[1 lettre de Auguste-Emmanuel Vaucorbeil à Jacques-Léopold Heugel, 13 juin 1879]

Rend compte des différentes auditions de chanteurs qu'il a menées et va mener avant sa prise de fonction de directeur de l'Opéra. Fait ainsi l'éloge des capacités de Zélie Trebelli et de Christine Nilsson qu'il va entendre dans "Faust", "son meilleur rôle dit-on". Se montre plus réservé sur son rôle dans "Les Huguenots". N'a pas encore entendu Victor Maurel, mais l'audition est imminente. Evoque le protégé d'Heugel, Jacques Roudil, qui a des prétentions exorbitantes : "Il me demande 10000 francs par mois, deux mois de congés et un engagement de trois années, sans résiliation après la première : c'est fou!" Relate également le concert de Julian Gayarre qui a une jolie voix, mais qui doit "perdre son accent, ceci est capital". Lui indique enfin qu'il a signé le contrat de Pédro Gailhard. - Remercie également son ami pour "l'exhumation de la ballade serbe dans le Figaro"

[1 lettre d'Auguste-Emmanuel Vaucorbeil à Jacques-Léopold Heugel, 13 juillet 1881]

Au sujet de trois ou quatre planches à regraver

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.

[Magnificentiores selectioresque Urbis Venetiarum prospectus quos olim Michael Marieschi, Venetus pictor et architectus in plerisque tabulis depinxit, nunc vero ab ipsomet acurate delineante, incidente, tyspisque mandante, iterum in sexdecim aereis tabulis in lucem aeduntur]. [13], Forum maius, et Basilica D: Marci, cum insula procul S. Georgii maioris et aedes D: Marci Procuratorum, vulgo novae ad dexteram : omnia ab horologia prospecta. : [estampe] / Mich.l Marieschi del.t et inci.t

Référence bibliographique : Toledano, Marieschi, 2f

Vie religieuse en Savoie : mentalités, associations / actes du XXXIe Congrès des sociétés savantes de Savoie, Annecy, 13-14 septembre 1986

Collection : Mémoires et documents publiés par l'Académie salésienne ; 95

Emergency department visits for non-life-threatening conditions : evolution over 13 years in a Swiss urban teaching hospital

INTRODUCTION: A large proportion of visits to our Emergency Department (ED) are for non-life-threatening conditions. We investigated whether patients' characteristics and reasons for consultation had changed over 13 years. METHODS: Consecutive adult patients with non-life-threatening conditions at triage were included in the spring of 2000 and in the summer of 2013. In both years patients completed a similar questionnaire, which addressed their reasons for consultation and any previous consultation with a general practitioner (GP). RESULTS: We included 581 patients in 2013 vs 516 in 2000, with a mean age of 44.5 years vs 46.4 years (p=0.128). Of these patients, 54.0% vs 57.0% were male (p=0.329), 55.5% vs 58.7% were Swiss (p=0.282), 76.4% were registered with a GP in both periods, but self-referral increased from 52.0% to 68.8% (p<0.001); 57.7% vs., 58.3% consulted during out-of- hours (p=0.821). Trauma-related visits decreased from 34.2% to 23.7% (p<0.001). Consultations within 12 hours of onset of symptoms dropped from 54.5% to 30.9%, and delays of ≥1 week increased from 14.3% to 26.9% (p<0.001). The primary motive for self-referral remained unawareness of an alternative, followed in 2013 by dissatisfaction with the GP's treatment or appointment. Patients who believed that their health problem would not require hospitalisation increased from 52.8% to 74.2% and those who were actually hospitalised decreased from 24.9% to 13.9% (all p<0.001). CONCLUSION: The number of visits for non-life-threatening consultations continue to increase. Our ED is used by a large proportion of patients as a convenient alternative source of primary care.