Ein neues psychoendokrin-validiertes Verfahren zur Erfassung von Stressbewältigungsfertigkeiten (ISBF)

Background: We previously found good psychometric properties of the Inventory for assessment of stress management skills (German translation: Inventar zur Erfassung von Stressbewältigungsfertigkeiten), ISBF, a short questionnaire for combined assessment of different perceived stress management skills in the general population. Here, we investigate whether stress management skills as measured by ISBF relate to cortisol stress reactivity in two independent studies, a laboratory study (study 1) and a field study (study 2). Methods: 35 healthy non-smoking and medication-free men in study 1 (age mean±SEM:38.0±1.6) and 35 male and female employees in study 2 (age mean±SEM:32.9±1.2) underwent an acute standardized psychosocial stress task combining public speaking and mental arithmetic in front of an audience. We assessed stress management skills (ISBF) and measured salivary cortisol before and after stress and several times up to 60 min (study 2) and 120 min (study 1) thereafter. Potential confounders were controlled. Results:. General linear models controlling for potential confounders revealed that in both studies, higher stress management skills (ISBF total score) were independently associated with lower cortisol levels before and after stress (main effects ISBF: p’s<.055) and lower cortisol stress reactivity (interaction ISBF-by-stress: p’s<.029). Post-hoc-testing of ISBF subscales suggest lower cortisol stress reactivity with higher “relaxation abilities” (both studies) and higher scores in the scale “cognitive strategies and problem solving” (study 2). Conclusions: Our findings suggest blunted increases in cortisol following stress with increasing stress management skills as measured by ISBF. This suggests that the ISBF not only relates to subjective psychological but also objective physiological stress indicators which may further underscore the validity of the questionnaire.

Estrogen action during early mouse mammary gland development

Estrogens have been implicated in the normal and neoplastic development of the mammary gland. Although estradiol is essential for early mammary differentiation, its role in postnatal ductal morphogenesis is poorly defined. We have found that neonatal estradiol exposure promotes precocious ductal outgrowth and terminal end bud formation in 21 day-old female mice. In contrast to this precocious phenotype, day 21 estradiol-treated epithelium, transplanted into control host fatpads, grows more slowly than control epithelium. Western and immunohistochemical (IHC) analyses indicate that neonatally-estrogenized glands have significantly less total ER than controls at days 7 and 21, and significantly more stromal ER at day 35. Estrogen receptor α (ER) is present in the gland when treatment is initiated at day 1. We propose that the premature activation of ER by neonatal estradiol exposure, during this critical perinatal period, is a key factor in the alteration of mammary growth and ER expression. ^ To address the role of ER function in mammary morphogenesis, we have developed an in vitro system to study the effect of estradiol exposure in vivo. Keratin and ER-positive mammary epithelial cell lines from 7, 21 and 35 day-old oil or estradiol treated mice have been established. Cell lines derived from estradiol-treated mice grow significantly slower than cells from control glands. Although the level of ER expressed by each cell line is correlated to its rate of growth, epithelial growth in vitro is estradiol-independent and antiestrogen-insensitive. Estradiol-induced transcription from an ERE-reporter in transiently-transfected cell lines confirms the functionality of the ER detected by western and IHC. However, there are no differences in estradiol-stimulated transcription between cell lines. ^ In conclusion, neonatal estradiol treatment alters the pattern of ER expression in mammary epithelial and stromal cells in vivo, and the growth of mammary epithelial cells in vivo and in vitro. When grown outside of the estrogenized host, exposed epithelium grows more slowly than the control. Therefore, an extra-epithelial factor is necessary for enhanced epithelial growth. Our model, which couples an in vivo-in vitro approach, can be used in the future to identify factors involved in the period of early mammary outgrowth and carcinogen susceptibility. ^

A novel form of CYP3A from rat brain: cDNA cloning, protein characterization and gene regulation of cytochrome P450 3A9

One full length cDNA clone, designated 3aH15, was isolated from a rat brain cDNA library using a fragment of CYP3A2 cDNA as a probe. 3aH15 encoded a protein composed of 503 amino acid residues. The deduced amino acid sequence of 3aH15 was 92% identical to mouse Cyp3a-13 and had a 68.4% to 76.5% homology with the other reported rat CYP3A sequences. Clone 3aH15 was thus named CYP3A9 by Cytochrome P450 Nomenclature Committee. CYP3A9 seems to the major CYP3A isozyme expressed in rat brain. Sexual dimorphism of the expression of CYP3A9 was shown for the first time in rat brain as well as in rat liver. CYP3A9 appears to be female specific in rat liver based on the standards proposed by Kato and Yamazoe who defined sex specific expression of P450s as being a 10-fold or higher expression level in one sex compared with the other. CYP3A9 gene expression was inducible by estrogen treatment both in male and in female rats. Male rats treated with estrogen had a similar expression level of CYP3A9 mRNA both in the liver and brain. Ovariectomy of adult female rats drastically reduced the mRNA level of CYP3A9 which could be fully restored by estrogen replacement. On the other hand, only a two-fold induction of CYP3A9 expression by dexamethasone was observed in male liver and no significant induction of CYP3A9 mRNA was observed in female liver or in the brains. These results suggest that estrogen may play an important role in the female specific expression of the CYP3A9 gene and that CYP3A9 gene expression is regulated differently from other CYP3A isozymes. ^ P450 3A9 recombinant protein was expressed in E. coli using the pCWOri+ expression vector and the MALLLAVF amino terminal sequence modification. This construct gave a high level of expression (130 nmol P450 3A9/liter culture) and the recombinant protein of the modified P450 3A9 was purified to electrophoretic homogeneity (10.1 nmol P450/mg protein) from solubilized fractions using two chromatographic steps. The purified P450 3A9 protein was active towards the metabolism of many clinically important drugs such as imipramine, erythromycin, benzphetamine, ethylmorphine, chlorzoxazone, cyclosporine, rapamycin, etc. in a reconstituted system containing lipid and rat NADPH-P450 reductase. Although P450 3A9 was active towards the catabolism of testosterone, androstenedione, dehydroepiandrosterone (DHEA) and 17β-estradiol, P450 3A9 preferentially catalyzes the metabolism of progesterone to form four different hydroxylated products. Optimal reconstitution conditions for P450 3A9 activities required a lipid mixture and GSH. The possible mechanisms of the stimulatory effects of GSH on P450 3A9 activities are discussed. Sexually dimorphic expression of P450 3A9 in the brain and its involvement in many neuroactive drugs as well as neurosteroids suggest the possible role of P450 3A9 in some mental disorders and brain functions. ^

The Gender of Chinese Christianity: Evaluating a New Research Perspective

This paper will discuss how the gender perspective can be applied to the study of the Early Modern Jesuit China mission. I will show that the category of gender provides a promising research perspective on Sino-Western cultural exchange, for it brings to the forefront important aspects of social life in the “contact zone” of Chinese Christian communities. I will argue that through the intercultural contact initiated by the Jesuit China mission, gender roles started to shift slightly on both sides. On the one hand, the Jesuits adopted the Confucian ideal of the separation of the sexes (nannü zhi bie), building for example separate Churches for women, something unknown in Europe. On the other hand, Chinese Christians were urged to reconsider aspects of their traditional gender norms, when for instance some men left their concubines in order to become Christian. The paper will be divided in three parts. First, it will focus on the history of concepts and discuss what gender relations meant in the context of the Early Modern China mission. Then it will turn to the representation of female religiosity in Jesuit Annual Letters and show how the gender perspective can lead to a re-evaluation this source genre. Finally, it will reflect on how the gender perspective can give us fresh insights into well-known paradigms on Sino-Western relations, taking the accommodation paradigm as an example.

Eine typologische Analyse des schweizerischen Lehrstellenmarktes: Strukturelle Benachteiligung von jungen Frauen

Empirische Studien zeigen, dass junge Frauen in der Schweiz mehr Mühe in der Lehrstellensuche bekunden als Männer. Die Studie überprüft die Hypothesen, dass dies auch in einem geringeren Angebot an Lehrberufen und Lehrstellen sowie tendenziell höheren schulischen Anforderungen in ihren typischen Interessensbereichen im Vergleich zu den typischen Interessensbereichen von Männern begründet liegt. Dazu wird eine typologische Analyse des Schweizer Lehrstellenmarktes 2006 aufgrund der RIASEC Typologie von Holland (1997) vorgenommen und in direkten Bezug zur gut fundierten beruflichen Interessenforschung gestellt. Beide Hypothesen wurden bestätigt. Implikationen für Theorie und Praxis werden beschrieben.

The relation of secondary student's career choice readiness to a six-phase model of career decision-making

Based on common aspects of recent models of career decision-making (CDM) a sixphase model of CDM for secondary students is presented and empirically evaluated. The study tested the hypothesis that students who are in later phases possess more career choice readiness and consider different numbers of career alternatives. 266 Swiss secondary students completed measures tapping phase of CDM, career choice readiness, and number of considered career options. Career choice readiness showed an increase with phase of CDM. Later phases were generally associated with a larger increase in career choice readiness. Number of considered career options showed a curve-linear development with fewer options considered at the beginning and at the end of the process. Male students showed a larger variability in their distribution among the process with more male than female students in the first and last phase of the process. Implications for theory and practice are presented.

Exculpating victims and the reversal of hindsight bias

This experiment examines the role of the hindsight bias and of motivational forces such as the motive to believe in a just world as possible causes of the derogation of victims effect in the context of rape. The hindsight bias is the tendency of people to falsely believe that they would have predicted the outcome of an event once the outcome is known. Participants read descriptions of an interaction between a man and a woman that ended with one of four possible outcomes: The woman was raped with very severe consequences for her future life vs. rape with only minor consequences for her future life vs. no rape (assailant was forced to retreat by the strong defense of the victim) vs. no outcome information. To test motivational predictions the hindsight bias and the derogation effect were analyzed as a consequence of the sex of participants, the seriousness of the consequences of the rape, the belief in a just world and the acceptance of rape myths. Results supported the assumption that derogation effects are at least partly driven by hindsight bias and that motivational processes work via the hindsight bias. However, in this study we did not find a classical hindsight bias but a reversed hindsight bias: Especially female participants in the severe consequences of rape condition and those participants who did not accept rape myths rated the likelihood of rape in the rape outcome condition as smaller than participants in the no outcome information control group. They also derogated the victim less than participants in the no information control group. These effects were interpreted in terms of self-serving or in-group serving functions of the hindsight bias. Finally no support was found for the assumption that derogation effects are driven by the motive to believe in a just world.

Comparison of health behaviors of Mexican American and non -Hispanic White females: Implications for health promotion programs

Hispanics form the second-largest minority group in the United States totaling 22 million people. Health data on this population are sparse and inconsistent. This study seeks to determine use of preventative services and risk factor behaviors of Mexican American and non-Hispanic White females residing in South Texas.^ Baseline data from female respondents in household surveys in six South Texas counties (Ramirez and McAlister, 1988; McAlister et al., 1992) were analyzed to test the following hypotheses: (1) Mexican American and Non-Hispanic White females exhibit different patterns of health behaviors; (2) Mexican American females will exhibit different health behaviors regardless of age; and (3) the differences between Mexican American women and non-Hispanic White females are due to education and acculturation factors.^ Over the past decade, the traditional behaviors of Mexican American females have begun to change due to education, acculturation, and their participation in the labor force. The results from this study identify some of the changes that will require immediate attention from health care providers. Results revealed that regardless of ethnicity, age, education, and language preference, non-Hispanic White females were significantly more likely to participate in preventive screening practices than were Mexican American females. Risk factor analysis revealed a different pattern with Mexican American females significantly more likely to be non-smokers, non-alcoholic drinkers, and to have good fat avoidance practices compared to non-Hispanic White females. However, compared to those who are less-educated or Spanish-speaking, Mexican American females with higher levels of education and preference for speaking English only showed positive and negative health behaviors that were more similar to the non-Hispanic White females. The positive health behaviors that come with acculturation, e.g., more participation in preventive care and more physical activity, are welcome changes. But this study has implications for global health development and reinforces a need for "primordial" prevention strategies to deter the unwanted concomitants of economic development and acculturation. Smoking and drinking behaviors among Mexican American females need to be kept at low levels to prevent increased morbidity and premature deaths in this population. ^

Ciudadanía femenina en El Salvador : Prudencia Ayala

El relato de la historia mundial, y de la historia de América Latina, ha sido escrito mayoritaria- mente por hombres. Por esa razón, este trabajo da cuenta de la participación y contribución del género masculino, con la excepción de contadas mujeres en el Salvador. Si bien es cierto que muchos campos estuvieron vedados a las mujeres por siglos, éstas no cesaron de defender la igualdad de derechos, constituyéndose en verdaderas protagonistas de nuestra historia en el campo de la política y la ciudadanía femenina. Por ello centramos el foco en el proceso de lucha de las mujeres salvadoreñas para ejercer este derecho, a través de la figura Prudencia Ayala, una mujer indígena y pobre, candidata a la presidencia en 1930.

El ordenamiento del sistema jurídico ateniense a partir del vocabulario de la legalidad en Antígona de Sófocles

Abordamos en Antígona la voz nómos utilizada por la protagonista en su último discurso (vv. 908 y 914). Con ese término califica la razón de su proceder, que justifica contraponiendo su condición como hermana del muerto a una potencial situación como esposa o madre de un difunto. Pese al uso de nómos, observa Etxabe (2009: 61), tales palabras no han sido articuladas con un argumento legal; no obstante, a un estudio con tales propósitos pareciera poder objetarse el hecho de que el léxico jurídico implica ante todo generalidad, lo que entraría en contradicción con la particularidad y excepcionalidad que caracteriza aquello que Antígona califica como nómos. Revisamos entonces qué implica para Antígona el entierro de su hermano y luego abordamos el asunto desde los estudios más recientes sobre la legalidad griega, atendiendo especialmente al ordenamiento del sistema jurídico que tiene lugar en el siglo V a.C., y que implica un cambio de actitud con respecto a las leyes no escritas frecuentemente asociadas a Antígona

El tópico de la afrenta por el abandono y por la risa de los otros en Filoctetes de Sófocles y en Medea de Eurípides

En este trabajo abordaremos el tópico de la afrenta, en los personajes protagónicos masculino y femenino de las tragedias de Sófocles y de Eurípides respectivamente. En Filoctetes como en Medea visualizamos el mencionado tópico en sus dos momentos: por un lado el abandono, que padecen sus personajes como materialización objetiva de la afrenta, y por otro lado, la consecuencia de este abandono: la risa, que provoca en los otros. Filoctetes deja de pertenecer a la griega, por el relegamiento de sus mismos compañeros; en cambio Medea siempre significó para los griegos la alteridad, la presencia de una amenaza que era necesario desechar. Será la afrenta por traición, abandono-olvido y burla de los otros, que involucra a estos personajes. Afrenta que en Filoctetes se subsume en la humanidad del héroe sofocleo y en su reivindicación posterior. Afrenta que en Medea adquiere los ribetes contestatarios del castigo

Relaciones de género y militancia política : Las obreras textiles y el comunismo entre 1936 y 1946

Aquí se analiza una de las estrategias de integración política del Partido Comunista Argentino hacia las obreras de la industria textil: la de la organización de las mujeres. Para analizar las relaciones de género dentro de la clase obrera se desarrolló una metodología específica que consiste en examinar las relaciones intra e intersexo-género/clase. Como resultado de esta investigación se advirtió que esta política implementada por el comunismo influyó en el aumento de la militancia femenina en la Unión Obrera Textil durante la década del treinta y la primera mitad de los cuarenta

La donna diavolo nella grecia antica : Lamia, Circe, Empusa e le stagioni della vita umana

El objetivo de este trabajo es investigar la historia de la monstruosidad femenina en la literatura griega antigua para recuperar algunas estructuras arquetípicas de pensamiento que se ocupan de la antigua y moderna conciencia colectiva sobre el problema del mal, su naturaleza, sus razones y también su falta de razones. De este modo yo repasé las "vidas paralelas" de tres famosas mujeres fatales de la mitología clásica que, colocadas en puntos decisivos de árboles genealógicos horribles llenas de 'maldiciones genéticas', son capaces de formar un tríptico bien definido de "medallones" enmarcados por un fil rouge de la monstruosidad ininterrumpida. Paradigmático de la dialéctica ambigua entre hombre-mujer, bien-mal, víctima-verdugo, normalidad-desviación, y de las dinámicas incontrolables entre los crímenes y los castigos, miedos ancestrales y deseo de descubrimiento, demonios buenos y malos, los mitos de Lamia, Circe y Empusa destacan la atracción irracional que, en la cultura griega antigua, tan racionalista, las personificaciones femeninas del mal son imaginadas moviéndose, con el fin de influir en la conducta humana en las principales etapas de la vida

La ciudadanía política de las mujeres y las elecciones de 1951

Este estudio analiza los derechos políticos de las mujeres en la Argentina después de la ley 13010 (1947) que les permitió acceder al voto y se electas. El propósito del artí culo es comprender tres diferentes dimensiones de la ciudadanía política. Primero, se enfoca en un grupo de mujeres que votaron por primera vez en 1951 con el objetivo de comprender sus ideas sobre su nuevo status. Segundo, se analiza el comportamiento electoral de varones y mujeres en las urnas en 1951. Tercero, se explora cómo Eva Perón influenció la percepción de la representación y los límites del poder femenino en las relaciones políticas.

¿Ampliación política o crisis orgánica? : Un análisis del Cuerpo de Patricios, 1806-1810

El artículo intenta examinar el proceso político iniciado en 1806, en Buenos Aires, conocido como militarización, a partir de un análisis de caso. Así, se toma como objeto al Cuerpo de Patricios. Se analiza su fuerza material, los enfrentamientos y su composición social. La evidencia encontrada permitiría poner en duda las explicaciones hasta ahora vigentes. En primer lugar, la superioridad criolla no sería una realidad en los inicios del proceso. En segundo, la participación de los propietarios rurales en lugares de dirección tendría un peso hasta ahora inexplorado. En tercero, los cuerpos habrían sido agentes de una polarización política, antes que árbitros. Por lo tanto, el programa político que cada uno de ellos esgrime reviste mayor importancia, para su caracterización, que las similitudes organizativas.