[Nicht-ärztliches Tagebuch: 1757 - 1759]

Handschrift

[Ärztliches Tagebuch: 1759]

Handschrift

Die Stellungnahme der bayerischen Staatsregierung zu den Reformrabbinerversammlungen : (1837 - 1846)

Adolf Eckstein

Die Juden im preußischen Staate von 1837

Georg Robert Davidsohn

Mutation Update of the CLCN5 Gene Responsible for Dent Disease 1

Dent disease is a rare X-linked tubulopathy characterized by low molecular weight proteinuria, hypercalciuria, nephrocalcinosis and/or nephrolithiasis, progressive renal failure, and variable manifestations of other proximal tubule dysfunctions. It often progresses over a few decades to chronic renal insufficiency, and therefore molecular characterization is important to allow appropriate genetic counseling. Two genetic subtypes have been described to date: Dent disease 1 is caused by mutations of the CLCN5 gene, coding for the chloride/proton exchanger ClC-5; and Dent disease 2 by mutations of the OCRL gene, coding for the inositol polyphosphate 5-phosphatase OCRL-1. Herein, we review previously reported mutations (n = 192) and their associated phenotype in 377 male patients with Dent disease 1 and describe phenotype and novel (n = 42) and recurrent mutations (n = 24) in a large cohort of 117 Dent disease 1 patients belonging to 90 families. The novel missense and in-frame mutations described were mapped onto a three-dimensional homology model of the ClC-5 protein. This analysis suggests that these mutations affect the dimerization process, helix stability, or transport. The phenotype of our cohort patients supports and extends the phenotype that has been reported in smaller studies.

Geschichte der Vereinigten Staaten von Nord-Amerika, vom Jahre 1497 - 1837

aus dem Engl. übers. und hrsg. von Wilh. L. J. Kiderlen

Georges Rodenbach [Illustration] : (Porträt)

Lucien Levy-Dhurmer

Theodor Ritter von Goldschmidt [Illustration] : geb. 1837 - gest. 1909 ; Vize-Präsident: 1907 - 1909

Scan von Monochrom-Mikroform

Isak Löw Hofmann v. Hofmannsthal [Illustration] : geb. 1759 - 1849

Scan von Monochrom-Mikroform

Ms. lat. qu. 142 Abbildungsband - Catalogue de la collection de tableaux de Mr Frédéric Wilmans à Francfort s/M.

Alte Signatur: Art.Ff. 528

Use of Otolith Strontium:Calcium Ratios for Hindcasting Larval Cod Gadus Morhua Distributions Relative to Water Masses on Georges Bank

The concentration ratios of strontium to calcium in laboratory-reared larval cod otoliths are shown to be related to the water temperature (T) at the time of otolith precipitation. This relationship is curvilinear, and is best described by a simple exponential equation of the form (Sr/Ca x 1000 = a exp(-T/b). We show that when Sr/Ca elemental analyses are related to the daily growth increments in the larval otoliths, relative temperature histories of individual field-caught larvae can be reconstructed from the egg stage to the time of capture. We present preliminary examples of how such reconstructed temperature histories of Atlantic cod Gadus morhua larvae, collected on Georges Bank during April and May 1993, may be interpreted in relation to the broad-scale larval distributions and the hydrography of the Bank.

Chajjim Josef Pollak [Illustration] : Ereignisse des Jahres 1836-1837

Chajim Josef Pollak

Georges Duhamel: Spiegel der Zukunft [Rezension]

N. H.