Northern Ireland Firecode (PDF 139KB)

Northern Ireland Fire Technical Memorandum 81 Fire precautions in new healthcare premises

Northern Ireland Firecode (PDF 297KB)

Practice Note 11 Reducing unwanted fire signals in healthcare premises

Northern Ireland Firecode (PDF 333KB)

Practice Note 7 Fire Precautions in patient hotels

Northern Ireland Firecode (PDF 153KB)

Practice Note 6 The prevention and control of wilful fire raising in healthcare premises

Northern Ireland Firecode (PDF142KB)

Practice Note 5 Commercial enterprises on hospital premises

Penetrance of marked cognitive impairment in older male carriers of the FMR1 gene premutation.

BACKGROUND: Male carriers of the FMR1 premutation are at risk of developing the fragile X-associated tremor/ataxia syndrome (FXTAS), a newly recognised and largely under-diagnosed late onset neurodegenerative disorder. Patients affected with FXTAS primarily present with cerebellar ataxia and intention tremor. Cognitive decline has also been associated with the premutation, but the lack of data on its penetrance is a growing concern for clinicians who provide genetic counselling. METHODS: The Mattis Dementia Rating Scale (MDRS) was administered in a double blind fashion to 74 men aged 50 years or more recruited from fragile X families (35 premutation carriers and 39 intrafamilial controls) regardless of their clinical manifestation. Based on previous publications, marked cognitive impairment was defined by a score <or=123 on the MDRS. RESULTS: Both logistic and survival models confirmed that in addition to age and education level, premutation size plays a significant (p<0.01 and p<0.03 for logistic and survival model, respectively) role in cognitive impairment. The estimated penetrance of marked cognitive impairment in our sample (adjusted for the mean age 63.4 years and mean education level 9.7 years) for midsize/large (70-200 CGG) and small (55-69 CGG) premutation alleles was 33.3% (relative risk (RR) 6.5; p = 0.01) and 5.9% (RR 1.15; p = 0.9) respectively. Penetrance in the control group was 5.1%. CONCLUSIONS: Male carriers of midsize to large premutation alleles had a sixfold increased risk of developing cognitive decline and the risk increases with allele size. In addition, it was observed that cognitive impairment may precede motor symptoms. These data provide guidance for genetic counselling although larger samples are required to refine these estimates.

Northern Ireland Fire (PDF 75KB)

Practice Note 3 Escape bed lifts

Northern Ireland Firecode (PDF 61KB)

Practice Note 2 Policy and Principles

Northern Ireland Firecode (PDF 91KB)

A Model Management Structure for Fire Safety

Device Bulletins

NIAIC Device Bulletins

HSC(F) 07/2014

DAO (DFP) 01/14 - Audit Of Grants To Local Government Bodies

HSC(F)05-2014 (PDF 201 KB)

Update to Procurement Guidance Note 03/11 - Award of Contracts without a Competition

HSC(F) 02/2014 (PDF 174KB)

Treasury minutes On The 2nd, 6th, 13th and 14th, 17th -19th, 21st åÊ22nd and 24th Reports From Westminster PAC Session 2013-2014

HSC(F) 1-2014 (PDF131KB)

DFP Approval Of Expenditure On External Consultancy Assigments Co-Funding By The Strategic Investment Board

HSC(F) 34-2013 Supplement 1 (PDF 448 KB)

Guidance On The Completion Of Revised Revenue Business Case Templates And Post Project Evaluation - The Need To Complete A Relevant Business Case Relating To Leased Accommodation