First insights into the phylogenetic diversity of Mycobacterium tuberculosis in Nepal

Background Tuberculosis (TB) is a major public health problem in Nepal. Strain variation in Mycobacterium tuberculosis may influence the outcome of TB infection and disease. To date, the phylogenetic diversity of M. tuberculosis in Nepal is unknown. Methods and Findings We analyzed 261 M. tuberculosis isolates recovered from pulmonary TB patients recruited between August 2009 and August 2010 in Nepal. M. tuberculosis lineages were determined by single nucleotide polymorphisms (SNP) typing and spoligotyping. Drug resistance was determined by sequencing the hot spot regions of the relevant target genes. Overall, 164 (62.8%) TB patients were new, and 97 (37.2%) were previously treated. Any drug resistance was detected in 50 (19.2%) isolates, and 16 (6.1%) were multidrug-resistant. The most frequent M. tuberculosis lineage was Lineage 3 (CAS/Delhi) with 106 isolates (40.6%), followed by Lineage 2 (East-Asian lineage, includes Beijing genotype) with 84 isolates (32.2%), Lineage 4 (Euro-American lineage) with 41 (15.7%) isolates, and Lineage 1 (Indo-Oceanic lineage) with 30 isolates (11.5%). Based on spoligotyping, we found 45 different spoligotyping patterns that were previously described. The Beijing (83 isolates, 31.8%) and CAS spoligotype (52, 19.9%) were the dominant spoligotypes. A total of 36 (13.8%) isolates could not be assigned to any known spoligotyping pattern. Lineage 2 was associated with female sex (adjusted odds ratio [aOR] 2.58, 95% confidence interval [95% CI] 1.42–4.67, p = 0.002), and any drug resistance (aOR 2.79; 95% CI 1.43–5.45; p = 0.002). We found no evidence for an association of Lineage 2 with age or BCG vaccination status. Conclusions We found a large genetic diversity of M. tuberculosis in Nepal with representation of all four major lineages. Lineages 3 and 2 were dominating. Lineage 2 was associated with clinical characteristics. This study fills an important gap on the map of the M. tuberculosis genetic diversity in the Asian region.

The Semantics and Typology of Yes/No Particles (A Cross-Linguistic Study)

Taking the three basic systems of Yes/No particles the group looked at the relative deep and surface structures, and asked what types of systems are present in the Georgian, Polish and Armenian languages. The choice of languages was of particular interest as the Caucasian and Indo-European languages usually have different question-answering systems, but Georgian (Caucasian) and Polish (Indo-European) in fact share the same system. The Armenian language is Indo-European, but the country is situated in the southern Caucasus, on Georgia's southern border, making it worth analysing Armenian in comparison with Georgian (from the point of view of language interference) and with Polish (as two relative languages). The group identified two different deep structures, tracing the occurrence of these in different languages, and showed that one is more natural in the majority of languages. They found no correspondence between relative languages and their question-answer systems and demonstrated that languages in the same typological class may show different systems, as with Georgian and the North Caucasian languages. It became clear that Georgian, Armenian and Polish all have an agree/disagree question-answering system defined by the same deep structure. From this they conclude that the lingual mentalities of Georgians, Armenians and Poles are more oriented to the communicative act. At the same time the Yes/No system, in which a positive particle stands for a positive answer and a negative particle for a negative answer, also functions in these languages, indicating that the second deep structure identified also functions alongside the first.

The Separation of Tungstic Oxide from Scheelite and its Subsequent Reduction with Hydrogen

The largest known deposits of tungsten ores occur in the continuation of the Indo-Malayan Mountains, which extends through Burma, Malaya, China, Japan, and Chosen. Production of tungsten concentrates was started in 1910 in Burma, and in 1911 this country was the world's largest producer. China produced but little until 1916, but has since supplied over fifty per cent of the world's requirements.

Riten, Gesten, Zeremonien. Gesellschaftliche Symbolik in Mittelalter und Früher Neuzeit

Ritualisiertes Handeln, der Gebrauch von Gesten und zeremonielle Vorgänge bildeten insbesondere in vormodernen Gesellschaften zentrale Mittel für die Herstellung und den Ausdruck sozialer Ordnung. Gegliedert nach den drei Kernbereichen Liturgie, Recht und Politik präsentiert der vorliegende Band in interdisziplinärem Zugriff ausgewählte Aspekte der Anlage und Wirkung von Ritualen. Einleitend werden methodische Grundsatzfragen an exemplarischen Gegenständen aus der Sicht der Kunstgeschichte, der Theaterwissenschaft und der Geschichtswissenschaft dargestellt.

The evolutionary diversification of parrots supports a taxon pulse model with multiple trans-oceanic dispersal events and local radiations

Vicariance is thought to have played a major role in the evolution of modern parrots. However, as the relationships especially of the African taxa remained mostly unresolved, it has been difficult to draw firm conclusions about the roles of dispersal and vicariance. Our analyses using the broadest taxon sampling of old world parrots ever based on 3219 bp of three nuclear genes revealed well-resolved and congruent phylogenetic hypotheses. Agapornis of Africa and Madagascar was found to be the sister group to Loriculus of Australasia and Indo-Malayasia and together they clustered with the Australasian Loriinae, Cyclopsittacini and Melopsittacus. Poicephalus and Psittacus from mainland Africa formed the sister group Of the Neotropical Arini and Coracopsis from Madagascar and adjacent islands may be the closest relative of Psittrichas from New Guinea. These biogeographic relationships are best explained by independent colonization of the African continent via trans-oceanic dispersal from Australasia and Antarctica in the Paleogene following what may have been vicariance events in the late Cretaceous and/or early Paleogene. Our data support a taxon pulse model for the diversification of parrots whereby trans-oceanic dispersal played a more important role than previously thought and was the prerequisite for range expansion into new continents. (C) 2009 Elsevier Inc. All rights reserved

The Postmodern ‘Turn’ in Social Work: The Challenges of Identity and Equality

Diversity and demands for equality have challenged fixed notions of identity amongst the diverse populations of Europe. This development has prompted discourses about the significance of fluidity and multiplicity in identities that have given prominence to postmodern theories in the profession of social work. A number of social work educators have contributed to the ensuing debates. Walter Lorenz’s work has contributed substantially to developments on this front by:highlighting the dangers of essentialising fixed identities in professional practice, referring to the failure of social workers to live up to professional values and ideals in the Nazi attack on Jews and others who were different from the Aryan norms that Hitler’s regime sought to impose; arguing for racial equality in multicultural Europe; and ensuring that social work theories and practice engaged with innovations in the social sciences more generally to improve the profession’s research, theoretical and practice bases. In this article, I engage with crucial debates that have shaped the profession during the post-war period, honouring Walter Lorenz’s contributions to them in the process.

Transformations in French Anti-Semitism?

The increase in the number of anti-Semitic acts since the start of the Second Intifada has sparked off a broad debate on the return of anti-Semitism in France. This article focuses on the question whether this anti-Semitism is still based on the alleged superiority of the Aryan race as in the time of Nazism, or if it represents the birth of a “new Judeophobia” that is more based on anti-Zionism and the polemical mixing of “Jews,” “Israelis,” and “Zionists.” One supposed effect of this transformation is that anti-Semitism is in the process of changing camps and migrating from the extreme right to the extreme left of the political arena, to the “altermondialistes,” the communists, and the “neo-Trotskyists.” The article provides answers to the following questions: Are anti-Jewish views on the increase in France today? Do these opinions correlate with negative opinions of other minorities, notably Maghrebians and Muslims? Do they tend to develop among voters and sympathizers with the extreme right or on the extreme left of the political spectrum? And how are they related to opinions concerning Zionism and the Israeli-Palestinian conflict? My evaluation of the transformations in French anti-Semitism relies on two types of data. The first is police and gendarmerie statistics published by the National Consultative Committee on Human Rights (CNCDH), which is charged with presenting the prime minister with an annual report on the struggle against racism and xenophobia in France. The other is data from surveys, notably surveys commissioned by CNCDH for its annual report and surveys conducted at the Center for Political Research (CEVIPOF) at Sciences Po (Paris Institute for Political Research). The data show that anti-Semitic opinions follow a different logic from acts, that the social, cultural, and political profile of anti-Semites remains very close to that of other types of racists, and that anti-Zionism and anti-Semitism do not overlap exactly.