982 resultados para Good, John Mason, 1774-1841.
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Este trabalho tem como principal objetivo fazer uma reflexão sobre três revoltas dos rendeiros na ilha de Santiago em Cabo Verde, entre os anos de 1822 a 1910. Propõe mostrar a especificidade das revoltas dos Engenhos (1822), de Achada Falcão (1841) e de Ribeirão Manuel (1910), compreendendo além do panorama cultural, a importância das confrontações políticas, como elementos condicionadores dessas revoltas. Por outro lado, propõe demonstrar que além das causas econômicas e culturais apontadas pela historiografia, as revoltas foram buscar sua inspiração nas disputas políticas. Propõe ainda demonstrar como as elites políticas locais apropriaram das festas religiosas para mobilizar os rendeiros do interior da ilha de Santiago. Além disso, analisa como as revoltas dos rendeiros devem ser compreendidas a partir das reivindicações pelo livre acesso às terras cultivadas.
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Alphomelon brasiliensis sp. nov. (from São Paulo) and A. rugosus sp. nov. (from Rio Grande do Sul) are described and a key to species is presented.
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The Attorney General’s Consumer Protection Division receives hundreds of calls and consumer complaints every year. Follow these tips to avoid unexpected expense and disappointments. This record is about: Credit Insurance: Is it a Good Idea for You?
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Plants continually encounter many microorganisms. Some are good, but many are bad. Two studies show how beneficial fungi tell the plant to let them in and how the fungus avoids setting off the plant's defense reaction.
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PURPOSE: The prognostic impact of complete response (CR) achievement in multiple myeloma (MM) has been shown mostly in the context of autologous stem-cell transplantation. Other levels of response have been defined because, even with high-dose therapy, CR is a relatively rare event. The purpose of this study was to analyze the prognostic impact of very good partial response (VGPR) in patients treated with high-dose therapy. PATIENTS AND METHODS: All patients were included in the Intergroupe Francophone du Myelome 99-02 and 99-04 trials and treated with vincristine, doxorubicin, and dexamethasone (VAD) induction therapy followed by double autologous stem-cell transplantation (ASCT). Best post-ASCT response assessment was available for 802 patients. RESULTS: With a median follow-up of 67 months, median event-free survival (EFS) and 5-year EFS were 42 months and 34%, respectively, for 405 patients who achieved at least VGPR after ASCT versus 32 months and 26% in 288 patients who achieved only partial remission (P = .005). Five-year overall survival (OS) was significantly superior in patients achieving at least VGPR (74% v 61% P = .0017). In multivariate analysis, achievement of less than VGPR was an independent factor predicting shorter EFS and OS. Response to VAD had no impact on EFS and OS. The impact of VGPR achievement on EFS and OS was significant in patients with International Staging System stages 2 to 3 and for patients with poor-risk cytogenetics t(4;14) or del(17p). CONCLUSION: In the context of ASCT, achievement of at least VGPR is a simple prognostic factor that has importance in intermediate and high-risk MM and can be informative in more patients than CR.
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Sari Oikarinen
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Some models of sexual selection predict that individuals vary in their genetic quality and reveal some of this variation in their secondary sexual characteristics. Alpine whitefish (Coregonus sp.) develop breeding tubercles shortly before their spawning season. These tubercles are epidermal structures that are distributed regularly along the body sides of both males and females. There is still much unexplained variation in the size of breeding tubercles within both sexes and with much overlap between the sexes. It has been suggested that breeding tubercles function to maintain body contact between the mating partners during spawning, act as weapons for defence of spawning territories, or are sexual signals that reveal aspects of genetic quality. We took two samples of whitefish from their spawning place, one at the beginning and one around the peak of spawning season. We found that females have on average smaller breeding tubercles than males, and that tubercle size partly reveals the stage of gonad maturation. Two independent full-factorial breeding experiments revealed that embryo mortality was significantly influenced by male and female effects. This finding demonstrates that the males differed in their genetic quality (because offspring get nothing but genes from their fathers). Tubercle size was negatively linked to some aspects of embryo mortality in the first breeding experiment but not significantly so in the second. This lack of consistency adds to inconsistent results that were reported before and suggests that (i) some aspects of genetic quality are not revealed in breeding tubercles while others are, or (ii) individuals vary in their signaling strategies and the information content of breeding tubercles is not always reliable. Moreover, the fact that female whitefish have breeding tubercles of significant size while males seem to have few reasons to be choosy suggests that the tubercles might also serve some functions that are not linked to sexual signaling.