999 resultados para Cibber, Theophilus, 1703-1758.


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Échelle(s) : [1:1 682 000 environ], Lieues comunes de France de 25 au degré, 20 [= 5,2 cm]

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The cytokine macrophage migration inhibitory factor plays a central role in inflammation, cell proliferation and tumorigenesis. Moreover, macrophage migration inhibitory factor levels correlate with tumor aggressiveness and metastatic potential. Histone deacetylase inhibitors are potent antitumor agents recently introduced in the clinic. Therefore, we hypothesized that macrophage migration inhibitory factor would represent a target of histone deacetylase inhibitors. Confirming our hypothesis, we report that histone deacetylase inhibitors of various chemical classes strongly inhibited macrophage migration inhibitory factor expression in a broad range of cell lines, in primary cells and in vivo. Nuclear run on, transient transfection with macrophage migration inhibitory factor promoter reporter constructs and transduction with macrophage migration inhibitory factor expressing adenovirus demonstrated that trichostatin A (a prototypical histone deacetylase inhibitor) inhibited endogenous, but not episomal, MIF gene transcription. Interestingly, trichostatin A induced a local and specific deacetylation of macrophage migration inhibitory factor promoter-associated H3 and H4 histones which did not affect chromatin accessibility but was associated with an impaired recruitment of RNA polymerase II and Sp1 and CREB transcription factors required for basal MIF gene transcription. Altogether, this study describes a new molecular mechanism by which histone deacetylase inhibitors inhibit MIF gene expression, and suggests that macrophage migration inhibitory factor inhibition by histone deacetylase inhibitors may contribute to the antitumorigenic effects of histone deacetylase inhibitors.

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Preuves de noblesse de Charles de Montsaunin (1), — et de dom François de Calvo (4 et 6), pour les Ordres du roi ; — de Marie-Jeanne-Françoise d'Alesso d'Eragni (8), — des demoiselles Marie et Louise Lois de Boussens (10), — d'Anne Raimond de Villogon (12), — Marie-Françoise de Saint-Martin (16), — Barbe de Limosin d'Alheim (18), — Marie-Louise de Houlei (20), pour Saint-Cyr ; — de Charles Acary de La Suze (22), — Pierre de Brie (24), — Joseph-Emmanuel d'Orillac (27), — François-Jacques Petit de La Borde (29). — Jean-Joseph de Rastel de Rocheblave (33), — Charles de Fautereau (39), — Pierre de Baud du Castelet (41), pour l'École militaire. — Parchemin. — Blasons peints. Épreuves de gravure des « Statuts de l'Ordre du St-Esprit. De l'Imprimerie royale, 1703 » (fol. 43). « Généalogie de la maison de Noailles » (fol. 56), avec nombreux dessins, blasons et encadrements, au crayon.

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