Die vornehme Dame : Winke und Rathschläge für Erzieherinnen und junge Mädchen von Stand bei ihrem Eintritte in die Welt

von Ulrike von Eindhofen

Healing of localized gingival recessions treated with coronally advanced flap alone or combined with either a resorbable collagen matrix or subepithelial connective tissue graft: A preclinical study.

OBJECTIVES To histologically evaluate the effectiveness of a porcine derived collagen matrix (CM) and a subepithelial connective tissue graft (CTG) for coverage of localized gingival recessions. MATERIALS AND METHODS Chronic single Miller Class I-like recessions were created at the buccal at the canines and at the third and fourth premolars in the upper and lower jaws of six beagle dogs. The defects were randomly treated with (1) coronally advanced flap surgery (CAF) + CM, (2) CAF + CTG, or (3) CAF alone. At 12 weeks, histometric measurements were made, e.g., between a reference point (N) - and the gingival margin (GM) - and the outer contour of the adjacent soft tissue (gingival thickness [GT]). RESULTS The postoperative healing was uneventful in all animals. No complications such as allergic reactions, abscesses or infections were noted throughout the entire study period. All three treatments resulted in coverage of localized gingival recessions. The histological analysis failed to identify any residues of CM or CTG. The histometric measurements revealed comparable outcomes for N-GM and GT values for all three groups (CAF + CM: 1.04 ± 0.69 mm/0.68 ± 0.33 mm; CAF + CTG: 1.15 ± 1.12 mm/0.76 ± 0.37 mm; CAF: 1.43 ± 0.45 mm/0.79 ± 0.24 mm). CONCLUSIONS In the used defect model, the application of CTG or CM in conjunction with CAF did not have an advantage over the use of CAF alone. CLINICAL RELEVANCE The use of CAF alone is a valuable option for the treatment localized Miller Class I recessions.

Ansprache an die Bau-Gewerke im Preußenlande zu den bevorstehenden Kammer-Wahlen: Mitbürger! Meister, Gehülfen und Gesellen von den Bau-Gewerken! Ein jeder Stand hofft, daß mit der neuen Sonne, welche über Deutschland aufgegangen ...

Boberach: Meister, Gehilfen und Gesellen des Baugewerbes sollen Männer wählen, die die Gewerbefreiheit beschränken und soziale Einrichtungen für die Arbeitnehmer schaffen wollen

Der vierte Stand und die Monarchie

Boberach: Wie in Frankreich die Republik, muß in Deutschland die Monarchie sich für die unteren Klassen einsetzen und die Freiheit aller verwirklichen. Die Herrschaft der Bürokratie soll beseitigt werden. Das Bürgertum soll seine politische Macht nutzen, mit Krone und Adel gemeinsam die soziale Frage zu lösen. - Wentzke: Aufgezeichnet nach mündlichen Erörterungen Rohmers. Gegen die Bureaukratie und das Klassenregiment des dritten Standes. Nach dem Sieg des nicht regierungsfähigen vierten Standes muß in Deutschland das Bürgertum in den vollen Genuß der konstitutionellen Rechte treten, ohne doch der Krone ihre Selbständigkeit, dem Adel seine Standschaft zu nehmen. Diese drei Stände müssen dann für den vierten Stand sorgen, und nur die Monarchie kann hierin die Leitung übernehmen. "Nur derjenige Staat wird in Deutschland zur Hegemonie gelangen, der jenes Gleichgewicht verwirklicht, nur der Fürst die Kaiserkrone tragen, der jene Aufgabe der Monarchie ergreift."

Hochwichtiges der Gegenwart in Sieben Bildern, betreffend die gegenwärtigen gedrückten Verhältnisse des Mittelstandes : nämlich: der Handwerker und Arbeiter, so wie des Handels und aller Gewerbe in Deutschland, und wie diesem wichtigen Stand des deutschen Volks geholfen werden kann

Boberach: Im Interesse der allgemeinen Wohlfahrt wird [die] Gründung einer deutschen Kriegsflotte, eines Deutschen Handelskongresses, einer Nationalbank und von Kolonien in Übersee gefordert; das Staatsoberhaupt soll Exekutivgewalt haben

Telegraphische Depesche aus Petersburg: Aufstand in Petersburg. Die Cholera wüthet. Rückzug der Grenzbesatzung: Mittelst einer besonders eingerichteten Telegraphen-Linie sind wir in den Stand gesetzt, das Publikum von den neuesten wichtigen Ereigenissen der russischen Hauptstadt zu unterrichten und veröffentlichen hiermit nachfolgende so eben eingetroffene Depesche unseres Petersburger Correspondenten: Petersburg ist im Aufstand: Seit drei Stunden wird in der ganzen Stadt Generalmarsch geschlagen ...

Welsch (Projektbearbeiter): Bericht über den Ausbruch von Straßenkämpfen in Sankt Petersburg aus konservativ/reaktionärer Sicht: "eine gewöhnliche Straßen-Emeute ... ohne politische Ansicht und Zweck ...". Zurückweisung von Gerüchten über einen bevorstehenden Angriff Rußlands auf Preußen

T- and B-cell responses and previous exposure to hepatitis B virus in 'anti-HBc alone' patients.

A serologic response to hepatitis B virus (HBV) defined as 'anti-HBc alone' is commonly observed, but its significance remains unclear. This study aimed to define the relationship between 'anti-HBc alone' serostatus and HBV infection, including HBV-specific T- and B-cell memory responses. We enrolled 31 'anti-HBc alone' patients. Total HBV DNA and cccDNA were tested by nested polymerase chain reaction (PCR) analysis in liver samples from 22 'anti-HBc alone' patients vs controls (chronic or resolved HBV infection), followed by HBsAg/HBcAg immunohistochemical (IHC) staining. IFN-γ secretion by HBV-specific T cells was compared in individuals who were 'anti-HBc alone' (n = 27), resolved HBV (n = 21), chronic HBV (n = 24) and 12 healthy controls using enzyme-linked immunospot (ELISpot) assays. An HBsAg-IgG B-cell ELISpot assay was performed in 'anti-HBc alone' patients before and after one dose of recombinant HBsAg vaccine. The majority (23/31, 74.2%) of the 'anti-HBc alone' individuals were co-infected with HCV. Infrequent intrahepatic total HBV DNA (2/22, 9.1%) and cccDNA (1/22, 4.5%) were detected in biopsies; HBsAg and HBcAg IHC staining was negative. HBV-specific T-cell responses were similar between 'anti-HBc alone' individuals and HBV resolvers. Circulating HBV-memory B-cell responses were detected in all 'anti-HBc alone' individuals, consistent with an HBsAg-specific memory pool. After one HBV vaccine dose, increased anti-HBs antibody levels were observed, accompanied by an expansion of HBsAg-specific memory B cells (P = 0.0226). 'Anti-HBc alone' individuals showed HBV-specific T-cell and memory B-cell responses typical of previous viral exposure and protective memory, suggesting a resolved infection.

Involuntary reflexive pelvic floor muscle training in addition to standard training versus standard training alone for women with stress urinary incontinence: study protocol for a randomized controlled trial

BACKGROUND Pelvic floor muscle training is effective and recommended as first-line therapy for female patients with stress urinary incontinence. However, standard pelvic floor physiotherapy concentrates on voluntary contractions even though the situations provoking stress urinary incontinence (for example, sneezing, coughing, running) require involuntary fast reflexive pelvic floor muscle contractions. Training procedures for involuntary reflexive muscle contractions are widely implemented in rehabilitation and sports but not yet in pelvic floor rehabilitation. Therefore, the research group developed a training protocol including standard physiotherapy and in addition focused on involuntary reflexive pelvic floor muscle contractions. METHODS/DESIGN The aim of the planned study is to compare this newly developed physiotherapy program (experimental group) and the standard physiotherapy program (control group) regarding their effect on stress urinary incontinence. The working hypothesis is that the experimental group focusing on involuntary reflexive muscle contractions will have a higher improvement of continence measured by the International Consultation on Incontinence Modular Questionnaire Urinary Incontinence (short form), and - regarding secondary and tertiary outcomes - higher pelvic floor muscle activity during stress urinary incontinence provoking activities, better pad-test results, higher quality of life scores (International Consultation on Incontinence Modular Questionnaire) and higher intravaginal muscle strength (digitally tested) from before to after the intervention phase. This study is designed as a prospective, triple-blinded (participant, investigator, outcome assessor), randomized controlled trial with two physiotherapy intervention groups with a 6-month follow-up including 48 stress urinary incontinent women per group. For both groups the intervention will last 16 weeks and will include 9 personal physiotherapy consultations and 78 short home training sessions (weeks 1-5 3x/week, 3x/day; weeks 6-16 3x/week, 1x/day). Thereafter both groups will continue with home training sessions (3x/week, 1x/day) until the 6-month follow-up. To compare the primary outcome, International Consultation on Incontinence Modular Questionnaire (short form) between and within the two groups at ten time points (before intervention, physiotherapy sessions 2-9, after intervention) ANOVA models for longitudinal data will be applied. DISCUSSION This study closes a gap, as involuntary reflexive pelvic floor muscle training has not yet been included in stress urinary incontinence physiotherapy, and if shown successful could be implemented in clinical practice immediately. TRIAL REGISTRATION NCT02318251 ; 4 December 2014 First patient randomized: 11 March 2015.