Tamanho de amostra e estimativa de custo em levantamento epidemiológico de cárie dentária

This study aimed to analyze how the prevalence and the distribution of dental caries influence the sample size in epidemiological surveys, and how much are the costs. Secondary data of oral health surveys in 12-year-old schoolchildren from Bauru in 1976, 1984, 1990, 1994, and 2001, and from Piracicaba in 2001 and 2005 were studied. Sample sizes were estimated taking into account the mean DMFT and standard deviation of each survey, establishing sampling errors of 1%, 2%, 5%, and 10%. Costs were estimated considering permanent material, consumption material and human resources. The sample size in both towns needed to be increased, ranging from 119 in 1976 to 1,118 in 2001 in Bauru, and from 954 in 2001 to 1,252 in 2005 in Piracicaba, when a sampling error of 10% was considered. The cost of dental caries surveys was verified considering different sampling errors. This cost depends on how acceptable is the margin of difference between the true mean and the one found in the survey. In conclusion, the reduction in the prevalence of dental caries has determined the need for increase in sample size and in costs for conducting the surveys.

An Integrative Genomic and Transcriptomic Analysis Reveals Potential Targets Associated with Cell Proliferation in Uterine Leiomyomas

Background: Uterine Leiomyomas (ULs) are the most common benign tumours affecting women of reproductive age. ULs represent a major problem in public health, as they are the main indication for hysterectomy. Approximately 40-50% of ULs have non-random cytogenetic abnormalities, and half of ULs may have copy number alterations (CNAs). Gene expression microarrays studies have demonstrated that cell proliferation genes act in response to growth factors and steroids. However, only a few genes mapping to CNAs regions were found to be associated with ULs. Methodology: We applied an integrative analysis using genomic and transcriptomic data to identify the pathways and molecular markers associated with ULs. Fifty-one fresh frozen specimens were evaluated by array CGH (JISTIC) and gene expression microarrays (SAM). The CONEXIC algorithm was applied to integrate the data. Principal Findings: The integrated analysis identified the top 30 significant genes (P<0.01), which comprised genes associated with cancer, whereas the protein-protein interaction analysis indicated a strong association between FANCA and BRCA1. Functional in silico analysis revealed target molecules for drugs involved in cell proliferation, including FGFR1 and IGFBP5. Transcriptional and protein analyses showed that FGFR1 (P = 0.006 and P<0.01, respectively) and IGFBP5 (P = 0.0002 and P = 0.006, respectively) were up-regulated in the tumours when compared with the adjacent normal myometrium. Conclusions: The integrative genomic and transcriptomic approach indicated that FGFR1 and IGFBP5 amplification, as well as the consequent up-regulation of the protein products, plays an important role in the aetiology of ULs and thus provides data for potential drug therapies development to target genes associated with cellular proliferation in ULs. © 2013 Cirilo et al.

Stress analysis in bone tissue around single implants with different diameters and veneering materials: A 3-D finite element study

The aimof this study was to evaluate the stress distribution on bone tissue with a single prosthesis supported by implants of large and conventional diameter and presenting different veneering materials using the 3-D finite elementmethod. Sixteenmodels were fabricated to reproduce a bone block with implants, using two diameters (3.75 × 10 mmand 5.00 × 10 mm), four different veneering materials (composite resin, acrylic resin, porcelain, and NiCr crown), and two loads (axial (200 N) and oblique (100 N)). For data analysis, the maximum principal stress and vonMises criterion were used. For the axial load, the cortical bone in allmodels did not exhibit significant differences, and the trabecular bone presented higher tensile stresswith reduced implant diameter. For the oblique load, the cortical bone presented a significant increase in tensile stress on the same side as the loading for smaller implant diameters. The trabecular bone showed a similar but more discreet trend. There was no difference in bone tissue with different veneering materials. The veneering material did not influence the stress distribution in the supporting tissues of single implant-supported prostheses. The large-diameter implants improved the transference of occlusal loads to bone tissue and decreased stress mainly under oblique loads.Oblique loading was more detrimental to distribution stresses than axial loading. © 2013 Elsevier B.V. All rights reserved.

A influência da carga imposta pela mochila escolar em alunos do ensino fundamental e médio: uma contribuição para estudos ergonômicos

Pós-graduação em Design - FAAC

Educação moral, escola e comunidade: uma relação (des)articulada?

Pós-graduação em Educação - FCT

Estimativa da vulnerabilidade natural do aquífero livre no município de Rio Claro/SP

Pós-graduação em Geociências e Meio Ambiente - IGCE

Competitividade e território: uma análise do arranjo produtivo local potencial de cerâmica artística do município de Porto Ferreira - SP

Pós-graduação em Geografia - IGCE

Caracterização do meio físico em bacias hidrográficas com suportes de sensoriamento remoto e geoprocessamento

Pós-graduação em Geografia - IGCE

Expressão de citocinas na glândula mamária de cadelas e sua relação com a malignidade dos tumores mamários

Pós-graduação em Medicina Veterinária - FCAV

Práticas corporais alternativas: um caminho para a formação em educação física

Pós-graduação em Ciências da Motricidade - IBRC

A COAGRO e seu processo de territorialização no sudoeste do Paraná

Pós-graduação em Geografia - FCT

Regional study on Women's unrecognized contribution to the economy

The findings and analysis of this study are based on desk review and secondary data to substantiate this growing phenomenon, especially among the female population. Further the recommendations that will be put forward in this study will be added to the literature and serve as a baseline for further study in the Caribbean region. The study is sectionalized as follows. Chapter one discusses in brief the demographics, social and economic profiles of Barbados, Dominica, Jamaica and Trinidad and Tobago. This chapter also examines the employment rate, gender and poverty, and the achievements and progress of member states as it relates to the MDGs especially goal number 3. Men are more likely to be employed in the formal sector than women, and earn higher wages and salaries in the labour market despite the fact women may have obtained tertiary level education. The literature showed that women are at home spending more time on child care and other household related responsibilities but this can still be considered employment. This chapter also addresses the achievements and progress of member states as it relates to the MDGs especially Goal 3. Chapter 2 identifies the literature review of related subjects for this study. Chapter 3 discusses the categories and type of labour activities in the informal economies in the Caribbean Region, for example, paid and unpaid work, time use, women working and their caring, responsibilities for their relatives, domestic workers being undervalued and under paid, street and market vendors, micro-enterprises the services sector and commercial sex workers. Chapter 4 examines the importance of social protection for those employed in the informal labour market and the self employed. Chapter 5 provides a preliminary analysis of the findings from this study. Chapter 6 details the preliminary conclusions and recommendations.

Ambiente data cleaning: suporte extensível, semântico e automático para análise e transformação de dados

Pós-graduação em Ciência da Computação - IBILCE

Amazônia Legal e o estado de Mato Grosso: dois ensaios sobre o processo de convergência espacial para o desmatamento

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Contraste entre o manejo pesqueiro na Orinoquia venezuelana e na Amazônia brasileira

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)