J. R. Tengström

Z. Topeliuksen kokoelman kuva

Dikter [1]

Helsingfors : G. O. Wasenius 1830

Sommarnäs : J. Knutson fec.

Sommarnäs eli Sominainen on kartano Orimattilassa

Ilo-laulu Jesuxesta

Turku : Johan Winter 1690

Kuvaus Tampereen kaupungista pohjoispuolelta : pinx. J. Knutson

Helsingfors : K.E. Holm 1885, A. Weger

Fänrik Ståls sägner

Helsingfors : G. W. Edlund 1883 : Stockholm, Central-tryckeriet

Icones novae. [A]

Aboae : [Johan Larsson Wall] 1683

Yxinkertainen puhe, pidetty Kärkölän kirkon mäellä...

Turku : Johan Christopher Frenckell 1772

Vänrikki Stoolin tarinat - [Kansi]

Kuvat piirtänyt Albert Edelfelt. - Kirja ilmestyi 10 vihkona

Orbis sensualium pictus

Tshekki J. A. Comenius (Komenský) julkaisi 1680 käänteentekevän oppikirjan, jossa latinaa opetettiin kuvien avulla, Suomessa kirja ilmestyi 1684-1698 useina painoksina piispa Johannes Gezeliuksen kustantamana. - Osa kirjan kuvista väritetty myöhemmin.

Safety profile of prasugrel and clopidogrel in patients with acute coronary syndromes in Switzerland.

OBJECTIVE: To assess safety up to 1 year of follow-up associated with prasugrel and clopidogrel use in a prospective cohort of patients with acute coronary syndromes (ACS). METHODS: Between 2009 and 2012, 2286 patients invasively managed for ACS were enrolled in the multicentre Swiss ACS Bleeding Cohort, among whom 2148 patients received either prasugrel or clopidogrel according to current guidelines. Patients with ST-elevation myocardial infarction (STEMI) preferentially received prasugrel, while those with non-STEMI, a history of stroke or transient ischaemic attack, age ≥75 years, or weight <60 kg received clopidogrel or reduced dose of prasugrel to comply with the prasugrel label. RESULTS: After adjustment using propensity scores, the primary end point of clinically relevant bleeding events (defined as the composite of Bleeding Academic Research Consortium, BARC, type 3, 4 or 5 bleeding) at 1 year, occurred at a similar rate in both patient groups (prasugrel/clopidogrel: 3.8%/5.5%). Stratified analyses in subgroups including patients with STEMI yielded a similar safety profile. After adjusting for baseline variables, no relevant differences in major adverse cardiovascular and cerebrovascular events were observed at 1 year (prasugrel/clopidogrel: cardiac death 2.6%/4.2%, myocardial infarction 2.7%/3.8%, revascularisation 5.9%/6.7%, stroke 1.0%/1.6%). Of note, this study was not designed to compare efficacy between prasugrel and clopidogrel. CONCLUSIONS: In this large prospective ACS cohort, patients treated with prasugrel according to current guidelines (ie, in patients without cerebrovascular disease, old age or underweight) had a similar safety profile compared with patients treated with clopidogrel. CLINICAL TRIAL REGISTRATION NUMBER: SPUM-ACS: NCT01000701; COMFORTABLE AMI: NCT00962416.