UM Men's Swimming Team, 1973 UM Swimming

Front Row: Richard W. Dorney, Donald B. Peterson, Jr., Ray T. McCullough, Michael T. Whitaker, Paul A. Katz, Joseph L. Crawford, Christian E. Newcomer.

Second Row: Lawrence J. Day, Christopher A. Hanson, Stuart A. Isaac, Dan G. Fishburn, Thomas D. Szuba, Peter K. Agnew, Steven M. McCarthy

Third Row: Jose R.D. Aranha, Patrick J. Bauer, Mark J. Anderson, Richard M. Quint, Randy Reed, Bradley J. Brockway, diving coach Dick Kimball.

Back Row: Paul C. Fairman, Paul A. Foster, Patrick E. Stevens, Ian Pesses, Steve Clark, Augusto A. Gonzales-Virgil, coach Gus Stager.

Abbé Joseph Dobrowsky : biographische Skizze /

Bibliography: p. 29-36.

The law, without the advice of an attorney. Or, Every man his own counsellor. Containing the laws of Pennsylvania relative to bonds, promissory notes, deeds, mortgages, judgments, limitation of actions, leases by parol, property exempt from distress and levy, register and recorder, witnesses, jurors, and constables fees, education of poor children, interest, landlord and tenant, constables, innkeepers, livery stable keepers, mechanics' lien, stage drivers, carters, inland navigation, roads, bridges, fences, strays, swine, water courses, hunting &c. Together with a number of forms and other legal information useful to the farmer, mechanic, or man of business.

Mode of access: Internet.

Joseph Guarnerius, his work and his master : [Andreas Gisalberti] /

Mode of access: Internet.

Joseph Dennie: editor of "The Port folio" and author of "The lay preacher" ...

Xerox reprint, 1967, Univ. Microfilms.

Neurosurgery / Editor in chief, John Boyd Coates, Jr. ; editors for neurosurgery, R. Glen Spurling [and] Barnes Woodhall ; associate editor, Elizabeth M. McFetridge.

Includes bibliographical references and indexes.

Origines ecclesiasticae, or, The antiquities of the Christian church : and other works of the Rev. Joseph Bingham ; with many additional annotations and several original sermons : the whole revised and edited, together with a biographical account of the author

Includes bibliographical references and indexes.

Mellificium historicum integrum: cujus pars prima complectitur historiam trium monarchiarum: Chaldaic�� siue Assyriac��, Persic��, Græc��, et rerum omnium quæ à more Alexandri M. à successoribus ejus gesta sunt in regnis diuersis. Collecto flore et et succo ex optimis et præstantissimis autoribus: Herodoto, Thucydide, Xenephonte, Diodoro Siculo, Aridano, Q. Curtio, Justino, Plutarcho, &c. /

Part three by Johannes Lampadius.

Steatosis and liver cell apoptosis in chronic hepatitis C: A mechanism for increased liver injury

Steatosis is increasingly recognized as a cofactor influencing the progression of fibrosis in chronic hepatitis Q however, the mechanisms by which it contributes to liver injury remain uncertain. We studied 125 patients with chronic hepatitis C to assess the effect of steatosis on liver cell apoptosis and the expression of Bcl-2, Bd-x(L), Bax, and tumor necrosis factor alpha (TNF-alpha) and the relationship between liver cell apoptosis and disease severity. A significant increase in liver cell apoptosis was seen in liver sections with increasing grade of steatosis (r = 0.42; P < .0001). Hepatic steatosis and previous heavy alcohol consumption were the only two variables independently associated with the apoptotic index. Increasing steatosis was associated with decreased Bcl-2 mRNA levels and an increase in the proapoptotic Bax/Bcl-2 ratio (r = -0.32, P = .007; and r = 0.27, P = .02, respectively). In the absence of steatosis, increased liver cell apoptosis was not associated with stellate cell activation or fibrosis (r = 0.26, P = .11; r = 0.06, P = .71, respectively). In contrast, in the presence of steatosis, increasing apoptosis was associated with activation of stellate cells and increased stage of fibrosis (r = 0.35, P = .047; r = 0.33, P = .03, respectively), supporting the premise that the steatotic liver is more vulnerable to liver injury. In patients with hepatitis C virus genotype 3, there was a significant correlation between TNF-α mRNA levels and active caspase-3 (r = 0.54, P = .007). In conclusion, these observations suggest a mechanism whereby steatosis contributes to the progression of liver injury in chronic hepatitis C. Further investigation will be required to determine the molecular pathways responsible for the proapoptotic effect of steatosis and whether this increase in apoptosis contributes directly to fibrogenesis.

Adiponectin and its receptors in patients with chronic hepatitis C

Background/Aims: There is increasing interest in the influence of excess body weight and associated metabolic factors on the liver. In patients with non-alcoholic steatohepatitis, lower levels of adiponectin were associated with higher grades of hepatic steatosis and necroinflammatory activity, suggesting a pathophysiological role for this adipokine in liver disease. Methods: We studied 194 consecutive patients with untreated chronic HCV, to assess the relationship between adiponectin and its receptors and hepatic steatosis, fibrosis and inflammation. Results: Significant negative correlations between serum adiponectin and male gender, body mass index and serum insulin were observed. However, there was no association between serum adiponectin and stage of fibrosis and lower levels of serum adiponectin were associated with the presence of steatosis in males only. In contrast, there was a significant increase in serum adiponectin and hepatic adiponectin immunoreactivity with increasing inflammation. The hepatic mRNA expression of the adiponectin receptors, AdipoR1 and AdipoR2, displayed significant but opposite associations with phosphoenolpyruvate carboxykinase (PEPCK) gene expression, a substitute marker of hepatic insulin sensitivity. Conclusions: In patients with chronic HCV, adiponectin was associated with steatosis only in males and was paradoxically increased with inflammation. Our results suggest that the role of adiponectin in chronic liver diseases may be linked to gender and etiology. (c) 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Low level microsatellite instability may be associated with reduced cancer specific survival in sporadic stage C colorectal carcinoma

Background: Colorectal cancers (CRCs) may be categorised according to the degree of microsatellite instability (MSI) exhibited, as MSI-high (MSI-H), MSI-low (MSI-L), or microsatellite stable (MSS). MSI-H status confers a survival advantage to patients with sporadic CRC. Aims: To determine if low levels of MSI are related to the clinicopathological features and prognosis of sporadic stage C CRC. Patients: A total of 255 patients who underwent resection for sporadic stage C CRC were studied. No patient received chemotherapy. Minimum follow up was five years. Methods: DNA extracted from archival malignant and non-malignant tissue was amplified by polymerase chain reaction using a panel of 11 microsatellites. MSI-H was defined as instability at greater than or equal to40% of markers, MSS as no instability, and MSI-L as instability at >0% but,40% of markers. Patients with MSI-H CRC were excluded from analysis as they have previously been shown to have better survival. Results: Thirty three MSI-L and 176 MSS CRCs were identified. There was no difference in biological characteristics or overall survival of MSI-L compared with MSS CRC but MSI-L was associated with poorer cancer specific survival (hazard ratio 2.0 (95% confidence interval 1.1-3.6)). Conclusions: Sporadic MSI-L and MSS CRCs have comparable clinicopathological features. Further studies are required to assess the impact of MSI-L on prognosis.

Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: A meta-analysis of individual patient data

Background & Aims: Steatosis is a frequent histologic finding in chronic hepatitis C (CHC), but it is unclear whether steatosis is an independent predictor for liver fibrosis. We evaluated the association between steatosis and fibrosis and their common correlates in persons with CHC and in subgroup analyses according to hepatitis C virus (HCV) genotype and body mass index. Methods: We conducted a meta-analysis on individual data from 3068 patients with histologically confirmed CHC recruited from 10 clinical centers in Italy, Switzerland, France, Australia, and the United States. Results: Steatosis was present in 1561 patients (50.9%) and fibrosis in 2688 (87.6%). HCV genotype was 1 in :1694 cases (55.2%), 2 in 563 (18.4%), 3 in 669 (21.8%), and 4 in :142 (4.6%). By stepwise logistic regression, steatosis was associated independently with genotype 3, the presence of fibrosis, diabetes, hepatic inflammation, ongoing alcohol abuse, higher body mass index, and older age. Fibrosis was associated independently with inflammatory activity, steatosis, male sex, and older age, whereas HCV genotype 2 was associated with reduced fibrosis. In the subgroup analyses, the association between steatosis and fibrosis invariably was dependent on a simultaneous association between steatosis and hepatic inflammation. Conclusions: In this large and geographically different group of CHC patients, steatosis is confirmed as significantly and independently associated with fibrosis in CHC. Hepatic inflammation may mediate fibrogenesis in patients with liver steatosis. Control of metabolic factors (such as overweight, via lifestyle adjustments) appears important in the management of CHC.

Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1

Background: Interferon alpha (IFN-alpha) activated cellular signalling is negatively regulated by inhibitory factors, including the suppressor of cytokine signalling (SOCS) family. The effects of host factors such as obesity on hepatic expression of these inhibitory factors in subjects with chronic hepatitis C virus (HCV) are unknown. Objectives: To assess the independent effects of obesity, insulin resistance, and steatosis on response to IFN-alpha therapy and to determine hepatic expression of factors inhibiting IFN-alpha signalling in obese and nonobese subjects with chronic HCV. Methods: A total of 145 subjects were analysed to determine host factors associated with non-response to antiviral therapy. Treatment comprised IFN-alpha or peginterferon alpha, either alone or in combination with ribavirin. In a separate cohort of 73 patients, real time-polymerase chain reaction was performed to analyse hepatic mRNA expression. Immunohistochemistry for SOCS-3 was performed on liver biopsy samples from 38 patients with viral genotype 1 who had received antiviral treatment. Results: Non-response (NR) to treatment occurred in 55% of patients with HCV genotypes 1 or 4 and 22% with genotypes 2 or 3. Factors independently associated with NR were viral genotype 1/4 (p < 0.001), cirrhosis on pretreatment biopsy (p = 0.025), and body mass index >= 30 kg/m(2) (p = 0.010). Obese subjects with viral genotype 1 had increased hepatic mRNA expression of phosphoenolpyruvate carboxy kinase (p = 0.01) and SOCS-3 (p = 0.047), in comparison with lean subjects. Following multivariate analysis, SOCS-3 mRNA expression remained independently associated with obesity (p = 0.023). SOCS-3 immunoreactivity was significantly increased in obesity (p = 0.013) and in non-responders compared with responders (p = 0.014). Conclusions: In patients with chronic HCV viral genotype 1, increased expression of factors that inhibit interferon signalling may be one mechanism by which obesity reduces the biological response to IFN-alpha.

A CRÍTICA SOCIAL DO DITO DE JEREMIAS CONTRA O REI JEOAQUIM: Uma análise exegética de Jeremias 22,13-19 (609-598 a.C)

O presente estudo exegético tem por objetivo demonstrar a crítica social de Jeremias contra o rei Jeoaquim, tendo como fonte principal a crítica social de Jr 22,13-19. Para tal, partiremos da análise do contexto literário, histórico e religioso da crítica social de Jeremias, para então fazer a análise exegética do texto proposto, através da qual enfocaremos, dentre os diversos conteúdos, a justiça social inserida na perícope. Compreendendo que um texto surge dentro de um ambiente social, evidenciaremos, com base na crítica social, as práticas violentas do rei Jeoaquim em seu reinado, contra os trabalhadores injustiçados, o pobre e o necessitado na sociedade de Judá. Por fim, demonstrando as questões históricas do profeta Jeremias em sua vivencia internacional em meio aos impérios existentes, e o sistema opressor do rei Jeoaquim, contra os menos favorecidos da sociedade de Judá.