Propolis: Is there a potential for the development of new drugs?

Introduction: Propolis has plenty of biological and pharmacological properties and its mechanisms of action have been widely investigated in the last years, using different experimental models in vitro and in vivo. Researchers have been interested in the investigation of isolated compounds responsible for propolis action; however, there is lack of clinical research on the effects of propolis.Strategy and objectives: Since propolis-containing products have been marketed and humans have used propolis for different purposes, the goal of this review is to discuss the potential of propolis for the development of new drugs, by comparing data from the literature that suggest candidate areas for the establishment of drugs against tumors, infections, allergy, diabetes, ulcers and with immunomodulatory action.Conclusions: The efficacy of propolis in different protocols in vitro and in vivo suggests its therapeutic properties, but before establishing a strategy using this bee product, it is necessary to study: (a) the chemical nature of the propolis sample. (b) Propolis efficacy should be compared to well-established parameters, e.g. positive or negative controls in the experiments. Moreover, possible interactions between propolis and other medicines should be investigated in humans as well. (c) Clinical investigation is needed to evaluate propolis potential in patients or healthy individuals, to understand under which conditions propolis may promote health. Data point out the importance of this research field not only for the readers and researchers in the scientific community waiting for further clarification on the potential of propolis but also for the pharmaceutical industry that looks for new drugs. (C) 2010 Elsevier B.V. All rights reserved.

Forma/ação do professor de Matemática e suas concepções de mundo e de conhecimento

Esta pesquisa busca trabalhar com diferentes concepções de mundo e de conhecimento, investigando a articulação entre o sentido que elas possuem para os professores de Matemática e suas concepções de ensino e de Educação. O estudo gira em torno de discussões que ocorreram em um curso de extensão para professores de Matemática. Esse curso tratou de concepções de mundo e de conhecimento, relacionando-as com diferentes regiões do saber, como Matemática, Física, Ecologia e Artes, focando a transição entre a concepção de mundo da Época Moderna para a concepção de mundo que vem se construindo na denominada Época Pós-moderna ou Contemporânea. A meta é compreender o sentido que aquelas concepções têm para os professores e destacar possíveis momentos de metacompreensão sobre a articulação entre essas concepções e sua prática docente. A metodologia utilizada é qualitativa, de uma perspectiva fenomenológica.

A construção coletiva interdisciplinar em educação ambiental no ensino médio: a microbacia hidrográfica do Ribeirão dos Peixes como tema gerador

O Ribeirão dos Peixes é o principal corpo de água do município de Dois Córregos (SP), e as conseqüências das atividades antrópicas no local exigem urgentes providências para a recuperação do sistema. Considerando que as bacias hidrográficas representam uma temática bastante adequada para um programa de Educação Ambiental e, ainda, as dificuldades/necessidades apresentadas, pelos professores, para o desenvolvimento de práticas que estimulem a conscientização dos alunos com respeito às questões ambientais, o presente estudo visou à formação interdisciplinar de educadores que atuavam no terceiro ano do ensino médio de uma escola estadual, no sentido de possibilitar que trabalhassem posteriormente com seus alunos a dimensão ambiental da microbacia hidrográfica do Ribeirão dos Peixes. Uma investigação inicial sobre as práticas pedagógicas dos professores em relação à abordagem do tema e à Educação Ambiental forneceu subsídios para que este trabalho fosse conduzido, por meio da Pesquisa-ação-participativa e complementada pelo Ensino por pesquisa.

O uso de instrumentos e procedimentos de pesquisa sobre crenças: promovendo formação reflexiva

Sabe-se que as crenças do professor influenciam suas percepções, decisões e ações antes, durante ou depois da aula. Dessa forma, é importante que ele as conheça e reflita sobre as mesmas, o que pode levá-lo a possíveis alterações em suas práticas, possibilitando seu desenvolvimento profissional. Para levantar essas crenças é necessária a utilização de instrumentos e procedimentos que sejam eficientes e promovam reflexão. Neste artigo apresentaremos um trabalho cujo objetivo foi pesquisar quais tipos de crenças podemos detectar com o uso de diferentes instrumentos e procedimentos, investigando se estes afetam a maneira como os professores refletem sobre suas crenças e quais combinações entre eles são eficazes para a promoção de reflexão. O referencial teórico foi constituído de estudos sobre o pensamento do professor, crenças de professores e metodologia na investigação de crenças. Foi realizada uma pesquisa qualitativo-interpretativista de natureza etnográfica, com cinco professoras de inglês de uma escola de línguas de uma cidade do interior de SP. Para a coleta de dados foram aplicados cinco instrumentos e procedimentos de pesquisa: questionário, grupo focal, auto-relato, observação de aulas e entrevistas (com a técnica stimulated recall). Os resultados mostraram que é possível levantar crenças sobre aprendizagem e ensino com os instrumentos e procedimentos selecionados e que os mesmos interferem na maneira como os professores refletem sobre suas crenças, entretanto, a combinação deles pode ser um bom caminho para o desencadeamento do processo reflexivo.

Assessment of Gastrointestinal Motility in Renal Transplant Recipients by Alternate Current Biosusceptometry

Background. Gastrointestinal (GI) complications are common after renal transplantation, mainly owing to immunosuppressive therapy. Assessment of GI transit time can facilitate rational management of these disorders.Objective. We evaluate the GI transit parameters in renal transplant recipients taking tacrolimus, azathioprine, and prednisone with the use of the alternate current biosusceptometry (ACB) technique and compared them with healthy volunteers.Methods. Ten renal transplant recipients and 10 healthy volunteers were enrolled in this study. After an overnight fast, patients and volunteers ingested a standard meal containing magnetic markers. The biomagnetic monitoring was performed at 10-minute intervals for at least 8 hours to obtain gastric emptying as well as the colonic arrival time-intensity curves. Mean gastric emptying time (MGET), mean colon arrival time (MCAT), and mean small intestinal transit time (MSITT) were quantified and compared between control and patient groups with results expressed as mean +/- SD.Results. The MGET measured by the ACB technique was 48 +/- 31 minutes and 197 +/- 50 minutes for patients and healthy subjects, respectively. MSITT and MCAT values calculated for patients versus volunteers were 171 +/- 71 minutes versus 197 +/- 71 minutes and 219 +/- 83 minutes versus 373 +/- 52 minutes, respectively. Renal transplant recipients showed significantly faster; gastric emptying and colon arrival times (P < .001) compared with normal volunteers; however, small intestinal transit time was not significantly different (P = .44).Conclusions. In stable renal transplant recipients, the GI transit parameters were significantly faster than in normal healthy volunteers. ACB sensors are versatile technologies that can be used for clinical research, because they offer an excellent opportunity to evaluate GI transit in a noninvasive manner without the use of ionizing radiation.

Panorama atual da ética em pesquisa em seres humanos

In the last decades, medical care has been increasingly permeated by the concept of evidence-based-medicine, in which clinical research plays a crucial role in establishing diagnostic and treatment. Following the improvements in clinical research, we have a growing concern and understanding that some ethical issues must be respected when the subjects are human beings. Research with human subjects relies on the principles of autonomy, beneficence, no maleficence and justice. Ordinance 196/96 from the National Health Board adds to the Brazilian legislation such renowned bioethical principles.Aim: Discuss the main ethical aspects involved in research with human subjects.Materials and Methods: Critical analysis of Ordinance 196/96 and related literature.Conclusion: Ordinance 196/96 rules research with human subjects; nevertheless, it requires more in-depth discussions regarding the informed consent, use of placebo, research with vulnerable populations and research in developing countries.

SCHOOL PROTECTION SYSTEM: PROTECTING WHO, FROM WHOM?

The main objective of this article is to analyze the policy implanted in the schools in the State of São Paulo, Brazil, with a view to the prevention and intervention in the violence that occurs in the schools. The importance of such discussion is related to the analysis of the principles that are present and of the possible effectiveness of such a program in the school violence. This research is qualitative and the research methodology used was documentary analysis. The documents analyzed were those related to the policy of preventing violence in schools in the state of São Paulo/Brazil, called Protection System School. (C) 2012 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of The Association of Science, Education and Technology

Teledermatologia - Passado, presente e futuro

Teledermatology is the area of Telemedicine that studies the application of telecommunication and information technology to dermatology practice without the presence of a specialist. It is a potential manner to deliver health planning, research, education, clinical meetings, second medical opinions and dermatological care to populations who cannot easily travel. The evolution, cost reduction and dissemination of telecommunication and information technology have enabled the implementation of low cost and comprehensive teledermatology systems to support clinical practice all over the world. © 2005 by Anais Brasileiros de Dermatologia.

Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni

Mansonian schistosomiasis is caused by an intravascular digenetic trematode Schistosoma mansoni. Praziquantel (PZQ) and oxamniquine (OXA) are the drugs of choice for the treatment of this disease. However, both drugs are subject to some limitations in their action and cases of tolerance and resistance have been reported. Moreover, tolerance and resistance cases have been reported. For this reason, there is an urgent need for research on new alternatives aimed at improving the action of existing drugs, such as the incorporation of these drugs into liposomes. In this study, the efficiency of action of liposome- encapsulated praziquantel (lip.PZQ) on oviposition by S. mansoni, strain BH, was assessed in Mus musculus mices (SPF Swiss mice). Four PZQ and lip.PZQ doses (47; 60; 250 e 300mg/kg) were tested. Some mice were treated 30 days post-infection and others after 45 days. The oogram analyses showed that the most effective lip.PZQ treatment was 300mg/kg dose given on the 45th day post infection, which reduced the number of S. mansoni eggs per gram of tissue.

Achieving educational quality: what schools teach us: learning from Chile's P900 primary schools

Includes bibliography

Calculadoras, Computadores e Internet em Educação Matemática: dezoito anos de pesquisa

In this paper, we present GPIMEM, a group that has been developing research in Mathematics Education related to computers and other media since 1993 to understand how mathematical knowledge can be produced with these technological resources, in face-to-face as well as online distance education. Members of the group dialogue with different fields of knowledge such as philosophy, history, psychology, anthropology, sociology, arts and technology, among others, to inform their research. The research addresses various topics relevant to Mathematics Education, including methodological and epistemological aspects of teaching and learning, of mathematical modeling and teacher education, always within a qualitative research perspective. We begin with the historical presentation of the group, revealing its dynamics and organization of work, followed by reflections on qualitative research methodology and description of research conducted over the past five years. Finally, we present a synthesis of the theories developed by the group and expectations for the future.

What schools teach us about educating poor children in Chile?

Includes bibliography

Gestão ambiental em cadeias de suprimentos: Perspectivas atuais e futuras de pesquisa

This article aims to identify the main definitions, practices and related avenues for future research on green supply chain management (GSCM). From a systematic literature review and analysis in major journals related to the topic and indexed in Scopus, was possible: a) identify key research goals of the articles analyzed, b) the research methodology adopted, c) the predominant industrials sectors studied, and d) the practices of GSCM considered relevant by researchers. Results are presented in each of these analytical perspectives. These results may be useful both for those interested in environmental management and in supply chain management, in view of the growing interest in GSCM.