Transcranial Doppler after traumatic brain injury: is there a role?

PURPOSE OF REVIEW: To present the practical aspects of transcranial Doppler (TCD) and provide evidence supporting its use for the management of traumatic brain injury (TBI) patients. RECENT FINDINGS: TCD measures systolic, mean, and diastolic cerebral blood flow (CBF) velocities and calculates the pulsatility index from basal intracranial arteries. These variables reflect the brain circulation, provided there is control of potential confounding factors. TCD can be useful in patients with severe TBI to detect low CBF, for example, during intracranial hypertension, and to assess cerebral autoregulation. In the emergency room, TCD might complement brain computed tomography (CT) scan and clinical examination to screen patients at risk for further neurological deterioration after mild-to-moderate TBI. SUMMARY: The diagnostic value of TCD should be incorporated into other findings from multimodal brain monitoring and CT scan to optimize the bedside management of patients with TBI and help guide the choice of appropriate therapies.

Marseille. Collection de copies et de documents originaux concernant l'histoire de Marseille. Collection Mortreuil sur Marseille vol. 12 : Corps religieux (Préfecture des Bouches du Rhône. Archives de l’église d’Arcoules, du monastère de Saint Sauveur et des Grands Trinitaires de Marseille. Actes antérieurs au XIV e siècle. A.M. 1855.)

Copie manuscrite de documents d’archives : F. 1-91. Archives de l’Eglise d’Arcoules de Marseille. F. 92-104. Augustins. F. 105-149. Archives des Dominicains (precheurs) de Marseille. F. 150-153. Abbaye de l’Huveaune, prémontrés. F. 154-178. Frères Mineurs. F. 179-180. La Major. F. 181 -184. St Carmat. F. 185-186. St Etienne des îles Ratoneau. F. 187-191. St Jacques de Corrégie. F. 192-193. St Laurent. F. 194-195. Prieuré de St Lazare. F. 196-199. St Martin F. 200-206. St Michel et St Etienne du Plan. F. 207 -379. Archives du monastère de Saint Sauveur de Marseille. F. 381-387. Sainte Claire. F. 388-391. N.D. de Syon. F. 392 459. Archives des Grands Trinitaires de Marseille.

Jacobus de Vitriaco, Sermones vulgares seu ad omnes status.

Au f. 153, ex-libris lavé, du XIVe s. (lampe de Wood): "Iste liber est Hugoni de Villeni Sancti Ligari [...] quem emit ab exequo (?) defuncti domini Stephani de Susciaco presbiteri". Dans l'obituaire de la cathédrale de Paris, publié par A. Molinier (Obituaires de la province de Sens, I, Paris, 1902, 91-240), le décès de Stephanus de Susiaco [Etienne de Suizy], "presbiter cardinalis", est mentionné à la date du 11 décembre 1311 (p. 208). En-dessous, un second ex-libris du XIVe s. a été gratté: "Iste liber est [...] rectoris [...] Carnotensis dyocesis". Il est suivi par une mention d'achat partiellement lisible, du XIVe s.: "Vendidi [...] ante s. crucem text. sextio casus quosdam decretalium vendedi magister Stephanus de Lugello habuit [...] tamquam (?) de bonis iste [...] + Richardus ad bonum baculum tenetur presens I. et marg. emo [...], debet XXVII s. IIII d. par. medi augusti. Solvi V p. De quibus se [...] Anchi (?) Yvoni X sol. par. IIII d. par." Ce ms. a été acheté par Claude Joly, chantre de Notre-Dame de Paris, à Chaumont-en-Bassigny en 1655, comme l'indique la note de Claude Joly au contreplat sup.: "Cl. Joly M. oct. 1658. J'ay eu ce mss. a Chaumont en Bassigni en 1655". En-dessous de cette note figure l'ex-libris "A la bibliotheque de l'Eglise de Paris", précédé de la cote C18 (fin XVIIe s.-début XVIIIe s.). Notre-Dame.

Mélanges de Peiresc.

Litanies de S. Victor de Marseille (1). - Vie de s. Trophyme (5). - Philippus Cabassole, de B. M. Magdalena (7). - Lettres sur l'ancienne division de la Gaule (9 v°). - Notice de Besly sur la chronique de Julius Florus (15). - Antiquité des séparations dans les églises (17). - Commencement d'un traité historique sur les évêchés d'Angleterre (22). - Notes autographes de Peiresc sur des antiquités chrétiennes de Vienne (28). - Mémoires sur Embrun (32, 55 v°, 94 v°), le Dauphiné, le Comtat, la Provence, le Languedoc, les évêques de Digne (60 v°), de Sisteron (63) et de Vence (68 v°), Avignon (76), les évêques de Marseille (92), et ceux de Fréjus (95). - Vita b. Lamberti, ep. Venciensis (68 v°). - Origines de l'église de Reims (96). - Antiquités d'Orange (110). - Droits du roi en Bourgogne (140). - Pont du S. Esprit (153). - Seigneurie de Sault (154 v°). - Notes et documents généalogiques. - Copies de lettres et de documents du XVII s. - Idea sive designatio aliquot operum quae Jo. Ba. Donius partim absolvit partim incaepit (236). - Copie des anciens priviléges de l'église d'Arles (254).

Medida do impacto da doença: validade de constructo de instrumento entre coronariopatas

Este estudo estimou a validade de constructo pelo teste de grupos conhecidos do Instrumento para Mensuração do Impacto da Doença no Cotidiano do Valvopata (IDCV) quanto a sinais e sintomas, função ventricular sistólica, fração de ejeção do ventrículo esquerdo (FEVE) e qualidade de vida relacionada à saúde (QVRS) em 153 coronariopatas em seguimento ambulatorial. Os dados foram obtidos pela aplicação do IDCV e das versões brasileiras do The Medical Study 36-item Short Form Health Survey – SF-36 e MacNew Heart Disease Health-related Quality of Life Questionnair e. Foi utilizado o teste de Mann-Whitney para verificar a capacidade do IDCV em discriminar o impacto quanto a sinais e sintomas, FEVE e disfunção sistólica ventricular, bem como o teste de Kruskal-Wallis para verificar seu poder de discriminação em relação à QVRS. Constatou-se que o IDCV discriminou o impacto entre aqueles que pontuaram nos quartis (≤Q1, Q1-Q3, ≥Q3) de QVRS. Os achados deste estudo contribuem para o refinamento do IDCV na mensuração do impacto da doença entre coronariopatas.

CT arthrography of the glenohumeral joint: CT fluoroscopy versus conventional CT and fluoroscopy--comparison of image-guidance techniques.

PURPOSE: To compare examination time with radiologist time and to measure radiation dose of computed tomographic (CT) fluoroscopy, conventional CT, and conventional fluoroscopy as guiding modalities for shoulder CT arthrography. MATERIALS AND METHODS: Glenohumeral injection of contrast material for CT arthrography was performed in 64 consecutive patients (mean age, 32 years; age range, 16-74 years) and was guided with CT fluoroscopy (n = 28), conventional CT (n = 14), or conventional fluoroscopy (n = 22). Room times (arthrography, room change, CT, and total examination times) and radiologist times (time the radiologist spent in the fluoroscopy or CT room) were measured. One-way analysis of variance and Bonferroni-Dunn posthoc tests were performed for comparison of mean times. Mean effective radiation dose was calculated for each method with examination data, phantom measurements, and standard software. RESULTS: Mean total examination time was 28.0 minutes for CT fluoroscopy, 28.6 minutes for conventional CT, and 29.4 minutes for conventional fluoroscopy; mean radiologist time was 9.9 minutes, 10.5 minutes, and 9.0 minutes, respectively. These differences were not statistically significant. Mean effective radiation dose was 0.0015 mSv for conventional fluoroscopy (mean, nine sections), 0.22 mSv for CT fluoroscopy (120 kV; 50 mA; mean, 15 sections), and 0.96 mSv for conventional CT (140 kV; 240 mA; mean, six sections). Effective radiation dose can be reduced to 0.18 mSv for conventional CT by changing imaging parameters to 120 kV and 100 mA. Mean effective radiation dose of the diagnostic CT arthrographic examination (140 kV; 240 mA; mean, 25 sections) was 2.4 mSv. CONCLUSION: CT fluoroscopy and conventional CT are valuable alternative modalities for glenohumeral CT arthrography, as examination and radiologist times are not significantly different. CT guidance requires a greater radiation dose than does conventional fluoroscopy, but with adequate parameters CT guidance constitutes approximately 8% of the radiation dose.

Ferripyochelin uptake genes are involved in pyochelin-mediated signalling in Pseudomonas aeruginosa.

In response to iron starvation, Pseudomonas aeruginosa produces the siderophore pyochelin. When secreted to the extracellular environment, pyochelin chelates iron and transports it to the bacterial cytoplasm via its specific outer-membrane receptor FptA and the inner-membrane permease FptX. Exogenously added pyochelin also acts as a signal which induces the expression of the pyochelin biosynthesis and uptake genes by activating PchR, a cytoplasmic regulatory protein of the AraC/XylS family. The importance of ferripyochelin uptake genes in this regulation was evaluated. The fptA and fptX genes were shown to be part of the fptABCX ferripyochelin transport operon, which is conserved in Burkholderia sp. and Rhodospirillum rubrum. The fptB and fptC genes were found to be dispensable for utilization of pyochelin as an iron source, for signalling and for pyochelin production. By contrast, mutations in fptA and fptX not only interfered with pyochelin utilization, but also affected signalling and diminished siderophore production. It is concluded from this that pyochelin-mediated signalling operates to a large extent via the ferripyochelin transport system.

Laboratory-based versus non-laboratory-based CVD risk analysis.

Commentaire de: Gaziano TA, Young CR, Fitzmaurice G, Atwood S, Gaziano JM. Laboratory-based versus non-laboratory-based method for assessment of cardiovascular disease risk: the NHANES I Follow-up Study cohort. Lancet. 2008;371(9616):923-31. PMID: 18342687

Avaliação dinâmica do projecto de expansão do Aeroporto Internacional da Praia

Nos últimos anos, os benefícios das opções reais têm sido bastante estudados. Diversos autores debruçaram-se sobre o desenvolvimento de modelos adequados à sua avaliação, outros visaram, apenas, encontrar evidências empíricas que reforçam a concepção de que a inclusão de tais opções na avaliação de projectos cria valor para a empresa. Assim, considerando que as opções reais criam valor para as empresas, implicando que as decisões não só quanto ao montante do investimento mas também quanto ao momento óptimo para realizá-lo sejam repensadas, este estudo tem por objectivo avaliar o projecto de expansão do Aeroporto Internacional da Praia, em Cabo Verde, considerando as incertezas e as flexibilidades que lhes estão inerentes. Para o efeito, foi utilizada uma extensão do modelo de Armada, Pereira e Rodrigues (2008) e Rodrigues (2009). Nesta dissertação, admitimos que a opção de investimento em causa é, em todo, semelhante a uma opção de compra perpétua sob um activo que paga dividendos. Assumimos, ainda, que, o número de passageiros segue um movimento geométrico Browniano. Os resultados obtidos evidenciam que a opção de expansão acrescenta valor para a entidade responsável por este projecto. O número de passageiros para o qual é óptimo expandir revelou estar compreendido entre a capacidade actual instalada e a capacidade prevista com a expansão, o que significa que o investimento deve ser adiado. No entanto, uma análise de sensibilidade mostra, o quão sensível são o valor do projecto, a procura crítica para o investimento e o valor da opção às variações na taxa de crescimento do número de passageiros, na volatilidade, na taxa de juro isenta de risco, no risco do mercado, na taxa de retorno do mercado, na receita líquida actual e esperada por passageiro e no valor do investimento.

Pariisissa perjantaina illalla [22.10.]1931 syksy

Kirje