Molecular basis of copper transport: cellular and physiological functions of Menkes and Wilson disease proteins (ATP7A and ATPB)

Eukaryotic cells prevent copper-induced, free radical damage to cell components by employing copper-binding proteins and transporters that minimize the likelihood of free copper ions existing in the cell. In the cell, copper is actively transported from the cytoplasm during the biosynthesis of secreted coppercontaining proteins and, as a protective measure, when there is an excess of copper. In humans, this is accomplished by two related copper-transporting ATPases (ATP7A and ATP7B), which are the affected genes in two distinct human genetic disorders of copper transport, Menkes disease (copper deficiency) and Wilson disease (copper toxicosis). The study of these ATPases has revealed their molecular mechanisms of copper transport and their roles in physiological copper homeostasis. Both ATP7A and ATP7B are expressed in specific brain regions and neurological abnormalities are important clinical features in Menkes and Wilson disease.

Comparison of Two Methods for Caluculating the Partition Functions of Various Spatial Statistical Models

Likelihood computation in spatial statistics requires accurate and efficient calculation of the normalizing constant (i.e. partition function) of the Gibbs distribution of the model. Two available methods to calculate the normalizing constant by Markov chain Monte Carlo methods are compared by simulation experiments for an Ising model, a Gaussian Markov field model and a pairwise interaction point field model.

Interpolation of Lipschitz functions

This paper describes a new computational approach to multivariate scattered data interpolation. It is assumed that the data is generated by a Lipschitz continuous function f. The proposed approach uses the central interpolation scheme, which produces an optimal interpolant in the worst case scenario. It provides best uniform error bounds on f, and thus translates into reliable learning of f. This paper develops a computationally efficient algorithm for evaluating the interpolant in the multivariate case. We compare the proposed method with the radial basis functions and natural neighbor interpolation, provide the details of the algorithm and illustrate it on numerical experiments. The efficiency of this method surpasses alternative interpolation methods for scattered data.

A comparison of search functions and other navigational tools provided on government websites

This paper reports the outcomes of a study that evaluated the effectiveness of search functions compared to other navigational tools available on government websites. The study used an observation exercise triangulated with a post observation interview. Results suggest that while there wasn't any significant difference in effectiveness between search functions and other navigational tools, the skill with which the search function is implemented and participants' familiarity with the website, are fundamental determinants of users' opinions. Implications of the findings for research and practice are discussed.

The eight variable homogeneous degree three bent functions

We determine the affine equivalence classes of the eight variable degree three homogeneous bent functions using a new algorithm. Our algorithm applies to general bent functions and can systematically determine the automorphism groups. We provide a partial verification of the computer enumeration of bent functions by Meng et al.

Determination of yield and erosion damage functions using subjectively elicited data: application to small holder tea in Sri Lanka

Tea has been Sri Lanka's major export earner for several decades. However, soil erosion on tea-producing land has had considerable on-site and off-site effects. This study quantifies soil erosion impacts for smallholder tea farms in Sri Lanka by estimating a yield damage function and an erosion damage function using a subjective elicitation technique. The Mitscherlich-Spillman type of function was found to yield acceptable results. The study indicates that high rates of soil erosion require earlier adoption of soil conservation measures than do low rates of erosion. Sensitivity analysis shows the optimum year to change to a conservation practice is very sensitive to the discount rate but less sensitive to the cost of production and price of tea.