925 resultados para Fission-fusion


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"Office of Isotopes Development, U.S. Atomic Energy Commission."

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"Chemistry--Separation process for plutonium and uranium."

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"Chemistry--Separation process for plutonium and uranium."

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Prepared for U.S. Atomic Energy Commission.

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"Contract AT(30-1)-2789."

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Mode of access: Internet.

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Includes bibliographical references.

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Each plate accompanied by unnumbered descriptive leaf.

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"Originated in a series of seminars ... held in the Physics Department of the University of Pennsylvania in the fall of 1945."

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Subunit vaccines, based on one or more epitopes, offer advantages over whole vaccines in terms of safety but are less antigenic. We investigated whether fusion of the cytokine interleukin-2 (IL-2) to influenza-derived subunit antigens could increase their antigenicity. The fusion of IL-2 to the subunit antigens increased their antigenicity in vitro. Encapsulation of the subunit antigen in liposomes also increased its antigenicity in vitro, yet encapsulation of the subunit IL-2 fusion did not. The use of anti-IL-2 receptor beta (IL-2Rbeta) antibody to block the receptor subunit on macrophages suggested that the adjuvancy exerted by IL-2 in our in vitro system is due to, at least in part, a previously unreported IL-2Rbeta-mediated antigen uptake mechanism.