999 resultados para PULSARS: GENERAL


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A transcript of the Condition of the State of Iowa speech by Governor Culver delivered at the State Capitol.

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A transcript of the Condition of the State of Iowa speech by Governor Culver delivered at the State Capitol.

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A transcript of the Condition of the State of Iowa speech by Governor Culver delivered at the State Capitol.

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A transcript of the Condition of the State of Iowa speech by Governor Herring delivered at the State Capitol.

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A transcript of the Condition of the State of Iowa speech by Governor Hickenlooper delivered at the State Capitol.

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A transcript of the Governor's Inaugural Address by Governor Kendell.

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A transcript of the Governor's Inaugural Address by Governor Hammill.

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A transcript of the Governor's Inaugural Address by Governor Hammill.

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A transcript of the Governor's Inaugural Address by Governor Turner.

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A transcript of the Governor's Inaugural Address by Governor Herring.

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A transcript of the Governor's Inaugural Address by Governor Herring.

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Report on a review of selected general and application controls over the Iowa State University of Science and Technology student financial aid system for the period of April 22, 2013 through May 17, 2013

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As a result of debt enforcement problems, many high-productivity firms in emergingeconomies are unable to pledge enough future profits to their creditors and this constrains thefinancing they can raise. Many have argued that, by relaxing these credit constraints, reformsthat strengthen enforcement institutions would increase capital flows to emerging economies. Thisargument is based on a partial equilibrium intuition though, which does not take into account theorigin of any additional resources that flow to high-productivity firms after the reforms. We showthat some of these resources do not come from abroad, but instead from domestic low-productivityfirms that are driven out of business as a result of the reforms. Indeed, the resources released bythese low-productivity firms could exceed those absorbed by high-productivity ones so that capitalflows to emerging economies might actually decrease following successful reforms. This resultprovides a new perspective on some recent patterns of capital flows in industrial and emergingeconomies.

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Background: The arrangement of regulatory motifs in gene promoters, or promoterarchitecture, is the result of mutation and selection processes that have operated over manymillions of years. In mammals, tissue-specific transcriptional regulation is related to the presence ofspecific protein-interacting DNA motifs in gene promoters. However, little is known about therelative location and spacing of these motifs. To fill this gap, we have performed a systematic searchfor motifs that show significant bias at specific promoter locations in a large collection ofhousekeeping and tissue-specific genes.Results: We observe that promoters driving housekeeping gene expression are enriched inparticular motifs with strong positional bias, such as YY1, which are of little relevance in promotersdriving tissue-specific expression. We also identify a large number of motifs that show positionalbias in genes expressed in a highly tissue-specific manner. They include well-known tissue-specificmotifs, such as HNF1 and HNF4 motifs in liver, kidney and small intestine, or RFX motifs in testis,as well as many potentially novel regulatory motifs. Based on this analysis, we provide predictionsfor 559 tissue-specific motifs in mouse gene promoters.Conclusion: The study shows that motif positional bias is an important feature of mammalianproximal promoters and that it affects both general and tissue-specific motifs. Motif positionalconstraints define very distinct promoter architectures depending on breadth of expression andtype of tissue.