Constant wall heat flux boundary conditions in micro-channels filled with porous material with internal heat generation under local thermal non-equilibrium conditions

Forced convection heat transfer in a micro-channel filled with a porous material saturated with rarefied gas with internal heat generation is studied analytically in this work. The study is performed by analysing the boundary conditions for constant wall heat flux under local thermal non-equilibrium (LTNE) conditions. Invoking the velocity slip and temperature jump, the thermal behaviour of the porous-fluid system is studied by considering thermally and hydrodynamically fully-developed conditions. The flow inside the porous material is modelled by the Darcy–Brinkman equation. Exact solutions are obtained for both the fluid and solid temperature distributions for two primary approaches models A and B using constant wall heat flux boundary conditions. The temperature distributions and Nusselt numbers for models A and B are compared, and the limiting cases resulting in the convergence or divergence of the two models are also discussed. The effects of pertinent parameters such as fluid to solid effective thermal conductivity ratio, Biot number, Darcy number, velocity slip and temperature jump coefficients, and fluid and solid internal heat generations are also discussed. The results indicate that the Nusselt number decreases with the increase of thermal conductivity ratio for both models. This contrasts results from previous studies which for model A reported that the Nusselt number increases with the increase of thermal conductivity ratio. The Biot number and thermal conductivity ratio are found to have substantial effects on the role of temperature jump coefficient in controlling the Nusselt number for models A and B. The Nusselt numbers calculated using model A change drastically with the variation of solid internal heat generation. In contrast, the Nusselt numbers obtained for model B show a weak dependency on the variation of internal heat generation. The velocity slip coefficient has no noticeable effect on the Nusselt numbers for both models. The difference between the Nusselt numbers calculated using the two models decreases with an increase of the temperature jump coefficient.

CSR Communication - An Employee Perspective : Tailoring Internal Communication using Employee Preferences for Content, Style and Channel.

Corporate Social Responsibility (CSR) represents a theory and practice that is well-known and communicating its content has shown to play an important role in order to exploit its advantages and engage stakeholders on CSR issues. Even though, CSR communication has shown to be a real challenge, since corporations are encouraged to engage in CSR, but not to communicate too loud about this engagement. This study was inspired by Jenny Dawkins (2005) and her initial idea that tailoring CSR messages by exploring stakeholder preferences for content, style and channel, would solve the communication challenge. One stakeholder group that corporations are highly dependent on is employees and exploring their preferences for CSR communication became the purpose of this thesis: to understand employee preferences for style and channel within the content of CSR. This was of specific interest, since existing research on CSR communication has mainly been centered around financial and external issues on the expense of internal. In addition, the idea of a tailored approach has not gained any interest in research so far, and a possible explanation might be its diffuse meaning, a problem this thesis has addressed. In order to understand employee preferences for internal CSR communication, a qualitative case study research was conducted with in-depth interviews, observations and exercises at site. A total of 20 interviews were arranged in order to collect primary data during a one week prolong engagement at the case. The empirical findings from the respondents’ answers were then transcribed and analyzed using both inductive and theoretical thematic analysis. Based on the findings, the authors of this thesis contribute with two models that help practitioners to understand how to best communicate about various CSR content to employees. The first model developed suggests an implementation of the tailored approach for content, style and channel, and demonstrates a relationship between nature of content and constraint recognition. Also, the model explains how practitioners can provide CSR explanation in order to reduce skepticism and enable endorsement processes where employees communicate CSR to third parties. To show a more dependent relationship between how changes in nature of content and constraint recognition affect employee preferences, the authors created the "CSR Communication Grid". The authors made a theoretical contribution by clarifying and providing a framework for the tailoring approach as initially developed by Dawkins (2005). Additionally, the authors managed to draw a relation between Public Relations (PR) and CSR by referring models of PR to communication styles, which filled this gap in previous research.

Development of variable displacement oil pump for internal combustion engines

In the last years the need to develop more environmentally friendly and efficient cars as led to the development of several technologies to improve the performance of internal combustion engines, a large part of the innovations are focused in the auxiliary systems of the engine, including, the oil pump, this is an element of great importance in the dynamics of the engine as well a considerable energy consumer. Most solutions for oil pumps to this day are fixed displacement, for medium and high speeds, the pump flow rate is higher than the needs of the engine, this excess flow leads to the need for recirculation of the fluid which represents a waste of energy. Recently, technological advances in this area have led to the creation of variable displacement oil pumps, these have become a 'must have' due to the numerous advantages they bring, although the working principle of vane or piston pumps is relatively well known, the application of this technology for the automotive industry is new and brings new challenges. The focus of this dissertation is to develop a new concept of variable displacement system for automotive oil pumps. The main objective is to obtain a concept that is totally adaptable to existing solutions on the market (engines), both dimensionally as in performance specifications, having at the same time an innovative mechanical system for obtaining variable displacement. The developed design is a vane pump with variable displacement going in line with existing commercial solutions, however, the variation of the eccentricity commonly used to provide an variable displacement delivery is not used, the variable displacement is achieved without varying the eccentricity of the system but with a variation of the length of the pumping chamber. The principle of operation of the pump is different to existing solutions while maintaining the ability to integrate standard parts such as control valves and mechanical safety valves, the pump is compatible with commercial solutions in terms of interfaces for connection between engine systems and pump. A concept prototype of the product was obtained in order to better evaluate the validity of the concept. The developed concept represents an innovation in oil pumps design, being unique in its mechanical system for variable displacement delivery.

Yhteistä turvallisuutta rakentaen : poliisi- ja upseeriprofessioiden yhteiskehittelyn mahdollisuuksista

Poliisin rakenneuudistus Pora III ja Puolustusvoimauudistus 2011–2015 ovat olleet viime vuosien esimerkkejä julkisen sektorin työn tehostamisen vaatimuksista. Sekä Puolustusvoimilla että poliisilla, kahdella turvallisuusalan viranomaistaholla, on lakisääteiset tehtävänsä, jotka tulee työn tehostamisen vaatimuksista huolimatta suorittaa. Turvallisuusala yksityistyy vauhdilla, ja keskustelua käydään siitä, mitä tehtäviä viranomainen hoitaa itse, mitä annetaan kaupallisen toimijan tai järjestöjen hoidettavaksi ja mistä kansalainen vastaa itse jatkossa. Resurssi- ja tehostamisvaatimuksia mietittäessä nousee esille upseereiden kohdalla koko maan puolustus ja turvaaminen. Kyetäänkö tämän tehtävän täyttämiseen mahdollisessa sotatilanteessa enää nykyisellä tai mahdollisesti vähenevällä resursoinnilla? Poliisitoimen osalta vasteajat eri puolilla Suomea puhuttavat, samoin se, miten tehtäviä priorisoidaan hoidettavaksi. Saavatko kansalaiset enää perusoikeuksiinsa kuuluvaa arjen turvallisuutta, jonka vielä tänä päivänä katsotaan kuuluvan valtion perustehtäviin? Viranomaisten pitäisi tutkimukseen valittujen aineistojen sekä lakien perusteella hoitaa tehtävänsä laadukkaasti ja tasa-arvoisesti kaikkialla Suomessa. Nykyiset sisäistä ja ulkoista turvallisuutta käsittelevät asiakirjat, esimerkiksi strategiat, puhuvat laajasta turvallisuuskäsityksestä, sisäisen ja ulkoisen turvallisuuden rajojen hämärtymisestä globalisoitumisen seurauksena ja lisääntyvästä poikkihallinnollisesta yhteistyöstä toimintaa ohjaavana ajattelumallina. Viranomaisyhteisyötä tulisi lisätä osana normaalia toimintaa, samoin yhteistyötä järjestöjen, elinkeinoelämän ja jokaisen kansalaisen kanssa. Valtioneuvoston tulevaisuusselonteossa (2013) peräänkuulutetaan uusia, innovatiivisia tapoja hoitaa sekä valtion että kuntien tehtäviä. Yhteisen toiminnan kohteen eli laajan turvallisuuskäsityksen viitekehyksessä on mahdollisuus pohtia uudenlaista turvallisuusalan viranomaisyhteistyötä, eli etsiä perusteluja upseeri- ja poliisiprofession syvemmälle yhteistyölle – yhteiskehittelylle. Tutkimukseni tavoitteena on herätellä keskustelua siitä, onko yhteisen toiminnan kohteen löytymiselle edellytyksiä. Nähtävissä on, että valtiolle kuuluvia toimintoja tehostetaan jatkossakin. Yksi järkevä tapa tehostamisessa on löytää töiden rajapintoja ja yhdistää resurssit näiden osalta. Jotta toiminta olisi tehokasta, sen pitää olla osa jokapäiväistä toimintaa eikä perustua vain muutamiin yhteistoimintaharjoituksiin tai jo tapahtuneiden poikkeustilanteiden hoitoon. Suurin osa kriisiajan toiminnasta perustuu normaaliolojen toimintaan, jolloin sen lähtökohdat voisivat olla yhteisessä työssä ja alkaa jo koulutuksesta, mikä nostetaan tässä työssä yhtenä mahdollisuutena esille. Koulutuksellinen yhteistyö ja liikkuvuus ovat eurooppalaisen tutkintojen viitekehyksen perusteella mahdollista myös kahden eri hallinnonalan koulutuksessa. Tällaista koulutuksen tehostamista haetaan tällä hetkellä muualla yhteiskunnassa. Mutta halutaanko omasta toiminnasta ja tehtävistä luopua edes osittain ja tehdä yhteistyötä mahdollisesti oman työn hallinnan, vallan tai resurssien menettämisen pelossa? Vai onko kyse vain siitä, että yhteistyön syventämiselle ei ole nähty kovinkaan suurta tarvetta tai hyötyä eikä yhteistyö näytä tuovan mitään uutta ammattikuntien osaamiseen? Tutkimuksen aineisto koostuu valtionhallinnon aineistoista, kuten strategioista, mietinnöistä ja raporteista niin sisäisen kuin ulkoisen turvallisuuden alalta. Aineistona käytetään myös upseeri- (n=71) ja poliisipäällystöopiskelijoille (n=65) suunnattua kyselyä ja kirjoitelmaa tulevaisuuden turvallisuusasiantuntijuudesta vuonna 2030. Lisäksi opiskelijavastauksista tehtyä analyysia syvennetään molempien korkeakoulujen (Maanpuolustuskorkeakoulu ja Poliisiammattikorkeakoulu) rehtoreiden sekä molempien hallinnonalojen (puolustusministeriö sekä sisäministeriö) kansliapäälliköiden haastatteluilla. Aineistojen avulla pyritään herättelemään ajatuksia siitä, voisiko yhteisiä töitä löytyä yhteistyön pohjaksi. Tarkoituksena on perustella, miksi yhteistyötä kannattaa tehdä ja ikään kuin vastata etukäteen vastaväitteisiin, miksi sitä ei voitaisi tehdä. Strategioiden yhteistyön tahtotilaa verrataan muihin strategioiden toimenpide ehdotuksiin ja sitä kautta vielä kyselyaineistoon. Opiskelijakyselyllä haetaan näkemyksiä tulevaisuuden turvallisuusasiantuntijuudesta ja mahdollisesta yhteistyöstä sekä sen painopisteistä. Muilla asiantuntijahaastatteluilla haetaan korkeakoulujen sekä ministeriön tason näkemyksiä opiskelijoiden mielipiteisiin. Opiskelijakyselyn avulla on haluttu selvittää sitä, mitä jo työelämässä olleet mutta vaihteeksi opiskelevat sotatieteiden maisteriopiskelijat Maanpuolustuskorkeakoulussa ja poliisin päällystötutkinnon opiskelijat Poliisiammattikorkeakoulussa ajattelevat turvallisuusalan ja -asiantuntijuuden muutoksesta. Minkälaisena he näkevät oman tulevan työnsä ja yhteistyökentän muiden viranomaisten kanssa? Selvää opiskelijavastausten mukaan on se, että turvallisuus halutaan pitää jatkossakin viranomaisen vastuulla ja välttää viimeiseen asti yksityisen sektorin liiallista vastuuta enempää kuin on pakko. Yhteistyötä halutaan edelleen lisätä, ja erityisesti tämä koskee viranomaisten välistä yhteistyötä. Tutkimus on tietoisesti rajattu koskemaan kahta turvallisuusalan viranomaistoimijaa, ammattikorkeakoulutuksen käyneitä poliiseja ja Puolustusvoimien Maanpuolustuskorkeakoulussa opiskelevia upseereita, joiden tehtävistä ja koulutuksesta on löydettävissä yhteisiä rajapintoja ja yhteistyön alueita. Kiinnostus syventyä valittuun kahteen ammattialaan johtuu myös siitä, että usein esimerkiksi sisäasianhallinnon strategioissa Puolustusvoimat jätetään ulkopuolelle varsinkin normaaliolojen yhteistyötä tarkasteltaessa tai vain yksittäisen maininnan asteelle. Sama huomio on havaittavissa puolustushallinnon strategioista. Tämä nousee esille erityisesti alueellista yhteistyötä tai viranomaisyhteistyötä pohdittaessa. Silti sekä sisäministeriön että puolustusministeriön hallinnonalan strategiat ym. perustuvat laajaan turvallisuuskäsitykseen, ja usein eri ammattikuntia analysoitaessa puhutaan tehtävistä, joita tekevät useat ammattikunnat ja professiot. Puhutaan niin sanotuista harmaista alueista. Ministeriöiden tahtotilassa ja toiminnassa on tutkimukseni mukaan nähtävissä ristiriita. Koulutuksen osalta yhteistyön lisääminen on mahdollista etenkin nyt, kun Poliisiammattikorkeakoulussa peruskoulutus on muuttunut ammattikorkeakoulutasoiseksi ja näin tämän ammattikunnan professioasema koulutuksen näkökulmasta on vahvistunut entisestään. Käsittelenkin tutkimuksessani kahta professiota professiotutkimuksen perinteisiä kriteereitä käyttäen, eli rinnastaessani näitä kahta ammattia. Rinnastettavuus koulujen kesken on tullut mahdolliseksi sekä tutkintojen että osaamisen tarkastelun näkökulmasta. Tämän myötä myös molempia korkeakouluja hyödyttävää yhteistyötä olisi mahdollista miettiä osana muutakin hallinnon tehostamista ja rauhan ajan viranomaistoimintaa.

The use of animal models in multiple myeloma

International audience

Maintenance or loss of dialect Andalusian features: Internal and external factors

In the last sixty years a steadily maintained process of convergence towards the Castilian national standard has been occurring in Southern Spain affecting urban middle-class speakers’ varieties, particularly phonology and lexis. As a consequence, unmarked features characterising innovative southern pronunciation have become less frequent and, at the same time, certain standard marked features have been adapted to the southern phonemic inventory. Then, urban middle-class varieties have progressively been stretching out the distance separating them from working-class and rural varieties, and bringing them closer to central Castilian varieties. Intermediate, yet incipient koineised varieties have been described including also transitional Murcia and Extremadura dialects (Hernández & Villena 2009, Villena, Vida & von Essen 2015). (1) Some of the standard phonologically marked features have spread out among southern speakers exclusively based on their mainstream social prestige and producing not only changes in obstruent phoneme inventory –i.e. acquisition of /s/ vs. /θ/ contrast, but also standstill and even reversion of old consonant push- or pull-chain shifts –e.g. /h/ or /d/ fortition, affricate /ʧ/, etc. as well as traditional lexis shift (Villena et al. 2016). Internal (grammar and word frequency) and external (stratification, network and style) factors constraining those features follow similar patterns in the Andalusian speech communities analysed so far (Granada, Malaga) but when we zoom in on central varieties, which are closer to the national standard and then more conservative, differences in frequency increase and conflict sites emerge. (2) Unmarked ‘natural’ phonological features characterising southern dialects, particularly deletion of syllable-final consonant, do not keep pace with this trend of convergence towards the standard. Thus a combination of southern innovative syllable-final and standard conservative onset-consonant features coexist. (3). The main idea is that this intermediate variety is formed through changes suggesting that Andalusian speakers look for the best way of accepting marked prestige features without altering coherence within their inventory. Either reorganisation of the innovative phonemic system in such a way that it may include Castilian and standard /s/ vs. /θ/ contrast or re-syllabification of aspirated /s/ before dental stop are excellent examples of how and why linguistic features are able to integrate intermediate varieties between the dialect-standard continuum.

Report of the Working Group for the Bay of Biscay and the Iberian waters Ecoregion (WGBIE). 13-19 May 2016, ICES HQ, Copenhagen, Denmark

The ICES Working Group for the Bay of Biscay and the Iberic waters Ecoregion (WGBIE) met in Copenhagen, Denmark during 13–14 May 2016. There were 22 stocks in its remit distributed from ICES Divisions 3.a–4.a though mostly distributed in Sub Areas 7, 8 and 9. There were 21 participants, some of whom joined the meeting re-motely. The group was tasked with conducting assessments of stock status for 22 stocks using analytical, forecast methods or trends indicators to provide catch forecasts for eight stocks and provide a first draft of the ICES advice for 2016 for fourteen stocks. For the remaining stocks, the group had to update catch information and indices of abundance where needed. Depending on the result of this update, namely if it would change the perception of the stock, the working group drafted new advice. Analytical assessments using age-structured models were conducted for the northern and southern stocks of megrim and the Bay of Biscay sole. The two hake stocks and one southern stock of anglerfish were assessed using models that allow the use of only length-structured data (no age data). A surplus-production model, without age or length structure, was used to assess the second southern stocks of anglerfish. No ana-lytical assessments have been provided for the northern stocks of anglerfish after 2006. This is mostly due to ageing problems and to an increase in discards in recent years, for which there is no reliable data at the stock level. The state of stocks for which no analytical assessment could be performed was inferred from examination of commer-cial LPUE or CPUE data and from survey information. Three nephrops stocks from the Bay of Biscay and the Iberian waters are scheduled for benchmark assessments in October 2016. The WGBIE meeting spent some time review-ing the progress towards the benchmark (see Annex 6) together with longer term benchmarks (2017 and after, see section 1.) for sea bass in the Bay of Biscay, all an-glerfish and hake stocks assessed by the WG. For the northern megrim stock, the sched-ule an inter-benchmark meeting was completed successfully and the group reviewed the outcome and accepted the category 1 update assessment. A recurrent issue significantly constrained the group’s ability to address the terms of reference this year. Despite an ICES data call with a deadline of six weeks before the meeting, data for several stocks were resubmitted during the meeting which lead to increased workloads during the working group, as in that case, the assessments could not be carried out in National Laboratories prior to the meeting as mentioned in the ToRs. This is an important matter of concerns for the group members. Section 1 of the report presents a summary by stock and discusses general issues. Sec-tion 2 provides descriptions of the relevant fishing fleets and surveys used in the as-sessment of the stocks. Sections 3–18 contains the single stock assessments.

Flexibilidade no espaço doméstico

Dissertação para obtenção do grau de Mestre em Arquitectura, apresentada na Universidade de Lisboa - Faculdade de Arquitetura.

Changing family models in Spain: the impact of the sociodemographic factors

Abstract During the last few decades, there has been an increasing international recognition of the studies related to the analysis of the family models change, the focus being the determinants of the female employment and the problems related to the work family balance (Lewis, 2001; Petit & Hook, 2005Saraceno, Crompton & Lyonette, 20062008; Pfau-Effinger, 2012). The majority of these studies have been focused on the analysis of the work-family balance problems as well as the effectiveness of the family and gender policies in order to encourage female employment (Korpi et al., 2013). In Spain, special attention has been given to the family policies implemented, the employability of women and on the role of the father in the family (Flaquer et al., 2015; Meil, 2015); however, there has been far less emphasis on the analysis of the family cultural models (González and Jurado, 2012; Crespi and Moreno, 2016). The purpose of this paper is to present some of the first results on the influence of the socio-demographic factors on the expectations and attitudes about the family models. This study offers an analytical reflection upon the foundation of the determinants of the family ambivalence in Spain from the cultural and the institutional dimension. This study shows the Spanish family models of preferences following the Pfau-Effinger (2004) classification of the famiy living arrangements. The reason for this study is twofold; on the one hand, there is confirmed the scarcity of studies that have focused their attention on this objective in Spain; on the other hand, the studies carried out in the international context have confirmed the analytical effectiveness of researching on the attitude and value changes to explain the meaning and trends of the family changes. There is also presented some preliminary results that have been obtained from the multinomial analysis related to the influence of the socio-demographic factors on the family model chosen by the individuals in Spain (father and mother working full time; mother part-time father full-time; mother not at work father full-time; mother and father part-time). 3 The database used has been the International Social Survey Programme: Family and Changing Gender Roles IV- ISSP 2012-. Spain is the only country of South Europe that has participated in the survey. For this reason it has been considered as a representative case study.

ADVANCED COMPUTATIONAL MODELING OF THE INTERNAL STRUCTURE OF SMART WIND-TURBINE BLADES

Implementation of stable aeroelastic models with the ability to capture the complex features of Multi concept smartblades is a prime step in reducing the uncertainties that come along with blade dynamics. The numerical simulations of fluid structure interaction can thus be used to test a realistic scenarios comprising of full-scale blades at a reasonably low computational cost. A code which was a combination of two advanced numerical models was designed and was run with the help of paralell HPC supercomputer platform. The first model was based on a variation of dimensional reduction technique proposed by Hodges and Yu. This model was the one to record the structural response of heterogenous composite blades. This technique reduces the geometrical complexities of the heterogenous blade section into a stiffness matrix for an equivalent beam. This derived equivalent 1-D strain energy matrix is similar to the actual 3-D strain energy matrix in an asymptotic sense. As this 1-D matrix helps in accurately modeling the blade structure as a 1-D finite element problem, this substantially redues the computational effort and subsequently the computational cost that are required to model the structural dynamics at each step. Second model comprises of implementation of the Blade Element Momentum Theory. In this approach we map all the velocities and the forces with the help of orthogonal matrices that help in capturing the large deformations and the effects of rotations in calculating the aerodynamic forces. This ultimately helps us to take into account the complex flexo torsional deformations. In this thesis we have succesfully tested these computayinal tools developed by MTU’s research team lead by for the aero elastic analysis of wind-turbine blades. The validation in this thesis is majorly based on several experiments done on NREL-5MW blade, as this is widely accepted as a benchmark blade in the wind industry. Along with the use of this innovative model the internal blade structure was also changed to add up to the existing benefits of the already advanced numerical models.

Investigating the mesh dependency and upscaling of 3D grain-based models for the simulation of brittle fracture processes in low-porosity crystalline rock

The application of 3D grain-based modelling techniques is investigated in both small and large scale 3DEC models, in order to simulate brittle fracture processes in low-porosity crystalline rock. Mesh dependency in 3D grain-based models (GBMs) is examined through a number of cases to compare Voronoi and tetrahedral grain assemblages. Various methods are used in the generation of tessellations, each with a number of issues and advantages. A number of comparative UCS test simulations capture the distinct failure mechanisms, strength profiles, and progressive damage development using various Voronoi and tetrahedral GBMs. Relative calibration requirements are outlined to generate similar macro-strength and damage profiles for all the models. The results confirmed a number of inherent model behaviors that arise due to mesh dependency. In Voronoi models, inherent tensile failure mechanisms are produced by internal wedging and rotation of Voronoi grains. This results in a combined dependence on frictional and cohesive strength. In tetrahedral models, increased kinematic freedom of grains and an abundance of straight, connected failure pathways causes a preference for shear failure. This results in an inability to develop significant normal stresses causing cohesional strength dependence. In general, Voronoi models require high relative contact tensile strength values, with lower contact stiffness and contact cohesional strength compared to tetrahedral tessellations. Upscaling of 3D GBMs is investigated for both Voronoi and tetrahedral tessellations using a case study from the AECL’s Mine-by-Experiment at the Underground Research Laboratory. An upscaled tetrahedral model was able to reasonably simulate damage development in the roof forming a notch geometry by adjusting the cohesive strength. An upscaled Voronoi model underestimated the damage development in the roof and floor, and overestimated the damage in the side-walls. This was attributed to the discretization resolution limitations.

What Are Effective Program Characteristics of Self-Management Interventions in Patients With Heart Failure? : An Individual Patient Data Meta-analysis

Background To identify those characteristics of self-management interventions in patients with heart failure (HF) that are effective in influencing health-related quality of life, mortality, and hospitalizations. Methods and Results Randomized trials on self-management interventions conducted between January 1985 and June 2013 were identified and individual patient data were requested for meta-analysis. Generalized mixed effects models and Cox proportional hazard models including frailty terms were used to assess the relation between characteristics of interventions and health-related outcomes. Twenty randomized trials (5624 patients) were included. Longer intervention duration reduced mortality risk (hazard ratio 0.99, 95% confidence interval [CI] 0.97–0.999 per month increase in duration), risk of HF-related hospitalization (hazard ratio 0.98, 95% CI 0.96–0.99), and HF-related hospitalization at 6 months (risk ratio 0.96, 95% CI 0.92–0.995). Although results were not consistent across outcomes, interventions comprising standardized training of interventionists, peer contact, log keeping, or goal-setting skills appeared less effective than interventions without these characteristics. Conclusion No specific program characteristics were consistently associated with better effects of self-management interventions, but longer duration seemed to improve the effect of self-management interventions on several outcomes. Future research using factorial trial designs and process evaluations is needed to understand the working mechanism of specific program characteristics of self-management interventions in HF patients.

Modeling chemistry in massive star forming regions with internal PDRs

Over the past decades star formation has been a very attractive field because knowledge of star formation leads to a better understanding of the formation of planets and thus of our solar system but also of the evolution of galaxies. Conditions leading to the formation of high-mass stars are still under investigation but an evolutionary scenario has been proposed: As a cold pre-stellar core collapses under gravitational force, the medium warms up until it reaches a temperature of 100 K and enters the hot molecular core (HMC) phase. The forming central proto-star accretes materials, increasing its mass and luminosity and eventually it becomes sufficiently evolved to emit UV photons which irradiate the surrounding environment forming a hyper compact (HC) and then a ultracompact (UC) HII region. At this stage, a very dense and very thin internal photon-dominated region (PDR) forms between the HII region and the molecular core. Information on the chemistry allows to trace the physical processes occurring in these different phases of star formation. Formation and destruction routes of molecules are influenced by the environment as reaction rates depend on the temperature and radiation field. Therefore, chemistry also allows the determination of the evolutionary stage of astrophysical objects through the use of chemical models including the time evolution of the temperature and radiation field. Because HMCs host a very rich chemistry with high abundances of complex organic molecules (COMs), several astrochemical models have been developed to study the gas phase chemistry as well as grain chemistry in these regions. In addition to HMCs models, models of PDRs have also been developed to study in particular photo-chemistry. So far, few studies have investigated internal PDRs and only in the presence of outflows cavities. Thus, these unique regions around HC/UCHII regions remain to be examined thoroughly. My PhD thesis focuses on the spatio-temporal chemical evolution in HC/UC HII regions with internal PDRs as well as in HMCs. The purpose of this study is first to understand the impact and effects of the radiation field, usually very strong in these regions, on the chemistry. Secondly, the goal is to study the emission of various tracers of HC/UCHII regions and compare it with HMCs models, where the UV radiation field does not impact the region as it is immediately attenuated by the medium. Ultimately we want to determine the age of a given region using chemistry in combination with radiative transfer.

Revisión sistemática utilidad de asa y calcio con o sin vitamina d en la prevención de cáncer colorrectal y la recurrencia de pólipos adenomatosos en paciente con riesgo de padecer esta patología

Introducción: El cáncer colorrectal es una patología con alto impacto en la salud pública, debido a su prevalencia, incidencia, severidad, costo e impacto en la salud mental y física del individuo y la familia. Ensayos clínicos realizados en pacientes con antecedente de infarto al miocardio que consumían ácido acetil salicílico (asa), calcio con y sin vitamina D, mostraron asociación entre el consumo de estos medicamentos y disminución en la incidencia en cáncer colorrectal y pólipos adenomatosos. Objetivo: Evaluar la literatura sobre el uso de asa, calcio con y sin vitamina D con relación a su impacto en la prevención del cáncer colorrectal y pólipos adenomatosos. Métodos: Se realizó revisión sistemática buscando ensayos clínicos realizados en pacientes con factores de riesgo para cáncer colorrectal y pólipos adenomatosos que usaron asa, calcio con y sin vitamina D fueron incluidos. Resultados: se escogieron 105 para la revisión sistemática. Conclusiones: Es necesario desarrollar más estudios que lleven a evaluar el efecto protector de la aspirina, calcio y vitamina D. En los artículos revisados la aspirina a dosis de 81 a 325 mg día se correlaciona con reducción de riesgo de aparición de CRC aunque la dosis ideal, el tiempo de inicio y la duración de la ingesta continua no son claros. Hacen falta estudios que comparen poblaciones con ingesta de asa a diferentes dosis.

Predicamento de seguridad yemení

Con el inicio del periodo Post-Guerra Fría el Sistema Internacional comienza a experimentar un incremento en el fortalecimiento de su componente social; la Sociedad de Estados alcanza un mayor nivel de homogenización, el estado, unidad predominante de esta, comienzan atravesar una serie de transformaciones que obedecerán a una serie de cambios y continuidades respecto al periodo anterior. Desde la perspectiva del Realismo Subalterno de las Relaciones Internacionales se destacan el proceso de construcción de estado e inserción al sistema como las variables que determinan el sentimiento de inseguridad experimentado por las elites estatales del Tercer Mundo; procesos que en el contexto de un nuevo y turbulento periodo en el sistema, tomara algunas características particulares que darán un sentido especifico al sentimiento de inseguridad y las acciones a través de las cuales las elites buscan disminuirlo. La dimensión externa del sentimiento de inseguridad, el nuevo papel que toma la resistencia popular como factor determinante del sentimiento de inseguridad y de la cooperación, así como del conflicto, entre los miembros de la Sociedad Internacional, la inserción como promotor de estrategias de construcción de Estado, son alguno de los temas puntuales, que desde la perspectiva subalterna, parecen salir a flote tras el análisis del sistema en lo que se ha considerado como el periodo Post-Guerra Fría. En este sentido Yemen, se muestra como un caso adecuado no solo para poner a prueba las postulados de la teoría subalterna, veinte años después de su obra más prominente (The third world security Predicament), escrita por M. Ayoob, sino como un caso pertinente que permite acercarse más a la comprensión del papel del Tercer Mundo al interior de la Sociedad Internacional de Estados.