Os Projectos do Arquitecto Joaquim de Oliveira para as Bibliotecas-Museu de Frei Manuel do Cenáculo

Um conjunto de desenhos da Biblioteca Pública de Évora, da autoria do arquitecto Joaquim de Oliveira, podem ser identificados com projectos para edifícios de Bibliotecas e Museus idealizados por Frei Manuel do Cenáculo para as suas colecções, primeiro em Beja e depois em Évora, as duas cidades onde ocupou a Mitra. São dos primeiros desenhos de arquitectura conhecidos para Museus em Portugal. Cenáculo esteve ligado à criação de algumas das primeiras bibliotecas públicas portuguesas, como a Biblioteca da Academia das Ciências de Lisboa, a Biblioteca da Real Mesa Censória, antecessora da Biblioteca Nacional, e a Biblioteca Pública de Évora. Foi também o fundador do primeiro Museu Público, o Museu Sesinando Cenáculo Pacense, inaugurado em Beja, em 1791. A necessidade de unir a biblioteca e o museu como instrumentos essenciais de base da construção do edifício científico é exposta várias vezes no pensamento de Frei Manuel do Cenáculo que, até à sua morte, tentou por várias vezes dar forma a este projecto, finalmente concretizado na Biblioteca Pública de Évora em 1805, já depois da morte do arquitecto.

Human and murine clonal CD8+ T cell expansions arise during tuberculosis because of TCR selection

The immune system can recognize virtually any antigen, yet T cell responses against several pathogens, including Mycobacterium tuberculosis, are restricted to a limited number of immunodominant epitopes. The host factors that affect immunodominance are incompletely understood. Whether immunodominant epitopes elicit protective CD8+ T cell responses or instead act as decoys to subvert immunity and allow pathogens to establish chronic infection is unknown. Here we show that anatomically distinct human granulomas contain clonally expanded CD8+ T cells with overlapping T cell receptor (TCR) repertoires. Similarly, the murine CD8+ T cell response against M. tuberculosis is dominated by TB10.44-11-specific T cells with extreme TCRß bias. Using a retro genic model of TB10.44-11-specific CD8+ Tcells, we show that TCR dominance can arise because of competition between clonotypes driven by differences in affinity. Finally, we demonstrate that TB10.4-specific CD8+ T cells mediate protection against tuberculosis, which requires interferon-? production and TAP1-dependent antigen presentation in vivo. Our study of how immunodominance, biased TCR repertoires, and protection are inter-related, provides a new way to measure the quality of T cell immunity, which if applied to vaccine evaluation, could enhance our understanding of how to elicit protective T cell immunity.

Biographical narratives in teaching: a study of rofessors on postgraduate courses

Literature and research have shown that professional development constitutes an essential dimension in constructing both work and professional identity. An important aspect in such development is training. In the field of adult education, different authors (Pratt, 1993; Mezirow, 1985; Schön, 1996; Silva, 2007) emphasize the importance of placing trainees at the center of the learning and cognitive processes and within their corresponding social and historical contexts. Training is supported by a comprehensive adult learning theory. Therefore, the acquired knowledge is not only the result of an external and objective reality but also of a complex construction in which the appropriation of experience plays a relevant role. This paper reveals the findings obtained through biographical narratives in a five-year work program with teachers at different levels (from pre-school to higher education) on postgraduate courses. The core issue is the importance of biographical narratives, as an identification strategy for personal experience, knowledge construction and professional identity. This strategy provided the opportunity for recognition of practical experience, as a provider of learning, as well as his/her own authorship, which are important conditions in the understanding of professional identity.

Martini Vahlii, profess. botan. Haun. membr. societ. lit. plur. Enumeratio plantarum :vel ab aliis, vel, ab ipso observatum, cum earum differentiis specificis, synonymis selectis et descriptionibus succinctis.

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Martini Vahlii, profess. botan. Haun. membr. societ. lit. plur. Enumeratio plantarum :vel ab aliis, vel, ab ipso observatum, cum earum differentiis specificis, synonymis selectis et descriptionibus succinctis.

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Methodus plantas horti botanici et agri Marburgensis :a staminum situ describendi /auctore Conrado Moench.

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Methodus plantas horti botanici et agri Marburgensis :a staminum situ describendi /auctore Conrado Moench.

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Historia naturalis palmarum :opus tripartium / Carol. Frid. Phil. de Martius.

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Historia naturalis palmarum :opus tripartium / Carol. Frid. Phil. de Martius.

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Historia naturalis palmarum :opus tripartium / Carol. Frid. Phil. de Martius.

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Nicolai Thomae Host ... Icones et descriptiones graminum austriacorum.

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Les liliacees /par P.J. Redoute.

vol. 1

Les liliacees /par P.J. Redoute.

vol. 2