Histología de folículos post-ovulatorios de la sardina (Sardinops sagax) del Perú

El siguiente estudio se basa en la utilización de folículos post-ovulatorios como medio de estimación de desove. En este caso se abarcan los días 0, 1 y 2.

Acute painful diabetic neuropathy: an uncommon, remittent type of acute distal small fibre neuropathy.

INTRODUCTION: Acute painful diabetic neuropathy (APDN) is a distinctive diabetic polyneuropathy and consists of two subtypes: treatment-induced neuropathy (TIN) and diabetic neuropathic cachexia (DNC). The characteristics of APDN are (1.) the small-fibre involvement, (2.) occurrence paradoxically after short-term achievement of good glycaemia control, (3.) intense pain sensation and (4.) eventual recovery. In the face of current recommendations to achieve quickly glycaemic targets, it appears necessary to recognise and understand this neuropathy. METHODS AND RESULTS: Over 2009 to 2012, we reported four cases of APDN. Four patients (three males and one female) were identified and had a mean age at onset of TIN of 47.7 years (±6.99 years). Mean baseline HbA1c was 14.2% (±1.42) and 7.0% (±3.60) after treatment. Mean estimated time to correct HbA1c was 4.5 months (±3.82 months). Three patients presented with a mean time to symptom resolution of 12.7 months (±1.15 months). One patient had an initial normal electroneuromyogram (ENMG) despite the presence of neuropathic symptoms, and a second abnormal ENMG showing axonal and myelin neuropathy. One patient had a peroneal nerve biopsy showing loss of large myelinated fibres as well as unmyelinated fibres, and signs of microangiopathy. CONCLUSIONS: According to the current recommendations of promptly achieving glycaemic targets, it appears necessary to recognise and understand this neuropathy. Based on our observations and data from the literature we propose an algorithmic approach for differential diagnosis and therapeutic management of APDN patients.

Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study.

BACKGROUND: The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the first 60 days of hospitalization, and outcome of SA PVIE within the International Collaboration on Endocarditis-Prospective Cohort Study. METHODS: Participants were enrolled between June 2000 and December 2006. Cox proportional hazards modeling that included surgery as a time-dependent covariate and propensity adjustment for likelihood to receive cardiac surgery was used to evaluate the impact of EVS and 1-year all-cause mortality on patients with definite left-sided S. aureus PVIE and no history of injection drug use. RESULTS: EVS was performed in 74 of the 168 (44.3%) patients. One-year mortality was significantly higher among patients with S. aureus PVIE than in patients with non-S. aureus PVIE (48.2% vs 32.9%; P = .003). Staphylococcus aureus PVIE patients who underwent EVS had a significantly lower 1-year mortality rate (33.8% vs 59.1%; P = .001). In multivariate, propensity-adjusted models, EVS was not associated with 1-year mortality (risk ratio, 0.67 [95% confidence interval, .39-1.15]; P = .15). CONCLUSIONS: In this prospective, multinational cohort of patients with S. aureus PVIE, EVS was not associated with reduced 1-year mortality. The decision to pursue EVS should be individualized for each patient, based upon infection-specific characteristics rather than solely upon the microbiology of the infection causing PVIE.

Did Dumbo suffer a heart attack? independent association between earlobe crease and cardiovascular disease.

BACKGROUND: Earlobe crease (ELC) has been associated with cardiovascular diseases (CVD) or risk factors (CVRF) and could be a marker predisposing to CVD. However, most studies studied only a small number of CVRF and no complete assessment of the associations between ELC and CVRF has been performed in a single study. METHODS: Population-based study (n = 4635, 46.7 % men) conducted between 2009 and 2012 in Lausanne, Switzerland. RESULTS: Eight hundred six participants (17.4 %) had an ELC. Presence of ELC was associated with male gender and older age. After adjusting for age and gender (and medication whenever necessary), presence of ELC was significantly (p < 0.05) associated with higher levels of body mass index (BMI) [adjusted mean ± standard error: 27.0 ± 0.2 vs. 26.02 ± 0.07 kg/m(2)], triglycerides [1.40 ± 0.03 vs. 1.36 ± 0.01 mmol/L] and insulin [8.8 ± 0.2 vs. 8.3 ± 0.1 μIU/mL]; lower levels of HDL cholesterol [1.61 ± 0.02 vs. 1.64 ± 0.01 mmol/L]; higher frequency of abdominal obesity [odds ratio and (95 % confidence interval) 1.20 (1.02; 1.42)]; hypertension [1.41 (1.18; 1.67)]; diabetes [1.43 (1.15; 1.79)]; high HOMA-IR [1.19 (1.00; 1.42)]; metabolic syndrome [1.28 (1.08; 1.51)] and history of CVD [1.55 (1.21; 1.98)]. No associations were found between ELC and estimated cardiovascular risk, inflammatory or liver markers. After further adjustment on BMI, only the associations between ELC and hypertension [1.30 (1.08; 1.56)] and history of CVD [1.47 (1.14; 1.89)] remained significant. For history of CVD, further adjustment on diabetes, hypertension, total cholesterol and smoking led to similar results [1.36 (1.05; 1.77)]. CONCLUSION: In this community-based sample ELC was significantly and independently associated with hypertension and history of CVD.

Bulletin des armées de la République : réservé à la zone des armées

Périodicité : Quotidien (15 août-9 septembre 1914) ; bi-hebdomadaire (12 septembre 1914-18 mars 1916) ; hebdomadaire (22 mars 1916-décembre 1917)

La Terre sainte (1875)

Périodicité : Bimens

龐子遺詮

Contient : I, livres 1-3性薄錄Xing bo lu ; II, livre 4, feuillets 1-15詮天神魔鬼Quan tian shen mo gui ; III, livre 4, feuillets 16-31詮人類原始Quan ren lei yuan shi

Livre des Morts de Djéhoutyirydès. Egyptien 134

La grande scène au trait est celle du jugement du chapitre 125 du Livre des Morts. On y voit le défunt devant la déesse Maât, la balance où le coeur est pesé sous la surveillance d'Anubis, Horus et Thot en sa qualité de scribe. La grande dévoreuse est présente, devant Osiris, lequel est assis sur son trône.Texte :Col. 1, 1-14 et vignette : chapitre 137 A avec titre rubriqué : "Formule des quatres torches". La vignette montre le défunt assis entouré de quatre lampes.Col. 1, 15-25 et vignette : chapitre 138 avec titre rubriqué : "Formule pour entrer en Abydos". Le défunt est debout devant deux enseignes.Col. 2 et vignette : chapitre 141 avec titres rubriqués : "Formule pour connaître le nom des dieux du ciel méridional; Livre pour transfigurer les esprits, pour les dieux du ciel méridional et les dieux du ciel septentrional, et les dieux qui sont dans la nécropole septentrionale, et les dieux qui conduisent dans la Douat, que l'on fait pour un homme, pour son père ou pour sa mère lors de la fête ; pour le glorifier dans le coeur de Rê et dans le coeur des dieux, de sorte qu'il soit avec eux. La vignette montre le défunt en adoration derrière Horus qui présente le signe de la vie à Osiris.

Recueil de pièces concernant l'histoire de France, de 1560 à 1576.

Contient : 1-15 Lettres originales adressées à Gaspard de Saulx-Tavannes, lieutenant général au gouvernement de Bourgogne, par ; 1 Le pape PIE IV. Rome, 4 août 1562. En latin ; 2 « FRANCESCO BELTRAMINI,... Di Roma, alli 7 d'agosto 1562 ». En italien ; 3-7 Le roi FRANÇOIS II. 1560 ; 8-15 Le roi CHARLES IX. De 1560 à 1563 ; 16 Lettre de CHARLES IX audit Sr de Tavannes. 22 juillet 1563. Copie ; 17-18 Rôles de troupes ; 17 « Roolle des gentilhommes estans à la suite de Mr DE MAUGIRON,... Faict à Chalon, le 10 aoust 1562 ». Copie ; 18 « Roolle de la reveue faicte au lieu de Romanet des compagnies y estantz, venus en Bourgogne avec Monseigneur DE MAUGIRON, gouverneur et lieutenant general en Dauphiné, en l'absence de Monseigneur de Guyse, pour se joindre avec Monseigneur de Tavanes, lieutenant general de S. M. au gouvernement du pays de Bourgongne, par Mr de LEYSINS, en presence du Sr de Varassieu, commissaire ordinaire des guerres, et de Daragon, contrerolleur general du Dauphiné. 15 juillet 1562 ». Copie ; 19-24 Lettres originales adressées audit Sr de Tavannes par le roi CHARLES IX. 1562 et 1563 ; 25 Lettre du roi CHARLES IX audit Sr de Tavannes. 1563. Copie ; 26-36 Lettres originales adressées audit Sr de Tavannes par le roi CHARLES IX. 1564 à 1568 ; 37 Lettre du roi CHARLES IX audit Sr de Tavannes. Copie. 1567 ; 38-48 Lettres originales du roi CHARLES IX audit Sr de Tavannes. 1567 et 1568 ; 49 Ordonnance imprimée du roi CHARLES IX, par laquelle « est enjoinct tres expressement à tous baillis, seneschaulx et autres juges et officiers, de faire diligente information des meurtres, pilleries, volleries et autres torts et injures » que ses « subjects estans de la religion pretendue reformée... disent leur avoir esté faicts, et proceder, le plus brefvement que faire se pourra, à la perfection des procés des delinquans, et iceulx chastier et punir, selon l'exigence des cas, si exactement que chascun y prenne exemple... Faict à Boullongne, le 26 aoust 1568 » ; 50 Lettre originale de CHARLES IX audit Sr de Tavannes. 1er septembre 1568 ; 51-52 Lettres de FRANÇOIS II et de CHARLES IX audit Sr de Tavannes. 1560 et 1561. Copies ; 53-59 Lettres originales de CHARLES IX audit Sr de Tavannes et à son fils aîné. 1569 à 1573 ; 60-61 Lettres originales du roi HENRI III à Guillaume de Saulx, fils aîné dudit Sr de Tavannes. 1575 et 1576 ; 62-102 Lettres originales adressées à Gaspard de Saulx-Tavannes, lieutenant général pour le roi en Bourgogne, et à son fils aîné par ; 62-94 CATHERINE DE MEDICIS. 1560 à 1574 ; 95-102 HENRI DE FRANCE, duc D'ANJOU. 1568 à 1573 ; 103 Lettre originale adressée audit Sr de Tavannes par HENRI DE FRANCE, duc D'ANJOU, au bas de laquelle sont quatre lignes du roi CHARLES IX. 1567 ; 104-111 Lettres originales adressées audit Sr de Tavannes par ; 104 HENRI DE FRANCE, duc D'ANJOU. 1567 ; 105-106 FRANÇOIS DE FRANCE, duc D'ALENÇON. 1570 ; 107-111 ANTOINE DE BOURBON, roi DE NAVARRE. 1561 et 1562

The bees of Niagara: a test of the intermediate disturbance hypothesis /

This study examined the bee fauna of the Carolinian Zone in Ontario, Canada. In 2003, 15687 individuals from 152 species of bees were collected. Tliere were many rare species but few abundant species. There were three distinct bee seasons. The Niagara bee assemblage was less diverse compared to other Carolinian Zone assemblages and types of landscapes. This study also examined how anthropogenic disturbance affects the diversity of bee assemblages. The intermediate disturbance hypothesis (IDH) was tested by selecting field sites subject to low, intermediate, and high disturbance. Intermediate disturbance had the highest species richness (SR=1 15) and most bees (N=556I), followed by low disturbance (SR= 100, N=2975), then high disturbance (SR=72, N=1364), supporting the IDH. Increased species richness in areas of intermediate disturbance was due to higher abundance, possibly because more blooming flowers were found there. Bees were larger in high disturbance areas but smaller in areas of high and intermediate disturbance.

GABA accumulation and the hypersensitive response in isolated mesophyll cells treated with the G protein activator mastoparan

GABA (y-amino butyric acid) is a non-protein amino acid synthesized through the a-decarboxylation of L-glutamate. This reaction is catalyzed by L-glutamate decarboxylase (EC 4.1.1.15), a cytosolic Ca2+/calmodulin-stimulated enzyme. The purpose of this study is to determine whether or not GABA accumulation is associated with the hypersensitive response of isolated Asparagus sprengeri mesophyll cells. The addition of 25 J.lM mastoparan, a G protein activator, to suspensions of isolated asparagus mesophyll cells significantly increased GABA synthesis and cell death. Cell death was assessed using Evan's blue dye and fluorescein diacetate tests for cell viability. In addition, mastoparan stimulated pH-dependent alkalinization of the external medium, and a rapid and large 02 consumption followed by a loss of photosynthetic activity. The rate of 02 consumption and the net decrease in 02 in the dark was enhanced by light. The inactive mastoparan analogue Mas17 was ineffective in stimulating GABA accumulation, medium alkalinization, 02 uptake and cell death. Accumulation of H202 in response tomastoparan was not detected, however, mastoparan caused the cell-dependent degradation of added H202. The pH dependence of mastoparan-stimulated alkalinization suggests cellular electrolyte leakage, while the consumption of 02 corresponds to the oxidative burst in which 02 at the cell surface is reduced to form various active oxygen species. The results are indicative of the "hypersensitive response" of plants to pathogen attack, namely, the death of cells in the locality of pathogen invasion. The data are compatible with a model in which mastoparan triggers G protein activity, subsequent intracellular signal transduction pathway/s, and the hypersensitive response. It is postulated that the physiological elicitation of the hypersensitive response involves G protein signal transduction. The synthesis of GABA during the hypersensitive response has not been documented previously; however the role/s of GABA synthesis in the hypersensitive response, if any, remain unclear.

The effects of gramicidin on the structure of phospholipid assemblies /

Gramicidin is an antibiotic peptide that can be incorporated into the monolayers of cell membranes. Dimerization through hydrogen bonding between gramicidin monomers in opposing leaflets of the membrane results in the formation of an iontophoretic channel. Surrounding phospholipids, with various associated mechanical properties, have been shown to influence the gating properties of this channel. Conversely, gramicidin incorporation has been shown to affect the structure of spontaneously formed lipid assemblies. Using small-angle x-ray diffraction and model systems composed of phospholipids and gramicidin, the physical effects incurred by gramicidin incorporation were measured. The reverse hexagonal (H^) phase composed of dioleoylphosphatidylethanolamine (DOPE) monolayers decreased in lattice dimension with increasing incorporation of gramicidin. This indicated that gramicidin was adding negative curvature to the monolayers. In this system, gramicidin was measured to have an apparent intrinsic radius of curvature (Rop*™") of -7. 1 A. The addition of up to 4 mol% gramicidin in mixtures with DOPE did not result in the monolayers becoming stiffer, as indicated by unaltered bending moduli for each composition. Dioleoylphosphatidylcholine (DOPC) alone forms the lamellar (LJ phase when hydrated, but undergoes a transition into the H^ phase when mixed with gramicidin. The lattice repeat dimension decreases systematically with increased gramicidin content. Again, this indicated that gramicidin was adding negative curvature to the monolayers. At 12 mol% gramicidin in mixtures with DOPC, the apparent radius of intrinsic curvature of gramicidin (Rop*"^) was measured to be -7.4 A. This mixture formed monolayers that were very resistant to bending under osmotic pressure, with a measured bending modulus of 1 15 kT. The measurements made in this study demonstrate that peptides are able to modulate the spontaneous curvature and other mechanical properties of phospholipid assemblies.

Mastery, perceived stress and health-related behaviour in northeast Arnhem Land: a cross-sectional study

Affiliation: Mark Daniel : Département de médecine sociale et préventive, Faculté de médecine, Université de Montréal

Aboriginal status is a prognostic factor for mortality among antiretroviral naïve HIV-positive individuals first initiating HAART

Affiliation: Mark Daniel: Département de médecine sociale et préventive, Faculté de médecine, Université de Montréal et Centre de recherche du Centre hospitalier de l'Université de Montréal