Fritz Gottschalk's family in front of the hotel Kurhaus Brunig, Norderney; Germany.

Digital Image

The Gottschalk family on the beach; Norderney, Germany.

(l-r) Elizabeth, Hans Ludwing (Hal), the maid, Ursula, Walter, Freddy, Therese (in Strandkorg) and Kurt standing

Fritz Gottschalk family with other children on the beach; Norderney, Germany.

Digital Image

Studio portrait of Frieda Mendel; Vienna.

Digital Image

Studio portrait of Fritz and Liese Unger; Vienna.

Digital Image

Family portrait of (back l-r) Frieda Arens, Fritz Unger, Gustav Arens, Grete Glasner, (front l-r) Lise Arens, Gitta Unger and Ernst Glasner.

Digital Image

Portrait of Moritz Reiss in uniform taken by the Imperial photographer; Vienna Portraits Men

Digital Image

Portrait of Olga Reiss nee Kohn Portraits Women

Digital Image

Flora Lotte "Lola" Reiss walking in the street with her father Moritz; Karlovy Vary (Carlsbad) Portraits Family

Digital Image

Flora Lotte "Lola" Reiss walking in the street with her non-Jewish boyfriend Walter; Karlovy Vary (Carlsbad) Portraits Family

Digital Image

Reiss family on skiing trip; Arosa Portraits Family

Digital Image

Reiss family portrait on the occasion of the wedding of Harry Gould to Eva Fantl; Royal Connaught Hotel, Hamilton, Ontario.

Standing l-r: George? son of Max Reiss?, Max Reiss, Harry Gould, Moritz Reiss, Joe Reiss, and Herbert Reiss; Seated l-r: Trude Reiss (wife of Herbert), Else Reiss (mother of Joe), Lily Friedlander Gould, Eva Fantl Gould, Trude Reiss (wife of Joe), and Marta Reiss (wife of Max)

Kohnberger family portrait.

From left to right, back row: Ernst Schueller, Hermine Schueller, Laura Stiassny, Sigmund Stiassny, Martha Pollak, Johanna Mislap and Jacob Hermann; front row: Melanie Herrmann (or Irene Tiring), Conrad Tiring, Emilie Kohnberger and Solomon Kohnberger

Family portrait with Alfred Lichtenstein, his first wife Gerda, unidentified others (maman, tante, oncle, soeur).

Digital Image

A genomewide screen for autism susceptibility loci

We report the analysis of 335 microsatellite markers genotyped in 110 multiplex families with autism. All families include at least two "affected" siblings, at least one of whom has autism; the remaining affected sibs carry diagnoses of either Asperger syndrome or pervasive developmental disorder. Affected sib-pair analysis yielded multipoint maximum LOD scores (MLS) that reach the accepted threshold for suggestive linkage on chromosomes 5, X, and 19. Nominal evidence for linkage (point-wise P<.05) was obtained on chromosomes 2, 3, 4, 8, 10, 11, 12, 15, 16, 18, and 20, and secondary loci were found on chromosomes 5 and 19. Analysis of families sharing alleles at the putative X chromosomal linked locus and one or more other putative linked loci produced an MLS of 3.56 for the DXS470-D19S174 marker combination. In an effort to increase power to detect linkage, scan statistics were used to evaluate the significance of peak LOD scores based on statistical evidence at adjacent marker loci. This analysis yielded impressive evidence for linkage to autism and autism-spectrum disorders with significant genomewide P values <.05 for markers on chromosomes 5 and 8 and with suggestive linkage evidence for a marker on chromosome 19.