Reglas y conciencia de las reglas : Significado, ontología y escepticismo

La tesis analiza dos objeciones corrientes a la interpretación del problema de las reglas por el Wittgenstein de Kripke: el PROBLEMA DE LA OBJETIVIDAD DE LA REGLA, ¿puede un individuo estar acertado en contra de la opinión comunitaria consensuada?; y el PROBLEMA DE LAS RELACIONES INTERNAS entre reglas y casos, presuntamente violentada por el rol de la noción de acuerdo en la misma. La estrategia general de la tesis es examinar las vías de ataque al lenguaje privado (LP) previas a la de Kripke. El contraste con las mismas permite conceptualizar adecuadamente la propuesta de Kripke, para mostrar que las objeciones mencionadas no se le aplican. En el marco de la tesis, comprendemos por LP a cualquier tesis que sostenga que las condiciones de significatividad del lenguaje pueden ser provistas por estados mentales subjetivos, p.e. creencias, de ahí el solapamiento de la tesis del lenguaje privado con el escepticismo epistemológico y con posiciones solipsistas, y la convicción de que la refutación del LP acarrea la ruina del escepticismo epistemológico. Hay dos versiones clásicas del argumento del LP. Las versiones epistemológicas (Malcom, Fogelin son los representantes que examinamos) derivan la imposibilidad del LP de la imposibilidad de establecer la verdad/corrección de un uso en el contexto de privacidad. La crítica a estas versiones (Ayer, thomson) muestra un círculo justificatorio entre oraciones subjetivas y objetivas. Las versiones semánticas (Kenny, Canfield, Tugendhat) intentan evitar el círculo, elucidando las presuposiciones que le subyacen. Esta respuesta no es satisfactoria ya que o bien regenera el círculo en un nuevo nivel, o bien no logran derrocar al círculo de la justificación. Con Stroud identificamos el fallo común de estas estrategias en el hecho de que en su intento de derrotar al escéptico-privatista, requieren o bien una PREMISA FÁCTICA que indica que conocemos, o bien la especificación del conocimiento como una NOTA DEFINICIONAL de los criterios/condiciones de significatividad que el argumento trascendental elucida en la pregunta del escéptico. Kripke impone un cambio de rumbo en el argumento, al plantear el desafío como una forma de ESCEPTICISMO SEMÁNTICO ONTOLÓGICO, el cual ya no se basa en las limitaciones cognitivas de la privacidad, sino justamente en las presuntas ventajas que presenta. El desafío de Kripke pregunta por las razones que podemos aportar para sostener que no ha ocurrido un cambio en el uso, lo cual equivale a preguntar ¿cómo sabes que tu uso actual CORRESPONDE con tu intención/significado previo? De la imposibilidad de responder a la cuestión clave del realismo clásico (correspondencia) en el caso del significado, Kripke concluye que no puede haber condiciones de verdad para las oraciones semánticas. Esto motiva una paradoja escéptica y una SOLUCIÓN ESCÉPTICA de la paradoja en términos de condiciones de aseverabilidad. Tener en cuenta el abandono de las condiciones de verdad es la clave para responder al problema de la objetividad, mientras que la forma del desafío y el funcionamiento de la concordancia en los juicios como base de atribución, es la clave para la solución del problema de las relaciones internas.

E-MIS validity applied to TELMA enhanced learning environment

Enhanced learning environments are arising with great success within the field of cognitive skills training in minimally invasive surgery (MIS) because they provides multiple benefits since they avoid time, spatial and cost constraints. TELMA [1,2] is a new technology enhanced learning platform that promotes collaborative and ubiquitous training of surgeons. This platform is based on four main modules: an authoring tool, a learning content and knowledge management system, an evaluation module and a professional network. TELMA has been designed and developed focused on the user; therefore it is necessary to carry out a user validation as final stage of the development. For this purpose, e-MIS validity [3] has been defined. This validation includes usability, contents and functionality validities both for the development and production stages of any e-Learning web platform. Using e-MIS validity, the e-Learning is fully validated since it includes subjective and objective metrics. The purpose of this study is to specify and apply a set of objective and subjective metrics using e-MIS validity to test usability, contents and functionality of TELMA environment within the development stage.

Gestión de pruebas para equipos de vídeo

Desde hace ya muchos años, uno de los servicios de telecomunicaciones más demandado por los españoles ha sido la televisión de pago, complementando y ampliando la oferta de contenidos audiovisuales que habitualmente son ofrecidos de manera gratuita por la televisión analógica y recientemente por la televisión digital terrestre o TDT. Estos servicios de video, han sido tradicionalmente ofrecidos por operadores satélites, operadores de cable u otros operadores de telecomunicaciones con los que a través de una conexión de datos (ADSL, VDSL o fibra óptica), ofrecían sus contenidos a través de IP. La propia evolución y mejora de la tecnología utilizada para la emisión de contenidos sobre IP, ha permitido que a día de hoy, la televisión se conciba como un servicio Over The Top (OTT) ajeno al medio de transmisión, permitiendo a cualquier agente, distribuir sus contenidos audiovisuales de manera sencilla y a todos sus clientes en todas las partes del mundo; siendo solamente necesario disponer de una conexión a internet. De esta manera, el proyecto desarrollado va a girar en torno a la herramienta StormTest de la empresa S3Group, comprada por CENTUM Solutions (empresa especializada en ofrecer servicio de ingeniería para sistema de comunicaciones, control e inteligencia de señal) con el objetivo de satisfacer las necesidades de sus clientes y con la que en definitiva se ha contado para la realización de este proyecto. El principal objetivo de este proyecto es la definición e implementación de un banco de pruebas que permita optimizar los procesos de validación técnica, mejorando los tiempos de ejecución y concentrando la actividad de los ingenieros en tareas de mayor valor. Para la realización de este proyecto, se han fijado diversos objetivos necesarios para el desarrollo de este tipo de actividades. Los principales son los siguientes:  Análisis de la problemática actual: donde en los procesos de aceptación técnica se dedica muchas horas de trabajo para la realización de pruebas repetitivas y de poco valor las cuales se pueden automatizar por herramientas existentes en el mercado.  Búsqueda y selección de una herramienta que satisfaga las necesidades de pruebas.  Instalación en los laboratorios.  Configuración y adaptación de la herramienta a las necesidades y proyectos específicos. Con todo ello, este proyecto cubrirá los siguientes logros:  Reducir los tiempos de ejecución de las campañas de pruebas, gracias a la automatización de gran parte ellas.  Realizar medidas de calidad subjetiva y objetiva complejas, imposibles de ejecutar a través de las personas. Mejorar y automatizar los sistemas de reporte de resultados. Abstract: Many years ago, one of the telecommunications services most demanded in Spain has been pay television, complementing and extending the offer of audiovisual content which are usually offered for free by analog tv and recently by digital terrestrial televisión or TDT. These video services, have been traditionally offered by satellite operators, cable operators or other telecommunications operators that through a data connection (ADSL,VDSL or fiber optic), offered its content over IP. The evolution and improvement of the technology used for broadcasting over IP, has allowed that to date, television is conceived as a service Over The Top (OTT), not dependent on the transmission medium, allowing any agent to distribute audiovisual content in a very simple way and to all its customers in all parts of the world; being only necessary to have an decent internet connection. In this way, the project will have relation with S3Group’s StormTest tool, bought by CENTUM Solutions (company specialized in engineering services for communications, control and signal intelligence system) with the aim of satisfying the needs of its customers and which ultimately has counted for the realization of this project. The main objective of this project is the definition and implementation of a test bench that allows to optimize the processes of technical validation, improving execution times and concentrating the activities of engineers on higher value tasks. For the realization of this project, it has been defined several objectives necessary for the development of this type of activity. The most important tones are listed below:  Analysis of the current situation: where in technical acceptance processes it is dedicated many hours of work for the completion of repetitive testing and without value which can be automated by tools available on the market  Search and selection of a tool that meets the needs of testing.  Installation on the laboratories.  Configuration and customization of the tool to specific projects. With all this, this project will cover the following achievements: Reduce the execution time of the testing campaigns, thanks to the automation of many of them.  Measurements of subjective and objective quality tests, impossible to run with engineers (due to subjective perception). Improve and automate reporting of results systems

Efficacia della formazione alla salute e sicurezza sul lavoro: fattori di successo e criticità

Background: sulla base delle evidenze emerse dalle rassegne sistematiche in materia (Johnstone, 1994; Cohen et al.,1998; Robson et al., 2012; Burke et al., 2006; Ricci et al., 2015) si è ipotizzato che la formazione alla salute e sicurezza sul lavoro sia maggiormente efficace quando non è presentata come obbligatoria e venga articolata su più livelli di apprendimento, attraverso metodologie adeguate per ogni livello, con docenti che abbiano caratteristiche corrispondenti allo specifico obiettivo di apprendimento e la cui durata sia parametrata all’obiettivo stesso. Obiettivo di questa ricerca è valutare se esista e quanto sia intensa la relazione causale tra la formazione alla sicurezza sul lavoro e i suoi effetti sul miglioramento delle conoscenze, degli atteggiamenti, dei comportamenti, degli esiti per la salute, del clima di sicurezza aziendale, del controllo comportamentale percepito dai lavoratori, delle condizioni operative e procedure interne, oltre l’eventuale effetto di moderazione determinato da caratteristiche socio-demografiche dei partecipanti e dal gradimento della formazione. Metodo: la variabile indipendente è costituita dell’intervento formativo erogato, articolato in tre condizioni: formazione obbligatoria, formazione non obbligatoria, gruppo di controllo: sono stati posti a confronto due interventi di pari durata (16 settimane, per 10h complessive), realizzati con identiche modalità (step1 audio-visivo; step2 affiancamento su lavoro da parte del preposto; step3 discussione di auto-casi), ma differenziati rispetto all’essere presentati uno come formazione obbligatoria, l’altro come non obbligatoria. I due gruppi sono anche stati confrontati con un gruppo di controllo per il quale la formazione è prevista successivamente. I partecipanti sono stati assegnati in modo casuale al gruppo con obbligo formativo, senza obbligo formativo, di controllo. Sono stati presi come indicatori (variabili dipendenti) per valutare l’effetto della formazione: I livello – conoscenze: riconoscimento o produzione di un maggior numero di risposte corrette. II livello – atteggiamenti e credenze: maggiore propensione a mettere in atto comportamenti auto ed etero protettivi. III livello – comportamenti: comportamenti osservati più adeguati per la tutela della salute propria e altrui. IV livello – salute: maggior grado di benessere bio-psico-sociale auto-riferito. Le misure di esito consistono nella variazione tra la rilevazione iniziale e ogni rilevazione successiva, sulla base delle diverse misure registrate per ognuno dei quattro livelli dell’intervento formativo. Lo stesso confronto del tempo è stato realizzato per le misure del clima di sicurezza aziendale, del controllo comportamentale percepito dai lavoratori, delle condizioni operative e procedure interne, oltre l’eventuale effetto di moderazione determinato da caratteristiche socio-demografiche dei partecipanti e dal gradimento della formazione, quest’ultimo misurato solo immediatamente al termine dell’intervento. Risultati: le condizioni di intervento non differiscono in termini di efficacia, la formazione determina infatti gli stessi risultati per i partecipanti del gruppo obbligo formativo e di quello non obbligo, con una significativa differenza post-intervento rispetto al gruppo di controllo. La formazione ha un effetto forte nel miglioramento delle conoscenze che solo parzialmente decade nel tempo, ma comunque mantenendo un livello maggiore rispetto ai valori iniziali. In relazione al miglioramento di atteggiamenti e comportamenti sicuri nel lavoro al Videoterminale, l’effetto della formazione è modesto: per gli atteggiamenti si registra solo un miglioramento verso l’applicazione delle procedure come utili realmente e non come mero adempimento, ma tale effetto decade entro quattro mesi riportando i partecipanti su valori iniziali; i comportamenti invece migliorano nel tempo, ma con deboli differenze tra partecipanti alla formazione e gruppo di controllo, tuttavia tale miglioramento non decade in seguito. Non si registrano invece effetti della formazione nella direzione attesa in termini di esiti per la salute, per il miglioramento del clima di sicurezza e come maggior controllo comportamentale percepito, non risultano nemmeno dati evidenti di moderazione degli effetti dovuti a caratteristiche socio-demografiche dei partecipanti. Inoltre emerge che il gradimento per la formazione è correlato con migliori atteggiamenti (strumento audio-visivo), il miglioramento del clima di sicurezza e un maggior controllo comportamentale percepito (studio di auto-casi), ovvero gli step che hanno visto l’intervento di formatori qualificati. Infine, la formazione ha determinato migliori condizioni operative e l’adeguamento delle procedure interne. Conclusioni: la presente ricerca ci consente di affermare che la formazione erogata è stata efficace, oltre che molto gradita dai partecipanti, in particolare quando il formatore è qualificato per questa attività (step1 e 3). L’apprendimento prodotto è tanto più stabile nel tempo quanto più i contenuti sono in stretta relazione con l’esperienza lavorativa quotidiana dei partecipanti, mentre negli altri casi il decremento degli effetti è alquanto rapido, di conseguenza ribadiamo la necessità di erogare la formazione con continuità nel tempo. E’ risultato comunque modesto l’effetto della formazione per migliorare gli atteggiamenti e i comportamenti nel lavoro al VDT, ma, al di là di alcuni limiti metodologici, sono obiettivi ambiziosi che richiedono più tempo di quanto abbiamo potuto disporre in questa occasione e il cui conseguimento risente molto delle prassi reali adottate nel contesto lavorativo dopo il termine della formazione. Le evidenze finora prodotte non hanno poi chiarito in modo definitivo se attraverso la formazione si possano determinare effetti significativi nel miglioramento di esiti per la salute, anche eventualmente attraverso interventi di supporto individuale. Inoltre l’assenza di differenze significative negli effetti tra i partecipanti assegnati alla condizione di obbligo e quelli di non obbligo, eccezion fatta in direzione opposta alle attese per la misura del danno da lavoro, suggeriscono che nell’erogare la formazione, occorre sottolineare in misura molto rilevante l’importanza dell’intervento che viene realizzato, anche qualora esistesse una prescrizione normativa cogente. Infine, la ricerca ci ha fornito anche indicazioni metodologiche e misure valide che invitano ad estendere questa formazione, e la sua valutazione di efficacia, a diversi comparti economici e svariate mansioni. Nel fare questo è possibile fare riferimento, e testare nuovamente, un modello che indica la corretta percezione del rischio (conoscenza) come fattore necessario, ma non sufficiente per ottenere, con la mediazione di atteggiamenti favorevoli allo specifico comportamento, azioni sicure, attraverso le quali si rinforza l’atteggiamento e migliorano le conoscenze. La formazione, per raggiungere i propri obiettivi, deve tuttavia agire anche sui meccanismi di conformismo sociale favorevoli alla safety, questi originano da conoscenze e azioni sicure e reciprocamente le rinforzano.

Relational Memory Is Evident in Eye Movement Behavior despite the Use of Subliminal Testing Methods

While it is generally agreed that perception can occur without awareness, there continues to be debate about the type of representational content that is accessible when awareness is minimized or eliminated. Most investigations that have addressed this issue evaluate access to well-learned representations. Far fewer studies have evaluated whether or not associations encountered just once prior to testing might also be accessed and influence behavior. Here, eye movements were used to examine whether or not memory for studied relationships is evident following the presentation of subliminal cues. Participants (assigned to experimental or control groups) studied scene-face pairs and test trials evaluated implicit and explicit memory for these pairs. Each test trial began with a subliminal scene cue, followed by three visible studied faces. For experimental group participants, one face was the studied associate of the scene (implicit test); for controls none were a match. Subsequently, the Display containing a match was presented to both groups, but now it was preceded by a visible scene cue (explicit test). Eye movements were recorded and recognition Memory responses were made. Participants in the experimental group looked disproportionately at matching faces on implicit test trials and participants from both groups looked disproportionately at matching faces on explicit test trials, even when that face had not been successfully identified as the associate. Critically, implicit memory-based viewing effects seemed not to depend on residual awareness of subliminal scenes cues, as subjective and objective measures indicated that scenes were successfully masked from view. The reported outcomes indicate that memory for studied relationships can be expressed in eye movement behavior without awareness.

La evolucion social de Chile

Mode of access: Internet.

Effect of light-emitting diode colour temperature on magnifier reading performance of the visually impaired

Background: As light-emitting diodes become more common as the light source for low vision aids, the effect of illumination colour temperature on magnifier reading performance was investigated. Methods: Reading ability (maximum reading speed, critical print size, threshold near visual acuity) using Radner charts and subjective preference was assessed for 107 participants with visual impairment using three stand magnifiers with light emitting diode illumination colour temperatures of 2,700 K, 4,500 K and 6,000 K. The results were compared with distance visual acuity, prescribed magnification, age and the primary cause of visual impairment. Results: Reading speed, critical print size and near visual acuity were unaffected by illumination colour temperature (p > 0.05). Reading metrics decreased with worsening acuity and higher levels of prescribed magnification but acuity was unaffected by age. Each colour temperature was preferred and disliked by a similar number of patients and was unrelated to distance visual acuity, prescribed magnification and age (p > 0.05). Patients had better near acuity (p = 0.002), critical print size (p = 0.034) and maximum reading speed (p <0.001), and the improvement in near from distance acuity was greater (p = 0.004) with their preferred rather than least-liked colour temperature illumination. Conclusion: A range of colour temperature illuminations should be offered to all visually impaired individuals prescribed with an optical magnifier for near tasks to optimise subjective and objective benefits.

Measuring the operational performance of intensive care units using the analytic hierarchy process approach

Purpose - The purpose of this study is to develop a performance measurement model for service operations using the analytic hierarchy process approach. Design/methodology/approach - The study reviews current relevant literature on performance measurement and develops a model for performance measurement. The model is then applied to the intensive care units (ICUs) of three different hospitals in developing nations. Six focus group discussions were undertaken, involving experts from the specific area under investigation, in order to develop an understandable performance measurement model that was both quantitative and hierarchical. Findings - A combination of outcome, structure and process-based factors were used as a foundation for the model. The analyses of the links between them were used to reveal the relative importance of each and their associated sub factors. It was considered to be an effective quantitative tool by the stakeholders. Research limitations/implications - This research only applies the model to ICUs in healthcare services. Practical implications - Performance measurement is an important area within the operations management field. Although numerous models are routinely being deployed both in practice and research, there is always room for improvement. The present study proposes a hierarchical quantitative approach, which considers both subjective and objective performance criteria. Originality/value - This paper develops a hierarchical quantitative model for service performance measurement. It considers success factors with respect to outcomes, structure and processes with the involvement of the concerned stakeholders based upon the analytic hierarchy process approach. The unique model is applied to the ICUs of hospitals in order to demonstrate its effectiveness. The unique application provides a comparative international study of service performance measurement in ICUs of hospitals in three different countries. © Emerald Group Publishing Limited.

Problem solving in architectural design

This thesis is presented in two parts. The first part is an attempt to set out a framework of factors influencing the problem solving stage of the architectural design process. The discussion covers the nature of architectural problems and some of the main ways in which they differ from other types of design problems. The structure of constraints that both the problem and the architect impose upon solutions are seen as of great importance in defining the type of design problem solving situation. The problem solver, or architect, is then studied. The literature of the psychology of thinking is surveyed for relevant work . All of the traditional schools of psychology are found wanting in terms of providing a comprehensive theory of thinking. Various types of thinking are examined, particularly structural and productive thought, for their relevance to design problem solving. Finally some reported common traits of architects are briefly reviewed. The second section is a report of u~o main experiments which model some aspects of architectural design problem solving. The first experiment examines the way in which architects come to understand the structure of their problems. The performances of first and final year architectural students are compared with those of postgraduate science students and sixth form pupils. On the whole these groups show significantly different results and also different cognitive strategies. The second experiment poses design problems which involve both subjective and objective criteria, and examines the way in which final year architectural students are able to relate the different types of constraint produced. In the final section the significance of all the results is suggested. Some educational and methodological implications are discussed and some further experiments and investigations are proposed.

Ocular response to silicone-hydrogel contact lenses

The thesis investigates the ocular response to silicone-hydrogel (SiH) contact lens wear, a relatively new contact lens material that has a higher modulus of rigidity and different surface coating than used in conventional hydrogel materials. The properties of SiH materials differ significantly from conventional hydrogels and, using subjective and objective means of assessment, the thesis examines how these properties affect reflection and biometry, ocular physiology, tear film characteristics, symptomatology, adverse events and complications. A range of standard and newly designed investigative techniques were employed, and latter involving novel imaging techniques, for the objective assessment of physiological changes which occur with contact lens wear. The study is the first to combine these techniques with biochemical analyses of the tear film composition. Forty-seven subjects were fitted with SiH lenses and randomly allocated to one of the two materials currently on the market (Lotrafilcon A or Balafilcon A) on an either daily or continuous wear basis. An additional control group of 14 age-matched non-contact lens wearers were monitored over the same period. Measurements were taken before and 1, 3, 6, 12 and 18 months after initial fitting. The findings reported in this thesis will enable contact lens practitioners and manufacturers to understand further the optical, physiological and biochemical nature of the ocular response to SiH contact lenses and hence facilitate the development of this important generation of contact lens material.

Decision support system for spare parts warehousing

Spare parts warehousing decision-making plays an important role in today's manufacturing industry as it derives an optimum inventory policy for the organizations. Previous research on spare parts warehousing decision-making did not deal with the problem holistically considering all the subjective and objective criteria of operational and strategic needs of the manufacturing companies in the process industry. This study reviews current relevant literature and develops a conceptual framework (an integrated group decision support system) for selecting the most effective warehousing option for the process industry using the analytic hierarchy process (AHP). The framework has been applied to a multinational cement manufacturing company in the UK. Three site visits, eight formal interviews, and several discussions have been undertaken with personnel of the organization, many of which have more than 20 years of experience, in order to apply the proposed decision support system (DSS). Subsequently, the DSS has been validated through a questionnaire survey in order to establish its usefulness, effectiveness for warehousing decision-making, and the possibility of adoption. The proposed DSS is an integrated framework for selecting the best warehousing option for business excellence in any manufacturing organization.

Clinical performance of daily disposable soft contact lenses using sustained release technology

Purpose: Polyvinyl alcohol (PVA) is a successful tear film stabiliser and is widely used in comfort drops and some soft contact lens materials. A PVA-containing lens, nelfilcon A has been modified to include additional (non-functional) PVA in order to provide improved comfort. This study aims to examine the clinical performance of this nelfilcon A lens with AquaRelease™ (AquaRelease). Methods: Two contralateral, investigator masked, open label, subjective and objective evaluations were conducted. The first examined the effect of adding increased molecular weight PVA to nelfilcon A (n = 5), and the second compared this AquaRelease lens to ocufilcon B (n = 34). The principal measures were non-invasive break-up time (NIBUT) and subjective comfort, which were assessed at the beginning and end of a week of daily wear, and three times throughout 1 day at 8, 12 and 16 h. Results: All subjects successfully completed the daily wearing schedule of 16 h. On initial insertion, subjective comfort and NIBUT improved for AquaRelease than original nelfilcon A lenses (p < 0.05). Initial comfort was better for AquaRelease compared to ocufilcon B lenses (p = 0.01); however, NIBUT was not statistically different (11.7 ± 15.6 s versus 8.4 ± 6.8 s; p = 0.26). Subjective comfort decreased with time (p < 0.001), but there was no significant difference between AquaRelease and ocufilcon B lenses (p = 0.16). NIBUT was not significantly affected by time (p = 0.56) or between lenses (p = 0.33). At the end of a weeks' wear, subjective initial, end-of-day, overall comfort and vision were rated significantly better with AquaRelease than ocufilcon B (p < 0.01). Conclusions: Release of additional non-functionalised PVA from the nelfilcon A lenses appears to enhance comfortable contact lens wear. © 2006 British Contact Lens Association.

Iterative reconstruction as a novel method of radiation dose reduction at computed tomography in patients with Crohn's disease

Prior work of our research group, that quantified the alarming levels of radiation dose to patients with Crohn’s disease from medical imaging and the notable shift towards CT imaging making these patients an at risk group, provided context for this work. CT delivers some of the highest doses of ionising radiation in diagnostic radiology. Once a medical imaging examination is deemed justified, there is an onus on the imaging team to endeavour to produce diagnostic quality CT images at the lowest possible radiation dose to that patient. The fundamental limitation with conventional CT raw data reconstruction was the inherent coupling of administered radiation dose with observed image noise – the lower the radiation dose, the noisier the image. The renaissance, rediscovery and refinement of iterative reconstruction removes this limitation allowing either an improvement in image quality without increasing radiation dose or maintenance of image quality at a lower radiation dose compared with traditional image reconstruction. This thesis is fundamentally an exercise in optimisation in clinical CT practice with the objectives of assessment of iterative reconstruction as a method for improvement of image quality in CT, exploration of the associated potential for radiation dose reduction, and development of a new split dose CT protocol with the aim of achieving and validating diagnostic quality submillisiever t CT imaging in patients with Crohn’s disease. In this study, we investigated the interplay of user-selected parameters on radiation dose and image quality in phantoms and cadavers, comparing traditional filtered back projection (FBP) with iterative reconstruction algorithms. This resulted in the development of an optimised, refined and appropriate split dose protocol for CT of the abdomen and pelvis in clinical patients with Crohn’s disease allowing contemporaneous acquisition of both modified and conventional dose CT studies. This novel algorithm was then applied to 50 patients with a suspected acute complication of known Crohn’s disease and the raw data reconstructed with FBP, adaptive statistical iterative reconstruction (ASiR) and model based iterative reconstruction (MBIR). Conventional dose CT images with FBP reconstruction were used as the reference standard with which the modified dose CT images were compared in terms of radiation dose, diagnostic findings and image quality indices. As there are multiple possible user-selected strengths of ASiR available, these were compared in terms of image quality to determine the optimal strength for this modified dose CT protocol. Modified dose CT images with MBIR were also compared with contemporaneous abdominal radiograph, where performed, in terms of diagnostic yield and radiation dose. Finally, attenuation measurements in organs, tissues, etc. with each reconstruction algorithm were compared to assess for preservation of tissue characterisation capabilities. In the phantom and cadaveric models, both forms of iterative reconstruction examined (ASiR and MBIR) were superior to FBP across a wide variety of imaging protocols, with MBIR superior to ASiR in all areas other than reconstruction speed. We established that ASiR appears to work to a target percentage noise reduction whilst MBIR works to a target residual level of absolute noise in the image. Modified dose CT images reconstructed with both ASiR and MBIR were non-inferior to conventional dose CT with FBP in terms of diagnostic findings, despite reduced subjective and objective indices of image quality. Mean dose reductions of 72.9-73.5% were achieved with the modified dose protocol with a mean effective dose of 1.26mSv. MBIR was again demonstrated superior to ASiR in terms of image quality. The overall optimal ASiR strength for the modified dose protocol used in this work is ASiR 80%, as this provides the most favourable balance of peak subjective image quality indices with less objective image noise than the corresponding conventional dose CT images reconstructed with FBP. Despite guidelines to the contrary, abdominal radiographs are still often used in the initial imaging of patients with a suspected complication of Crohn’s disease. We confirmed the superiority of modified dose CT with MBIR over abdominal radiographs at comparable doses in detection of Crohn’s disease and non-Crohn’s disease related findings. Finally, we demonstrated (in phantoms, cadavers and in vivo) that attenuation values do not change significantly across reconstruction algorithms meaning preserved tissue characterisation capabilities with iterative reconstruction. Both adaptive statistical and model based iterative reconstruction algorithms represent feasible methods of facilitating acquisition diagnostic quality CT images of the abdomen and pelvis in patients with Crohn’s disease at markedly reduced radiation doses. Our modified dose CT protocol allows dose savings of up to 73.5% compared with conventional dose CT, meaning submillisievert imaging is possible in many of these patients.

Algunas consideraciones para la preparación de la pequeña y mediana empresa exportadora

El artículo describe el escenario comercial actual en que actúan las pequeñas y medianas empresas y señala los tipos de exportación que pueden utilizar las compañías que deseen insertarse en los mercados externos. Explica las condiciones subjetivas y objetivas que debe considerar las firmas al prepararse para participar en el proceso exportador, tales como los recursos financieros y humanos, las alianzas, la tecnología, la logística, la información, la producción, la gestión de la organización, la capacitación técnica, la experiencia y la infraestructura, entre otros, así como las ventajas y desafíos que enfrentan las empresas en las actividades comerciales internacionales. Abstract This article describes the current trade scenario where small and mid enterprises acts and emphasizes on the types of exportations companies can use to be part in international markets. At the same time, this scenario explains the subjective and objective conditions must be taken into account all firms to prepare themselves to participate in export processes, such as financial resources, strategic alliances, technology, information, production, organization process, technical training, expertise and infraestructure, among others as advantages and challenges enterprises faces in all international trade activities.

Does time ever fly or slow down? The difficult interpretation of psychophysical data on time perception.

Time perception is studied with subjective or semi-objective psychophysical methods. With subjective methods, observers provide quantitative estimates of duration and data depict the psychophysical function relating subjective duration to objective duration. With semi-objective methods, observers provide categorical or comparative judgments of duration and data depict the psychometric function relating the probability of a certain judgment to objective duration. Both approaches are used to study whether subjective and objective time run at the same pace or whether time flies or slows down under certain conditions. We analyze theoretical aspects affecting the interpretation of data gathered with the most widely used semi-objective methods, including single-presentation and paired-comparison methods. For this purpose, a formal model of psychophysical performance is used in which subjective duration is represented via a psychophysical function and the scalar property. This provides the timing component of the model, which is invariant across methods. A decisional component that varies across methods reflects how observers use subjective durations to make judgments and give the responses requested under each method. Application of the model shows that psychometric functions in single-presentation methods are uninterpretable because the various influences on observed performance are inextricably confounded in the data. In contrast, data gathered with paired-comparison methods permit separating out those influences. Prevalent approaches to fitting psychometric functions to data are also discussed and shown to be inconsistent with widely accepted principles of time perception, implicitly assuming instead that subjective time equals objective time and that observed differences across conditions do not reflect differences in perceived duration but criterion shifts. These analyses prompt evidence-based recommendations for best methodological practice in studies on time perception.