978 resultados para Sphaeroides 2.4.1(t)
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Digitalisat der Ausg. Warša, 1913
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von Telemann
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von Telemann
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von Teleman[n]. [Textverf.: Gottfried Simonis]
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Although CD8 T cells are key players in neuroinflammation, little is known about their trafficking cues into the central nervous system (CNS). We used a murine model of CNS autoimmunity to define the molecules involved in cytotoxic CD8 T-cell migration into the CNS. Using a panel of mAbs, we here show that the α4β1-integrin is essential for CD8 T-cell interaction with CNS endothelium. We also investigated which α4β1-integrin ligands expressed by endothelial cells are implicated. The blockade of VCAM-1 did not protect against autoimmune encephalomyelitis, and only partly decreased the CD8(+) T-cell infiltration into the CNS. In addition, inhibition of junctional adhesion molecule-B expressed by CNS endothelial cells also decreases CD8 T-cell infiltration. CD8 T cells may use additional and possibly unidentified adhesion molecules to gain access to the CNS.
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von Telemann. [Textdichter: Gottfried Simonis]
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von Telemann. [Text: Gottfried Simonis]
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di Graubner
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Vorbesitzer: Johann Maximilian Zum Jungen
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von Telemann. [Textverf.: Gottfried Simonis]
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von Telemann. [Text: Gottfried Simonis]
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di Telemann. [Text: Gottfried Simonis]
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di Georgio Filippo Telemann
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von Telemann. [Text: Gottfried Simonis]