A movement from traditional malarial chemoprophylaxis to the use of intermittent preventive treatment as a method of protection for children diagnosed with sickle-cell disease: A proposal for consideration based on a systematic review of the literature

Approximately 200,000 African children are born with sickle-cell anemia each year. Research has shown that individuals with hemoglobin disorders, particularly sickle-cell anemia, have increased susceptibility to contracting malaria. Currently it is recommended that patients diagnosed with sickle-cell anemia undergo malaria chemoprophylaxis in order to decrease their chances of malarial infection. However, studies have shown that routine administration of these drugs increases the risk of drug resistance and could possibly impair the development of naturally acquired immunity. Clinical trials have shown intermittent preventive treatment (IPT) to be an effective method of protection against malaria. The objective of this report was to review previously conducted clinical trials that study the effects of intermittent preventive treatment on malaria and anemia in infants and children. Based on the review, implications for its appropriateness as a protective measure against malaria for infants and children diagnosed with sickle-cell disease were provided.^ The 18 studies reviewed were randomized controlled trials that focused on IPT’s effect on malaria (7 studies), anemia (1 study), or both (8 studies). In addition to these 16, one study looks at IPT’s effect on molecular resistance to malaria, and another study is a follow-up to a study in order to review IPT’s potential to cause a rebound effect. The 18 th study in this review specifically looks at IPT’s protective efficacy in children with SCA. The studies in this report were restricted to randomized controlled trials that have been performed from 2000 to 2010. Reports on anemia were included to illustrate possible added benefits of the use of IPT specific to burdens associated with SCA other than malaria susceptibility. The outcomes of these studies address several issues of concern involving the administration of IPT: protective efficacy (in reference to age, seasonal versus perennial malaria regions, and overall effectiveness against malaria and anemia), drug resistance, drug rebound effect, drug side-effects, and long-term effects. Overall, these showed that IPT has a significant level of protective efficacy against malaria and/or anemia in children. More specifically, the IPT study evaluating children diagnosed with sickle-cell anemia proved IPT to be a more effective method of protection than traditional chemoprophylaxis. ^

The movement toward patient safety: State action related to reporting and disclosure of healthcare-associated infections

Increasing attention has been given to the problem of medical errors over the past decade. Included within that focused attention has been a strong interest in reducing the occurrence of healthcare-associated infections (HAIs). Acting concurrently with federal initiatives, the majority of U.S. states have statutorily required reporting and public disclosure of HAI data. Although the occurrence of these state statutory enactments and other state initiatives represent a recognition of the strong concern pertaining to HAIs, vast differences in each state’s HAI reporting and public disclosure requirements creates a varied and unequal response to what has become a national problem.^ The purpose of this research was to explore the variations in state HAI legal requirements and other state mandates. State actions, including statutory enactments, regulations, and other initiatives related to state reporting and public disclosure mechanisms were compared, discussed, and analyzed in an effort to illustrate the impact of the lack of uniformity as a public health concern.^ The HAI statutes, administrative requirements, and other mandates of each state and two U.S. territories were reviewed to answer the following seven research questions: How far has the state progressed in its HAI initiative? If the state has a HAI reporting requirement, is it mandatory or voluntary? What healthcare entities are subject to the reporting requirements? What data collection system is utilized? What measures are required to be reported? What is the public disclosure mechanism? How is the underlying reported information protected from public disclosure or other legal release?^ Secondary publicly available data, including state statutes, administrative rules, and other initiatives, were utilized to examine the current HAI-related legislative and administrative activity of the study subjects. The information was reviewed and analyzed to determine variations in HAI reporting and public disclosure laws. Particular attention was given to the seven key research questions.^ The research revealed that considerable progress has been achieved in state HAI initiatives since 2004. Despite this progress, however, when reviewing the state laws and HAI programs comparatively, considerable variations were found to exist with regards to the type of reporting requirements, healthcare facilities subject to the reporting laws, data collection systems utilized, reportable measures, public disclosure requirements, and confidentiality and privilege provisions. The wide variations in state statutes, administrative rules, and other agency directives create a fragmented and inconsistent approach to addressing the nationwide occurrence of HAIs in the U.S. healthcare system. ^

Liberation of hope: An ethnographic study of community-based initiatives in Houston, Texas

This is an ethnographic study about the worldview of community-based initiatives in Houston, Texas, and the people who work in them. People who participated in this study recognize that their direct constructive action is at the heart of authentic social change in their minority communities. Through qualitative data analysis, a constellation of relationships and process patterns were found to constitute themselves into the system of the community-based initiative. The predominant patterns identified from the findings in this study are: the pervasiveness of place, the importance of people, unique initiatory patterns, the concrete local sustainability, the ever-present action orientation, the resourceful use of networks and inter-relationships, the significance of church influence, the core sense of spirituality and the essence of hope. These patterns emerged out of the local knowledge, which is acutely sensitive to the elements of history and lived experience, embedded in the distinctive moral and visionary patterns of meaning and expression. Findings from the research reveal that these community-based initiatives are not programs--they are people--people who keep hope alive in their communities and who, by their daily practice, liberate others. ^

Internet sex among non-gay identifying men who have sex with men

The aim of this study was to examine the role of the Internet in Internal Homonegativity (IH) among Non gay identifying men who have sex with men (NGI-MSM). This study at University of Texas School of Public Health (UTSPH) had a mixed method research design and consisted of men 18 years of age and older who were residents of the US and Canada. The data were collected using an online survey called 'Men's Sexual Health Survey' which was developed in collaboration with Boston University School of Public Health and Denver Public Health. These surveys were administered in English, which took 30-minutes to complete, and were placed on gay oriented websites and chat rooms. 141 participants were presented with the module relating to IH. A Principal Component Analysis with varimax rotation on the nine questions that asked the participants about their feelings about gay men produced three factors of IH identified as (1) public identification as gay; (2) perception of stigma associated with being gay; and (3) social comfort with gay men. The factors significantly correlated with age, grade completed in school, income, openness about being gay and socializing with gay people, meeting partners online, dating on the Internet, attitude toward condom usage, alcohol and drug use before sex and having unprotected sex with Internet partners. These findings point toward the role of the Internet in determining IH and sexual behavior. Despite the risks, the Internet's popularity and outreach in NGI-MSM makes it an effective medium to spread public health programs.^

Impact of consciousness raising and social liberation on readiness to engage in regular physical activity among adults in Magnolia Park/Lawndale-Wayside, Houston, TX

According to the transtheoretical model, consciousness raising and social liberation are processes used to help individuals progress through the stages of change for a given behavior. This study assessed the impact of these two processes on readiness to engage in regular physical activity among a convenience sample of 35 adults in the Magnolia Park/Lawndale-Wayside area of Houston, TX. The duration of the study was approximately 4 weeks. All pre/post-test data were collected via self-administered surveys available in English or Spanish. Baseline data were used to determine the culturally relevant content of a one-dose intervention consisting of a presentation and dissemination of educational materials as well as a list of local physical activity opportunities. Although the intervention did not improve progression through the stages of change, significant increases were evident among 5 out of 6 processes of change. Based on these results and qualitative data, this study recommended that the Houston Parks and Recreation Department incorporate cultural competency into the design and publication of materials and revise the schedule of available programs (i.e.: increase the number of walking programs) in order to reflect the physical activity preferences of Magnolia Park/Lawndale-Wayside residents.^

Learning -dependent plasticity of movement representations in the primate primary motor cortex

Primary motor cortex (M1) is involved in the production of voluntary movement and contains a complete functional representation, or map, of the skeletal musculature. This functional map can be altered by pathological experiences, such as peripheral nerve injury or stroke, by pharmacological manipulation, and by behavioral experience. The process by which experience-dependent alterations of cortical function occur is termed plasticity. In this thesis, plasticity of M1 functional organization as a consequence of behavioral experience was examined in adult primates (squirrel monkeys). Maps of movement representations were derived under anesthesia using intracortical microstimulation, whereby a microelectrode was inserted into the cortex to electrically stimulate corticospinal neurons at low current levels and evoke movements of the forelimb, principally of the hand. Movement representations were examined before and at several times after training on behavioral tasks that emphasized use of the fingers. Two behavioral tasks were utilized that dissociated the repetition of motor activity from the acquisition of motor skills. One task was easy to perform, and as such promoted repetitive motor activity without learning. The other task was more difficult, requiring the acquisition of motor skills for successful performance. Kinematic analysis indicated that monkeys used a consistent set of forelimb movements during pellet extractions. Functional mapping revealed that repetitive motor activity during the easier task did not produce plastic changes in movement representations. Instead, map plasticity, in the form of selective expansions of task-related movement representations, was only produced following skill acquisition on the difficult task. Additional studies revealed that, in general, map plasticity persisted without further training for up to three months, in parallel with the retention of task-related motor skills. Also, extensive additional training on the small well task produced further improvements in performance, and further changes in movement maps. In sum, these experiments support the following three conclusions regarding the role of M1 in motor learning. First, behaviorally-driven plasticity is learning-dependent, not activity-dependent. Second, plastic changes in M1 functional representations represent a neural correlate of acquired motor skills. Third, the persistence of map plasticity suggests that M1 is part of the neural substrate for the memory of motor skills. ^

Tab. 1: Results of the movement measurements on the blue ice-field Blåisen

In January/February 1985 a German-South African expedition had the opportunity to repeat measurements made by means of stakes planted in 1951 (Norwegian-British-Swedish Antarctic Expedition 1949-52) and 1966 (SANAE VII). Although the rediscovery of the old stakes had not been expected, the stakes could be identified and it was possible to derive movement vectors on the basis of old and heterogenic measurement data. The long-term movement rates established basically confirm and complement the values determined in 1951. The flow rates of 9,1 cm/a to 66.4 cm/a proved to be extremly low. Observations of the stake lengths showed very little accumulation in the fringe areas of the blue ice-field (ca. 0.7 to 2.6 cm/a snow/firn); on bare ice an ablation of 2.6 cm/a water equivalent (2.9 cm/a ice) was measured. The paper begins with a description of the essential conditions for the formation of the blue ice-field. Subsequently the measurements are explained in detail and their results are discussed.

Lecturas de la violencia anarquista : una crítica al expansionismo del concepto "terrorismo"

El concepto “terrorismo", de presencia casi cotidiana debido al problema yihadista, suele ser utilizado por politólogos, sociólogos, periodistas e historiadores para cubrir un amplio espectro de acciones directas que poca relación tienen entre sí. De hecho, la violencia anarquista, desde su aparición en el Fin de Siècle europeo, fue caracterizada de esa forma, aunque principalmente por sus detractores. En este trabajo analizaremos el concepto “terrorismo anarquista" enunciando cuáles son sus principales límites a la hora de estudiar la violencia libertaria. Por otro lado, se cuestionarán las equiparaciones realizadas entre la violencia anarquista y la violencia yihadista, y las que se han hecho entre la primera y las acciones directas llevadas a cabo por hackers y movimientos de liberación animal, a los que cierta literatura suele asociar con lo libertario y lo terrorista.

Women in movement : Gender relations in quilombola community Buriti do Meio on the North of Minas Gerais/Brazil

In a civilisation space of Sao Francisco basin river. Women and men interlace on their relations building mutual and each one on your way in handling of the clay in politics fights and in life daily of Buriti do Meio Quilombo. The objective of this study was to do a ethnographically reflection of gender relations that link men and women in the black rural community Buriti do Meio in Sao Francisco municipal district on the North of Minas Gerais/Brazil. We tried to understand the meanings and the composed representations on the feminineness and the masculine ways in relation that men and women set up among themselves in handling workmanship for the information in politics fight of community group as quilombo remaining and to rights access derived and everyday life where they build and organize together the life of all their members reflecting in his symbolic order. Buriti do Meio is traditional known for its handcraft and for cultural manifestations, legacy of their ancestral, olds slaves that ran way to look for autonomy and freedom express signs of afrobrazilian culture inserted on the civilization space in Sao Francisco basin river

Ralf Köning, el comic queer y otros ejemplos : De la identidad gay en la cultura de la diversidad sexual

A partir de los años ochenta se produce en las narrativas alemanas y españolas una tematización creciente de la identidad gay surgida durante los años setenta, en lo que se denomina el período post-Stonewall. Esta tematización confronta y, al mismo tiempo, explora las raíces de los grandes escritores homoeróticos de la primera mitad del siglo XX. A su vez, este tema gay que se consolida durante los ochenta y noventa, paulatinamente, se va proyectando a otros géneros diferentes como el comic. El caso del historietista alemán Ralph König presenta un ejemplo de la interrelación entre las comunidades alemanas y españolas respecto a la identidad gay y la cultura, con casos como la temprana traducción del mencionado creador al mundo hispánico. En el género comic se proyecta, a nivel mundial, el fenómeno creciente de masificación de lo gay en la cultura global, con ejemplos en España, Alemania, Argentina o Estados Unidos. De modo tal que, la proyección de fenómenos sociales en el ámbito literario y en la producción de artistas como Ralph König generó la construcción de una cultura de la diversidad sexual que se asentó a nivel mundial en géneros y espacios muy diferentes de la industria cultural. En ese sentido, el caso de los superhéroes queer surgidos en Estados Unidos, la presencia del tema del matrimonio gay en la narrativa española o las referencias a los "hombres del triángulo rosa" en la industria cultural alemana actual, nos ejemplifican diferentes proyecciones de la identidad tematizada durante los años ochenta y noventa en el espacio literario. De forma tal que la temática gay en sí genera un entramado de relaciones que deriva en una suerte de literatura transcultural, cuyo eje vinculante sería la diversidad sexual

La narrativa gay de Eduardo Mendicutti : la identidad literaria como espacio de reivindicación de la diversidad

El español Eduardo Mendicutti nos presenta una idea en la que la diversidad sexual y humana está presente más allá de las marcas genéricas y las presiones sociales y editoriales. La diversidad se convierte en lo hegemónico y sobre ella se construye el universo ficcional del autor. Mendicutti no realiza la crónica marginal de un mundo oscuro como se ha dicho en muchas críticas a sus novelas, sino que este autor nos presenta a la comunidad gay en todo su esplendor, con sus puntos oscuros y luminosos, con su heterogeneidad más enriquecedora, en definitiva, con su diversidad. ¿Qué está haciendo Eduardo Mendicutti en su obra narrativa? Es simple. Está creando un continuo de obras literarias, periodísticas, testimoniales, en las que su posición respecto a la sexualidad humana se condensa en una defensa de la heterogeneidad del mundo gay, es decir, en una defensa, pocas veces vista en la literatura, de la diversidad sexual humana en su sentido más amplio y plural.

Qué es la literatura queer : Las compilaciones de literatura queer, gay y lésbica

La ponencia propone la construcción de una aproximación al estado del arte sobre las "otras" literaturas denominadas queer, gays y lesbianas, aparecidas y seleccionadas en compilaciones y antologías, procurando ubicar los principales lineamientos expuestos por los compiladores, editores o directores. Resaltar la construcción de un nuevo corpus y lo que se ha denominado pluralidad de cánones, en oposición a la reproducción de instituciones que se perpetúan a sí mismas e imponen valoraciones que refuerzan la superioridad de clase, cultura, género y nacionalidad. Literaturas de oposición a las tradiciones selectivas, que desequilibran las representaciones hegemónicas proponiendo otras lógicas de producción, comprensión y reproducción de sujetos, incidiendo precisamente en las formas de reproducción: el lenguaje, la producción de saber y las estructuras de poder

Identidad/es Gay? : Estereotipos y singularidades

Fil: Strelkov, Andrea Laura. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.