Refráns meteorolóxicos e atlas románicos, paremioloxía e territorio

Tras unha presentación da Base de datos sobre refranes del calendario y meteorológicos en la Romania (BADARE) e do progresivo baleirado nela de diversos atlas lingüísticos da Romania, preséntanse tres mostras da variación diatópica deste tipo de refráns no espazo iberorromance: (1) coa implicación do arco da vella, (2) dos roibéns e (3) das imaxes de ceo ovellado e afíns. Cómpre destacar o grande interese dos materiais contidos nos atlas románicos, que se poden complementar cos doutras obras vinculadas á lingua e ao territorio: repertorios paremiográficos, monografías dialectais, achegas diversas. Aínda que non parece factible un grande atlas paremiolóxico romance nin sequera de segunda xeración, pois os refráns (meteorolóxicos o de outros tipos) son nos atlas de primeira xeración unha propina ocasional, coidamos que mediante a base de datos BADARE se poden administrar eses materiais de xeito que faciliten o estudo da paremioloxía románica ligada ao territorio.

Interactome analysis reveals that FAM161A, deficient in recessive retinitis pigmentosa, is a component of the Golgi-centrosomal network.

Defects in FAM161A, a protein of unknown function localized at the cilium of retinal photoreceptor cells, cause retinitis pigmentosa, a form of hereditary blindness. By using different fragments of this protein as baits to screen cDNA libraries of human and bovine retinas, we defined a yeast two-hybrid-based FAM161A interactome, identifying 53 bona fide partners. In addition to statistically significant enrichment in ciliary proteins, as expected, this interactome revealed a substantial bias towards proteins from the Golgi apparatus, the centrosome and the microtubule network. Validation of interaction with key partners by co-immunoprecipitation and proximity ligation assay confirmed that FAM161A is a member of the recently recognized Golgi-centrosomal interactome, a network of proteins interconnecting Golgi maintenance, intracellular transport and centrosome organization. Notable FAM161A interactors included AKAP9, FIP3, GOLGA3, KIFC3, KLC2, PDE4DIP, NIN and TRIP11. Furthermore, analysis of FAM161A localization during the cell cycle revealed that this protein followed the centrosome during all stages of mitosis, likely reflecting a specific compartmentalization related to its role at the ciliary basal body during the G0 phase. Altogether, these findings suggest that FAM161A's activities are probably not limited to ciliary tasks but also extend to more general cellular functions, highlighting possible novel mechanisms for the molecular pathology of retinal disease.

Muutokset tutkimuksen suuntautumisessa

Artikkelissa tarkastellaan teoksen: Luovutetut : Suomen ihmisluovutukset Gestapolle / Elina Sana pohjalta jatkosodan aikaisia luovutuksia koskevaa tutkimusta

Muutosten kevät Suomen Akatemiassa

Suomen Akatemian pääjohtaja Raimo Väyrynen puhui Akatemian juhlatilaisuudessa Söäätytalolla

Päivitettyä kokonaistulkintaa

Kirjallisuutta

Täsmennys Urho Kekkonen ja Viro -kirjan arvosteluun : keskustelua

Kommentti kirja-arvosteluun: Estofennian moniottelija / Heikki Roiko-Jokela. // Historiallinen aikakauskirja. 105 (2007) : 1, s. 119-121

Professori Ylikangas ja talvisodan rauha : keskustelua

Kommentti Heikki Ylikankaan artikkeliin // Historiallinen aikakauskirja. 101 (2003) : 4, s. 569-576