De Platonis Phaedro : inclutae Societatis latinae Ienensis auctoritate /

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Grundriss der Philologie.

Mode of access: Internet.

Platon's Leben und Schriften : ein Versuch, im Leben wie in den Schriften der Platon das Wahre und Aechte vom Erdichteten und Untergeschobenen zu scheiden, und die Zeitfolge der achten Gespräche zu bestimmen : als Einleitung in das Studium der Platon herausgegeben /

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Annotationes in Platonis opera ...

Mode of access: Internet.

Astrographic catalogue 1900-0 Oxford section dec. +24⁰ to +32⁰: from photographs taken and measured at the University observatory, Oxford, under the direction of Herbert Hall Turner.

No more published?

Platon's Phaedros und Gastmahl /

Mode of access: Internet.

Grundlinien der Grammatik, Hermeneutik und Kritik /

Mode of access: Internet.

University of Michigan Football Team, 1942

1942 UM Football Team,

Tretʹi͡a kniga liriki /

Facsimile reprint of: Berlin : Izd-vo Z. I. Grzhebina, 1922.

Narrativ studie av sociala berättelser : Återberättning av perspektiv och mentala kausala samband för elev elever med autismspektrumtillstånd och lindrig utvecklingsstörning

Sammanfattning/Abstract Syftet med vår studie var att undersöka hur sociala berättelser kan öka färdigheter och förmågor av perspektivering och mentala kausala samband i återberättande av olika berättelser för elever med autismspektrumtillstånd (AST) och lindrig utvecklingsstörning. Metoden vi använde oss av var dels utifrån aktionsforskning att utgå från vår egen praktik och en single-case research-reversal design med två baslinjer och två interventionsfaser på fyra elever i åk 2 & 3 med AST och lindrig utvecklingsstörning på grundskolan och grundsärskolan.   Resultaten visade att interventionen med sociala berättelser utifrån bildstödsprogrammet Trippelverkstaden hade störst effekt på två elever i perspektivering. Interventionen med sociala berättelser utifrån symbol- och bildstödsprogrammet Inprint hade störst effekt av perspektivering på två av eleverna. Resultaten för mentala kausala samband gav störst effekt på två av eleverna i återberättande av sociala berättelser i interventionerna.   Slutsatserna vi kom fram till var att de rekommendationer och metoder ifrån sociala berättelser med basmeningar, enkelt språk, korta berättelser, bildstöd, användandet av fåtal karaktärer i berättelserna och relaterat till situationer/händelser eleven känner igen har gett effekt på elevernas återberättningar av perspektiv och mentala kausala samband. Interventionerna med sociala berättelser ger stöd för att användas som hjälpmedel för elever med AST och lindrig utvecklingsstörning i Theory of Mind (ToM), centrala koherens (CK) och exekutiva funktioner/arbetsminne (EF & AM) i att återberättningarna blir mer sammanhållna och ökad återberättning av perspektiv och mentala kausala samband. Vi hävdar utifrån undersökningens resultat och utfall att sociala berättelser kan utgöra ett återkommande inslag i undervisningen för att träna kognitiva-, språkliga- och kommunikativa färdigheter och förmågor av att göra olika perspektiveringar och mentala kausala samband i återberättningar av berättelser.    Nyckelord: sociala berättelser, narration, AST, lindrig utvecklingsstörning, single-case research design, aktionsforskning, perspektivering, mentala kausala samband, theory of mind, central koherens, exekutiva funktioner, arbetsminne.

Toward better outcomes with tacrolimus therapy: Population pharmacokinetics and individualized dosage prediction in adult liver transplantation

Patient outcomes in transplantation would improve if dosing of immunosuppressive agents was individualized. The aim of this study is to develop a population pharmacokinetic model of tacrolimus in adult liver transplant recipients and test this model in individualizing therapy. Population analysis was performed on data from 68 patients. Estimates were sought for apparent clearance (CL/F) and apparent volume of distribution (V/F) using the nonlinear mixed effects model program (NONMEM). Factors screened for influence on these parameters were weight, age, sex, transplant type, biliary reconstructive procedure, postoperative day, days of therapy, liver function test results, creatinine clearance, hematocrit, corticosteroid dose, and interacting drugs. The predictive performance of the developed model was evaluated through Bayesian forecasting in an independent cohort of 36 patients. No linear correlation existed between tacrolimus dosage and trough concentration (r(2) = 0.005). Mean individual Bayesian estimates for CL/F and V/F were 26.5 8.2 (SD) L/hr and 399 +/- 185 L, respectively. CL/F was greater in patients with normal liver function. V/F increased with patient weight. CL/F decreased with increasing hematocrit. Based on the derived model, a 70-kg patient with an aspartate aminotransferase (AST) level less than 70 U/L would require a tacrolimus dose of 4.7 mg twice daily to achieve a steady-state trough concentration of 10 ng/mL. A 50-kg patient with an AST level greater than 70 U/L would require a dose of 2.6 mg. Marked interindividual variability (43% to 93%) and residual random error (3.3 ng/mL) were observed. Predictions made using the final model were reasonably nonbiased (0.56 ng/mL), but imprecise (4.8 ng/mL). Pharmacokinetic information obtained will assist in tacrolimus dosing; however, further investigation into reasons for the pharmacokinetic variability of tacrolimus is required.

Electromechanical resonators as measuring transducers

With the increasing use of digital computers for data acquisition and digital process control, frequency domain transducers have become very attractive due to their virtual digital output. Essentially they are electrically maintained oscillators where the sensor is the controlling resonator.They are designed to make the frequency a function of the physical parameter being measured. Because of their high quality factor, mechanical resonators give very good frequency stability and are widely used as sensors. For this work symmetrical mechanical resonators such as the tuning fork were considered, to be the most promising. These are dynamically clamped and can be designed to have extensive regions where no vibrations occur.This enables the resonators to be robustly mounted in a way convenient for various applications. Designs for the measurement of fluid density and tension have been produced. The principle of the design of the resonator for fluid density measurement is a thin gap (trapping a lamina of fluid) between its two members which vibrate in antiphase.An analysis of the inter­ action between this resonator and the fluid lamina has carried out.In gases narrow gaps are needed for a good sensitivity and the use of the material fused quartz, because of its low density and very low temperature coefficient, is ideally suitable. In liquids an adequate sensitivity is achieved even with a wide lamina gap. Practical designs of such transducers have been evolved. The accuracy for liquid measurements is better than 1%. For gases it was found that, in air, a change of atmospheric pressure of 0.3% could be detected. In constructing a tension transducer using such a mechanical sensor as a wire or a beam, major difficulties are encountered in making an efficient clamping arrangement for the sensor. The use of dynamically clamped beams has been found to overcome the problem and this is the basis of the transducer investigated.

Measurement of scleral thickness in humans using anterior segment optical coherent tomography

Anterior segment optical coherent tomography (AS-OCT, Visante; Zeiss) is used to examine meridional variation in anterior scleral thickness (AST) and its association with refractive error, ethnicity and gender. Scleral cross-sections of 74 individuals (28 males; 46 females; aged between 18-40 years (27.7±5.3)) were sampled twice in random order in 8 meridians: [superior (S), inferior (I), nasal (N), temporal (T), superior-temporal (ST), superior-nasal (SN), inferior-temporal (IT) and inferior-nasal (IN)]. AST was measured in 1mm anterior-toposterior increments (designated the A-P distance) from the scleral spur (SS) over a 6mm distance. Axial length and refractive error were measured with a Zeiss IOLMaster biometer and an open-view binocular Shin-Nippon autorefractor. Intra- And inter-observer variability of AST was assessed for each of the 8 meridians. Mixed repeated measures ANOVAs tested meridional and A-P distance differences in AST with refractive error, gender and ethnicity. Only right eye data were analysed. AST (mean±SD) across all meridians and A-P distances was 725±46μm. Meridian SN was the thinnest (662±57μm) and I the thickest (806 ±60μm). Significant differences were found between all meridians (p<0.001), except S:ST, IT:IN, IT:N and IN:N. Significant differences between A-P distances were found except between SS and 6 mm and between 2 and 4mm. AST measurements at 1mm (682±48 μm) were the thinnest and at 6mm (818±49 μm) the thickest (p<0.001); a significant interaction occurred between meridians and A-P distances (p<0.001). AST was significantly greater (p<0.001) in male subjects but no significant differences were found between refractive error or ethnicity. Significant variations in AST occur with regard to meridian and distance from the SS and may have utility in selecting optimum sites for pharmaceutical or surgical intervention.

Parâmetros bioquímicos e níveis de IgE total e específicas para aeroalérgenos em mulheres obesas com síndrome dos ovários policísticos

Introduction: Polycystic ovary syndrome (PCOS) whose classic features (menstrual irregularity of oligo/ amenorrhea type, chronic anovulation, infertility and hyperandrogenism clinical and/ or biochemical), is associated with aspects of metabolic syndrome (MS), as obesity and insulin resistance. The level of obesity determines different levels of inflammation, increasing cytokines participants of metabolic and endocrine functions, beyond modulate the immune response. Metabolic changes, added to the imbalance of sex hormones underlying irregular menstruation observed in (PCOS) can trigger allergic processes and elevation of total and specific IgE antibodies indicate that a sensitization process was started. Objective: To evaluate the influence of PCOS on biochemical parameters and levels of total and specific IgE to aeroallergens in obese women. Methods: After approval by the Committee of Ethics in Research, were recruited 80 volunteers with BMI ≥ 30 kg/m2 and age between 18 and 45 years. Among these, 40 with PCOS according to the Rotterdam criteria and 40 women without PCOS (control group). All participants were analysed with regard to anthropometric, clinical, gynecological parameters, interviewed using a questionnaire, and underwent blood sampling for realization of laboratory tests of clinical biochemistry: Total cholesterol, LDL-cholesterol, HDL- cholesterol, Triglycerides, Fasting glucose, Urea, Creatinine, Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and immunological: total and specific IgE to Dermatophagoides pteronyssinus, Blomia tropicalis, Dermatophagoides farinae and Dermatophagoides microceras.Statistical analysis was performed using SPSS 15.0 software through the chi-square tests, Fisher, Student t test and binary logistic regression, with significance level (p <0.05). Results: It was observed in the group of obese women with PCOS that 29 (72.5%) had menstrual cycle variable and 27 (67.5%) had difficulty getting pregnant. According to waist-hip ratio, higher average was also observed in obese PCOS (0.87). Blood level of HDL (36.9 mg/dL) and ALT (29.3 U/L) were above normal levels in obese women with PCOS, with statistically significant relationship. In the analysis of total and specific IgE to D. pteronyssinus high results were also prevalent in obese PCOS, with blood level (365,22 IU/mL) and (6.83 kU/L), respectively, also statistically significant. Conclusions: Observed predominance of cases with high levels of total IgE in the group of obese women with PCOS, 28 (70%) of the participants, whose mean blood concentration of the group was 365.22 IU/mL. In the analysis of Specific IgE between the groups, the allergen Dermatophagoides pteronyssinus showed greater dispersion and average the results of sensitization in the group of obese PCOS, whose mean blood concentration was 6.83 kU/l. Keywords: Obesity, Allergens and Polycystic Ovary Syndrome