method for detecting superficial surgical transitional cell carcinoma of the bladder by light-induced fluorescence of protoporphyrin IX following the topical application of 5-aminolevulinic acid: preliminary results.

BACKGROUND AND OBJECTIVE: In bladder cancer, conventional white light endoscopic examination of the bladder does not provide adequate information about the presence of "flat" urothelial lesions such as carcinoma in situ. In the present investigation, we examine a new technique for the photodetection of such lesions by the imaging of protoporphyrin IX (PpIX) fluorescence following topical application of 5-aminolevulinic acid (ALA). STUDY DESIGN/MATERIALS AND METHODS: Several hours after bladder instillation of an aqueous solution of ALA in 34 patients, a Krypton ion laser or a filtered Xenon arc-lamp was used to excite PpIX fluorescence. Tissue samples for histological analysis were taken while observing the bladder wall either by means of a video camera, or by direct endoscopic observation. RESULTS: A good correlation was found between the PpIX fluorescence and the histopathological diagnosis. On a total of 215 biopsies, 143 in fluorescent and 72 in nonfluorescent areas, all visible tumors on white light cytoscopy appeared in a bright red fluorescence with the photodetection technique. In addition, this method permitted to discover 47 unsuspected carcinomatous lesions on white light observation, among which 40% were carcinoma in situ. CONCLUSION: PpIX fluorescence induced by instillation into the bladder of 5-ALA is an efficient method of mapping the mucosa in bladder carcinoma.

Análisis de rendimiento de aplicaciones en sistemas multicore

El rápido crecimiento del los sistemas multicore y los diversos enfoques que estos han tomado, permiten que procesos complejos que antes solo eran posibles de ejecutar en supercomputadores, hoy puedan ser ejecutados en soluciones de bajo coste también denominadas "hardware de comodidad". Dichas soluciones pueden ser implementadas usando los procesadores de mayor demanda en el mercado de consumo masivo (Intel y AMD). Al escalar dichas soluciones a requerimientos de cálculo científico se hace indispensable contar con métodos para medir el rendimiento que los mismos ofrecen y la manera como los mismos se comportan ante diferentes cargas de trabajo. Debido a la gran cantidad de tipos de cargas existentes en el mercado, e incluso dentro de la computación científica, se hace necesario establecer medidas "típicas" que puedan servir como soporte en los procesos de evaluación y adquisición de soluciones, teniendo un alto grado de certeza de funcionamiento. En la presente investigación se propone un enfoque práctico para dicha evaluación y se presentan los resultados de las pruebas ejecutadas sobre equipos de arquitecturas multicore AMD e Intel.

Recambios en un solo tiempo de prótesis de cadera y rodilla sobre terreno contaminado: nuestra experiencia

Objective: Evaluate the results obtained in the simultaneous replacement of a septic arthroplasty or a second septic replacement (implanting the prosthesis in a contaminated eld). Material and method: Series of 17 cases, with a mean age of 66.8 years and average follow-up of 49 months. The exclusion criteria were serious immunological depression and unknown germ or not sensitive to at least three antibiotics. After the intervention, the corresponding antibiotics were administered between six weeks and three months. Recovery was established as the normality for infection indicator variables at least nine months after the replacement. Results: 14 patients developed towards total recovery (follow-up at least 9 months and maximum 84 months). 3 cases presented relapse, all three carriers of Staphylococcus epidermidis (at 1, 3 and 7 months of follow-up respectively). The success percentage is 82.41% (average follow-up of 49 months). Conclusions: Simultaneous replacements is an interesting option for patients with plural pathologies as it o"ers a single operation, less morbidity, quicker return to activities to restore normal function and less associated costs

Superficial Acral Fibromyxoma involving the nail's apparatus. Case report and literature review.

Superficial Acral Fibromyxoma is a rare tumor of soft tissues. It is a relatively new entity described in 2001 by Fetsch et al. It probably represents a fibrohistiocytic tumor with less than 170 described cases. We bring a new case of SAF on the 5th toe of the right foot, in a 43-year-old woman. After surgical excision with safety margins which included the nail apparatus, it has not recurred (22 months of follow up). We carried out a review of the location of all SAF published up to the present day.

Contribuições da Copa da Inclusão para a consolidação do campo psicossocial

Este é um estudo descritivo e analítico de caráter qualitativo, cujo objeto é a ação dos trabalhadores na Copa da Inclusão (seus processos de trabalho). Busca compreender se tal ação considera a vida real do usuário de serviços de saúde mental e, para tal, adotou como categorias teóricas os elementos constitutivos do processo de trabalho, tecnologias em saúde e os pressupostos do campo psicossocial. Os dados empíricos foram coletados por meio de entrevista semi-estruturada e analisados segundo a técnica de análise de enunciação. Os resultados apontam transformações na vida dos usuários, dos serviços e da sociedade coerentes com os pressupostos da Reforma Psiquiátrica brasileira. A Copa da Inclusão prova que atividades intersetoriais são trabalhos vivos em ato, utilizam instrumentos de intervenção potentíssimos no resgate e construção da cidadania das pessoas portadoras de transtornos mentais. As transformações (finalidades dos processos de trabalho) podem estar ocorrendo porque o projeto de intervenção não é mais centrado na doença.

Evaluation de la qualité de vie après prélèvement de la veine fémorale superficielle lors de reconstructions infra-inguinales [Quality of life after superficial femoral vein harvest for infra-inguinal reconstructions]

BACKGROUND: The superficial femoral vein (SFV) is a well-established alternative conduit for infra-inguinal reconstructivenous hypertension after SFV harvest may however result in significant morbidity. This study reports the efficiency of SFV as conduit for infra-inguinal reconstructions and characterize the anatomic and physiologic changes in harvest limbs and their relationship to the development of venous complications. METHODS: From May 1999 through November 2003, 23 SFV were harvested from 21 patients undergoing infra-inguinal reconstructions. Bypasses were controlled by regular duplex-ultrasound. The venous morbidity was assessed by measurements of leg circumferences, strain-gauge plethysmography and quality of life, investigated by the VEINES-QOL scale. RESULTS: At a mean follow-up of 10.4 months (range 1-56), primary, secondary patency and limb salvage rates of infra-inguinal bypasses using SFV are 71.4%, 76.2% and 85.7% respectively. No patient had major venous claudication. Oedema was significantly present in nine patients. Strain-gauge plethysmography showed outflow obstruction in all patients. The VEINES-QOL assessment showed no limitation in social and domestic activity, moderate complain about leg heaviness despite presence of oedema. CONCLUSION: The SFV harvest is a reliable conduit for infra-inguinal reconstructions and results in moderate venous morbidity in terms of functional consequences and quality of life.

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[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]]

[Archives de la Parole]. , [Rangami gari] : [chant populaire en dialecte Kui] Inde, Malabar / [Sir George Grierson], éd. ; Linguistic survey of India ; Chant solo, homme

[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]]

[Archives de la Parole]. , [Chant] : Inde, Savara, prov[ince] de Madras / [Sir George Grierson], éd. ; Linguistic survey of India ; Chant solo, homme

[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]]

[Archives de la Parole]. , Marriage song : in Kharia / [Sir George Grierson], éd. ; Linguistic survey of India ; Homme, chant solo

[Traditions. Asie. Inde. Chotā Nāgpur]

[Archives de la Parole]. , [Santali songs] / [Sir George Grierson], éd. ; Linguistic survey of India ; Homme, chant solo

[Traditions. Asie. Inde. Chotā Nāgpur]