Univariate and bivariate truncated von Mises distributions

In this article we study the univariate and bivariate truncated von Mises distribution, as a generalization of the von Mises distribution (\cite{jupp1989}), (\cite{mardia2000directional}). This implies the addition of two or four new truncation parameters in the univariate and, bivariate cases, respectively. The results include the definition, properties of the distribution and maximum likelihood estimators for the univariate and bivariate cases. Additionally, the analysis of the bivariate case shows how the conditional distribution is a truncated von Mises distribution, whereas the marginal distribution that generalizes the distribution introduced in \cite{repe}. From the viewpoint of applications, we test the distribution with simulated data, as well as with data regarding leaf inclination angles (\cite{safari}) and dihedral angles in protein chains (\cite{prote}). This research aims to assert this probability distribution as a potential option for modelling or simulating any kind of phenomena where circular distributions are applicable.\par

Oracion funebre, que en las reales exequias de la ... reina Dñª. Maria Amalia Christina de Sajonia, celebradas en el Real Colegio de Corpus Cristi [Texto impreso] ... Talens ..]

Sign. : [ ]4, A2, B-E4, F2

Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

Mutations in the VHL tumor suppressor gene result in constitutive expression of many hypoxia-inducible genes, at least in part because of increases in the cellular level of hypoxia-inducible transcription factor HIF1α, which in normal cells is rapidly ubiquitinated and degraded by the proteasome under normoxic conditions. The recent observation that the VHL protein is a subunit of an Skp1-Cul1/Cdc53-F-box (SCF)-like E3 ubiquitin ligase raised the possibility that VHL may be directly responsible for regulating cellular levels of HIF1α by targeting it for ubiquitination and proteolysis. In this report, we test this hypothesis directly. We report development of methods for production of the purified recombinant VHL complex and present direct biochemical evidence that it can function with an E1 ubiquitin-activating enzyme and E2 ubiquitin-conjugating enzyme to activate HIF1α ubiquitination in vitro. Our findings provide new insight into the function of the VHL tumor suppressor protein, and they provide a foundation for future investigations of the mechanisms underlying VHL regulation of oxygen-dependent gene expression.

Vienna, Austria, 1838 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Wien, gestochen von Dominik Biller Ju. in Wien. It was published by Verlag und Eigenthum der Kartaria & Compe. in 1838. Scale [ca 1:16,000]. Map in German. The image inside the map neatline is georeferenced to the surface of the earth and fit to the MGI 3-Degree Gauss Kruger coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, canals, built-up areas and selected buildings, fortification, ground cover, parks, and more. Includes index. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

J.G. Albrechtsberger's sämmtliche Schriften über Generalbass, Harmonie-lehre, und Tonsetzkunst : zum Selbstunterrichte Systematisch geordnet, mit zahlreichen, aus dessen mündlichen Mittheilungen geschöpften Erläuterungs-beyspielen, und einer kurzen Anleitung zum Partitur-spiel, nebst Beschreibung aller bis jetzt gebräuchlichen Instrumente, vermehrt und herausgegeben von seinem Schüler, Ignaz Ritter von Seyfried.

"Verzeichniss der Werke": v. 3, p. 200-208.