Constitutional Haploinsufficiency of Tumor Suppressor Genes in Mentally Retarded Patients With Microdeletions in 17p13.1

Chromosome microdeletions or duplications are detected in 10-20% of patients with mental impairment and normal karyotypes. A few cases have been reported of mental impairment with microdeletions comprising tumor suppressor genes. By array-CGH we detected 4 mentally impaired individuals carrying de novo microdeletions sharing an overlapping segment of similar to 180 kb in 17p13.1. This segment encompasses 18 genes, including 3 involved in cancer, namely KCTD11/REN, DLG4/PSD95, and GPS2. Furthermore, in 2 of the patients, the deletions also included TP53, the most frequently inactivated gene in human cancers. The 3 tumor suppressor genes KCTD11, DLG4, and GPS2, in addition to the GABARAP gene, have a known or suspected function in neuronal development and are candidates for causing mental impairment in our patients. Among our 4 patients with deletions in 17p13.1, 3 were part of a Brazilian cohort of 300 mentally retarded individuals, suggesting that this segment may be particularly prone to rearrangements and appears to be an important cause (similar to 1%) of mental retardation. Further, the constitutive deletion of tumor suppressor genes in these patients, particularly TP53, probably confers a significantly increased lifetime risk for cancer and warrants careful oncological surveillance of these patients. Constitutional chromosome deletions containing tumor suppressor genes in patients with mental impairment or congenital abnormalities may represent an important mechanism linking abnormal phenotypes with increased risks of cancer. Copyright (C) 2009 S. Karger AG, Basel

The Trojan horse method in nuclear astrophysics: recent results

Difficulties in cross-section measurements at very low energies, when charged particles are involved, led to the development of some indirect methods. The Trojan horse method (THM) allows us to bypass the Coulomb effects and has been successfully applied to several reactions of astrophysical interest. A brief review of the THM applications is reported together with some of the most recent results.

Trojan Horse Method: a useful tool for electron screening effect investigation

Direct measurements in the last decades have highlighted a new problem related to the lowering of the Coulomb barrier between the interacting nuclei due to the presence of the ""electron screening"" in the laboratory measurements. It was systematically observed that the presence of the electronic cloud around the interacting ions in measurements of nuclear reactions cross sections at astrophysical energies gives rise to an enhancement of the astrophysical S(E)-factor as lower and lower energies are explored [1]. Moreover, at present Such an effect is not well understood as the value of the potential for screening extracted from these measurements is higher than the tipper limit of theoretical predictions (adiabatic limit). On the other hand, the electron screening potential in laboratory measurement is different from that occurring in stellar plasmas thus the quantity of interest in astrophysics is the so-called ""bare nucleus cross section"". This quantity can only be extrapolated in direct measurements. These are the reasons that led to a considerable growth on interest in indirect measurement techniques and in particular the Trojan Horse Method (THM) [2,3]. Results concerning the bare nucleus cross sections measurements will be shown in several cases of astrophysical interest. In those cases the screening potential evaluated by means of the THM will be compared with the adiabatic limit and results arising from extrapolation in direct measurements.

Low-energy d plus d fusion reactions via the Trojan Horse Method

The bare nucleus S(E) factors for the (2)H(d, p)(3)H and (2)H(d.n)(3)He reactions have been measured for the first time via the Trojan Horse Method off the proton in (3)He from 1.5 MeV down to 2 key. This range overlaps with the relevant region for Standard Big Bang Nucleosynthesis as well as with the thermal energies of future fusion reactors and deuterium burning in the Pre-Main-Sequence phase of stellar evolution. This is the first pioneering experiment in quasi free regime where the charged spectator is detected. Both the energy dependence and the absolute value of the S(E) factors deviate by more than 15% from available direct data with new S(0) values of 57.4 +/- 1.8 MeVb for (3)H + p and 60.1 +/- 1.9 MeV b for (3)He + n. None of the existing fitting curves is able to provide the correct slope of the new data in the full range, thus calling for a revision of the theoretical description. This has consequences in the calculation of the reaction rates with more than a 25% increase at the temperatures of future fusion reactors. (C) 2011 Elsevier By. All rights reserved.

Antimicrobial Activity of Ethylenediaminedisuccinate Metal Complexes

It is shown that metal complexes of the biodegradable ligand ethylenediaminedisuccinic acid (edds) present antimicrobial activity towards fungi and bacteria. [Cd(edds)], in particular, is more toxic than free Cd2+ to Aspergillus niger, behaving as a `Trojan Horse` in the facilitated delivery of the toxic metal into the fungus.

Accounting professionalism : a cultural perspective of developing countries

Purpose – The purpose of this study is to examine the effects of culture on accounting professionalism in 12 developing countries by applying Gray's 1988 model and Hofstede 1980 cultural study.
Design/methodology/approach – Connecting seven variables introduced within a testable model lead the finding to classify the twelve countries within a range from statutory control to professionalism. The data set was collected from 1996 to 2000 through different sources. Twelve developing countries have been chosen from the Middle East and South East Asia in this study and cluster analysis is used for analysing and classifying the countries.
Findings – The results show while the Gray's hypothesis of statutory control is positively confirmed for Iran, and moderately for Bangladesh, Jordan, Oman, and Qatar, it is negatively rejected for Pakistan, Turkey, Malaysia, and Indonesia.
Research limitations/implications – One limitation of this study is the improvised nature of the data set caused by the difficulty in collecting an extensive data set from developing countries.
Practical implications – The findings of the study provides a useful source of information about accounting authority in those developing countries in which improve the knowledge and literature about the accounting practice internationally.
Originality/value – The findings of the study are useful in harmonization process of the international accounting practices. Knowledge about important aspects of accounting setting of the countries is essential to realize the impediments of harmonization.

A conformity test of corporate financial disclosures in Asian and Middle East countries

This paper investigates the financial disclosure practices of corporate annual reports published in Asian countries including Bangladesh, Indonesian, Malaysia and the Middle East countries including Bahrain, Iran, Jordan, Kuwait, Oman, Pakistan, Qatar, Saudi Arabia and Turkey. The purpose of the study is to measure the financial disclosure diversity in these countries, with a view to developing a classification of their similarities and differences in respect to their compliance with International Accounting Standards (IASs). Annual reports of 132 public companies listed on the relevant countries stock exchanges are the central data source, supplemented with other reliable information about financial disclosure practices in each country. A disclosure checklist adopted from all IASs and summarised in 306 individual items of financial disclosures is used as a means of extending an understanding of financial reporting literature. Additionally, it provides an indication of voluntary progress towards harmonisation of international accounting practices in several Asian and Middle Eastern countries. Results show the degree of conformity with IASs from less to high conformity is: Saudi Arabia, Qatar, Bangladesh, Iran, Bahrain, Jordan, Pakistan, Oman, Turkey, Malaysia, Kuwait and Indonesia.

The generation of superstructure geometry in latina temples : a hybrid approach

The Nagara tradition of temple building created a rich corpus of Latina (single-spired) temples spread across Northern India between the fifth and thirteenth centuries. Computing methods offer a distinct methodology for reconstructing the genesis and evolution of geometry in this tradition over time. This paper reports a hybrid technique, comprising three distinct computations for recovering and explaining the geometry of temples. The application of the technique enables scholars to bring together fragments of evidence, construe "best-fit" strategies and unearth implicit or hidden relationships. The advantage of this approach is that changes in assumptions and testing of geometric alternatives can be easily simulated from multiple sources of information, such as texts, sacred diagrams and individual temples.

Anzac day commemorations at Gallipoli and the economic effects of attendance

Battlefield tourism is a growth sector of the tourism industry. This type of tourism is encouraged by the host countries due to its positive economic impact. For Australians, Gallipoli is the most visited battlefield site, in particular on Anzac Day. The attendance at Gallipoli is anticipated to reach a phenomenal number of 50,000 participants at the centenary of the campaign in 2015. It is important to understand the economic impact of the event to justify to the policy makers of the host country Turkey that holding such an event is in their national interest.

To elucidate the above matters, a methodology which relied upon a questionnaire based survey was utilized. The questionnaires were distributed and collected on buses going to Gallipoli on the eve of the Anzac Day in 2007. The respondents were travelling to Gallipoli to partake in the Anzac Day ceremonies. The 482 responses collected were then analysed for expenditure and duration of the visit which provided the basic data for economic impact estimation. From these responses it was possible to estimate the economic impact of the event.

Analysis of satisfaction at Gallipoli on ANZAC day, 2007 : results of a survey of event participants

This paper explores the critical success factors of special events, in this case the Anzac Day commemorations at Gallipoli, Turkey. This event has become increasingly popular in recent years with crowd numbers growing to around 20,000 people traveling to attend the 2005 Dawn Service at historic Anzac Cove on Anzac day. The aim of this research is to investigate the success factors associated with Anzac Day commemorations at Gallipoli and to assess how these influence visitor satisfaction. Data was collected from 331 attendees of Anzac Day commemorations at Gallipoli while they were in transit from Gallipoli to Istanbul on 25 April 2007. The analysis of this data was undertaken using exploratory and confirmatory factor analysis as a basis to the development of a model of satisfaction using structural equation modeling. In this case constructs relating to amenities, transport, ceremonies and recommending behavior were found to be significant predictors of event satisfaction. These issues during the event were found to be of equal importance for both genders and all age groups.

Compositional connections : temple form in early Southeast Asia

The temples of Southeast Asia are remarkable and intriguing in their architecture, in that they are obviously derivative from Indic canon and yet
profoundly original and different from the corpus of the subcontinent. Further, the regional nuances of these temples, whether in Java, Cambodia or Champa, defy obvious and linear connections within these traditions and with the pan-Indic corpus. While epigraphists, Sanskritists and historians have made significant connections between these temple building traditions, much work remains to be done on the compositional and architectural linkages along the trading routes of South and Southeast Asia. This paper is an early attempt at understanding the compositional connections, as evident in the temple forms of early southeast Asia. To elucidate the complex material, the authors deploy a comparative method on two levels. Between ideal notions of the Hindu temple and shared cosmogony on one hand and individual temples as a realization of the ideal on the other. The consideration of the compositional material yields some surprisingly rich and varied connections. For example, the affinities between 7th century cellas in Cambodia and early Gupta models from central India are difficult to ignore. Further, the linkages between these cellas and the early Deccan experiments in structural stone raise questions about both idioms. The range of experimentation in Cambodia
(in plan forms, superstructure and construction methods are discussed with reference to their Indic antecedents. The findings of the paper raise questions about the relation between temple and treatise; between theory and practice and between the individual temple and its collective corpus.

General practitioner and the control of sexually transmissible infections

Sexually transmissible infections (STIs), one of the major preventable health problems affecting the Australian population, are often asymptomatic and, if undetected, can cause sub-fertility, infertility and chronic morbidity. In addition to these significant and costly consequences, STIs increase the risk of transmission of HIV. Given that 80% of Australian patients attend their General Practitioner (GP) each year, GPs are well placed to have a significant impact on STI transmission by diagnosing and treating both asymptomatic and symptomatic disease. Good professional practice would suggest that all GPs will undertake certain actions when they are consulted by a patient who either has symptoms of an STI or who appears to be at risk of acquiring an STI. This expectation is based on the premise that all GPs share the same detailed knowledge of STI risk factors and symptoms. It assumes that they will have no difficulty in eliciting such information from the patient, that the patient will comply with STI testing and treatment and that the patient will return for follow-up, to ensure that they and their sexual partners have been adequately treated. Given the constraints of the real world in which general practice exists, the sensitive nature of sexual health, and the stigma associated with STIs, there are many barriers to achieving such an outcome. My own previous research has highlighted some of the difficulties experienced by GPs in the area of STI control. This study has used data from four different sources (policy and stakeholder documents, literature, key informant interviews and my own past research) to examine ideal practice and actual practice in the prevention and treatment of STIs. A number of discrepancies were identified, and from these arose a series of recommendations for ways of making STI control in general practice less complex. To ensure that the results of the study were firmly embedded in the reality of general practice, comments on the recommendations were sought from GPs employed in a variety of practice settings, including those with low STI caseloads. These comments were used to modify the recommendations to ensure they would offer a practical and effective contribution to STI control in Victoria.

Water, escaping sovereignty : the hydropolitics of the Tigris-Euphrates river and Turkish state formation

Develops a critical analysis of the domestic and international factors influencing the process of Turkish state formation. Focuses on the political economy of water resource development along the Tigris-Euphrates river basin, shared by the three riparian states, Turkey, Iraq and Syria. Turkey's large-scale development of the river is characterised as a state making imperative, highlighting the needs to improve regional resource diplomacy.

Dies of culture and religion : India and Australia, from settlement to post/modern times

In historical sketches of India-Australia or Australia-India relations, the important dimensions of the cultural and religious connections from the shared colonial period and Gandhi's nationalist voice echoing in all corners of the Empire, through to the diasporic migration, settlement and temple culture, is largely overlooked. This essay intends the redress that absence in current research and contribute toward a critical appraisal of that rather 'esoteric' part of history, arguably still in its infancy. The story begins close to the early white settlement period to the aftermath of the events of 9/11 (2001 in New York) and Bali (2002). The focus will be on Hindus with some reference to Sikhs, Muslims, Sri Lankan Tamils, and migrants from the subcontinent, as the conduits for the particular Indian-Australian diasporic connection and 'spiritual diplomacy' being explored.

It was an experience that totally blew up in my face : Steve Railsback and Turkey shoot

The schlock horror film Turkey Shoot is widely regarded as one of the most disreputable Australian exploitation titles in a genre already well noted for controversy. This short article frames the controversies that surround the film from production to critical reception, which sets the scene for an interview by Mark Harley with the film's star Steve Railsback, who reflects on the movie's production, his role, the controversy and the film's reception.