Reliure de : Isaaci Casauboni animadversionum in Athenaei Dipnosophistas libri XV, opus nunc primum in lucem editum, quo non solum Athenaei libri quindecem @ recensentur... verum etiam multorum aliorum scriptorum loci multi qua explicantur, qua corriguntur...

Numérisation partielle de reliure

Mesozoic sequence of Fuerteventura (Canary Islands): Witness of Early Jurassic sea-floor spreading in the central Atlantic

The Fuerteventura Jurassic sedimentary succession consists of oceanic and elastic deposits, the latter derived from the southwestern Moroccan continental margin. Normal mid-oceanic-ridge basalt (N-MORB) flows and breccias are found at the base of the sequence and witness sea-floor spreading events in the central Atlantic. These basalts were extruded in a postrift environment (post-late Pliensbachian), We propose a Toarcian age for the Atlantic oceanic floor in this region, on the basis of the presence higher up in the sequence of the Bositra buchi filament microfacies (Aalenian-Bajocian) and of elastic deposits reflecting tectono-eustatic events (e.g,, late Toarcian to mid-Callovian erosion of the rift shoulder). The S-l sea-floor oceanic magnetic anomaly west of Fuerteventura is therefore at least Toarcian in age. The remaining sequence records Atlantic-Tethyan basinal facies (e.g., Callovian-Oxfordian red clays, Aptian-Albian black shales) alternating with elastic deposits (e.g., Kimmeridgian-Berriasian periplatform calciturbidites and a Lower Cretaceous deep-sea fan system). The Fuerteventura N-MORB outcrops represent the only Early Jurassic oceanic basement described so far in the central Atlantic. They are covered by a 1600 m, nearly continuous sedimentary sequence which extends to Upper Cretaceous facies.

Reliure de : Le Théâtre d'agriculture et mesnage des champs, d'Olivier de Serres...

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Nouveaux traitements de l'hépatite C: aspects pharmacologiques et potentiel d'interaction [New hepatitis C treatments: pharmacological considerations and potential for drug interactions].

Progress in the understanding of the hepatitis C virus life cycle allowed the development of new, very promising antiviral therapies. Although these new drugs have a favourable profile in terms of efficacy, tolerance and interaction potential, their prescription in the setting of comedication and impaired renal or hepatic function remains a challenge. Here, we provide a summary of pharmacological considerations, focusing on sofosbuvir, simeprevir and daclatasvir. A better understanding of their metabolic pathways and transporters may help the prescriber to identify and manage drug interactions especially in patients under immunosuppressive or anti-HIV therapy. Recommendations for the prescription of these drugs in specific situations are also discussed.

The efficacy of a protective cream in a real-world apprentice hairdresser environment.

The object of this study was to compare the protective action of a new barrier cream (Excipial Protect, Spirig Pharma AG, Egerkingen, Switzerland) to its vehicle in the context of hand irritation of apprentice hairdressers caused by repeated shampooing and exposure to hair-care products. This was a double-blind cross-over comparing Excipial Protect (containing aluminium chlorohydrate 5% as active ingredient) against its vehicle alone. The efficacy of the creams was evaluated taking into account: (1) clinical scores by researchers, (2) biometric measurements, (3) subjective opinions of the subjects. An analysis of variance was performed considering order of application, degree of atopy, and reported number of shampoos. We observed very little difference in efficacy between the protective cream and its vehicle. The presence, however, of aluminium chlorhydrate in the protective cream was shown to have a positive effect against work-related irritation. The cosmetic qualities of the creams seemed, to the participants, to be as important as their real protective and hydrating properties, an important factor in compliance issues.

Geometría del margen S.E. de la Cuenca del Ebro: discordancias progresivas en el Grupo Scala Dei, Serra de la Llena (Tarragona)

El Grupo Scala Dei, localizado en el margen meridional oriental de la cuenca del Ebro, representa la respuesta sedimentaria a los cabalgamientos desarrollados en las Cadenas Costeras Catalanas. En la Serra de la Llena los 1600 m de materiales aluviales se organizan en cuatro megasecuencias principales (M,-M,) separadas por discordancias angulares. Los nuevos datos paleomastológicos indican un influjo de materiales terrígenos gruesos durante un período que abarca desde un Luteciense superior-Bartoniense en la base, hasta un Catiense medio-superior. La sedimentación en la Serra del Montsant continua hasta la parte media del Catiense superior. La tasa media de acumulación (expresada en términos de centímetros cada mil años- kilo años- K. a,), en la Serra de la Llena, es de 13 crn1K.a. para la megasecuencia inferior (M,), de 7,5 cm/ K.a. para M,-M, y de 6 cm /K.a. para la última y mas fina (M,). La disposición general de los depósitos de la Serra de la Llena con una doble flexión monoclinal buzante al NW indica un control tectónico de la deposición mediante dos estructuras diferentes en profundidad. Las discordancias progresivas desarrolladas en los anteflancos de los anticlinales indican una moción continuada, así como un equilibrio entre la tasa de levantamiento vertical y la tasa de acumulación de sedimentos. Las discordancias progresivas se han desarrollado principalmente en función de la componente tectónica vertical y por la rotación continuada del flanco de antepaís de los anticlinales.

[Illustrations de La Cena de le Ceneri] / [Non identifié] ; Giordano Bruno, aut. du texte

Comprend : [ Bandeau et lettre historiée p. 1. Début du Dialogue Premier. Cerfs et aigle dans le bandeau. Figure d'homme tenant un calamme et un encrier, dans le lettre. XVIè siècle.] [ Cote : BNF B 35646. ] ; [ Planche p. 56. Astronomie. Figure de la terre et tracés géométriques illustrant le Dialogue Trois. XVIè siècle.] [ Cote : BNF B 35647. ] ; [ Planche p. 58. Astronomie. Figure de la Terre et du Soleil illustrant le Dialogue Trois. XVIè siècle.] [ Cote : BNF B 35648. ] ; [ Planche p. 60. Astronomie. Figure de la terre illustrant le Dialogue Trois. XVIè siècle.] [ Cote : BNF B 35649. ] ; [ Planche p. 62. Astronomie. Figure géométrique illustrant le Dialogue Trois. XVIè siècle.] [ Cote : BNF B 35650. ] ; [ Planche p. 75. Astronomie. Figure géométrique illustrant le Dialogue Trois. XVIè siècle.] [ Cote : BNF B 35651. ] ; [ Figure p. 79 illustrant le Dialogue Trois. Navire en mer, vents. XVIè siècle.] [ Cote : BNF B 35652. ] ; [ Planche p. 98. Astronomie. Figure géométrique illustrant le Dialogue Quatre. XVIè siècle.] Ptolemaeus copernicus. [ Cote : BNF B 35653. ] ; [ Planche p. 104. Astronomie. Figure géométrique illustrant le Dialogue Cinq. XVIè siècle.] [ Cote : BNF B 35654. ] ; [ Planche p. 125. Astronomie. Figure géométrique illustrant le Dialogue Cinq. XVIè siècle.] [ Cote : BNF B 35655. ]

[Illustrations de Arlequin] / Tristano Martinelli, aut. du texte

Comprend : [Fig. p. de titre : Arlequin ou] Arlechin. [Cote : microfilm R 26976] ; [Fig. p. 5 : la demande d'Arlequin ]. [Cote : microfilm R 26976] ; [Pl. en reg. p.7 :] Quantumque la chaine et la Medaglia Pour la monstrer à ces Messieurs d'Itaglia. [Cote : microfilm R 26976] ; [Pl. p. 48 :] A Dieu mon Roy et Reine et mes Amis Pour vous obeyr je m'en vay à Paris. [Cote : microfilm R 26976] ; [Pl. p. 50 :] Fradeli à menenuo con Arlechin A guadagnar un poco di quatrin. [Cote : microfilm R 26976] ; [Pl. p. 51 :] Vammo à Paris à fé da Cavagler Que gannaremo aglia bien da comer. [Cote : microfilm R 26976]

Postoperative Cognitive Dysfunction (POCD) and Inflammatory Markers in Elderly Patients

Introduction: Particularly in elderly patients, the brain responds to a systemic inflammatory response with an increased production of inflammatory mediators. This has hypothetically been linked to the development of postoperative cognitive dysfunction (POCD). Methods: We investigated 31 patients aged >65 yrs undergoing elective major surgery under standardized general anaesthesia (thiopental, sevoflurane, fentanyl, atracurium). Cognitive function was measured preoperatively and 7 days postoperatively using the extended version of the Consortium to Establish a Registry for Alzheimer's Disease - Neuropsychological Assessment Battery (CERAD-NAB, validated German version) for which we developed a diagnostic cut-off in healthy elderly volunteers. Systemic C-reactive protein (CRP) and interleukin 6 (IL-6) were measured preoperatively, 2 days postoperatively, and 7 days postoperatively. Values for CRP, IL-6, operative characteristics and hospital length of stay in patients with POCD and without POCD were compared using the Mann- Whitney U test and are shown as median [range]. Results: Fourteen patients (45%) developed POCD. Values for CRP were not statistically different in patients with POCD and without POCD but tended to be higher in patients with POCD 2 days postoperatively. Patients with POCD had significantly higher IL-6 values on postoperative days 2 and 7 (table 1). These patients also had a significantly longer duration of anaesthesia (305 [195-620] vs.190 [150-560] min, p = 0.034), larger intraoperative blood loss (425 [0-1600] vs. 100 [0-1500] ml, p = 0.018) and longer hospital stays (15 [8-45] vs. 8 [4-40] days, p = 0.008). Table 1 POCD (n = 14) No POCD (n = 17) p value CRP (mg/dl) preop. 4.0 [1.0-245] 4.2 [0.3-36.2] 0.6 2 days postop. 223 [20-318] 98 [4.5-384] 0.07 7 days postop. 58 [15-147] 44 [11-148] 0.2 IL-6 (U/ml) preop. 2[2-28.1] 2 [2-7.3] 0.8 2 days postop. 56 [17-315] 20 [2-123] 0.009 7 days postop. 9[2-77] 4 [2-16] 0.03 Interpretation: In this small group of patients, high IL-6 values postoperatively were associated with POCD supporting a role for systemic inflammation in the development of POCD. In patients with POCD, duration of anaesthesia was significantly longer, and intraoperative blood losses were larger. These risk factors will need to be confirmed in a larger group of patients. The difference in length of stay may be indicative of postoperative complications, which have been linked to POCD earlier.