Maisteri Kalevi Kilpi 22/12 1964

Kirje 22.12.1964

Puheenvuoro eduskunnassa 22.11.1938

Puhe

Professori L.A. Puntila 22/3 1961

Kirje 22.3.1961

Motor Vehicle Crash Fatalities for Week Ending, August 22, 2008

Motor Vehicle Crash Fatalities

Evaluación de la calidad del medio marino en Bahía Pisco-Paracas (22 - 24 Febrero 1995)

Se analizan parámetros biológicos y de calidad de agua en una época de veda pesquera a fin de determinar la calidad del medio marino. Las determinaciones de oxígeno, ph y sólidos a nivel superficial se ajustaron a los requisitos de calidad para la vida acuática. Se presentaron problemas de contaminación de hidrocarburos en área frente a PETROPERÚ, la más contaminada por este compuesto.

EPI Update, August 22, 2008

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

Ylipormestari Lauri Aho 22/2 1971

Kirje 22.2.1971

Professori B.A. Salmiala 22/1 1968

Kirje 22.1.1968

Transcription factors link mouse WAP-T mammary tumors with human breast cancer.

Mouse models are important tools to decipher the molecular mechanisms of mammary carcinogenesis and to mimic the respective human disease. Despite sharing common phenotypic and genetic features, the proper translation of murine models to human breast cancer remains a challenging task. In a previous study we showed that in the SV40 transgenic WAP-T mice an active Met-pathway and epithelial-mesenchymal characteristics distinguish low- and high-grade mammary carcinoma. To assign these murine tumors to corresponding human tumors we here incorporated the analysis of expression of transcription factor (TF) coding genes and show that thereby a more accurate interspecies translation can be achieved. We describe a novel cross-species translation procedure and demonstrate that expression of unsupervised selected TFs, such as ELF5, HOXA5 and TFCP2L1, can clearly distinguish between the human molecular breast cancer subtypes-or as, for example, expression of TFAP2B between yet unclassified subgroups. By integrating different levels of information like histology, gene set enrichment, expression of differentiation markers and TFs we conclude that tumors in WAP-T mice exhibit similarities to both, human basal-like and non-basal-like subtypes. We furthermore suggest that the low- and high-grade WAP-T tumor phenotypes might arise from distinct cells of tumor origin. Our results underscore the importance of TFs as common cross-species denominators in the regulatory networks underlying mammary carcinogenesis.