Washington, D.C., 1839 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of the city of Washington in the District of Columbia : established as the permanent seat of the government of the United States of America, W.J. Stone sc. Wash'n. It was published ca. 1839. Scale [ca. 1:12,250]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Maryland State Plane Coordinate System Meters NAD83 (Fipszone 1900). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, block numbers, wards, selected government buildings, and more. Relief is shown by hachures. Includes indexed table of "References." This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Washington, D.C., 1840 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of the city of Washington, drawn by F.C. De Krafft, city surveyor ; eng'd by Mrs. W.I. Stone. It was published by Wm. M. Morrison in 1840. Scale [ca. 1:18,400]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Maryland State Plane Coordinate System Meters NAD83 (Fipszone 1900). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, block numbers, city wards, selected government buildings, and more. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Washington, D.C., 1855 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Colton's Georgetown and the city of Washington : the capital of the United States of America. It was published by J.H. Colton in 1855. Scale [ca. 1:25,750]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Maryland State Plane Coordinate System Meters NAD83 (Fipszone 1900). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, block numbers, city wards, built-up areas, selected government buildings, parks, and more. Includes views: Smithsonian Institution -- The Capitol -- Washington Monument. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Washington, D.C., 1933 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Base map of the District of Columbia showing railroads, main thoroughfares, alley blocks, and public (government) buildings, base prepared in the Office of the Surveyor, D.C., by direction of the Engineer Commissioner, D.C. It was published in 1936. Scale [ca. 1:19,000]. Base map "Complete to June 13, 1933." The image inside the map neatline is georeferenced to the surface of the earth and fit to the Maryland State Plane Coordinate System Meters NAD83 (Fipszone 1900). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, railroads and stations, drainage, selected public buildings and points of interest, parks, cemeteries, and more. Also shows block numbers and proposed streets. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Juvenile Delinquents, Washington, D.C., 1935 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Spot map showing residences of juvenile delinquents in the District of Columbia as of July 1, 1935. Data furnished by Juvenile Court of the District of Columbia. It was published in 1936. Scale [ca. 1:19,200]. Base map "Complete to June 13, 1933." The image inside the map neatline is georeferenced to the surface of the earth and fit to the Maryland State Plane Coordinate System Meters NAD83 (Fipszone 1900). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows location of juvenile delinquents' residences by race and sex. Shows also features such as block numbers and alley dwelling areas, roads, railroads and stations, drainage, selected public buildings and points of interest, parks, cemeteries, and more. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Zoning and Open Spaces, Washington, D.C., 1936 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Base map of the District of Columbia showing public and zoning areas, base prepared in the Office of the Surveyor, D.C., by direction of the Engineer Commissioner, D.C. It was published by Engineer Commissioner in 1936. Scale [ca. 1:19,200]. Base map "complete to June 13, 1933." The image inside the map neatline is georeferenced to the surface of the earth and fit to the Maryland State Plane Coordinate System Meters NAD83 (Fipszone 1900). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as residential areas, open spaces, commercial and industrial areas, alley dwelling areas, roads, block numbers, railroads and stations, drainage, selected public buildings and points of interest, parks, cemeteries, and more. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury.

UNLABELLED Bok (Bcl-2-related ovarian killer) is a Bcl-2 family member that, because of its predicted structural homology to Bax and Bak, has been proposed to be a pro-apoptotic protein. In this study, we demonstrate that Bok is highly expressed in neurons of the mouse brain but thatbokwas not required for staurosporine-, proteasome inhibition-, or excitotoxicity-induced apoptosis of cultured cortical neurons. On the contrary, we found thatbok-deficient neurons were more sensitive to oxygen/glucose deprivation-induced injuryin vitroand seizure-induced neuronal injuryin vivo Deletion ofbokalso increased staurosporine-, excitotoxicity-, and oxygen/glucose deprivation-induced cell death inbax-deficient neurons. Single-cell imaging demonstrated thatbok-deficient neurons failed to maintain their neuronal Ca(2+)homeostasis in response to an excitotoxic stimulus; this was accompanied by a prolonged deregulation of mitochondrial bioenergetics.bokdeficiency led to a specific reduction in neuronal Mcl-1 protein levels, and deregulation of both mitochondrial bioenergetics and Ca(2+)homeostasis was rescued by Mcl-1 overexpression. Detailed analysis of cell death pathways demonstrated the activation of poly ADP-ribose polymerase-dependent cell death inbok-deficient neurons. Collectively, our data demonstrate that Bok acts as a neuroprotective factor rather than a pro-death effector during Ca(2+)- and seizure-induced neuronal injuryin vitroandin vivo SIGNIFICANCE STATEMENT Bcl-2 proteins are essential regulators of the mitochondrial apoptosis pathway. The Bcl-2 protein Bok is highly expressed in the CNS. Because of its sequence similarity to Bax and Bak, Bok has long been considered part of the pro-apoptotic Bax-like subfamily, but no studies have yet been performed in neurons to test this hypothesis. Our study provides important new insights into the functional role of Bok during neuronal apoptosis and specifically in the setting of Ca(2+)- and seizure-mediated neuronal injury. We show that Bok controls neuronal Ca(2+)homeostasis and bioenergetics and, contrary to previous assumptions, exerts neuroprotective activitiesin vitroandin vivo Our results demonstrate that Bok cannot be placed unambiguously into the Bax-like Bcl-2 subfamily of pro-apoptotic proteins.

Fair housing in Louisville : the community development block grant program : a report /

Item 288-A

The distribution of salinity in the waters of Long Island Sound, Block Island Sound, and Newport Bight : Cruise STIRNI-III, January-February, 1952 /

"Status report no. 21, Contract N6 onr-264, Task 15, NR-#083-033, Cornell University, November 1952."

The distribution of temperature in the waters of Long Island Sound, Block Island Sound, and Newport Bight : Cruise STIRNI-III, January-February, 1952 /

Caption title.

A winter survey of oxygen distribution in Long Island Sound and Block Island Sound : Cruise STIRNI-III, January-February 1952 /

"Status report no. 24, Contract N6 onr-264, Task 15, NR-083-033, Cornell University, April 1953"

Wind turbine generator system, Block Island, Rhode Island : final environmental impact statement /

"DOE/EIS-0006; UC 11, 13, 60."

The distribution of salinity in the waters of New York Bight, Block Island Sound, and Newport Bight : Cruise STIRNI I, July-September, 1951 /

Caption title.

Software tools : a building block approach /

"Partially sponsored by The National Science Foundation ... " -t.p.

...Annual report of block signals, automatic train control, and the use of train orders.

The 1st-3d are pub. also, without illus. or appendixes, in the 22d-24th annual reports of the Interstate Commerce Commission.