James Kwast, Brustbild

Signatur des Originals: S 36/G01337

Mle. Lescot, Reçu͏̈e à la Comedie Italienne en 1780

Signatur des Originals: S 36/G01423

James Smith, Ganzfigurbildnis

Signatur des Originals: S 36/G02262

View of the Orchesta Organ in Westminster Abbey under the Direction of Mr. James Wyatt, for the Commemoration of Handel

Signatur des Originals: S 36/G02677

James Bartleman, Brustbild, Profil

Signatur des Originals: S 36/G02742

James Cook, Brustbild, Profil - James King, Brustbild

Signatur des Originals: S 36/G02908

An Inside View of the Pantheon exhibiting their Majesties Box & c. as fitted up under the direction of Mr. James Wyatt, for the Commemoration of Handel.

Signatur des Originals: S 36/G03858

James Bartleman, Brustbild

Signatur des Originals: S 36/G03906

Fanny Cerrito als Sylphide, Gustave Carey als James Reuben, Rollenbild, Doppelbildnis, in: Jean-Madeleine Schweitzhoeffer: La Sylphide

Signatur des Originals: S 36/G04001

Travels and researches among the lakes and mountains of Eastern & Central Africa : from the journals of the late James Frederick Elton

from the journals of the late J. Frederick Elton, F.R.G.S., H.B.M. Consul at Mozambique ; edited and compiled by H.B. Cotterill

"Die Familie Mozart" von J. N. della Croce, 1780/81

Signatur des Originals: S 36/F12453

Aristote amoureux : ou le philosophe bridé ; opéra-comique, en un acte & en Vaudeville ; représenté pour la première fois par les Comédiens Italiens ordinaires du Roi, le vendredi 22 août 1780

[Musique de Pierre-Antoine-Augustin de Piis. Texte de Pierre Yon Barré]

The installation sermon of the very Rev. Dr. Joseph Herman Hertz : Chief rabbi of the United Hebrew Congregations of the British Empire ; Monday, April 14th, 5673-1913 ; at the Great Synagogue London

Digitalisiert in Kooperation mit dem YIVO Institute for Jewish Research am Center for Jewish History, NY

Clinical relevance of polymorphic DNA copy number variation (CNV) in African American women with stage I-II breast cancer

Objectives. The chief goal of this study was to analyze copy number variation (CNV) in breast cancer tumors from 25 African American women with early stage breast cancer (BC) using molecular inversion probes (MIP) in order to: (1) compare the degree of CNV in tumors compared to normal lymph nodes, and (2) determine whether gains and/or losses of genes in specific chromosomes differ between pathologic subtypes of breast cancer defined by known prognostic markers, (3) determine whether gains/losses in CN are associated with known oncogenes or tumor suppressor genes, and (4) determine whether increased gains/losses in CN for specific chromosomes were associated with differences in breast cancer recurrence. ^ Methods. Twenty to 37 nanograms of DNA extracted from 25 formalin-fixed paraffin embedded (FFPE) tumor samples and matched normal lymph nodes were added to individual tubes. Oligonucleotide probes with recognition sequences at each terminus were hybridized with a genomic target sequence to form a circular structure. Probes are released from genomic DNA obtained from FFPE samples, and those which have been correctly "circularized" in the proper allele/nucleotide reaction combination are amplified using polymerase chain reaction (PCR) primers. Amplicons were fluorescently labeled and the tag sequences released from the genome homology regions by treatment with uracil-N-glycosylase to cleave the probe at the site where uracils are present, and detected using a complementary tag array developed by Affymetrix. ^ Results. Analysis of CN gains and losses from tumors and normal tissues showed marked differences in tumors with numerous chromosomes affected. Similar changes were not observed in normal lymph nodes. When tumors were stratified into four groups based on expression or lack of expression of the estrogen receptor and HER2/neu, distinct patterns of CNV for different chromosomes were observed. Gains or losses in CN for specific chromosomes correlated with amplifications/deletions of particular oncogenes or tumor suppressor genes (i.e. such as found on chromosome 17) known to be associated with aggressive tumor phenotype and poor prognosis. There was a trend for increases in CN observed for chromosome 17 to correlate inversely with time to recurrence of BC (p=0.14 for trend). CNV was also observed for chromosomes 5, 8, 10, 11, and 16, which are known sites for several breast cancer susceptibility alleles. ^ Conclusions. This study is the first to validate the MIP technique, to correlate differences in gene expression with known prognostic tumor markers, and to correlate significant increases/decreases in CN with known tumor markers associated with prognosis. The results of this study may have far reaching public health implications towards identifying new high-risk groups based on genomic differences in CNP, both with respect to prognosis and response to therapy, and to eventually identify new therapeutic targets for prevention and treatment of this disease. ^

Perceptions of chief executives of Texas Catholic health care institutions regarding the poor and the provision of Catholic health care

Perceptions of chief executive officers (CEOs) of Texas Catholic health care institutions regarding the poor and the provision of Catholic health care were the focus for this study. A total of 40 health care administrators were asked to participate in a survey. Thirty-seven CEOs responded, including seven religious superiors, six health system CEOs and 24 hospital CEOs. Survey items concerning Catholic health for the poor centered on obligations and responsibilities of Catholic hospitals, means of achieving those obligations, and assessment of whether hospitals' objectives were being met. In addition, respondents' attitudes and beliefs about poor people in general were examined. Independent variables were CEO type, gender, religious preference, member of a religious order, and educational preparation. For purposes of analysis, most survey items were classified by level of consensus exhibited by respondents. The respondents to this survey agreed on most issues concerning poor people and the provision of Catholic health care. However, there were areas of disagreement particularly in Part I of the survey which dealt with responsibility/obligation, means/methods, and assessment of health care delivery for the poor. ^