Objective Detection and Delineation of Oral Neoplasia Using Autofluorescence Imaging

Although the oral cavity is easily accessible to inspection, patients with oral cancer most often present at a late stage, leading to high morbidity and mortality. Autofluorescence imaging has emerged as a promising technology to aid clinicians in screening for oral neoplasia and as an aid to resection, but current approaches rely on subjective interpretation. We present a new method to objectively delineate neoplastic oral mucosa using autofluorescence imaging. Autofluorescence images were obtained from 56 patients with oral lesions and 11 normal volunteers. From these images, 276 measurements from 159 unique regions of interest (ROI) sites corresponding to normal and confirmed neoplastic areas were identified. Data from ROIs in the first 46 subjects were used to develop a simple classification algorithm based on the ratio of red-to-green fluorescence; performance of this algorithm was then validated using data from the ROIs in the last 21 subjects. This algorithm was applied to patient images to create visual disease probability maps across the field of view. Histologic sections of resected tissue were used to validate the disease probability maps. The best discrimination between neoplastic and nonneoplastic areas was obtained at 405 nm excitation; normal tissue could be discriminated from dysplasia and invasive cancer with a 95.9% sensitivity and 96.2% specificity in the training set, and with a 100% sensitivity and 91.4% specificity in the validation set. Disease probability maps qualitatively agreed with both clinical impression and histology. Autofluorescence imaging coupled with objective image analysis provided a sensitive and noninvasive tool for the detection of oral neoplasia.

Graduate School and University Center Archives Finding Aid - Record Group VIII: Doctoral Students' Council

This is part of the finding aid to the Graduate School and University Center (GSUC) Archives. Record Group VIII is the files from the Doctoral Students' Council (DSC).

Graduate School and University Center Archives Finding Aid - Record Group VI: Vice-President for Finance and Administration

This is part of the finding aid to the Graduate School and University Center (GSUC) Archives. Record Group VI is the files of the Vice-Presidents for Finance and Administration.

Graduate School and University Center Archives Finding Aid - Record Group V-D: Presidents' Files: Kelly

This is part of the finding aid to the Graduate School and University Center (GSUC) Archives. Record Group V-D is the papers of William P. Kelly from when he was president of the GSUC (2005-2013).

Graduate School and University Center Archives Finding Aid - Record Group V-C: Presidents' Files: Horowitz

This is part of the finding aid to the Graduate School and University Center (GSUC) Archives. Record Group V-C is the papers of Frances Degen Horowitz from when she was president of the GSUC (1991-2005).

Graduate School and University Center Archives Finding Aid - Record Group V-B: Presidents' Files: Proshansky

This is part of the finding aid to the Graduate School and University Center (GSUC) Archives. Record Group V-B is the papers of Harold M. Proshansky from when he was president of the GSUC (1972-1990).

Graduate School and University Center Archives Finding Aid - Record Group V-A: Presidents' Files: Rees

This is part of the finding aid to the Graduate School and University Center (GSUC) Archives. Record Group V-A is the papers of Mina S. Rees from when she was president of the GSUC (1969-1972).

Graduate School and University Center Archives Finding Aid - Record Group V: Presidents' Files

This is part of the finding aid to the Graduate School and University Center (GSUC) Archives. Record Group V explains the record groups in the "Presidents' Files" series.

Graduate School and University Center Archives Finding Aid - Record Group IV: Committee Records

This is part of the finding aid to the Graduate School and University Center (GSUC) Archives. Record Group t IV is records from various GSUC committees.

Graduate School and University Center Archives Finding Aid - Record Group III: Periodicals

This is part of the finding aid to the Graduate School and University Center (GSUC) Archives. Record Group III is periodicals by and/or about the GSUC.

Graduate School and University Center Archives Finding Aid - Record Group I: Subjects

This is part of the finding aid to the Graduate School and University Center (GSUC) Archives, City University of New York. Record Group I lists the subjects covered in the collection.

Medical treatment and the good death: an ethical analysis of euthanasia, physician assisted suicide, and the right to die

Frequent advances in medical technologies have brought fonh many innovative treatments that allow medical teams to treal many patients with grave illness and serious trauma who would have died only a few years earlier. These changes have given some patients a second chance at life, but for others. these new treatments have merely prolonged their dying. Instead of dying relatively painlessly, these unfortunate patients often suffer from painful tenninal illnesses or exist in a comatose state that robs them of their dignity, since they cannot survive without advanced and often dehumanizing forms of treatment. Due to many of these concerns, euthanasia has become a central issue in medical ethics. Additionally, the debate is impacted by those who believe that patients have the right make choices about the method and timing of their deaths. Euthanasia is defined as a deliberate act by a physician to hasten the death of a patient, whether through active methods such as an injection of morphine, or through the withdrawal of advanced forms of medical care, for reasons of mercy because of a medical condition that they have. This study explores the question of whether euthanasia is an ethical practice and, as determined by ethical theories and professional codes of ethics, whether the physician is allowed to provide the means to give the patient a path to a "good death," rather than one filled with physical and mental suffering. The paper also asks if there is a relevant moral difference between the active and passive forms of euthanasia and seeks to define requirements to ensure fully voluntary decision making through an evaluation of the factors necessary to produce fully informed consent. Additionally, the proper treatments for patients who suffer from painful terminal illnesses, those who exist in persistent vegetative states and infants born with many diverse medical problems are examined. The ultimate conclusions that are reached in the paper are that euthanasia is an ethical practice in certain specific circumstances for patients who have a very low quality of life due to pain, illness or serious mental deficits as a result of irreversible coma, persistent vegetative state or end-stage clinical dementia. This is defended by the fact that the rights of the patient to determine his or her own fate and to autonomously decide the way that he or she dies are paramount to all other factors in decisions of life and death. There are also circumstances where decisions can be made by health care teams in conjunction with the family to hasten the deaths of incompetent patients when continued existence is clearly not in their best interest, as is the case of infants who are born with serious physical anomalies, who are either 'born dying' or have no prospect for a life that is of a reasonable quality. I have rejected the distinction between active and passive methods of euthanasia and have instead chosen to focus on the intentions of the treating physician and the voluntary nature of the patient's request. When applied in equivalent circumstances, active and passive methods of euthanasia produce the same effects, and if the choice to hasten the death of the patient is ethical, then the use of either method can be accepted. The use of active methods of euthanasia and active forms of withdrawal of life support, such as the removal of a respirator are both conscious decisions to end the life of the patient and both bring death within a short period of time. It is false to maintain a distinction that believes that one is active killing. whereas the other form only allows nature to take it's course. Both are conscious choices to hasten the patient's death and should be evaluated as such. Additionally, through an examination of the Hippocratic Oath, and statements made by the American Medical Association and the American College of physicians, it can be shown that the ideals that the medical profession maintains and the respect for the interests of the patient that it holds allows the physician to give aid to patients who wish to choose death as an alternative to continued suffering. The physician is also allowed to and in some circumstances, is morally required, to help dying patients whether through active or passive forms of euthanasia or through assisted suicide. Euthanasia is a difficult topic to think about, but in the end, we should support the choice that respects the patient's autonomous choice or clear best interest and the respect that we have for their dignity and personal worth.

O desafio da formação do policial militar do estado do Rio de Janeiro: utopia ou realidade possível?

This work of research treats of the police military formation in the state of the Rio de Janeiro. The academic approach to be adopted in respect to verify the state actions for the adaptation of the course of the soldier¿s formation to the national curriculum mould (NCM) for the police education, proposed by the National General Office of Public Security in the year of 2000. It¿s part of a group of actions of the federal government to format the police education in all country. The aim of this action is to form policemen to act in an appropriate way in a democratic society. The result of the research revealed that the Military Police of the state of the Rio de Janeiro, did not effect actions for the adoption the of NCM in the period of 2000-2005, as well as it¿s not preparing the militaries polices to act with base in the values of a democratic society. The empirical material show us the view the of the military police in relation to the education in the Military Police, as well as its performance day by day in the resolution of the social conflicts.

Uma avaliação estratégica da situação de crise e mudança das universidades federais brasileiras

Este trabalho de dissertação trata da administração universitária na área do governo federal. A pesquisa realizada investiga a situação de crise e mudança das Universidades Federais Brasileiras, através de três instmmentos: pesquisa bibliográfica que compõe a base teórica da investigação; entrevistas tendo como amostra a opinião de dirigentes universitários das Universidades Federais localizadas no Rio de Janeiro, quais sejam: Universidade Federal do Rio de Janeiro: Universidade Federal Fluminense: Universidade do Rio de Janeiro e Universidade Federal Rural do Rio de Janeiro; e um questionário fechado contendo questões pontuais sobre a situação de crise das Universidades Federais Brasileiras, também aplicado ao mesmo gmpo entrevistado. O estudo realizado aborda questões relevantes para a compreensão da crise nestas instituições tais como: missão das Universidades Federais Brasileiras; Ensino, Pesquisa e Extensão e sua indissociabilidade; a relação Governo - Universidades Federias Brasileiras: a relação Universidade -Sociedade; diferenças entre ensino superior público e privado no país; a questão da gratuidade nas Universidades Federais no Brasil; a massificação do ensino superior; a questão do corporativismo; a autonomia universitária, e as avaliações do sistema federal de ensino superior no país. Finalmente, um enfoque conclusivo avalia a situação de crise e a necessidade efetiva de implementar mudanças.

Política e burocracia no Brasil: o controle sobre a execução das políticas públicas

Esta tese é um estudo de caso sobre a criação da Secretaria Federal de Controle Interno (SFC) do Executivo federal e das suas atividades como órgão de monitoramento da execução das políticas públicas. Através da análise de depoimentos e de documentos oficiais foi possível demonstrar que: a) a atividade de monitoramento sobre a execução das políticas federais existe, b) que ela é desempenhada por um órgão ¿ a SFC - criado recentemente e que é fruto de uma ampla reforma do sistema de controle interno do Executivo federal, e c) que essa atividade representa um recurso de poder do governo federal para controlar a direção da burocracia federal e a distribuição de poder na coalizão de governo. As principais contribuições desta tese são: 1) demonstrou como e em quais condições o monitoramento das políticas públicas se caracteriza como uma das formas do controle político sobre a burocracia, 2) analisou a construção institucional da SFC enquanto um recurso de poder do governo federal em face da burocracia e da coalizão de governo, 3) realizou um estudo inédito do órgão de monitoramento da execução das políticas públicas no Executivo federal, e 4) apontou os desdobramentos da atuação da SFC do ponto de vista do funcionamento do sistema político, levantando novas hipóteses e perspectivas de trabalho.