970 resultados para Couzins, Phoebe Wilson--1839-1913


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Microfilm.. Valencia: BV, ca. 1990.

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Microfilm.. Valencia: BV, ca. 1990.

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Microfilme.. Valencia: BV, ca. 1990.

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Margaret Bush Wilson was a woman of highly exceptional stature. Bush accomplished much in her life; the most prominent being the first female on the N.A.A.C.P. national board of Directors. Much of her career consisted of civil rights and urban development. Before Mrs. Bush focused on her civil rights path, she was valedictorian of her graduating high school class. After completing her high school career, she began to study abroad, traveling to over six countries. These included: England, France, Ceylon, Japan, the Hawaiian Islands and her most extraordinary visit to India. Here Margaret met and spoke with Mahatma Gandhi which fueled her passion of the civil rights movement in the United States. Mrs. Bush pursued a law degree at Lincoln University Law School after completing her Bachelor’s at Talladega University. On top of her extraordinary accomplishments, Margaret Bush possessed the unique quality of appearing 10 years younger than her real age, reflecting her strong spirit and compassion towards humanity.

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Yvonne Wilson is a woman of achievement, accomplishment, and ambition. It all started when she enrolled in Lincoln University; the only public institution for higher education in Missouri that admitted African Americans. She later went on to become a teacher, principal and systems director in the Kansas City School District. Mrs. Wilson was involved in many civic/social activities including the Metropolitan Community Colleges and the Bruce Watkins Cultural Heritage Center. She had many accomplishments including her positions as the President of Lincoln University Board of Curators and the first African American President of the Missouri Association of Elementary School Principals. Finally, one of her top accomplishments was being appointed to the Missouri House of Representatives.

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Drawing on the work of Wendell Berry, among others, allows us to see through claims that science has on limits (scientism). Berry shows what follies scientism generates and provides his own guidelines to what the limits of science are or ought to be.

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Peer reviewed

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The delivery of copper to specific sites within the cell is mediated by distinct intracellular carrier proteins termed copper chaperones. Previous studies in Saccharomyces cerevisiae suggested that the human copper chaperone HAH1 may play a role in copper trafficking to the secretory pathway of the cell. In this current study, HAH1 was detected in lysates from multiple human cell lines and tissues as a single-chain protein distributed throughout the cytoplasm and nucleus. Studies with a glutathione S-transferase-HAH1 fusion protein demonstrated direct protein–protein interaction between HAH1 and the Wilson disease protein, which required the cysteine copper ligands in the amino terminus of HAH1. Consistent with these in vitro observations, coimmunoprecipitation experiments revealed that HAH1 interacts with both the Wilson and Menkes proteins in vivo and that this interaction depends on available copper. When these studies were repeated utilizing three disease-associated mutations in the amino terminus of the Wilson protein, a marked diminution in HAH1 interaction was observed, suggesting that impaired copper delivery by HAH1 constitutes the molecular basis of Wilson disease in patients harboring these mutations. Taken together, these data provide a mechanism for the function of HAH1 as a copper chaperone in mammalian cells and demonstrate that this protein is essential for copper homeostasis.