High prevalence of HIV-1 and hepatitis C virus coinfection among injection drug users in the southeastern region of Yunnan, China

The southeastern region of Yunnan province is a key site for drug trafficking and HIV-1 infection spread from the west of Yunnan and Laos to southeastern China. To investigate the prevalence of HIV-1 infection and hepatitis C virus (HCV) coinfection among injection drug users (IDUs) in southeastern Yunnan, three cohorts of 285 addicts, including 242 IDUs and 43 oral drug users, living in the cities of Gejiu and Kaiyuan and the county of Yanshan were studied. HIV-1 and HCV infections were detected by enzyme-linked immunosorbent assay and/or polymerase chain reaction. Data on the age, sex, risk behavior, drug use history, employment, ethnic background, and marriage status were obtained by interview. The overall prevalence of HIV-1 infection was 71.9%. The rate of HCV coinfection among 138 HIV-1-infected IDUs was 99.3%. Most HIV-infected IDUs were 20 to 35 years old (86.7%) and were ethnic Han (75.9%), suggesting that the epidemic in Yunnan is no longer confined to non-Han ethnic minorities, HIV prevalence in female IDUs (81.2%) was significantly higher than in male IDUs (68.2%) (p <.05). The prevalence of HIV infection reached 68.4% after 1 year of injection drug use. Needle/syringe sharing is the major high risk factor for the spread of HIV-1 and HCV infections. Large-scale educational campaigns are urgently needed to reduce the spread of HIV and HCV infection in these regions.

Spatial correlation of heat release rate and sound emission from turbulent premixed flames

The two-point spatial correlation of the rate of change of fluctuating heat release rate is central to the sound emission from open turbulent flames, and a few attempts have been made to address this correlation in recent studies. In this paper, the two-point correlation and its role in combustion noise are studied by analysing direct numerical simulation (DNS) data of statistically multi-dimensional turbulent premixed flames. The results suggest that this correlation function depends on the separation distance and direction but, not on the positions inside the flame brush. This correlation can be modelled using a combination of Hermite-Gaussian functions of zero and second order, i.e. functions of the form (1-Ax2)e-Bx2 for constants A and B, to include its possible negative values. The integral correlation volume obtained using this model is about 0.2δL3 with the length scale obtained from its cube root being about 0.6δ L, where δ L is the laminar flame thermal thickness. Both of the values are slightly larger than the values reported in an earlier study because of the anisotropy observed for the correlation. This model together with the turbulence-dependent parameter K, the ratio of the root-mean-square (RMS) value of the rate of change of reaction rate to the mean reaction rate, derived from the DNS data is applied to predict the far-field sound emitted from open flames. The calculated noise levels agree well with recently reported measurements and show a sensitivity to K values. © 2012 The Combustion Institute.

Shape vs. volume: Invariant shape descriptors for 3D region of interest characterization in MRI

We propose a new approach for quantifying regions of interest (ROIs) in medical image data. Rotationally invariant shape descriptors (ISDs) were applied to 3D brain regions extracted from MRI scans of 5 Parkinson's patients and 10 control subjects. We concentrated on the thalamus and the caudate nucleus since prior studies have suggested they are affected in Parkinson's disease (PD). In the caudate, both the ISD and volumetric analyses found significant differences between control and PD subjects. The ISD analysis however revealed additional differences between the left and right caudate nuclei in both control and PD subjects. In the thalamus, the volumetric analysis showed significant differences between PD and control subjects, while ISD analysis found significant differences between the left and right thalami in control subjects but not in PD patients, implying disease-induced shape changes. These results suggest that employing ISDs for ROI characterization both complements and extends traditional volumetric analyses. © 2006 IEEE.

Effects of Boundary Layer Ingestion on the Aero-Acoustics of Transonic Fan Rotors

The use of boundary-layer-ingesting, embedded propulsion systems can result in inlet flow distortions where the interaction of the boundary layer vorticity and the inlet lip causes horseshoe vortex formation and the ingestion of streamwise vortices into the inlet. A previously-developed body-force-based fan modeling approach was used to assess the change in fan rotor shock noise generation and propagation in a boundary-layer-ingesting, serpentine inlet. This approach is employed here in a parametric study to assess the effects of inlet geometry parameters (offset-to-diameter ratio and downstream-to-upstream area ratio) on flow distortion and rotor shock noise. Mechanisms related to the vortical inlet structures were found to govern changes in the rotor shock noise generation and propagation. The vortex whose circulation is in the opposite direction to the fan rotation (counter-swirling vortex) increases incidence angles on the fan blades near the tip, enhancing noise generation. The vortex with circulation in the direction of fan rotation (co-swirling vortex) creates a region of subsonic relative flow near the blade tip radius which decreases the sound power propagated to the far-field. The parametric study revealed that the overall sound power level at the fan leading edge is set by the ingested streamwise circulation, and that for inlet designs in which the streamwise vortices are displaced away from the duct wall, the sound power at the upstream inlet plane increased by as much as 9 dB. By comparing the far-field noise results obtained to those for a conventional inlet, it is deduced that the changes in rotor shock noise are predominantly due to the ingestion of streamwise vorticity.

Effects of Boundary Layer Ingestion on the Aero-Acoustics of Transonic Fan Rotors

The use of boundary-layer-ingesting, embedded propulsion systems can result in inlet flow distortions where the interaction of the boundary layer vorticity and the inlet lip causes horseshoe vortex formation and the ingestion of streamwise vortices into the inlet. A previously-developed body-force-based fan modeling approach was used to assess the change in fan rotor shock noise generation and propagation in a boundary-layer-ingesting, serpentine inlet. This approach is employed here in a parametric study to assess the effects of inlet geometry parameters (offset-to-diameter ratio and downstream-to-upstream area ratio) on flow distortion and rotor shock noise. Mechanisms related to the vortical inlet structures were found to govern changes in the rotor shock noise generation and propagation. The vortex whose circulation is in the opposite direction to the fan rotation (counter-swirling vortex) increases incidence angles on the fan blades near the tip, enhancing noise generation. The vortex with circulation in the direction of fan rotation (co-swirling vortex) creates a region of subsonic relative flow near the blade tip radius which decreases the sound power propagated to the far-field. The parametric study revealed that the overall sound power level at the fan leading edge is set by the ingested streamwise circulation, and that for inlet designs in which the streamwise vortices are displaced away from the duct wall, the sound power at the upstream inlet plane increased by as much as 9 dB. By comparing the far-field noise results obtained to those for a conventional inlet, it is deduced that the changes in rotor shock noise are predominantly due to the ingestion of streamwise vorticity.

Review of computational aeroacoustics for application in electronics cooler noise

A review of computational aeroacoustics (CCA) was made for application in electronics cooler noise. Computational aeroacoustics encompasses all numerical methods where the purposes is to predict the noise emissions from a simulated flow. Numerical simulation of the flow inside and around heat sinks and fans can lead to a prediction of the emitted noise while they are still in the design phase. Direct CCA is theoretically the best way to predict flow-based acoustic phenomena numerically. It is typically used only for low-frequency sound prediction. The boundary element method offers low computational cost and does not use a computational grid, but instead use vortex-surface calculations to determine tonal noise. Axial fans are commonly used to increase the airflow and thus the heat transfer over the heat sinks within the computer cases. Very detailed source simulations in the fan and heat sink region coupled with the use of analogy methods could result in excellent simulation results with a reasonable computational effort.