The blue-grass region of Kentucky : and other Kentucky articles /

The blue-grass region.--Uncle Tom at home.--County court day in Kentucky.--Kentucky fairs.--A home of the silent brotherhood.--Homesteads of the blue grass.--Through Cumberland gap on horseback.--Mountain passes of the Cumberland.

Spanish and French rivalry in the Gulf region of the United States, 1678-1702; the beginnings of Texas and Pensacola,

Published also as thesis (PH. D.) Columbia University, 1917.

Aerial assessment of red spruce & balsam fir condition in the Adirondack region of New York, the Green Mountains of Vermont, the White Mountains of New Hampshire, and the mountains of western Maine, 1985-1986 /

Shipping list no.: 93-0567-P.

Forest resources of the ponderosa pine region of Washington and Oregon /

Investigation conducted by the Pacific Northwest forest and range experiment station. cf. p. ii.

Seed crops of forest trees in the pine region of California /

Caption title.

Pilgrims in the region of faith: Amiel, Tolstoy, Pater, Newman; a thesis with illus.

Mode of access: Internet.

Observations on the topography of the plain of Troy; and on the principal objects within, and around it described, or alluded to, in the Iliad : shewing that the system of M. de Chevalier [i.e. Lechevalier], so long upheld, is founded on a most erroneous topography : and also, that the two sources, denominated the warm, and the cold, spring, on which his system materially rests, do not present any contrast; but are exactly alike in point of temperature; that is cold : with a map, in which the topography set forth by M. de Chevalier, is contrasted with the several statements of three other travellers in the Troad : also, a sketch of the western part of the region of Mount Ida /

Includes index.

A general introduction to Domesday book; accompanied by indexes of the tenants-in-chief, and under-tenants, at the time of the survey: as well as of the holders of lands mentioned in Domesday anterior to the formation of that record: with an abstract of the population of England at the close of the region of William the Conqueror, so far as the same is actually entered. Illustrated by numerous notes and comments.

Mode of access: Internet.

A wonderland of the East, comprising the lake and mountain region of New England and eastern New York; a book for those who love to wander among beautiful lakes and rivers, valleys and mountains, or in places made famous by historic men and events; to which is added an afterword on the worth-while in this wonderland of the East, with some suggestions to motor-tourists on how best to find it,

Colored plates accompanied by guard sheets with descriptive letterpress.

The lake region of western Vermont.

On cover: Lakes of western Vermont.

Down east latch strings; or, Seashore, lakes and mountains by the Boston & Maine Railroad. Descriptive of the tourist region of New England.

Mode of access: Internet.

Calibration procedure for a daily flow model of small watersheds with snowmelt runoff in the Green River coal region of Colorado /

Mode of access: Internet.

[Current information on federally-listed endangered and threatened species within the Southeast region of the U.S. Fish and Wildlife Service]

Title from shipping list.

Polymorphisms in the 5 '-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression

We present evidence of complex balancing regulation of HTR1B transcription by common polymorphisms in its promoter. Computational analysis of the HTR1B gene predicted that a 50 segment, spanning common DNA sequence variations, T-261G, A-161T, and -182INS/DEL-181, contained a putative functional promoter. Using a secreted alkaline phosphatase (SEAP) reporter gene system, we found that the haplotype -261G_-182INS-181_A-161 enhanced transcriptional activity 2.3-fold compared with the haplotype T-261_-182INS-181_A-161. Conversely, -161T reversed this, and the net effect when -261G and -161T were in the same haplotype (-261G_-182INS-181_-161T) was equivalent to the major haplotype (T-261_-182INS-181_A-161). Electrophoretic mobility shift experiments showed that -261G and -161T modify the binding of transcription factors (TFs): -261G generates a new AP2 binding site, while alleles A-161 and -161T exhibit different binding characteristics to AP1. T-261G and A-161T were found to be in linkage disequilibrium (LD) with G861C in a European ancestry population. Interestingly, G861C has been reported to be associated with several psychiatric disorders. Our results indicate that HTR1B is the target of substantial transcriptional genetic regulation by common haplotypes, which are in LD with the HTR1B single-nucleotide polymorphism (SNP) most commonly used in association studies.