Diffuse large B-cell lymphoma of Waldeyer's ring has distinct clinicopathologic features: a GELA study.

BACKGROUND: Diffuse large B-cell lymphomas (DLBCLs) arising in specific extranodal sites have peculiar clinicopathologic features. PATIENTS AND METHODS: We analyzed a cohort of 187 primary Waldeyer's ring (WR) DLBCLs retrieved from GELA protocols using anthracyclin-based polychemotherapy. RESULTS: Most patients (92%) had stage I-II disease. A germinal center B-cell-like (GCB) immunophenotype was observed in 61%, and BCL2 expression in 55%, of WR DLBCLs. BCL2, BCL6, IRF4 and MYC breakpoints were observed in, respectively, 3 of 42 (7%), 9 of 36 (25%), 2 of 26 (8%) and 4 of 40 (10%) contributive cases. A variable follicular pattern was evidenced in 30 of 68 (44%) large biopsy specimens. The 5-year progression-free survival (PFS) and the overall survival (OS) of 153 WR DLBCL patients with survival information were 69.5% and 77.8%, respectively. The GCB immunophenotype correlated with a better OS (P = 0.0015), while BCL2 expression predicted a worse OS (P = 0.037), an effect overcome by the GCB/non-GCB classification. Compared with matched nodal DLBCLs, WR DLBCLs with no age-adjusted international prognostic index factor disclosed a better 5-year PFS rate (77.5% versus 70.7%; P = 0.03). CONCLUSIONS: WR DLBCLs display distinct clinicopathologic features compared with conventional DLBCLs, with usual localized-stage disease, common follicular features and a high frequency of GCB immunophenotype contrasting with a low rate of BCL2 rearrangements. In addition, they seem to be associated with a better outcome than their nodal counterpart.

Audit report on the City of Montrose, Iowa for the year ended June 30, 2009

Audit report on the City of Montrose, Iowa for the year ended June 30, 2009

Agreed upon procedures report on the City of Bevington, Iowa for the period July 1, 2008 through June 30, 2009

Agreed upon procedures report on the City of Bevington, Iowa for the period July 1, 2008 through June 30, 2009

Whose Interest Is Being Served? An Investigation of a Walker City Council Member’s Conflict of Interest, April 15, 2010

The Ombudsman received a complaint concerning Bill Smith, a city council member who is also the Walker Fire Department Chief. The complainant stated that Mr. Smith votes regularly as a city council member on matters before the Walker City Council (Council) pertaining to the Walker Fire Department. These actions were alleged to be conflicts of interest in violation of Iowa law.

Special investigation of the City of Collins Library for the period July 1, 2007 through July 30, 2009

Special investigation of the City of Collins Library for the period July 1, 2007 through July 30, 2009

Audit report on the City of Red Oak, Iowa for the year ended June 30, 2009

Audit report on the City of Red Oak, Iowa for the year ended June 30, 2009

Audit report on the City of Cincinnati, Iowa for the year ended June 30, 2009

Audit report on the City of Cincinnati, Iowa for the year ended June 30, 2009

Audit report on the City of Guttenberg, Iowa, for the years ended June 30, 2009 and 2008

Audit report on the City of Guttenberg, Iowa, for the years ended June 30, 2009 and 2008

Report of Recommendations to the State University of Iowa, Iowa City, Iowa for the year ended June 30, 2009

Report on the State University of Iowa, Iowa City, Iowa for the year ended June 30, 2009

Report on a special investigation of the City of Alburnett for the period January 1, 2006 through December 31, 2009

Report on a special investigation of the City of Alburnett for the period January 1, 2006 through December 31, 2009

Audit report on the City of Hiawatha, Iowa for the year ended June 30, 2010

Audit report on the City of Hiawatha, Iowa for the year ended June 30, 2010

Audit report on the City of Auburn, Iowa for the year ended June 30, 2009

Audit report on the City of Auburn, Iowa for the year ended June 30, 2009

Audit report on the City of Cumming, Iowa for the year ended June 30, 2009

Audit report on the City of Cumming, Iowa for the year ended June 30, 2009

Audit report on the City of Griswold, Iowa for the years ended June 30, 2010 and 2009

Audit report on the City of Griswold, Iowa for the years ended June 30, 2010 and 2009

Old Capitol, Iowa City, 1928.

Story of Iowa's Old Capitol and complete record of the state's advancement from the days of the mid-western Indian down to our time