La frontera enquistada: el reino de Murcia a fines de la Edad Media

Con el final de las grandes conquistas del siglo XIII, la frontera con el recién creado reino de Granada quedó prácticamente estancada. El presente artículo estudia la situación del territorio murciano y el efecto que la presencia de la cercana frontera ejerció sobre él. Se hace referencia a organización del territorio, a la concentración de la población en grandes núcleos como Lorca, Caravaca, Cehegín y otros. Se alude también a la función que la frontera murciana ejerció, como lugar de refugio político, en el contexto de las luchas internas de la región entabladas en el siglo XV. Todo ello permite a los autores trazar un amplio parorama sobre la realidad de la región murciana durante el último siglo de la Edad Media e, incluso, analizar las repercusiones que tuvo para el territorio murciano la desaparición del reino nazarí de Granada tras su capitulación en 1492.

Intérêt biogéographique de la côte basque rocheuse

During recent decades, works on rocky shore biodiversity have been multiplied in the southern part of the Bay of Biscay and more precisely on intertidal and subtidal area were communities present a great interest. Necessity of conservation of coastal habitats and their communities and a growing pressure on coastal environments explain awareness of services provided by these ecosystems. Those communities are very sensitive to water quality change. Moreover, since the beginning of the XXI century various European directives require a good ecological status of coastal waters and conservation of their communities : Water Framework Directive (WFD), Marine Strategy Framework Directive (MSFD) and conservation of habitats with Directive Habitat Fauna and Flora (DHFF).... Integrated environmental status assessment approach is needed for this requirement in front of specific component at the regional scale of the Bay of Biscay. This analyze, at this regional scale, bring a particular interest to follow some biological groups in front of their ecological sensitivity. Among them, some example are listed like algae, invertebrate as species of mollusc opistobranch and fishes of the family blennidae are targets of interest for future monitoring. The biogeographic specificity of species of these groups is to present strong ecological requirements, in a trophic point of view for example, as well as boundary in local distribution in the southern part of the Bay of Biscay. Thus, monitoring of their distribution and abundance should be a relevant indicator of environmental change. If the presence of individuals is relatively easy to implement, monitoring in terms of abundance are more complex to develop to obtain representative data in coastal areas. The mobile character of the individual and their high location variability based on fluctuating environmental conditions is a challenge that needs to be considered. Interest concerns both the development of their number and their migration to the north for species in northern limit, and/or disappearance for species in southern distribution limits. Moreover, acquisition of knowledge on the taxonomy of local species is a way to improve biodiversity knowledge and assessment of global change as climatic change.

Lugares de fronteira: as tascas localizadas nas portas da muralha Fernandina de Évora

Esta dissertação de mestrado tem por objecto de estudo o conjunto das tascas localizadas nas portas da Muralha Fernandina de Évora. Praticamente desaparecidos espaços ainda íntegros, pode-se considerar que estas construções integram uma rede de estabelecimentos composta por estruturas militares, religiosas, de lazer e de carácter colectivo, que se encontram associadas e caracterizam as portas medievais de Évora. O objectivo desta investigação é o estudo urbanístico e arquitectónico das portas urbanas, e o modo como os estabelecimentos de venda de bebida configuraram as diversas narrativas urbanas a partir de diferentes orientações políticas ao longo dos tempos. O caso de Évora é tomado como base de trabalho por ser legível ainda uma imagem de conjunto, a partir de vestígios, exemplares minimamente conservados, fontes históricas, impressas e fotográficas. A articulação urbana típica e recorrente, na relação directa tasca-porta, pode-se encontrar noutras cidades alentejanas, e nas cidades amuralhadas em geral; PLACES OF FRONTIER: THE TAVERNS LOCATED IN THE GATES OF EVORA'S FERNANDINA WALL ABSTRACT: This dissertation has as subject the study of the taverns located in the gates of Évora's Fernandina Wall. Despite the almost disappearance of intact spaces, it can be considered that these buildings are part of a network of institutions composed of various structures such as military, religious, recreational and collective character, which are associated and feature the ancient medieval gates of Évora. The aim of this investigation is the urban and architectural study of the urban gates, and how the beverage outlets have represented the various urban narratives from different political orientations over time. The case of Évora is the base of work by being a readable group, from traces, minimally preserved specimens, historical, printed and photographic sources. The typical and recurrent urban articulation, in a direct relation tavern-gate, can be seen in other Alentejo towns, and walled cities in general.

HBsAg seroclearance or seroconversion induced by peg-interferon alpha and lamivudine or adefovir combination therapy in chronic hepatitis B treatment: a meta-analysis and systematic review

Background and aims: Seroclearance or seroconversion of hepatitis B surface antigen (HBsAg) is generally considered as a clinical endpoint. The purpose of the present meta-analysis was to evaluate the effect of combined therapy with pegylated interferon alpha (PEG-IFNα) with or without lamivudine (LAM) or adefovir (ADV) on HBsAg seroclearance or seroconversion in subjects with chronic hepatitis B (CHB). Methods: Randomized controlled trials performed through May 30th 2015 in adults with CHB receiving PEG-IFNα and LAM or ADV combination therapy or monotherapy for 48-52 weeks were included. The Review Manager Software 5.2.0 was used for the meta-analysis. Results: No statistical differences in HBsAg seroclearance (9.9% vs. 7.1%, OR = 1.47, 95% CI: 0.75, 2.90; p = 0.26) or HBsAg seroconversion (4.2% vs. 3.7%, OR = 1.17, 95% CI: 0.57, 2.37; p = 0.67) rates were noticed between PEG-IFNα + LAM and PEG-IFN α + placebo during post-treatment follow-up for 24-26-weeks in subjects with hepatitis Be antigen (HBeAg)-positive CHB. No statistical differences in HBsAg clearance (10.5% vs. 6.4%, OR = 1.68, 95% CI: 0.75, 3.76; p = 0.21) were seen, but statistical differences in HBsAg seroconversion (6.3% vs. 0%, OR = 7.22, 95% CI: 1.23, 42.40; p = 0.03) were observed, between PEG-IFNα + ADV and PEG-IFNα for 48-52 weeks of treatment in subjects with HBeAg-positive CHB. A systematic evaluation showed no differences in HBsAg disappearance and seroconversion rates between PEG-IFNα + placebo and PEG-IFNα + LAM for 48-52 weeks in subjects with HBeAg-positive CHB. A systematic assessment found no differences in HBsAg disappearance and seroconversion rates between PEG-IFNα + placebo and PEG-IFNα + LAM during 24 weeks' to 3 years' follow-up after treatment in subjects with HBeAg-negative CHB. Conclusion: Combined therapy with PEG-IFNα and LAM or ADV was not superior to monotherapy with PEG-IFNα in terms of HBsAg seroclearance or seroconversion.

Forensic Injustice: Human Rights, Archival Science and Racialized Feminicide in Guatemala

The call to access and preserve the state records that document crimes committed by the state during Guatemala’s civil war has become an archival imperative entangled with neoliberal human rights discourses of “truth, justice, and memory.” 200,000 people were killed and disappeared in Guatemala’s civil war including acts of genocide in which 85% of massacres involved sexual violence committed against Mayan women. This dissertation argues that in an attempt to tell the official story of the civil war, American Human Rights organizations and academic institutions have constructed a normative identity whose humanity is attached to a scientific and evidentiary value as well as an archival status representing the materiality and institutionality of the record. Consequently, Human Rights discourses grounded in Western knowledges, in particular archival science and law, which prioritize the appearance of truth erase the material and epistemological experience of indigenous women during wartimes. As a result, the subjectivity that has surfaced on the record as most legible has mostly pertained to non-indigenous, middle class, urban, leftist men who were victims of enforced disappearance not genocide. This dissertation investigates this conflicting narrative that remembers a non-indigenous revolutionary masculine hero and grants him justice in human rights courtrooms simply because of a document attesting to his death. A main research question addressed in this project is why the promise of "truth and justice" under the name of human rights becomes a contentious site for gendered indigenous bodies? I conduct a discursive and rhetorical analysis of documentary film, declassified Guatemalan police and military records such as Operation Sofia, a military log known for “documenting the genocide” during rural counterinsurgencies executed by the military. I interrogate the ways in which racialized feminicides or the hyper-sexualized racial violence that has historically dehumanized indigenous women falls outside of discourses of vision constructed by Western positivist knowledges to reinscribe the ideal human right subject. I argue for alternative epistemological frames that recognize genocide as sexualized and gendered structures that have simultaneously produced racialized feminicides in order to disrupt the colonial structures of capitalism, patriarchy and heterosexuality. Ironically, these structures of power remain untouched by the dominant human rights discourse and its academic, NGO, and state collaborators that seek "truth and justice" in post-conflict Guatemala.

INVESTIGATING THE POSTWAR DECLINE OF RACE IN SCIENCE

Race as a biological category has a long and troubling history as a central ordering concept in the life and human sciences. The mid-twentieth century has been marked as the point where biological concepts of race began to disappear from science. However, biological definitions of race continue to penetrate scientific understandings and uses of racial concepts. Using the theoretical frameworks of critical race theory and science and technology studies and an in-depth case study of the discipline of immunology, this dissertation explores the appearance of a mid-century decline of concepts of biological race in science. I argue that biological concepts of race did not disappear in the middle of the twentieth century but were reconfigured into genetic language. In this dissertation I offer a periodization of biological concepts of race. Focusing on continuities and the effects of contingent events, I compare how biological concepts of race articulate with racisms in each period. The discipline of immunology serves as a case study that demonstrates how biological concepts of race did not decline in the postwar era, but were translated into the language of genetics and populations. I argue that the appearance of a decline was due to events both internal and external to the science of immunology. By framing the mid-twentieth century disappearance of race in science as the triumph of an antiracist racial project of science, it allows us to more clearly see the more recent resurgence of race in science as a recycling of older themes and tactics from the racist science projects of the past.

Body reserves mediate trade-offs between life-history traits: new insights from small pelagic fish reproduction

Limited resources in the environment prevent individuals from simultaneously maximizing all life-history traits, resulting in trade-offs. In particular, the cost of reproduction is well known to negatively affect energy investment in growth and maintenance. Here, we investigated these trade-offs during contrasting periods of high versus low fish size and body condition (before/after 2008) in the Gulf of Lions. Female reproductive allocation and performance in anchovy (Engraulis encrasicolus) and sardine (Sardina pilchardus) were examined based on morphometric historical data from the 1970s and from 2003 to 2015. Additionally, potential maternal effects on egg quantity and quality were examined in 2014/2015. After 2008, the gonadosomatic index increased for sardine and remained steady for anchovy, while a strong decline in mean length at first maturity indicated earlier maturation for both species. Regarding maternal effects, for both species egg quantity was positively linked to fish size but not to fish lipid reserves, while the egg quality was positively related to lipid reserves. Atresia prevalence and intensity were rather low regardless of fish condition and size. Finally, estimations of total annual numbers of eggs spawned indicated a sharp decrease for sardine since 2008 but a slight increase for anchovy during the last 5 years. This study revealed a biased allocation towards reproduction in small pelagic fish when confronted with a really low body condition. This highlights that fish can maintain high reproductive investment potentially at the cost of other traits which might explain the present disappearance of old and large individuals in the Gulf of Lions.

A (in)capacidade estatal de defesa dos direitos humanos : o incidente de deslocamento de competência nº 3 e a violência policial no estado de Goiás

Dissertação (mestrado)—Universidade de Brasília, Centro de Estudos Avançados Multidisciplinares, Programa de Pós-Graduação em Direitos Humanos e Cidadania, 2015.

Radio Frequency Superconducting Quantum Interference Device Meta-atoms and Metamaterials: Experiment, Theory, and Analysis

Metamamterials are 1D, 2D or 3D arrays of articial atoms. The articial atoms, called "meta-atoms", can be any component with tailorable electromagnetic properties, such as resonators, LC circuits, nano particles, and so on. By designing the properties of individual meta-atoms and the interaction created by putting them in a lattice, one can create a metamaterial with intriguing properties not found in nature. My Ph. D. work examines the meta-atoms based on radio frequency superconducting quantum interference devices (rf-SQUIDs); their tunability with dc magnetic field, rf magnetic field, and temperature are studied. The rf-SQUIDs are superconducting split ring resonators in which the usual capacitance is supplemented with a Josephson junction, which introduces strong nonlinearity in the rf properties. At relatively low rf magnetic field, a magnetic field tunability of the resonant frequency of up to 80 THz/Gauss by dc magnetic field is observed, and a total frequency tunability of 100% is achieved. The macroscopic quantum superconducting metamaterial also shows manipulative self-induced broadband transparency due to a qualitatively novel nonlinear mechanism that is different from conventional electromagnetically induced transparency (EIT) or its classical analogs. A near complete disappearance of resonant absorption under a range of applied rf flux is observed experimentally and explained theoretically. The transparency comes from the intrinsic bi-stability and can be tuned on/ off easily by altering rf and dc magnetic fields, temperature and history. Hysteretic in situ 100% tunability of transparency paves the way for auto-cloaking metamaterials, intensity dependent filters, and fast-tunable power limiters. An rf-SQUID metamaterial is shown to have qualitatively the same behavior as a single rf-SQUID with regards to dc flux, rf flux and temperature tuning. The two-tone response of self-resonant rf-SQUID meta-atoms and metamaterials is then studied here via intermodulation (IM) measurement over a broad range of tone frequencies and tone powers. A sharp onset followed by a surprising strongly suppressed IM region near the resonance is observed. This behavior can be understood employing methods in nonlinear dynamics; the sharp onset, and the gap of IM, are due to sudden state jumps during a beat of the two-tone sum input signal. The theory predicts that the IM can be manipulated with tone power, center frequency, frequency difference between the two tones, and temperature. This quantitative understanding potentially allows for the design of rf-SQUID metamaterials with either very low or very high IM response.

The Role of Lung Ultrasound in Diagnosis of Respiratory Distress Syndrome in Newborn Infants

Background: Respiratory distress syndrome (RDS) is one of the most common causes of neonatal respiratory failure and mortality. The risk of developing RDS decreases with both increasing gestational age and birth weight. Objectives: The aim of this study was to evaluate the value of lung ultrasound in the diagnosis of respiratory distress syndrome (RDS) in newborn infants. Materials and Methods: From March 2012 to May 2013, 100 newborn infants were divided into two groups: RDS group (50 cases) and control group (50 cases). According to the findings of chest x-ray, there were 10 cases of grade II RDS, 15 grade III cases, and 25 grade IV cases in RDS group. Lung ultrasound was performed at bedside by a single expert. The ultrasound indexes observed in this study included pleural line, A-line, B-line, lung consolidation, air bronchograms, bilateral white lung, interstitial syndrome, lung sliding, lung pulse etc. Results: In all of the infants with RDS, lung ultrasound consistently showed generalized consolidation with air bronchograms, bilateral white lung or alveolar-interstitial syndrome, pleural line abnormalities, A-line disappearance, pleural effusion, lung pulse, etc. The simultaneous demonstration of lung consolidation, pleural line abnormalities and bilateral white lung, or lung consolidation, pleural line abnormalities and A-line disappearance co-exists with a sensitivity and specificity of 100%. Besides, the sensitivity was 80% and specificity 100% of lung pulse for the diagnosis of neonatal RDS. Conclusions: This study indicates that using an ultrasound to diagnose neonatal RDS is accurate and reliable too. A lung ultrasound has many advantages over other techniques. Ultrasound is non-ionizing, low-cost, easy to operate, and can be performed at bedside, making this technique ideal for use in NICU.

Acerca da existência de pensadoras no Brasil e na América Latina

Neste texto, procuramos pelas pensadoras latino-americanas, com ênfase nas pensadoras brasileiras. O pensamento de autoria feminina abre-se para um campo multidisciplinar; nele reconhecemos um protagonismo revelador de identidades femininas reflexivas exemplares. Buscamos fazer um inventário inicial da reflexão protagonizada por mulheres, entre nós, e constatamos a necessidade de uma obra de referência que se dedique exclusivamente ao pensamento delas, no contexto latino-americano e brasileiro, para evitar que a marginalização da produção filosófica feminina se dissolva no problema mais geral do desaparecimento da filosofia latino-americana. Dialogamos com o Diário de um Filósofo no Brasil, de Julio Cabrera, perguntando por categorias capazes de revelar as nossas pensadoras, em suas singularidades e diferenças. Neste sentido, apresentamos duas categorias, abrangentes e inaugurais: párias e exiladas, recuperando, para os nossos propósitos, algumas reflexões de Flora Tristán, Hannah Arendt e María Zambrano. _________________________________________________________________________________ ABSTRACT

Desarrollo de la Medicina Social en la escuela de medicina de la Universidad de Cuenca

ANTECEDENTES: La Escuela de Medicina es una de las primeras de la Universidad de Cuenca en ser fundadas, no obstante el desarrollo de la Medicina Social ha sido paulatino cobrando impulso desde la década de los sesenta. Es un tema poco investigado y reportado. La enseñanza de la Medicina Social se relaciona con los cambios surgidos en la práctica de la Medicina con la ciudad y la llegada de profesores formados en el extranjero que enseñaban Higiene y Salud Pública. La Medicina Social parte desde una Medicina caritativa cuyo objetivo era el buen morir de las personas y no se centraba en su curación; para luego desarrollarse la privatización de los servicios de salud, también se produce la intervención del estado y los municipios en el área médica y social, posteriormente existe la desaparición de la Medicina Caritativa realizada por religiosas y médicos de la facultad, para surgir en una tendencia hacia un Sistema de Salud basado en el concepto de la salud como mercancía Posteriormente existe un enfoque principal en la Medicina que abarca la prevención, promoción y el desarrollo de la Atención Primaria en Salud.

Síntese enzimática de ésteres de açúcar: surfactantes e polímeros como novos materiais ambientalmente seguros

Sugar esters are substances which possess surfactant, antifungical and bactericidal actions and can be obtained through two renewable sources of raw materials: sugars and vegetable oils. Their excellent biodegradability, allied to lhe fact that they are non toxic, insipid, inodorous, biocompatible, no-ionic, digestible and because they can resist to adverse conditions of temperature, pH and salinity, explain lhe crescent use of these substances in several sections of lhe industry. The objective of this thesis was to synthesize and characterize surfactants and polymers containing sugar branched in their structures, through enzymatic transesterification of vinyl esters and sugars, using alkaline protease from Bacillus subtilis as catalyst, in organic medium (DMF).Three types of sugars were used: L-arabinose, D-glucose and sucrose and two types of vinyl esters: vinyl laurate and vinyl adipate. Aiming to reach high conversions from substrates to products for a possible future large scale industrial production, a serie of variables was optimized, through Design of Experiments (DOE), using Response Surface Methodology (RSM).The investigated variables were: (1) enzyme concentration; (2) molar reason of substrates; (3) water/solvent rale; (4) temperature and (5) time. We obtained six distinct sugar esters: 5-0-lauroyl L-arabinose, 6-0-lauroyl D-glucose, 1'-O-lauroyl sucrose, 5-0-vinyladipoyl L-arabinose, 6-0-vinyladipoyl D-glucose and 1 '-O-vinyladipoyl sucrose, being lhe last three polymerizable. The progress of lhe reaction was monitored by HPLC analysis, through lhe decrease of sugar concentration in comparison to lhe blank. Qualitative analysis by TLC confirmed lhe formation of lhe products. In lhe purification step, two methodologies were adopted: (1) chromatographic column and (2) extraction with hot acetone. The acylation position and lhe chemical structure were determined by 13C-RMN. The polymerization of lhe three vinyl sugar esters was possible, through chemical catalysis, using H2O2 and K2S2O8 as initiators, at 60°C, for 24 hours. IR spectra of lhe monomers and respective polymers were compared revealing lhe disappearance of lhe vinyl group in lhe polymer spectra. The molar weights of lhe polymers were determined by GPC and presented lhe following results: poly (5-0-vinyladipoyl L-arabinose): Mw = 7.2 X 104; PD = 2.48; poly (6-0-vinyladipoyl D-glucose): Mw = 2.7 X 103; PD = 1.75 and poly (1'-O-vinyladipoyl sucrose): Mw = 4.2 X 104; PD = 6.57. The six sugar esters were submitted to superficial tension tests for determination of the critical micelle concentrations (CMC), which varied from 122 to 167 ppm. Finally, a study of applicability of these sugar esters, as lubricants for completion fluids of petroleum wells was' accomplished through comparative analysis of lhe efficiency of these sugar esters, in relation to three commercial lubricants. The products synthesized in this thesis presented equivalent or superior action to lhe tested commercial products

Beach nourishment impact on Posidonia oceanica: Case study of Poniente Beach (Benidorm, Spain)

The importance of nourishment processes on the beaches of Mediterranean Sea has been increasing since the end of the 20th century due to its socio-economical awareness (tourismboost) and environmental implications (possible impact on Posidonia oceanica meadows and important processes of dredging and earth movements). However, in many cases, and especially in eastern Spain, relevant actions have been made which had caused that, after 20 years, the beaches in which these works were carried out will be in a similar situation with the original one. The present study analyzed the Poniente Beach (Benidorm, Spain), a beach where the nourishment works of 1991 have caused the disappearance of the Posidonia oceanica meadows and a regression process that will lead to the disappearance of the beach in a few years. To this end, data from bathymetry, georeferenced orthophotos, grain size analysis and swell study have been obtained and analyzed, understanding the importance of the works done to be consistent with the environment in which they were developed, and providing a work process which can ensure the existence of the nourished beach starting from the maintenance of Posidonia oceanica meadows.

Big Manistee River Tributaries as Potential Arctic Grayling Habitat

The Big Manistee River was one of the most well known Michigan rivers to historically support a population of Arctic grayling (Thymallus arctics). Overfishing, competition with introduced fish, and habitat loss due to logging are believed to have caused their decline and ultimate extirpation from the Big Manistee River around 1900 and from the State of Michigan by 1936. Grayling are a species of great cultural importance to Little River Band of Ottawa Indian tribal heritage and although past attempts to reintroduce Arctic grayling have been unsuccessful, a continued interest in their return led to the assessment of environmental conditions of tributaries within a 21 kilometer section of the Big Manistee River to determine if suitable habitat exists. Although data describing historical conditions in the Big Manistee River is limited, we reviewed the literature to determine abiotic conditions prior to Arctic grayling disappearance and the habitat conditions in rivers in western and northwestern North America where they currently exist. We assessed abiotic habitat metrics from 23 sites distributed across 8 tributaries within the Manistee River watershed. Data collected included basic water parameters, streambed substrate composition, channel profile and areal measurements of channel geomorphic unit, and stream velocity and discharge measurements. These environmental condition values were compared to literature values, habitat suitability thresholds, and current conditions of rivers with Arctic grayling populations to assess the feasibility of the abiotic habitat in Big Manistee River tributaries to support Arctic grayling. Although the historic grayling habitat in the region was disturbed during the era of major logging around the turn of the 20th century, our results indicate that some important abiotic conditions within Big Manistee River tributaries are within the range of conditions that support current and past populations of Arctic grayling. Seven tributaries contained between 20-30% pools by area, used by grayling for refuge. All but two tributaries were composed primarily of pebbles, with the remaining two dominated by fine substrates (sand, silt, clay). Basic water parameters and channel depth were within the ranges of those found for populations of Arctic grayling persisting in Montana, Alaska, and Canada for all tributaries. Based on the metrics analyzed in this study, suitable abiotic grayling habitat does exist in Big Manistee River tributaries.